메뉴 건너뛰기




Volumn 60, Issue , 2009, Pages 233-245

Primary Myelofibrosis: Update on definition, pathogenesis, and treatment

Author keywords

Chronic myelogenous leukemia (CML); Essential thrombocythemia (ET); Extramedullary hematopoiesis (EMH); Janus kinase 2 (JAK2); Myeloproliferative neoplasm (MPN); Polycythemia vera (PV); Primary myelofibrosis (PMF)

Indexed keywords

ANDROGEN; ANTIANEMIC AGENT; AT 9283; AURORA KINASE INHIBITOR; BUSULFAN; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DANAZOL; FLUDARABINE; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; INCB 01824; ITF 2357; JANUS KINASE 2; JANUS KINASE INHIBITOR; LENALIDOMIDE; LESTAURTINIB; PREDNISONE; TG 101209; TG 101348; THALIDOMIDE; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG; XL 019;

EID: 67649300979     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.60.041707.160528     Document Type: Review
Times cited : (86)

References (59)
  • 1
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. 1951. Some speculations on the myeloproliferative syndromes. Blood 6:372-75
    • (1951) Blood , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 2
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al. 2005. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054-61
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 3
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al. 2005. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434:1144-48
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 4
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. 2005. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352:1779-90
    • (2005) N. Engl. J. Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 5
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. 2005. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387-97
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 6
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. 2006. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 3:e270
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 8
    • 34248364065 scopus 로고    scopus 로고
    • Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the International Working Group for Myelofibrosis Research and Treatment (IWG-MRT)
    • Mesa RA, Verstovsek S, Cervantes F, et al. 2007. Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): consensus on terminology by the International Working Group for Myelofibrosis Research and Treatment (IWG-MRT). Leuk. Res. 31:737-40
    • (2007) Leuk. Res , vol.31 , pp. 737-740
    • Mesa, R.A.1    Verstovsek, S.2    Cervantes, F.3
  • 9
    • 34548042964 scopus 로고    scopus 로고
    • Proposals and rationale for revision of theWorld Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
    • Tefferi A, Thiele J, Orazi A, et al. 2007. Proposals and rationale for revision of theWorld Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood 110:1092-97
    • (2007) Blood , vol.110 , pp. 1092-1097
    • Tefferi, A.1    Thiele, J.2    Orazi, A.3
  • 10
    • 0034988764 scopus 로고    scopus 로고
    • Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia
    • Tefferi A, Mesa RA, Schroeder G, et al. 2001. Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia. Br. J. Haematol. 113:763-71
    • (2001) Br. J. Haematol , vol.113 , pp. 763-771
    • Tefferi, A.1    Mesa, R.A.2    Schroeder, G.3
  • 11
    • 0030748326 scopus 로고    scopus 로고
    • Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: A study of 106 cases
    • Reilly JT, Snowden JA, Spearing RL, et al. 1997. Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases. Br. J. Haematol. 98:96-102
    • (1997) Br. J. Haematol , vol.98 , pp. 96-102
    • Reilly, J.T.1    Snowden, J.A.2    Spearing, R.L.3
  • 12
    • 0025630602 scopus 로고
    • Acute myelofibrosis - a leukemia of pluripotent stem cell. A report of three cases and review of the literature
    • Amberger DM, Saleem A, Kemp BL, et al. 1990. Acute myelofibrosis - a leukemia of pluripotent stem cell. A report of three cases and review of the literature. Ann. Clin. Lab. Sci. 20:409-14
    • (1990) Ann. Clin. Lab. Sci , vol.20 , pp. 409-414
    • Amberger, D.M.1    Saleem, A.2    Kemp, B.L.3
  • 13
    • 33750304807 scopus 로고    scopus 로고
    • JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?
