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Volumn 39, Issue 1, 2016, Pages 82-91

Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction after Testosterone Replacement in Men with Type 2 Diabetes

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; C REACTIVE PROTEIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FATTY ACID; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 1BETA; LEPTIN; METFORMIN; PLACEBO; PROTEIN KINASE B BETA; SODIUM CHLORIDE; SULFONYLUREA DERIVATIVE; TESTOSTERONE CIPIONATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IL1B PROTEIN, HUMAN; TESTOSTERONE; TUMOR NECROSIS FACTOR;

EID: 84961617337     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-1518     Document Type: Article
Times cited : (227)

References (41)
  • 2
    • 80052530001 scopus 로고    scopus 로고
    • Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity
    • Dandona P, Dhindsa S. Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab 2011;96: 2643-2651
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2643-2651
    • Dandona, P.1    Dhindsa, S.2
  • 3
    • 33845467935 scopus 로고    scopus 로고
    • Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes
    • Bhatia V, Chaudhuri A, Tomar R, Dhindsa S, Ghanim H, Dandona P. Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes. Diabetes Care 2006;29:2289-2294
    • (2006) Diabetes Care , vol.29 , pp. 2289-2294
    • Bhatia, V.1    Chaudhuri, A.2    Tomar, R.3    Dhindsa, S.4    Ghanim, H.5    Dandona, P.6
  • 5
    • 79851506306 scopus 로고    scopus 로고
    • Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy
    • Oxf
    • Hamilton EJ, Gianatti E, Strauss BJ, et al. