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Volumn 2015, Issue 1, 2015, Pages 329-339

Looking forward: Novel therapeutic approaches in chronic and advanced phases of myelofibrosis

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2 INHIBITOR; ANTINEOPLASTIC AGENT; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; LIGAND; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; RUXOLITINIB;

EID: 85010931861     PISSN: 15204391     EISSN: 15204383     Source Type: Journal    
DOI: 10.1182/asheducation-2015.1.329     Document Type: Article
Times cited : (13)

References (73)
  • 1
    • 84894045284 scopus 로고    scopus 로고
    • Pathogenesis and management of acute myeloid leukemia that has evolved from a myeloproliferative neoplasm
    • Rampal R, Mascarenhas J. Pathogenesis and management of acute myeloid leukemia that has evolved from a myeloproliferative neoplasm. Curr Opin Hematol. 2014;21:65-71.
    • (2014) Curr Opin Hematol , vol.21 , pp. 65-71
    • Rampal, R.1    Mascarenhas, J.2
  • 2
    • 84922693801 scopus 로고    scopus 로고
    • Effect of mutation order on myeloproliferative neoplasms
    • Ortmann CA, Kent DG, Nangalia J, et al. Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015;372:601-612.
    • (2015) N Engl J Med , vol.372 , pp. 601-612
    • Ortmann, C.A.1    Kent, D.G.2    Nangalia, J.3
  • 3
    • 0029767865 scopus 로고    scopus 로고
    • Prognostic factors in agnogenic myeloid metaplasia: A report on 195 cases with a new scoring system
    • Dupriez B, Morel P, Demory JL, et al. Prognostic factors in agnogenic myeloid metaplasia: a report on 195 cases with a new scoring system. Blood. 1996;88:1013-1018.
    • (1996) Blood , vol.88 , pp. 1013-1018
    • Dupriez, B.1    Morel, P.2    Demory, J.L.3
  • 4
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • Cervantes F, Dupriez B, Pereira A, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113:2895-2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3
  • 5
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115:1703-1708.
    • (2010) Blood , vol.115 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3
  • 6
    • 79952087335 scopus 로고    scopus 로고
    • DiPSS plus: A refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • Gangat N, Caramazza D, Vaidya R, et al. DiPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29:392-397.
    • (2011) J Clin Oncol , vol.29 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3
  • 7
    • 84930340282 scopus 로고    scopus 로고
    • Integration of mutations and karyotype towards a genetics-based prognostic scoring system (GPSS) for primarymyelofibrosis
    • Tefferi A, Guglielmelli P, Finke C, et al. Integration of mutations and karyotype towards a genetics-based prognostic scoring system (GPSS) for primarymyelofibrosis. Blood. 2014;124:406.
    • (2014) Blood , vol.124 , pp. 406
    • Tefferi, A.1    Guglielmelli, P.2    Finke, C.3
  • 8
    • 84930368507 scopus 로고    scopus 로고
    • Mutation-enhanced international prognostic scoring system (MIPSS) for primarymyelofibrosis: An AGIMM & IWG-MRT project
    • Vannucchi A, Guglielmelli P, Rotunno G, et al. Mutation-enhanced international prognostic scoring system (MIPSS) for primarymyelofibrosis: an AGIMM & IWG-MRT project. Blood. 2014;124(21):405.
    • (2014) Blood , vol.124 , Issue.21 , pp. 405
    • Vannucchi, A.1    Guglielmelli, P.2    Rotunno, G.3
  • 9
    • 84883742034 scopus 로고    scopus 로고
    • Mutations and prognosis in primary myelofibrosis
    • Vannucchi AM, Lasho TL, Guglielmelli P, et al. Mutations and prognosis in primary myelofibrosis. Leukemia. 2013;27:1861-1869.
    • (2013) Leukemia , vol.27 , pp. 1861-1869
    • Vannucchi, A.M.1    Lasho, T.L.2    Guglielmelli, P.3
  • 10
    • 84905990634 scopus 로고    scopus 로고
    • Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
    • Rumi E, Pietra D, Pascutto C, et al. Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis. Blood. 2014;124:1062-1069.