    • Verstovsek S, Silver RT, Cross NC, Tefferi A. 2006. JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less? Leukemia 20:2067
    • (2006) Leukemia , vol.20 , pp. 2067
    • Verstovsek, S.1    Silver, R.T.2    Cross, N.C.3    Tefferi, A.4
  • 14
    • 45149113001 scopus 로고    scopus 로고
    • JAK2 mutations are present in all cases of polycythemia vera
    • Wang YL, Vandris K, Jones A, et al. 2008. JAK2 mutations are present in all cases of polycythemia vera. Leukemia 22:1289
    • (2008) Leukemia , vol.22 , pp. 1289
    • Wang, Y.L.1    Vandris, K.2    Jones, A.3
  • 15
    • 47249150213 scopus 로고    scopus 로고
    • Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001 - 2004, using data from the NAACCR and SEER programs
    • Rollison DE, Howlader N, Smith MT, et al. 2008. Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001 - 2004, using data from the NAACCR and SEER programs. Blood 112:45-52
    • (2008) Blood , vol.112 , pp. 45-52
    • Rollison, D.E.1    Howlader, N.2    Smith, M.T.3
  • 16
    • 0025237668 scopus 로고
    • Myelofibrosis with myeloid metaplasia: Clinical and haematological parameters predicting survival in a series of 133 patients
    • Visani G, Finelli C, Castelli U, et al. 1990. Myelofibrosis with myeloid metaplasia: clinical and haematological parameters predicting survival in a series of 133 patients. Br. J. Haematol. 75:4-9
    • (1990) Br. J. Haematol , vol.75 , pp. 4-9
    • Visani, G.1    Finelli, C.2    Castelli, U.3
  • 17
    • 0032916213 scopus 로고    scopus 로고
    • Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: An Olmsted County study, 1976-1995
    • Mesa RA, Silverstein MN, Jacobsen SJ, et al. 1999. Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County study, 1976-1995. Am. J. Hematol. 61:10-15
    • (1999) Am. J. Hematol , vol.61 , pp. 10-15
    • Mesa, R.A.1    Silverstein, M.N.2    Jacobsen, S.J.3
  • 18
    • 0141705389 scopus 로고    scopus 로고
    • Nonhepatosplenic extramedullary hematopoiesis: Associated diseases, pathology, clinical course, and treatment
    • Koch CA, Li CY, Mesa RA, et al. 2003. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin. Proc. 78:1223-33
    • (2003) Mayo Clin. Proc , vol.78 , pp. 1223-1233
    • Koch, C.A.1    Li, C.Y.2    Mesa, R.A.3
  • 19
    • 40749160047 scopus 로고    scopus 로고
    • Choosing between stem cell therapy and drugs in myelofibrosis
    • Kroger N, Mesa RA. 2008. Choosing between stem cell therapy and drugs in myelofibrosis. Leukemia 22:474-86
    • (2008) Leukemia , vol.22 , pp. 474-486
    • Kroger, N.1    Mesa, R.A.2
  • 20
    • 0036890863 scopus 로고    scopus 로고
    • Thalidomide in myelofibrosis with myeloid metaplasia: A pooled-analysis of individual patient data from five studies
    • Giovanni B, Michelle E, Letizia C, et al. 2002. Thalidomide in myelofibrosis with myeloid metaplasia: a pooled-analysis of individual patient data from five studies. Leuk. Lymphoma 43:2301-7
    • (2002) Leuk. Lymphoma , vol.43 , pp. 2301-2307
    • Giovanni, B.1    Michelle, E.2    Letizia, C.3
  • 21
    • 84948722053 scopus 로고
    • Treatment of anemia in myeloproliferative disorders: A randomized study of fluoxymesterone v transfusions only
    • Brubaker LH, Briere J, Laszlo J, et al. 1982. Treatment of anemia in myeloproliferative disorders: a randomized study of fluoxymesterone v transfusions only. Arch. Intern. Med. 142:1533-37
    • (1982) Arch. Intern. Med , vol.142 , pp. 1533-1537
    • Brubaker, L.H.1    Briere, J.2    Laszlo, J.3
  • 22
    • 0029767865 scopus 로고    scopus 로고
    • Prognostic factors in agnogenic myeloid metaplasia: A report on 195 cases with a new scoring system
    • Dupriez B, Morel P, Demory JL, et al. 1996. Prognostic factors in agnogenic myeloid metaplasia: a report on 195 cases with a new scoring system. Blood 88:1013-18
    • (1996) Blood , vol.88 , pp. 1013-1018
    • Dupriez, B.1    Morel, P.2    Demory, J.L.3
  • 23
    • 0032697583 scopus 로고    scopus 로고
    • Initial (prefibrotic) stages of idiopathic (primary) myelofibrosis (IMF) - a clinicopathological study
    • Thiele J, Kvasnicka HM, Boeltken B, et al. 1999. Initial (prefibrotic) stages of idiopathic (primary) myelofibrosis (IMF) - a clinicopathological study. Leukemia 13:1741-48
    • (1999) Leukemia , vol.13 , pp. 1741-1748
    • Thiele, J.1    Kvasnicka, H.M.2    Boeltken, B.3
  • 24
    • 1842509221 scopus 로고    scopus 로고
    • Prefibrotic chronic idiopathic myelofibrosis-a diagnostic enigma?
