Effects of 5HTTLPR on cardiovascular response to an emotional stressor

Psychosomatic Medicine

Volumn 73, Issue 4, 2011, Pages 318-322

  Brummett, Beverly H ^a   Siegler, Ilene C ^a   Ashley Koch, Allison ^a   Williams, Redford B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cardiovascular reactivity; caregiving; emotion recall; Serotonin transporter gene promoter

Indexed keywords

SEROTONIN TRANSPORTER; SEROTONIN TRANSPORTER GENE PROMOTER; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; EMOTIONAL STRESS; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEART RATE REACTIVITY; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

AFRICAN AMERICANS; ALLELES; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CAREGIVERS; EMOTIONS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART RATE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIOECONOMIC FACTORS; STRESS, PSYCHOLOGICAL;

EID: 79955876558     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3182118c16     Document Type: Article

References (35)

1. Treiber FA, Kamarck T, Schneiderman N, Sheffield D, Kapuku G, Taylor T. Cardiovascular reactivity and development of preclinical and clinical disease states. Psychosom Med 2003;65:46-62. (Pubitemid 36143196)
2. Barnett PA, Spence JD, Manuck SB, Jenninngs JR. Psychological stress and the progression of carotid artery disease. J Hypertens 1997;15:49-55. (Pubitemid 27075986)
3. Everson SA, Lynch JW, Kaplan GA, Lakka TA, Sivenius J, Salonen JT. Stress-induced blood pressure reactivity and incident stroke in middle-aged men. Stroke 2001; 32:1263-70.
4. Moan A, Nordby G, Rostrup M, Eide I, Kjeldsen SE. Insulin sensitivity, sympathetic activity, and cardiovascular reactivity in young men. Am J Hypertens 1995;8:268-75.
5. Burker EJ, Fredrikson M, Rifai N, Siegel W, Blumenthal JA. Serum lipids, neuroendocrine, and cardiovascular responses to stress in men and women with mild hypertension. Behav Med 1994;19:155-61. (Pubitemid 24127749)
6. Matthews KA, Zhu S, Tucker DC, Whooley MA. Blood pressure reactivity to psychological stress and coronary calcification in the coronary artery risk development in young adults study. Hypertension 2006;47:391-5. (Pubitemid 43740280)
7. Boomsma DI, Snieder H, de Geus EJ, van Doornen LJ. Heritability of blood pressure increases during mental stress. Twin Res 1998;1:15-24. (Pubitemid 128560426)
8. Uemura K, Kohara K, Nakura J, Miki T. Deletion polymorphism of the ACE gene is associated with higher blood pressure after hospitalization in normotensive subjects. Hypertens Res 2000;23:201-5. (Pubitemid 30326247)
9. Whitaker-Azmitia PM, Peroutka SJ. The neuropharmacology of serotonin. Ann NY Acad Sci 1990;600:ix.
10. Dinan TG. Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life Sci 1996;58:1683-94. (Pubitemid 26147104)
11. Lowry CA. Functional subsets of serotontergic neurons: implications for control of the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol 2002;14:911-23. (Pubitemid 35378709)
12. Williams RB. Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosom Med 1994;56:308-15. (Pubitemid 24233890)
13. Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M, Suarez EC, Clary GL, Svenson IK, Siegler IC. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med 2001;63: 300-5. (Pubitemid 32249955)
14. Williams RB, Marchuk DA, Siegler IC, Barefoot JC, Helms MJ, Brummett BH, Surwit RS, Lane JD, Kuhn CM, Gadde KM, Ashley-Koch A, Svenson IK, Schanberg SM. Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. Psychosom Med 2008;70:32-9.
15. Arinami T, Ohtsuki T, Yamakawa-Kobayashi K, Amemiya H, Fujiwara H, Kawata K, Ishiguro H, Hamaguchi H. A synergistic effect of serotonin transporter gene polymorphism and smoking in association with CHD. Thromb Haemost 1999;81:853-6. (Pubitemid 29312695)
16. Fumeron F, Betoulle D, Nicaud V, Evans A, Kee F, Ruidavets JB, Arveiler D, Luc G, Cambien F. Serotonin transporter gene polymorphism and myocar-dial infarction. Circulation 2002;105:2943-5.
17. Coto E, Reguero JR, Alvarez V, Morales B, Batalla A, Gonzalez P, Martin M, Garcia-Castro M, Iglesias-Cubero G, Cortina A. 5-Hytroxytrptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction. Clin Sci 2003;104:241-5. (Pubitemid 36308169)
18. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Traubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006;78:815-26.
19. Schulz R, O'Brien AT, Bookwala J, Fleissner K. Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates, and causes. Gerontologist 1995;35:771-91.
20. Baumgarten M, Battista RN, Infante-Rivard C, Hanley JA, Becker R, Gauthier S. The psychological and physical health of family members caring for an elderly person with dementia. J Clin Epidemiol 1992;45: 61-70.
21. Kiecolt-Glaser JK, Dura JR, Speicher CE, Trask J, Glaser R. Spousal caregivers of dementia victims: longitudinal changes in immunity and health. Psychosom Med 1991;53:345-62.
22. Vitaliano PP, Russo J, Niaura R. Plasma lipids and their relationships with psychosocial factors in older adults. J Gerontol B Psychol Soc Sci 1995;50:P18-24.
23. Schulz R, Beach SR. Caregiving as a risk factor for mortality: the caregiver health effects study. JAMA 1999;282:2215-9. (Pubitemid 30002964)
24. Brummett BH, Siegler IC, Rohe WM, Barefoot JC, Vitaliano PP, Surwit RS, Feinglos MN, Williams RB. Neighborhood characteristics moderate effects of caregiving on glucose functioning. Psychosom Med 2005;67: 752-8. (Pubitemid 41396022)
25. Brummett BH, Babyak MA, Siegler IC, Vitaliano PP, Ballard EL, Gwyther LP, Williams RB. Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and non-caregivers. Health Psychol 2006;25:220-5.
26. Matthews KA, Gump BB, Owens JF. Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men. Health Psychol 2001;20:403-10. (Pubitemid 33032792)
27. Brummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC, Williams RB, Ashley-Koch A: 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet 2008; 38:476-83.
28. Matthews KA, Gump BB, Owens JF. Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men. Health Psychol 2001;20:403-10. (Pubitemid 33032792)
29. Brummett BH, Boyle SH, Siegler IC, Kuhn C, Surwit RS, Kail ME, Züchner S, Collins A, Ashley-Koch A, Williams RB. HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Biol Psychol 2008;79:250-5.
30. Schmaus BJ, Laubmeier KK, Boquiren VM, Herzer M, Zakowski SG. Gender and stress: differential psychophysiological reactivity to stress re-exposure in the laboratory. Int J Psychophysiol 2008;69:101-6.
31. Bloor LE, Uchino BN, Hicks A, Smith TW. Social relationships and physiological function: the effects of recalling social relationships on cardiovascular reactivity. Ann Behav Med 2004;28:29-38. (Pubitemid 38988532)
32. Uchino BN. Are older adults less or more physiologically reactive? A meta-analysis of age-related differences in cardiovascular reactivity to laboratory tasks. J Gerontol B Psychol Sci Soc Sci 2010;65B:154-62.
33. Ramage AG. Central cardiovascular regulation and 5-hydroxytryptamine receptors. Brain Res Bull 2001;56:425-39. (Pubitemid 34031778)
34. McCaffery JM, Bleil M, Pogue-Geile MF, Ferrell RE, Manuck SB. Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent. Psychosom Med 2003;65:721-8. (Pubitemid 37163375)
35. Brummett BH, Boyle SH, Kuhn C, Siegler IC, Williams RB. Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol. Psychophysiology 2009;46:862-9.