    • (2014) Blood , vol.124 , pp. 1062-1069
    • Rumi, E.1    Pietra, D.2    Pascutto, C.3
  • 11
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Verstovsek S, Kantarjian H, Mesa RA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363:1117-1127.
    • (2010) N Engl J Med , vol.363 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3
  • 12
    • 84943245244 scopus 로고    scopus 로고
    • Type II inhibition of JAK2 with NVP-CHZ868 reverses type i JAK inhibitor persistence and demonstrates increased efficacy in MPN models
    • Abstract 160
    • Meyer SC, Keller MD, Koppikar P, et al. Type II inhibition of JAK2 with NVP-CHZ868 reverses type I JAK inhibitor persistence and demonstrates increased efficacy in MPN models. Blood. 2014;124: Abstract 160.
    • (2014) Blood , vol.124
    • Meyer, S.C.1    Keller, M.D.2    Koppikar, P.3
  • 13
    • 84946040970 scopus 로고    scopus 로고
    • Phase i dose escalation study of lestaurtinib in patients with myelofibrosis
    • Hexner EO, Mascarenhas J, Prchal J, et al. Phase I dose escalation study of lestaurtinib in patients with myelofibrosis. Leuk Lymphoma. 2015: 1-9.
    • (2015) Leuk Lymphoma , pp. 1-9
    • Hexner, E.O.1    Mascarenhas, J.2    Prchal, J.3
  • 14
    • 84894253077 scopus 로고    scopus 로고
    • Phase i evaluation of XL019, an oral, potent, and selective JAK2 inhibitor
    • Verstovsek S, Tam CS, Wadleigh M, et al. Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor. Leuk Res. 2014;38:316-322.
    • (2014) Leuk Res , vol.38 , pp. 316-322
    • Verstovsek, S.1    Tam, C.S.2    Wadleigh, M.3
  • 15
    • 84907912086 scopus 로고    scopus 로고
    • The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: A putative mechanism for the onset of Wernicke's encephalopathy
    • Zhang Q, Zhang Y, Diamond S, et al. The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy. Drug Metab Dispos. 2014;42:1656-1662.
    • (2014) Drug Metab Dispos , vol.42 , pp. 1656-1662
    • Zhang, Q.1    Zhang, Y.2    Diamond, S.3
  • 16
    • 77953198579 scopus 로고    scopus 로고
    • Phase i dose-escalation trial of SB1518, a Novel JAK2/FLT3 inhibitor, in acute and chronic myeloid diseases, including primary or post-essential thrombocythemia/polycythemia vera myelofibrosis
    • Abstract 3905
    • Verstovsek S, Odenike O, Scott B, et al. Phase I dose-escalation trial of SB1518, a Novel JAK2/FLT3 inhibitor, in acute and chronic myeloid diseases, including primary or post-essential thrombocythemia/polycythemia vera myelofibrosis. ASH Annual Meeting Abstracts. 2009;114: Abstract 3905.
    • (2009) ASH Annual Meeting Abstracts , vol.114
    • Verstovsek, S.1    Odenike, O.2    Scott, B.3
  • 17
    • 79551604399 scopus 로고    scopus 로고
    • First report of the phase i study of the novel oral JAK2 inhibitor SB1518 in patients with myelofibrosis
    • Abstract 1144
    • Seymour JF, To B, Goh A, et al. First report of the phase I study of the novel oral JAK2 inhibitor SB1518 in patients with myelofibrosis. Haematologica. 2010;95(Suppl 2):472: Abstract 1144.
    • (2010) Haematologica , vol.95 , pp. 472
    • Seymour, J.F.1    To, B.2    Goh, A.3
  • 18
    • 84928901823 scopus 로고    scopus 로고
    • Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
    • Komrokji RS, Seymour JF, Roberts AW, et al. Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis. Blood. 2015;125:2649-2655.
