Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer

Cancer Letters

Volumn 376, Issue 1, 2016, Pages 62-73

  Zhang, Zheying ^a,b   Zhou, Chang ^c   Chang, Yaya ^a   Zhang, Zuoyang ^a   Hu, Yuhan ^a   Zhang, Fan ^a   Lu, Yanxia ^a   Zheng, Lin ^a   Zhang, Wenjuan ^a   Li, Xiaomin ^a   Li, Xuenong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

CASC11; Colorectal cancer; HnRNP K; LncRNA; catenin

Indexed keywords

BETA CATENIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; LONG UNTRANSLATED RNA; WNT PROTEIN; CTNNB1 PROTEIN, HUMAN; HISTONE; LONG NONCODING RNA CASC11, HUMAN; MYC PROTEIN; MYC PROTEIN, HUMAN; PROTEIN BINDING; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER STAGING; CASC11 GENE; CELL PROLIFERATION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; GENE; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LYMPH NODE METASTASIS; MALE; METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN RNA BINDING; TRANSCRIPTION REGULATION; TUMOR INVASION; TUMOR VOLUME; UPREGULATION; ACETYLATION; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL MOTION; COLORECTAL TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; HT-29 CELL LINE; METABOLISM; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; TIME FACTOR; WNT SIGNALING PATHWAY; XENOGRAFT;

ACETYLATION; ANIMALS; BETA CATENIN; BIOMARKERS, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HEK293 CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K; HETEROGRAFTS; HISTONES; HT29 CELLS; HUMANS; MALE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOPLASM TRANSPLANTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, LONG NONCODING; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 84961696345     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.03.022     Document Type: Article

References (48)

