DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Chemical Research in Toxicology

Volumn 29, Issue 3, 2016, Pages 380-389

  Zarth, Adam T ^a,b   Upadhyaya, Pramod ^a   Yang, Jing ^a   Hecht, Stephen S ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; DRINKING WATER; ENZYME; NITROSONORNICOTINE; CYTOCHROME P450; DNA ADDUCT; N'-NITROSONORNICOTINE; NITROSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TEMPERATURE; LIVER; LIVER CELL; LUNG; METABOLISM; NONHUMAN; NOSE CAVITY; RAT; TISSUE DISTRIBUTION; TOBACCO; ADOLESCENT; ADULT; AGED; ANIMAL; CHEMISTRY; CHILD; FEMALE; MALE; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOGENS; CHILD; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; FEMALE; HUMANS; HYDROXYLATION; MALE; MIDDLE AGED; NITROSAMINES; RATS; TOBACCO; YOUNG ADULT;

EID: 84961725619     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00520     Document Type: Article

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