    • (2015) Blood , vol.125 , pp. 2649-2655
    • Komrokji, R.S.1    Seymour, J.F.2    Roberts, A.W.3
  • 19
    • 84878951826 scopus 로고    scopus 로고
    • Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Pardanani A, Laborde RR, Lasho TL, et al. Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis. Leukemia 2013;27:1322-1327.
    • (2013) Leukemia , vol.27 , pp. 1322-1327
    • Pardanani, A.1    Laborde, R.R.2    Lasho, T.L.3
  • 20
    • 84896984163 scopus 로고    scopus 로고
    • Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis
    • Pardanani AD, Gotlib J, Gupta V, et al. Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis. Blood. 2013;122(21):108.
    • (2013) Blood , vol.122 , Issue.21 , pp. 108
    • Pardanani, A.D.1    Gotlib, J.2    Gupta, V.3
  • 21
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebocontrolled trial of ruxolitinib for myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebocontrolled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366: 799-807.
    • (2012) N Engl J Med , vol.366 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 22
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366:787-798.
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 23
    • 84928476375 scopus 로고    scopus 로고
    • Ruxolitinib versus standard therapy for the treatment of polycythemia vera
    • Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372:426-435.
    • (2015) N Engl J Med , vol.372 , pp. 426-435
    • Vannucchi, A.M.1    Kiladjian, J.J.2    Griesshammer, M.3
  • 24
    • 84886405838 scopus 로고    scopus 로고
    • Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts
    • Talpaz M, Paquette R, Afrin L, et al. Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts. J Hematol Oncol. 2013;6:81.
    • (2013) J Hematol Oncol , vol.6 , pp. 81
    • Talpaz, M.1    Paquette, R.2    Afrin, L.3
  • 25
    • 84937760566 scopus 로고    scopus 로고
    • Current and future treatment options for polycythemia vera
    • Griesshammer M, Gisslinger H, Mesa R. Current and future treatment options for polycythemia vera. Ann Hematol. 2015;94(6):901-910.
    • (2015) Ann Hematol , vol.94 , Issue.6 , pp. 901-910
    • Griesshammer, M.1    Gisslinger, H.2    Mesa, R.3
  • 26
    • 84982827169 scopus 로고    scopus 로고
    • Outcome of patients (pts) with myelofibrosis (MF) after ruxolutinib (Rux) therapy [abstract]
    • abstract 1584
    • Jabbour E, Kantarjian H, Garcia-Manero G, et al. Outcome of patients (pts) with myelofibrosis (MF) after ruxolutinib (Rux) therapy [abstract]. Blood. 2013;122(21):abstract 1584.
    • (2013) Blood , vol.122 , Issue.21
    • Jabbour, E.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 27
    • 84936980189 scopus 로고    scopus 로고
    • Ruxolitinib-induced modulation of bone marrow microenvironment in patients with myelofibrosis is associated with inflammatory cytokine levels [abstract]
    • abstract 3182
    • Kvasnicka HM, Thiele J, Bueso-Ramos CE, et al. Ruxolitinib-induced modulation of bone marrow microenvironment in patients with myelofibrosis is associated with inflammatory cytokine levels [abstract]. Blood. 2014;124(21):abstract 3182.
    • (2014) Blood , vol.124 , Issue.21
    • Kvasnicka, H.M.1    Thiele, J.2    Bueso-Ramos, C.E.3
  • 28
    • 84865192181 scopus 로고    scopus 로고
    • Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: Survival advantage in comparison to matched historical controls
    • Verstovsek S, Kantarjian HM, Estrov Z, et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls. Blood. 2012;120:1202-1209.
    • (2012) Blood , vol.120 , pp. 1202-1209
    • Verstovsek, S.1    Kantarjian, H.M.2    Estrov, Z.3
  • 29
    • 84896997474 scopus 로고    scopus 로고
    • A Pooled overall survival analysis of the COMFORT studies: 2 randomized phase 3 trials of Ruxolitinib for the treatment of myelofibrosis
    • Vannucchi A, Kantarjian H, Kiladjian JJ, et al. A Pooled overall survival analysis of the COMFORT studies: 2 randomized phase 3 trials of Ruxolitinib for the treatment of myelofibrosis. Blood. 2013;39:138-139.
    • (2013) Blood , vol.39 , pp. 138-139
    • Vannucchi, A.1    Kantarjian, H.2    Kiladjian, J.J.3
  • 30
    • 84904527552 scopus 로고    scopus 로고
    • Beyond JAK inhibitor therapy in myelofibrosis
    • Odenike O. Beyond JAK inhibitor therapy in myelofibrosis. Hematology Am Soc Hematol Educ Program. 2013;2013:545-552.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 545-552
    • Odenike, O.1
  • 31
    • 0042674370 scopus 로고    scopus 로고
    • A novel telomerase template antagonist (GRN163) as a potential anticancer agent
    • Asai A, Oshima Y, Yamamoto Y, et al. A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res. 2003;63:3931-3939.
    • (2003) Cancer Res , vol.63 , pp. 3931-3939
    • Asai, A.1    Oshima, Y.2    Yamamoto, Y.3
  • 32
    • 14944381162 scopus 로고    scopus 로고
    • High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia
    • Ferraris AM, Mangerini R, Pujic N, et al. High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia. Blood. 2005;105:2138-2140.
    • (2005) Blood , vol.105 , pp. 2138-2140
    • Ferraris, A.M.1    Mangerini, R.2    Pujic, N.3
  • 33
    • 60349111072 scopus 로고    scopus 로고
    • Telomere length is severely and similarly reduced in JAK2V617F-positive and-negative myeloproliferative neoplasms
    • Bernard L, Belisle C, Mollica L, et al. Telomere length is severely and similarly reduced in JAK2V617F-positive and-negative myeloproliferative neoplasms. Leukemia. 2009;23:287-291.
    • (2009) Leukemia , vol.23 , pp. 287-291
    • Bernard, L.1    Belisle, C.2    Mollica, L.3
  • 34
    • 85006816399 scopus 로고    scopus 로고
    • Effects of Imetelstat on CD34 cells of patients with myelofibrosis
    • Wang X, Hu CS, Qiu J, Lam M, Eng K, Hoffman R. Effects of Imetelstat on CD34 cells of patients with myelofibrosis. Blood. 2014;124(21):1879
    • (2014) Blood , vol.124 , Issue.21 , pp. 1879
    • Wang, X.1    Hu, C.S.2    Qiu, J.3    Lam, M.4    Eng, K.5    Hoffman, R.6
  • 35
    • 85006751967 scopus 로고    scopus 로고
    • Imetelstat (GRN163L), a telomerase inhibitor selectively affects malignant megakaryopoiesis in myeloproliferative neoplasms (MPN) [abstract]
    • abstract 4582
    • Iancu-Rubin C, Mosoyan G, Parker CC, Eng K, Hoffman R. Imetelstat (GRN163L), a telomerase inhibitor selectively affects malignant megakaryopoiesis in myeloproliferative neoplasms (MPN) [abstract]. Blood. 2014;124(21):abstract 4582.
    • (2014) Blood , vol.124 , Issue.21
    • Iancu-Rubin, C.1    Mosoyan, G.2    Parker, C.C.3    Eng, K.4    Hoffman, R.5
  • 36
    • 84897000773 scopus 로고    scopus 로고
    • Imetelstat, a telomerase inhibitor, induces morphologic and molecular remissions in myelofibrosis and reversal of bone marrow fibrosis
    • Tefferi A, Begna K, Laborde RR, et al. Imetelstat, a telomerase inhibitor, induces morphologic and molecular remissions in myelofibrosis and reversal of bone marrow fibrosis. Blood. 2013;122(21):662.
    • (2013) Blood , vol.122 , Issue.21 , pp. 662
    • Tefferi, A.1    Begna, K.2    Laborde, R.R.3
  • 37
    • 84950269499 scopus 로고    scopus 로고
    • Imetelstat, a telomerase inhibitor, therapy for myelofibrosis: A pilot study
    • Tefferi A, LaPlant B, Begna K, et al. Imetelstat, a telomerase inhibitor, therapy for myelofibrosis: a pilot study. Blood. 2014;124(21):634.
    • (2014) Blood , vol.124 , Issue.21 , pp. 634
    • Tefferi, A.1    LaPlant, B.2    Begna, K.3
  • 38
    • 84868117632 scopus 로고    scopus 로고
    • FcgammaRI mediates serum amyloid P inhibition of fibrocyte differentiation
    • Crawford JR, Pilling D, Gomer RH. FcgammaRI mediates serum amyloid P inhibition of fibrocyte differentiation. J Leukoc Biol. 2012;92:699-711.
    • (2012) J Leukoc Biol , vol.92 , pp. 699-711
    • Crawford, J.R.1    Pilling, D.2    Gomer, R.H.3
  • 39
    • 84936862080 scopus 로고    scopus 로고
    • Phase 2 trial of PRM-151, an anti-fibrotic agent, in patients with myelofibrosis: Stage 1 results
    • Verstovsek S, Mesa R, Foltz LM, et al. Phase 2 trial of PRM-151, an anti-fibrotic agent, in patients with myelofibrosis: stage 1 results. Blood. 2014;124(21):713.
    • (2014) Blood , vol.124 , Issue.21 , pp. 713
    • Verstovsek, S.1    Mesa, R.2    Foltz, L.M.3
  • 40
    • 84971519066 scopus 로고    scopus 로고
    • Bone marrow fibrosis by WHO grade and quantitative image analysis is reduced by PRM-151 in patients with myelofibrosis and associated with improved bone marrow morphology and increased platelet counts
    • Pozdnyakova O, Hasserjian R, Salama M, et al. Bone marrow fibrosis by WHO grade and quantitative image analysis is reduced by PRM-151 in patients with myelofibrosis and associated with improved bone marrow morphology and increased platelet counts. Haematologica. 2015;100:677.
    • (2015) Haematologica , vol.100 , pp. 677
    • Pozdnyakova, O.1    Hasserjian, R.2    Salama, M.3
  • 41
    • 79953704027 scopus 로고    scopus 로고
    • Copy number variations of EphA3 are associated with multiple types of hematologic malignancies
    • Guan M, Liu L, Zhao X, et al. Copy number variations of EphA3 are associated with multiple types of hematologic malignancies. Clin Lymphoma Myeloma Leuk. 2011;11:50-53.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 50-53
    • Guan, M.1    Liu, L.2    Zhao, X.3
  • 42
    • 84863790430 scopus 로고    scopus 로고
    • EPHA3 as a novel therapeutic target in the hematological malignancies
    • Keane N, Freeman C, Swords R, Giles FJ. EPHA3 as a novel therapeutic target in the hematological malignancies. Expert Rev Hematol. 2012;5: 325-340.
    • (2012) Expert Rev Hematol , vol.5 , pp. 325-340
    • Keane, N.1    Freeman, C.2    Swords, R.3    Giles, F.J.4
  • 43
    • 85011007568 scopus 로고    scopus 로고
    • KB004, a novel non-fucosylated humaneered antibody, targeting epha3, is active and well tolerated in a phase i/II study of advanced hematologic malignancies
    • Swords R, A.H. W, Durrant S, et al. KB004, a novel non-fucosylated Humaneered antibody, targeting EphA3, is active and well tolerated in a phase I/II study of advanced hematologic malignancies. Blood. 2014; 124(21):3756.
    • (2014) Blood , vol.124 , Issue.21 , pp. 3756
    • Swords, R.A.H.W.1    Durrant, S.2
  • 44
    • 84888123497 scopus 로고    scopus 로고
    • JAK1/2 and Pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease
    • Evrot E, Ebel N, Romanet V, et al. JAK1/2 and Pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clin Cancer Res. 2013;19: 6230-6241.
    • (2013) Clin Cancer Res , vol.19 , pp. 6230-6241
    • Evrot, E.1    Ebel, N.2    Romanet, V.3
  • 45
    • 84880321219 scopus 로고    scopus 로고
    • Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis
    • DeAngelo DJ, Mesa RA, Fiskus W, et al. Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis. Br J Haematol. 2013;162:326-335.