    • Thiele J, Kvasnicka HM. 2004. Prefibrotic chronic idiopathic myelofibrosis-a diagnostic enigma? Acta Haematol. 111:155-59
    • (2004) Acta Haematol , vol.111 , pp. 155-159
    • Thiele, J.1    Kvasnicka, H.M.2
  • 25
    • 47249092413 scopus 로고    scopus 로고
    • MPL mutations in myeloproliferative disorders: Analysis of the PT-1 cohort
    • Beer PA, Campbell PJ, Scott LM, et al. 2008. MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort. Blood 112:141-49
    • (2008) Blood , vol.112 , pp. 141-149
    • Beer, P.A.1    Campbell, P.J.2    Scott, L.M.3
  • 26
    • 12844284481 scopus 로고    scopus 로고
    • Leukemic transformation in myelofibrosis with myeloid metaplasia: A single-institution experience with 91 cases
    • Mesa RA, Li CY, Ketterling RP, et al. 2005. Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases. Blood 105:973-77
    • (2005) Blood , vol.105 , pp. 973-977
    • Mesa, R.A.1    Li, C.Y.2    Ketterling, R.P.3
  • 27
    • 33749434271 scopus 로고    scopus 로고
    • Mutation of JAK2 in the myeloproliferative disorders: Timing, clonality studies, cytogenetic associations, and role in leukemic transformation
    • Campbell PJ, Baxter EJ, Beer PA, et al. 2006. Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation. Blood 108:3548-55
    • (2006) Blood , vol.108 , pp. 3548-3555
    • Campbell, P.J.1    Baxter, E.J.2    Beer, P.A.3
  • 28
    • 34347394712 scopus 로고    scopus 로고
    • Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
    • Theocharides A, Boissinot M, Girodon F, et al. 2007. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood 110:375-79
    • (2007) Blood , vol.110 , pp. 375-379
    • Theocharides, A.1    Boissinot, M.2    Girodon, F.3
  • 29
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. 1977. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med. 63:125-30
    • (1977) Am. J. Med , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 30
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson RJ, et al. 1981. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 58:916-19
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, R.J.3
  • 31
    • 0030043357 scopus 로고    scopus 로고
    • Detection of chromosome 20q deletions in bone marrow metaphases but not peripheral blood granulocytes in patients with myeloproliferative disorders or myelodysplastic syndromes
    • Asimakopoulos FA, Holloway TL, Nacheva EP, et al. 1996. Detection of chromosome 20q deletions in bone marrow metaphases but not peripheral blood granulocytes in patients with myeloproliferative disorders or myelodysplastic syndromes. Blood 87:1561-70
    • (1996) Blood , vol.87 , pp. 1561-1570
    • Asimakopoulos, F.A.1    Holloway, T.L.2    Nacheva, E.P.3
  • 32
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C, Pisani DF, Tulliez M, et al. 2006. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 108:1652-60
    • (2006) Blood , vol.108 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3
  • 33
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G, Mercher T, Okabe R, et al. 2006. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 107:4274-81
    • (2006) Blood , vol.107 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3
  • 34
    • 0035045092 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase 2 ( JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
    • Lindauer K, Loerting T, Liedl KR, et al. 2001. Prediction of the structure of human Janus kinase 2 ( JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Eng. 14:27-37
    • (2001) Protein Eng , vol.14 , pp. 27-37
    • Lindauer, K.1    Loerting, T.2    Liedl, K.R.3
  • 35
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • Saharinen P, Takaluoma K, Silvennoinen O. 2000. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell Biol. 20:3387-95
    • (2000) Mol. Cell Biol , vol.20 , pp. 3387-3395
    • Saharinen, P.1    Takaluoma, K.2    Silvennoinen, O.3
  • 36
    • 34548240698 scopus 로고    scopus 로고
    • Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
    • Levine RL, Pardanani A, Tefferi A, et al. 2007. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat. Rev. Cancer 7:673-83
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 673-683
    • Levine, R.L.1    Pardanani, A.2    Tefferi, A.3
  • 37
