A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs

BMC Bioinformatics

Volumn 16, Issue 18, 2015, Pages

  Kao, Hui Ju ^a   Huang, Chien Hsun ^a,b   Bretaña, Neil Arvin ^c   Lu, Cheng Tsung ^a   Huang, Kai Yao ^a   Weng, Shun Long ^d,e,f   Lee, Tzong Yi ^a  

^a YUAN ZE UNIVERSITY   (Taiwan)

^b TAO YUAN GENERAL HOSPITAL   (Taiwan)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

^e MACKAY JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^f MACKAY MEDICAL COLLEGE   (Taiwan)

Author keywords

O GlcNAc transferase (OGT); O GlcNAcylation; O linked glycosylation; Profile hidden Markov model; Substrate motif; Support vector machine

Indexed keywords

AMINO ACIDS; ARTIFICIAL INTELLIGENCE; GLYCOSYLATION; HIDDEN MARKOV MODELS; LEARNING SYSTEMS; MARKOV PROCESSES; MASS SPECTROMETRY; MOLECULAR BIOLOGY; SUPPORT VECTOR MACHINES;

MACHINE LEARNING METHODS; O-LINKED; PREDICTIVE MODELING; PRELIMINARY ANALYSIS; PROFILE HIDDEN MARKOV MODEL; SITE-SPECIFIC INFORMATION; SUBSTRATE MOTIFS; SUBSTRATE SPECIFICITY;

PROTEINS;

N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINYLTRANSFERASE; O-GLCNAC TRANSFERASE; PEPTIDE; PROTEIN;

ALGORITHM; CHEMISTRY; COMPUTER INTERFACE; ENZYME SPECIFICITY; GLYCOSYLATION; INTERNET; MACHINE LEARNING; MASS SPECTROMETRY; METABOLISM; PROTEIN MOTIF; SUPPORT VECTOR MACHINE;

ACETYLGLUCOSAMINE; ALGORITHMS; AMINO ACID MOTIFS; GLYCOSYLATION; INTERNET; MACHINE LEARNING; MASS SPECTROMETRY; N-ACETYLGLUCOSAMINYLTRANSFERASES; PEPTIDES; PROTEINS; SUBSTRATE SPECIFICITY; SUPPORT VECTOR MACHINE; USER-COMPUTER INTERFACE;

EID: 84961635261     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-16-S18-S10     Document Type: Article

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