    • (2013) Br J Haematol , vol.162 , pp. 326-335
    • DeAngelo, D.J.1    Mesa, R.A.2    Fiskus, W.3
  • 46
    • 84875032119 scopus 로고    scopus 로고
    • A phase i study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and postpolycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF)
    • Mascarenhas J, Lu M, Li T, et al. A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and postpolycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF). Br J Haematol. 2013;161:68-75.
    • (2013) Br J Haematol , vol.161 , pp. 68-75
    • Mascarenhas, J.1    Lu, M.2    Li, T.3
  • 47
    • 84940437716 scopus 로고    scopus 로고
    • Efficacy, safety, and confirmation of the recommended phase 2 dose of ruxolitinib plus panobinostat in patients with intermediate or high-risk myelofibrosis
    • Kiladjian JJ, Heidel F, Vannucchi A, et al. Efficacy, safety, and confirmation of the recommended phase 2 dose of ruxolitinib plus panobinostat in patients with intermediate or high-risk myelofibrosis. Blood. 2014;124(21):711.
    • (2014) Blood , vol.124 , Issue.21 , pp. 711
    • Kiladjian, J.J.1    Heidel, F.2    Vannucchi, A.3
  • 48
    • 84865735256 scopus 로고    scopus 로고
    • Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
    • Koppikar P, Bhagwat N, Kilpivaara O, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012;489:155-159.
    • (2012) Nature , vol.489 , pp. 155-159
    • Koppikar, P.1    Bhagwat, N.2    Kilpivaara, O.3
  • 49
    • 84897556667 scopus 로고    scopus 로고
    • Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms
    • Bhagwat N, Koppikar P, Keller M, et al. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood. 2014;123:2075-2083.
    • (2014) Blood , vol.123 , pp. 2075-2083
    • Bhagwat, N.1    Koppikar, P.2    Keller, M.3
  • 50
    • 84896936901 scopus 로고    scopus 로고
    • Improved efficacy of combination of JAK2 and hedgehog inhibitors in myelofibrosis
    • Bhagwat N, Keller MD, Rampal R, et al. Improved efficacy of combination of JAK2 and hedgehog inhibitors in myelofibrosis. Blood. 2013;122(21):666.
    • (2013) Blood , vol.122 , Issue.21 , pp. 666
    • Bhagwat, N.1    Keller, M.D.2    Rampal, R.3
  • 51
    • 84938153251 scopus 로고    scopus 로고
    • Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis
    • Sasaki K, Gotlib JR, Mesa RA, et al. Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis. Leuk Lymphoma. 2015:1-6.
    • (2015) Leuk Lymphoma , pp. 1-6
    • Sasaki, K.1    Gotlib, J.R.2    Mesa, R.A.3
  • 52
    • 84879390119 scopus 로고    scopus 로고
    • Characterization of the TGF-beta1 signaling abnormalities in the Gata1low mouse model of myelofibrosis
    • Zingariello M, Martelli F, Ciaffoni F, et al. Characterization of the TGF-beta1 signaling abnormalities in the Gata1low mouse model of myelofibrosis. Blood. 2013;121:3345-3363.
    • (2013) Blood , vol.121 , pp. 3345-3363
    • Zingariello, M.1    Martelli, F.2    Ciaffoni, F.3
  • 53
    • 84947569454 scopus 로고    scopus 로고
    • Phase 1b dose-escalation study of Sonidegib (LDE225) in Combination with Ruxolitinib (INC424) in patients with myelofibrosis
    • Gupta V, Koschmieder S, Harrison C, et al. Phase 1b dose-escalation study of Sonidegib (LDE225) in Combination with Ruxolitinib (INC424) in patients with myelofibrosis. Blood. 2014;124(21):712.