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T, et al. 2006. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108:3472-76
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3
  • 38
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
    • Ding J, Komatsu H, Wakita A, et al. 2004. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 103:4198-200
    • (2004) Blood , vol.103 , pp. 4198-4200
    • Ding, J.1    Komatsu, H.2    Wakita, A.3
  • 39
    • 49449094277 scopus 로고    scopus 로고
    • New mutations of MPL in primitive myelofibrosis: Only the MPLW515 mutations promote a G(1)/S-phase transition
    • Chaligne R, Tonetti C, Besancenot R, et al. 2008. New mutations of MPL in primitive myelofibrosis: only the MPLW515 mutations promote a G(1)/S-phase transition. Leukemia 22(8):1557-66
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1557-1566
    • Chaligne, R.1    Tonetti, C.2    Besancenot, R.3
  • 40
    • 33750221616 scopus 로고    scopus 로고
    • Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
    • Funakoshi-Tago M, Pelletier S, Matsuda T, et al. 2006. Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J. 25:4763-72
    • (2006) EMBO J , vol.25 , pp. 4763-4772
    • Funakoshi-Tago, M.1    Pelletier, S.2    Matsuda, T.3
  • 41
    • 41949128334 scopus 로고    scopus 로고
    • Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders
    • Pardanani A, Fridley BL, Lasho TL, et al. 2008. Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. Blood 111:2785-89
    • (2008) Blood , vol.111 , pp. 2785-2789
    • Pardanani, A.1    Fridley, B.L.2    Lasho, T.L.3
  • 42
    • 30844443469 scopus 로고    scopus 로고
    • Pathogenesis of myelofibrosis with myeloid metaplasia
    • Tefferi A. 2005. Pathogenesis of myelofibrosis with myeloid metaplasia. J. Clin. Oncol. 23:8520-30
    • (2005) J. Clin. Oncol , vol.23 , pp. 8520-8530
    • Tefferi, A.1
  • 43
    • 0031667526 scopus 로고    scopus 로고
    • Systemic transforming growth factor-beta in patients with bone marrow fibrosis - pathophysiological implications
    • Rameshwar P, Chang VT, Thacker UF, et al. 1998. Systemic transforming growth factor-beta in patients with bone marrow fibrosis - pathophysiological implications. Am. J. Hematol. 59:133-42
    • (1998) Am. J. Hematol , vol.59 , pp. 133-142
    • Rameshwar, P.1    Chang, V.T.2    Thacker, U.F.3
  • 44
    • 0030718597 scopus 로고    scopus 로고
    • High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
    • Villeval JL, Cohen-Solal K, Tulliez M, et al. 1997. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 90:4369-83
    • (1997) Blood , vol.90 , pp. 4369-4383
    • Villeval, J.L.1    Cohen-Solal, K.2    Tulliez, M.3
  • 45
    • 0029956149 scopus 로고    scopus 로고
    • A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation
    • Yan XQ, Lacey D, Hill D, et al. 1996. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 88:402-9
    • (1996) Blood , vol.88 , pp. 402-409
    • Yan, X.Q.1    Lacey, D.2    Hill, D.3
  • 46
    • 67650734484 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 47
    • 0035760303 scopus 로고    scopus 로고
    • (+) cells in myelofibrosis with myeloid metaplasia
    • (+) cells in myelofibrosis with myeloid metaplasia. Blood 98:3249-55
    • (2001) Blood , vol.98 , pp. 3249-3255
    • Barosi, G.1    Viarengo, G.2    Pecci, A.3
  • 48
    • 0028845438 scopus 로고
    • Relevance of marrow fibrosis in bone marrow transplantation: A retrospective analysis of engraftment
    • Soll E, Massumoto C, Clift RA, et al. 1995. Relevance of marrow fibrosis in bone marrow transplantation: a retrospective analysis of engraftment. Blood 86:4667-73
    • (1995) Blood , vol.86 , pp. 4667-4673
    • Soll, E.1    Massumoto, C.2    Clift, R.A.3
  • 50
    • 41849114476 scopus 로고    scopus 로고
    • Dose-reduced conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis. Results from a multicenter prospective trial of the Chronic LeukemiaWorking Party of the European group for Blood and Marrow Transplantation (EBMT)
    • Abstr
    • Kroeger N, Holler E, Kobbe G, et al. 2007. Dose-reduced conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis. Results from a multicenter prospective trial of the Chronic LeukemiaWorking Party of the European group for Blood and Marrow Transplantation (EBMT). Blood 110:683 (Abstr.)
