Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib

Cancer Chemotherapy and Pharmacology

Volumn 77, Issue 6, 2016, Pages 1125-1142

  Bryan, Jeffrey C ^a   Verstovsek, Srdan ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

JAK inhibition; Myelofibrosis; Myeloproliferative neoplasm; Polycythemia vera; Ruxolitinib

Indexed keywords

BIOLOGICAL MARKER; HYDROXYUREA; JANUS KINASE 1; JANUS KINASE 2 INHIBITOR; RUXOLITINIB; JANUS KINASE 2; PYRAZOLE DERIVATIVE;

ABDOMINAL PAIN; ANEMIA; ASTHENIA; CLINICAL FEATURE; CYTOPENIA; DIARRHEA; DIZZINESS; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; ECCHYMOSIS; FATIGUE; HEADACHE; HEMATOCRIT; HEMATOPOIETIC STEM CELL; HIGH RISK PATIENT; HISTORY; HUMAN; IC50; INFECTION RISK; LEUKOPENIA; LONG TERM CARE; LYMPHOCYTOPENIA; MANAGEMENT; MYELOFIBROSIS; MYELOPROLIFERATIVE NEOPLASM; NEUTROPENIA; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHENOTYPE; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; REVIEW; RISK ASSESSMENT; SPLEEN; SPLENOMEGALY; SURVIVAL; THROMBOCYTOPENIA; THROMBOEMBOLISM; TREATMENT INTERRUPTION; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; GENETICS; PRIMARY MYELOFIBROSIS; TREATMENT OUTCOME;

ANIMALS; CLINICAL TRIALS, PHASE III AS TOPIC; HUMANS; JANUS KINASE 1; JANUS KINASE 2; POLYCYTHEMIA VERA; PRIMARY MYELOFIBROSIS; PYRAZOLES; QUALITY OF LIFE; SPLENOMEGALY; TREATMENT OUTCOME;

EID: 84961644976     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-016-3012-z     Document Type: Review

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