A fully validated LC-MS/MS method for simultaneous determination of nicotine and its metabolite cotinine in human serum and its application to a pharmacokinetic study after using nicotine transdermal delivery systems with standard heat application in adult smokers

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1020, Issue , 2016, Pages 67-77

  Abdallaha, Inas A ^a,b   Hammell, Dana C ^a   Stinchcomb, Audra L ^a   Hassan, Hazem E ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Egypt   (Egypt)

^c Helwan   (Egypt)

Author keywords

Cotinine; HILIC; LC MS MS; Nicotine; TDS

Indexed keywords

ASSAYS; BODY FLUIDS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; SPECTROMETRY;

COTININE; HILIC; LC-MS/MS; POSITIVE ELECTROSPRAY IONIZATION; SIMULTANEOUS DETERMINATIONS; STABLE ISOTOPE LABELED INTERNAL STANDARDS; TANDEM MASS SPECTROMETRIC DETECTION; TRANSDERMAL DELIVERY SYSTEMS;

NICOTINE;

COTININE; DRUG METABOLITE; NICOTINE; NICOTINE PATCH; NICOTINE GUM;

ADULT; ANALYTIC METHOD; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HEAT TREATMENT; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MEASUREMENT ACCURACY; PHARMACOKINETIC PARAMETERS; PRIORITY JOURNAL; SMOKING; TANDEM MASS SPECTROMETRY; TRANSDERMAL DRUG DELIVERY SYSTEM; VALIDATION STUDY; BLOOD; CHEMISTRY; DRUG STABILITY; METABOLISM; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SMOKING CESSATION; STATISTICAL MODEL; THERMOTHERAPY; TOBACCO USE DISORDER;

CHROMATOGRAPHY, LIQUID; COTININE; DRUG STABILITY; HUMANS; HYPERTHERMIA, INDUCED; LINEAR MODELS; NICOTINE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SMOKING CESSATION; TANDEM MASS SPECTROMETRY; TOBACCO USE CESSATION PRODUCTS; TOBACCO USE DISORDER;

EID: 84961655105     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2016.03.020     Document Type: Article

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