Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation

Cancer Chemotherapy and Pharmacology

Volumn 77, Issue 5, 2016, Pages 963-972

  Zhao, Fei ^a   Ming, Jia ^b   Zhou, Yan ^b   Fan, Linjun ^b  

^a NO 281 Hospital of PLA   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Chemotherapy; Glut1 inhibitor; Irradiation resistance; WZB117

Indexed keywords

BETA ACTIN; CASPASE 3; GLUCOSE; GLUCOSE TRANSPORTER 1; HEXOKINASE; HEXOKINASE 2; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WZB 117; HYDROXYBENZOIC ACID DERIVATIVE; RADIOSENSITIZING AGENT; SLC2A1 PROTEIN, HUMAN; WZB117;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER RADIOTHERAPY; CANCER RESISTANCE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; PRIORITY JOURNAL; RADIOSENSITIVITY; UPREGULATION; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL CULTURE TECHNIQUE; CELL SURVIVAL; DRUG EFFECTS; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; REAL TIME POLYMERASE CHAIN REACTION;

BREAST NEOPLASMS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; HYDROXYBENZOATES; IMMUNOHISTOCHEMISTRY; MCF-7 CELLS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 84961618710     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-016-3007-9     Document Type: Article

References (23)

1. Tinoco G, Warsch S, Glück S, Avancha K, Montero AJ (2013) Treating breast cancer in the 21st century: emerging biological therapies. J Cancer 4: 117-132
2. Sledge GW, Mamounas EP, Hortobagyi GN, Burstein HJ, Goodwin PJ, Wolff AC (2014) Past, present, and future challenges in breast cancer treatment. J Clin Oncol 32: 1979-1986
3. Hassan MS, Ansari J, Spooner D, Hussain SA (2010) Chemotherapy for breast cancer. Oncol Rep 24: 1121-1131
4. Delaney G, Jacob S, Featherstone C, Barton M (2005) The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 104: 1129-1137
5. Jameel JK, Rao VS, Cawkwell L, Drew PJ (2004) Radioresistance in carcinoma of the breast. Breast 13: 452-460
6. Huang EY, Chen YF, Chen YM, Lin IH, Wang CC, Su WH, Chuang PC, Yang KD (2012) A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells. Cell Death Dis 3: e251
7. Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M (2012) Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun 3: 783
8. Dang CV (2012) Links between metabolism and cancer. Genes Dev 26: 877-890
9. Ganapathy-Kanniappan S, Geschwind JF (2013) Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer 12: 152
10. Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, Kalra N, Dwarakanath BS (2015) Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells. BMC Cancer 15: 335
11. Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, Batinic-Haberle I, Dewhirst MW (2013) Radiation induces aerobic glycolysis through reactive oxygen species. Radiother Oncol 106: 390-396
12. Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, Akbar H, Colvin R, Ding J, Tong L, Wu S, Hines J, Chen X (2012) A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 11: 1672-1682
13. Shibuya KI, Okada M, Suzuki S, Seino MI, Seino S, Takeda H, Kitanaka C (2015) Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget 6: 651-661
14. Liu W, Fang Y, Wang XT, Liu J, Dan X, Sun LL (2014) Overcoming 5-Fu resistance of colon cells through inhibition of Glut1 by the specific inhibitor WZB117. Asian Pac J Cancer Prev 15: 7037-7041
15. Andrisse S, Koehler RM, Chen JE, Patel GD, Vallurupalli VR, Ratliff BA, Warren DE, Fisher JS (2014) Role of GLUT1 in regulation of reactive oxygen species. Redox Biol 2: 764-771
16. North PE, Waner M, Mizeracki A, Mihm MC Jr (2000) GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31: 11-22
17. Loar P, Wahl H, Kshirsagar M, Gossner G, Griffith K, Liu JR (2010) Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cells. Am J Obstet Gynecol. 202: 371. e1-8
18. Shin YK, Yoo BC, Hong YS, Chang HJ, Jung KH, Jeong SY, Park JG (2009) Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance. Electrophoresis 30: 2182-2192
19. Bean JF, Qiu YY, Yu S, Clark S, Chu F, Madonna MB (2014) Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma. J Pediatr Surg 49: 981-984
20. Lomax ME, Folkes LK, O’Neill P (2013) Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. Clin Oncol (R Coll Radiol) 25: 578-585
21. Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441
22. Quennet V, Yaromina A, Zips D, Rosner A, Walenta S, Baumann M, Mueller-Klieser W (2006) Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. Radiother Oncol 81: 130-135
23. Shimura T, Noma N, Sano Y, Ochiai Y, Oikawa T, Fukumoto M, Kunugita N (2014) AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells. Radiother Oncol 112: 302-307