    • (2014) Blood , vol.124 , Issue.21 , pp. 712
    • Gupta, V.1    Koschmieder, S.2    Harrison, C.3
  • 54
    • 70350446987 scopus 로고    scopus 로고
    • Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms
    • Grimwade LF, Happerfield L, Tristram C, et al. Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms. Br J Haematol. 2009;147:495-506.
    • (2009) Br J Haematol , vol.147 , pp. 495-506
    • Grimwade, L.F.1    Happerfield, L.2    Tristram, C.3
  • 55
    • 84866868568 scopus 로고    scopus 로고
    • Increased phospho-mTOR expression in megakaryocytic cells derived from CD34 progenitors of essential thrombocythaemia and myelofibrosis patients
    • Vicari L, Martinetti D, Buccheri S, et al. Increased phospho-mTOR expression in megakaryocytic cells derived from CD34 progenitors of essential thrombocythaemia and myelofibrosis patients. Br J Haematol. 2012;159:237-240.
    • (2012) Br J Haematol , vol.159 , pp. 237-240
    • Vicari, L.1    Martinetti, D.2    Buccheri, S.3
  • 56
    • 80052184481 scopus 로고    scopus 로고
    • Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis
    • Guglielmelli P, Barosi G, Rambaldi A, et al. Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis. Blood. 2011;118:2069-2076.
    • (2011) Blood , vol.118 , pp. 2069-2076
    • Guglielmelli, P.1    Barosi, G.2    Rambaldi, A.3
  • 57
    • 84891162350 scopus 로고    scopus 로고
    • Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms
    • Bartalucci N, Tozzi L, Bogani C, et al. Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms. J Cell Mol Med. 2013;17:1385-1396.
    • (2013) J Cell Mol Med , vol.17 , pp. 1385-1396
    • Bartalucci, N.1    Tozzi, L.2    Bogani, C.3
  • 58
    • 84877670562 scopus 로고    scopus 로고
    • Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells
    • Fiskus W, Verstovsek S, Manshouri T, et al. Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells. Mol Cancer Therapeut. 2013;12:577-588.
    • (2013) Mol Cancer Therapeut , vol.12 , pp. 577-588
    • Fiskus, W.1    Verstovsek, S.2    Manshouri, T.3
  • 59
    • 84947589191 scopus 로고    scopus 로고
    • HARMONY: An open-label, multicenter, 2-arm, dose-finding, phase 1b study of the combination of ruxolitinib and buparlisib (BKM120) in patients with myelofibrosis (MF)
    • Durrant S, Koren-Michowitz M, Lavie D, et al. HARMONY: an open-label, multicenter, 2-arm, dose-finding, phase 1b study of the combination of ruxolitinib and buparlisib (BKM120) in patients with myelofibrosis (MF). Blood. 2014;124(21):710.
    • (2014) Blood , vol.124 , Issue.21 , pp. 710
    • Durrant, S.1    Koren-Michowitz, M.2    Lavie, D.3
  • 60
    • 84890911661 scopus 로고    scopus 로고
    • Reduced-intensity hematopoietic cell transplantation for patients with primary myelofibrosis: A cohort analysis from the center for international blood and marrow transplant research
    • Gupta V, Malone AK, Hari PN, et al. Reduced-intensity hematopoietic cell transplantation for patients with primary myelofibrosis: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2014;20:89-97.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 89-97
    • Gupta, V.1    Malone, A.K.2    Hari, P.N.3
  • 61
    • 84905986086 scopus 로고    scopus 로고
    • MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis
    • Rondelli D, Goldberg JD, Isola L, et al. MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. Blood. 2014;124:1183-1191.
    • (2014) Blood , vol.124 , pp. 1183-1191
    • Rondelli, D.1    Goldberg, J.D.2    Isola, L.3
  • 62
    • 84899758497 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation in patients with polycythemia vera or essential thrombocythemia transformed to myelofibrosis or acute myeloid leukemia: A report from the MPN Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation
    • Lussana F, Rambaldi A, Finazzi MC, et al. Allogeneic hematopoietic stem cell transplantation in patients with polycythemia vera or essential thrombocythemia transformed to myelofibrosis or acute myeloid leukemia: a report from the MPN Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation. Haematologica. 2014;99:916-921.
