Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome

Molecular Genetics and Metabolism

Volumn 116, Issue 4, 2015, Pages 305-313

  Tekola Ayele, Fasil ^a   Doumatey, Ayo P ^a   Shriner, Daniel ^a   Bentley, Amy R ^a   Chen, Guanjie ^a   Zhou, Jie ^a   Fasanmade, Olufemi ^b   Johnson, Thomas ^b   Oli, Johnnie ^c   Okafor, Godfrey ^c   Eghan, Benjami A ^d   Agyenim Boateng, Kofi ^d   Adebamowo, Clement ^e   Amoah, Albert ^f   Acheampong, Joseph ^d   Adeyemo, Adebowale ^a   Rotimi, Charles N ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF LAGOS   (Nigeria)

^c UNIVERSITY OF NIGERIA   (Nigeria)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF GHANA   (Ghana)

Author keywords

African ancestry; Genome wide association study; Metabolic syndrome; Pleiotropy

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; GLUCOSE; KINASE SUPPRESSOR OF RAS 2; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ALPHA CATENIN; CA10 PROTEIN, HUMAN; CETP PROTEIN, HUMAN; CTNNA3 PROTEIN, HUMAN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN GROUP C; KSR2 PROTEIN, HUMAN; LIPOPROTEIN LIPASE; LPL PROTEIN, HUMAN; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE; RALY PROTEIN, HUMAN;

ACCURACY; ADULT; AFRICAN; ALLELE; ARTICLE; BAI3 GENE; BLOOD PRESSURE MEASUREMENT; BODY MASS; BRAIN FUNCTION; CA10 GENE; COMPARATIVE STUDY; CONTROLLED STUDY; CTNNA3 GENE; DIASTOLIC BLOOD PRESSURE; ETHNIC DIFFERENCE; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENETIC VARIABILITY; GENOME; GENOME ANALYSIS; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PLEIOTROPY; PREVALENCE; PRIORITY JOURNAL; RALYL GENE; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; WEST AFRICAN; BLACK PERSON; BLOOD; BLOOD PRESSURE; CAUCASIAN; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GHANA; KENYA; NIGERIA; PATHOLOGY; PHENOTYPE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALPHA CATENIN; BLOOD PRESSURE; CHOLESTEROL ESTER TRANSFER PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GHANA; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP C; HUMANS; KENYA; LIPOPROTEIN LIPASE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NERVE TISSUE PROTEINS; NIGERIA; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; TRIGLYCERIDES;

EID: 84961639691     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2015.10.008     Document Type: Article

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