Relationship between 5-HTTLPR polymorphism and post-stroke depression

Genetics and Molecular Research

Volumn 15, Issue 1, 2016, Pages

  Guo, W Y ^a   Zhang, Z H ^a   Mu, J L ^a   Liu, D ^a   Zhao, L ^a   Yao, Z Y ^a   Song, J G ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

5 HT transporter gene linked polymorphic region; Gene polymorphism; Post stroke depression; Stroke

Indexed keywords

5 HTTLPR GENE; AGED; ALLELE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DSM-IV; FEMALE; GENE; GENE AMPLIFICATION; GENE CONTROL; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOTYPE; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; POST STROKE DEPRESSION; ASIAN CONTINENTAL ANCESTRY GROUP; COMPLICATION; DEPRESSION; DNA SEQUENCE; ETHNOLOGY; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; STROKE;

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; DEPRESSION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STROKE;

EID: 84961695920     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/gmr.15017460     Document Type: Article

References (23)

1. Bilge C, Koçer E, Koçer A and Türk Börü U (2008). Depression and functional outcome after stroke: the effect of antidepressant therapy on functional recovery. Eur. J. Phys. Rehabil. Med. 44: 13-18.
2. Brummett BH, Siegler IC, Ashley-Koch A and Williams RB (2011). Effects of 5HTTLPR on cardiovascular response to an emotional stressor. Psychosom. Med. 73: 318-322. http: //dx. doi. org/10. 1097/PSY. 0b013e3182118c16
3. Choi-Kwon S, Han K, Choi S, Suh M, et al. (2012). Poststroke depression and emotional incontinence: factors related to acute and subacute stages. Neurology 78: 1130-1137. http: //dx. doi. org/10. 1212/WNL. 0b013e31824f8090
4. Cole J, Weinberger DR, Mattay VS, Cheng X, et al. (2011). No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes Brain Behav. 10: 756-764. http: //dx. doi. org/10. 1111/j. 1601-183X. 2011. 00714. x
5. Fang J and Cheng Q (2009). Etiological mechanisms of post-stroke depression: a review. Neurol. Res. 31: 904-909. http: // dx. doi. org/10. 1179/174313209X385752
6. Fang J, Yan W, Jiang GX, Li W, et al. (2011). Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study. Stroke 42: 1461-1463. http: //dx. doi. org/10. 1161/STROKEAHA. 110. 598672
7. Goenjian AK, Bailey JN, Walling DP, Steinberg AM, et al. (2012). Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. J. Affect. Disord. 140: 244-252.
8. Gonda X, Fountoulakis KN, Rihmer Z, Lazary J, et al. (2009). Towards a genetically validated new affective temperament scale: a delineation of the temperament phenotype of 5-HTTLPR using the TEMPS-A. J. Affect. Disord. 112: 19-29. http: //dx. doi. org/10. 1016/j. jad. 2008. 03. 012
9. Grabe HJ, Spitzer C, Schwahn C, Marcinek A, et al. (2009). Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. Am. J. Psychiatry 166: 926-933. http: // dx. doi. org/10. 1176/appi. ajp. 2009. 08101542
10. Hackett ML, Carter G, Crimmins D, Clarke T, et al. (2010). imProving Outcomes after STroke (POST): results from the randomized clinical pilot trial. Int. J. Stroke 5: 52-56. http: //dx. doi. org/10. 1111/j. 1747-4949. 2009. 00388. x
11. Iversen L (2006). Neurotransmitter transporters and their impact on the development of psychopharmacology. Br. J. Pharmacol. 147 (Suppl 1): S82-S88. http: //dx. doi. org/10. 1038/sj. bjp. 0706428
12. Kim JM, Stewart R, Bae KY, Kim SW, et al. (2012). Serotonergic and BDNF genes and risk of depression after stroke. J. Affect. Disord. 136: 833-840. http: //dx. doi. org/10. 1016/j. jad. 2011. 09. 029
13. Kolassa IT, Ertl V, Eckart C, Glöckner F, et al. (2010). Association study of trauma load and SLC6A4 promoter polymorphism in posttraumatic stress disorder: evidence from survivors of the Rwandan genocide. J. Clin. Psychiatry 71: 543-547. http: // dx. doi. org/10. 4088/JCP. 08m04787blu
14. Lasky-Su JA, Faraone SV, Glatt SJ and Tsuang MT (2005). Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 133B: 110-115. http: //dx. doi. org/10. 1002/ajmg. b. 30104
15. Lee JH, Kim HT and Hyun DS (2003). Possible association between serotonin transporter promoter region polymorphism and impulsivity in Koreans. Psychiatry Res. 118: 19-24. http: //dx. doi. org/10. 1016/S0165-1781(03)00065-9
16. Lee HJ, Lee MS, Kang RH, Kim H, et al. (2005). Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress. Anxiety 21: 135-139. http: //dx. doi. org/10. 1002/da. 20064
17. Mak KK, Kong WY, Mak A, Sharma VK, et al. (2013). Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis. J. Neurol. Neurosurg. Psychiatry 84: 322-328. http: //dx. doi. org/10. 1136/jnnp-2012-303791
18. Marazziti D, Baroni S, Picchetti M, Piccinni A, et al. (2013). New developments on the serotonin hypothesis of depression: shunt of tryptophan. Riv. Psichiatr. 48: 23-34.
19. Niedermaier N, Bohrer E, Schulte K, Schlattmann P, et al. (2004). Prevention and treatment of poststroke depression with mirtazapine in patients with acute stroke. J. Clin. Psychiatry 65: 1619-1623. http: //dx. doi. org/10. 4088/JCP. v65n1206
20. Ramasubbu R, Tobias R and Bech-Hansen NT (2008). Extended evaluation of serotonin transporter gene functional polymorphisms in subjects with post-stroke depression. Can. J. Psychiatry 53: 197-201.
21. Rasmussen A, Lunde M, Poulsen DL, Sørensen K, et al. (2003). A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 44: 216-221. http: //dx. doi. org/10. 1176/appi. psy. 44. 3. 216
22. Robinson RG, Jorge RE, Moser DJ, Acion L, et al. (2008). Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA 299: 2391-2400. http: //dx. doi. org/10. 1001/jama. 299. 20. 2391
23. Paolucci S (2008). Epidemiology and treatment of post-stroke depression. Neuropsychiatr. Dis. Treat. 4: 145-154.