    • (2014) Haematologica , vol.99 , pp. 916-921
    • Lussana, F.1    Rambaldi, A.2    Finazzi, M.C.3
  • 63
    • 84908069791 scopus 로고    scopus 로고
    • Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis
    • Robin M, Giannotti F, Deconinck E, et al. Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis. Biol Blood Marrow Transplant. 2014;20:1841-1846.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1841-1846
    • Robin, M.1    Giannotti, F.2    Deconinck, E.3
  • 64
    • 84902581112 scopus 로고    scopus 로고
    • Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
    • Spoerl S, Mathew NR, Bscheider M, et al. Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. Blood. 2014;123:3832-3842.
    • (2014) Blood , vol.123 , pp. 3832-3842
    • Spoerl, S.1    Mathew, N.R.2    Bscheider, M.3
  • 65
    • 84902652715 scopus 로고    scopus 로고
    • Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis : A preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc
    • Robin M, Francois S, Huynh A, et al. Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis : a preliminary descriptive report of the JAK ALLO study, a phase ii trial sponsored by Goelams-FIM in collaboration with the Sfgmtc. Blood. 2013;122(21):2111.
    • (2013) Blood , vol.122 , Issue.21 , pp. 2111
    • Robin, M.1    Francois, S.2    Huynh, A.3
  • 66
    • 84893812843 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
    • Jaekel N, Behre G, Behning A, et al. Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib. Bone Marrow Transplant. 2014;49:179-184.
    • (2014) Bone Marrow Transplant , vol.49 , pp. 179-184
    • Jaekel, N.1    Behre, G.2    Behning, A.3
  • 67
    • 84897487192 scopus 로고    scopus 로고
    • 5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic activity
    • Stubig T, Badbaran A, Luetkens T, et al. 5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic activity. Mediators Inflamm. 2014;2014:418292.
    • (2014) Mediators Inflamm , vol.2014 , pp. 418292
    • Stubig, T.1    Badbaran, A.2    Luetkens, T.3
  • 68
    • 84918570809 scopus 로고    scopus 로고
    • Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
    • Rampal R, Ahn J, Abdel-Wahab O, et al. Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proc Nat Acad Sci U S A. 2014;111:E5401-E5410.
    • (2014) Proc Nat Acad Sci U S A , vol.111 , pp. E5401-E5410
    • Rampal, R.1    Ahn, J.2    Abdel-Wahab, O.3
  • 69
    • 84878225843 scopus 로고    scopus 로고
    • Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms
    • Kennedy JA, Atenafu EG, Messner HA, et al. Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms. Blood. 2013;121:2725-2733.
    • (2013) Blood , vol.121 , pp. 2725-2733
    • Kennedy, J.A.1    Atenafu, E.G.2    Messner, H.A.3
  • 70
    • 84861216420 scopus 로고    scopus 로고
    • Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia
    • Eghtedar A, Verstovsek S, Estrov Z, et al. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia. Blood. 2012;119:4614-4618.
    • (2012) Blood , vol.119 , pp. 4614-4618
    • Eghtedar, A.1    Verstovsek, S.2    Estrov, Z.3
  • 71
    • 84923611231 scopus 로고    scopus 로고
    • A phase I/II study of the Janus kinase (JAK)1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia
    • Pemmaraju N, Kantarjian H, Kadia T, et al. A phase I/II study of the Janus kinase (JAK)1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015;15:171-176.
    • (2015) Clin Lymphoma Myeloma Leuk , vol.15 , pp. 171-176
    • Pemmaraju, N.1    Kantarjian, H.2    Kadia, T.3
  • 73
    • 78149453788 scopus 로고    scopus 로고
    • Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: A report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM)
    • Thepot S, Itzykson R, Seegers V, et al. Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM). Blood. 2010;116:3735-3742.
    • (2010) Blood , vol.116 , pp. 3735-3742
    • Thepot, S.1    Itzykson, R.2    Seegers, V.3


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