1. Hajjari M., Salavaty A. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol. Med 2015, 12:1-9.
2. Gutschner T., Hammerle M., Eissmann M., Hsu J., Kim Y., Hung G., et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 2013, 73:1180-1189.
3. Petrovics G., Zhang W., Makarem M., Street J.P., Connelly R., Sun L., et al. Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Oncogene 2004, 23:605-611.
4. Han D., Wang M., Ma N., Xu Y., Jiang Y., Gao X. Long noncoding RNAs: novel players in colorectal cancer. Cancer Lett 2015, 361:13-21.
5. Prensner J.R., Iyer M.K., Sahu A., Asangani I.A., Cao Q., Patel L., et al. The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat. Genet 2013, 45:1392-1398.
6. Kotake Y., Nakagawa T., Kitagawa K., Suzuki S., Liu N., Kitagawa M., et al. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene 2011, 30:1956-1962.
7. Prensner J.R., Chen W., Iyer M.K., Cao Q., Ma T., Han S., et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 2014, 74:1651-1660.
8. Huarte M., Guttman M., Feldser D., Garber M., Koziol M.J., Kenzelmann-Broz D., et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010, 142:409-419.
9. Tseng Y.Y., Moriarity B.S., Gong W., Akiyama R., Tiwari A., Kawakami H., et al. PVT1 dependence in cancer with MYC copy-number increase. Nature 2014, 512:82-86.
10. Ling H., Spizzo R., Atlasi Y., Nicoloso M., Shimizu M., Redis R.S., et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 2013, 23:1446-1461.
11. Yang F., Xue X., Bi J., Zheng L., Zhi K., Gu Y., et al. Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J. Cancer Res. Clin. Oncol 2013, 139:437-445.
12. Riquelme E., Suraokar M.B., Rodriguez J., Mino B., Lin H.Y., Rice D.C., et al. Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. J. Thorac. Oncol 2014, 9:998-1007.
13. Guttman M., Amit I., Garber M., French C., Lin M.F., Feldser D., et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009, 458:223-227.
14. Ponjavic J., Oliver P.L., Lunter G., Ponting C.P. Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet 2009, 5:e1000617.
15. Kiemeney L.A., Thorlacius S., Sulem P., Geller F., Aben K.K., Stacey S.N., et al. Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat. Genet 2008, 40:1307-1312.
16. Morton L.M., Purdue M.P., Zheng T., Wang S.S., Armstrong B., Zhang Y., et al. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. Cancer Epidemiol. Biomarkers Prev 2009, 18:1259-1270.
17. Zhou C., Liu G., Wang L., Lu Y., Yuan L., Zheng L., et al. MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1. PLoS ONE 2013, 8:e63142.
18. Lu Y.X., Yuan L., Xue X.L., Zhou M., Liu Y., Zhang C., et al. Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism. Clin. Cancer Res 2014, 20:2631-2642.
19. Wang Z., Wang L., Hu J., Fan R., Zhou J., Wang L., et al. RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer. Am. J. Cancer Res 2015, 5:1988-1999.
20. Yuan L., Zhou C., Lu Y., Hong M., Zhang Z., Zhang Z., et al. IFN-gamma-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1. Cancer Lett 2015, 359:136-147.
21. Salzman J., Gawad C., Wang P.L., Lacayo N., Brown P.O. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE 2012, 7:e30733.
22. Rinn J.L., Kertesz M., Wang J.K., Squazzo S.L., Xu X., Brugmann S.A., et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007, 129:1311-1323.
23. Liu X., Li D., Zhang W., Guo M., Zhan Q. Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay. EMBO J. 2012, 31:4415-4427.
24. Bomsztyk K., Denisenko O., Ostrowski J. hnRNP K: one protein multiple processes. Bioessays 2004, 26:629-638.
25. Bomsztyk K., Van Seuningen I., Suzuki H., Denisenko O., Ostrowski J. Diverse molecular interactions of the hnRNP K protein. FEBS Lett 1997, 403:113-115.
26. Loayza-Puch F., Agami R. Lncing protein translation to metastasis. EMBO J. 2013, 32:2657-2658.
27. Yang F., Xue X., Zheng L., Bi J., Zhou Y., Zhi K., et al. Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J. 2014, 281:802-813.
28. Barboro P., Ferrari N., Balbi C. Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression. Cancer Lett 2014, 352:152-159.
29. Yang G., Biswasa C., Lin Q.S., La P., Namba F., Zhuang T., et al. Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: role of beta-catenin/hnRNPK signaling. Redox Biol 2013, 1:234-243.
30. Clevers H., Nusse R. Wnt/beta-catenin signaling and disease. Cell 2012, 149:1192-1205.
31. Fu Y., Zheng S., An N., Athanasopoulos T., Popplewell L., Liang A., et al. beta-catenin as a potential key target for tumor suppression. Int. J. Cancer 2011, 129:1541-1551.
32. Barsyte-Lovejoy D., Lau S.K., Boutros P.C., Khosravi F., Jurisica I., Andrulis I.L., et al. The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res 2006, 66:5330-5337.
33. Wapinski O., Chang H.Y. Long noncoding RNAs and human disease. Trends Cell Biol 2011, 21:354-361.
34. Kim T., Cui R., Jeon Y.J., Lee J.H., Lee J.H., Sim H., et al. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:4173-4178.
35. McCleland M.L., Mesh K., Lorenzana E., Chopra V.S., Segal E., Watanabe C., et al. CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J. Clin. Invest 2016, 126:639-652.
36. Xiang J.F., Yin Q.F., Chen T., Zhang Y., Zhang X.O., Wu Z., et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res 2014, 24:513-531.
37. Zhu H.Q., Zhou X., Chang H., Li H.G., Liu F.F., Ma C.Q., et al. Aberrant expression of CCAT1 regulated by c-Myc predicts the prognosis of hepatocellular carcinoma. Asian Pac. J. Cancer Prev 2015, 16:5181-5185.
38. Prensner J.R., Chen W., Han S., Iyer M.K., Cao Q., Kothari V., et al. The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through c-Myc. Neoplasia 2014, 16:900-908.
39. Rinn J.L., Chang H.Y. Genome regulation by long noncoding RNAs. Annu. Rev. Biochem 2012, 81:145-166.
40. Carrieri C., Cimatti L., Biagioli M., Beugnet A., Zucchelli S., Fedele S., et al. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature 2012, 491:454-457.
41. Kretz M. TINCR, staufen1, and cellular differentiation. RNA Biol 2013, 10:1597-1601.
42. Yoon J.H., Abdelmohsen K., Srikantan S., Yang X., Martindale J.L., De S., et al. LincRNA-p21 suppresses target mRNA translation. Mol. Cell 2012, 47:648-655.
43. Yoon J.H., Abdelmohsen K., Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. J. Mol. Biol 2013, 425:3723-3730.
44. Faghihi M.A., Modarresi F., Khalil A.M., Wood D.E., Sahagan B.G., Morgan T.E., et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat. Med 2008, 14:723-730.
45. Sebio A., Kahn M., Lenz H.J. The potential of targeting Wnt/beta-catenin in colon cancer. Expert Opin. Ther. Targets 2014, 18:611-615.
46. Fu Y., Huang B., Shi Z., Han J., Wang Y., Huangfu J., et al. SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing beta-catenin biosynthesis. EMBO Mol. Med 2013, 5:737-750.
47. He X., Tan X., Wang X., Jin H., Liu L., Ma L., et al. C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumor Biol 2014, 35:12181-12188.
48. Gil J., Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell Biol 2006, 7:667-677.