    • (2007) Blood , vol.110 , pp. 683
    • Kroeger, N.1    Holler, E.2    Kobbe, G.3
  • 51
    • 0024212665 scopus 로고
    • Management of polycythaemia vera, essential thrombocythaemia and myelofibrosis with hydroxyurea
    • Lofvenberg E, Wahlin A. 1988. Management of polycythaemia vera, essential thrombocythaemia and myelofibrosis with hydroxyurea. Eur. J. Haematol. 41:375-81
    • (1988) Eur. J. Haematol , vol.41 , pp. 375-381
    • Lofvenberg, E.1    Wahlin, A.2
  • 52
    • 33747167338 scopus 로고    scopus 로고
    • Lenalidomide therapy in myelofibrosis with myeloid metaplasia
    • Tefferi A, Cortes J, Verstovsek S, et al. 2006. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood 108:1158-64
    • (2006) Blood , vol.108 , pp. 1158-1164
    • Tefferi, A.1    Cortes, J.2    Verstovsek, S.3
  • 53
    • 42449108162 scopus 로고    scopus 로고
    • Erythropoiesis stimulating agents and the risk of leukemic transformation in primary myelofibrosis
    • Abstr
    • Huang J, Li CY, Mesa RA, et al. 2007. Erythropoiesis stimulating agents and the risk of leukemic transformation in primary myelofibrosis. Blood 110:683 (Abstr.)
    • (2007) Blood , vol.110 , pp. 683
    • Huang, J.1    Li, C.Y.2    Mesa, R.A.3
  • 54
    • 33745811661 scopus 로고    scopus 로고
    • Palliative goals, patient selection, and perioperative platelet management: Outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
    • Mesa RA, Nagorney DS, Schwager S, et al. 2006. Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic. Cancer 107:361-70
    • (2006) Cancer , vol.107 , pp. 361-370
    • Mesa, R.A.1    Nagorney, D.S.2    Schwager, S.3
  • 55
    • 0031784441 scopus 로고    scopus 로고
    • Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia
    • Elliott MA, Chen MG, Silverstein MN, et al. 1998. Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia. Br. J. Haematol. 103:505-11
    • (1998) Br. J. Haematol , vol.103 , pp. 505-511
    • Elliott, M.A.1    Chen, M.G.2    Silverstein, M.N.3
  • 56
    • 0035141985 scopus 로고    scopus 로고
    • Radiation therapy for symptomatic hepatomegaly in myelofibrosis with myeloid metaplasia
    • Tefferi A, Jimenez T, Gray LA, et al. 2001. Radiation therapy for symptomatic hepatomegaly in myelofibrosis with myeloid metaplasia. Eur. J. Haematol. 66:37-42
    • (2001) Eur. J. Haematol , vol.66 , pp. 37-42
    • Tefferi, A.1    Jimenez, T.2    Gray, L.A.3
  • 57
    • 38349053791 scopus 로고    scopus 로고
    • JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials
    • Pardanani A. 2008. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia 22:23-30
    • (2008) Leukemia , vol.22 , pp. 23-30
    • Pardanani, A.1
  • 58
    • 39749118802 scopus 로고    scopus 로고
    • INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and postpolycythemia vera/essential thrombocythemia (post-PV/ET MF)
    • Verstovsek S, Kantarjian H, Pardanani A, et al. 2007. INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and postpolycythemia vera/essential thrombocythemia (post-PV/ET MF). Blood 110:558
    • (2007) Blood , vol.110 , pp. 558
    • Verstovsek, S.1    Kantarjian, H.2    Pardanani, A.3
  • 59
    • 34447627350 scopus 로고    scopus 로고
    • TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
    • Pardanani A, Hood J, Lasho T, et al. 2007. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia 21:1658-68
    • (2007) Leukemia , vol.21 , pp. 1658-1668
    • Pardanani, A.1    Hood, J.2    Lasho, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.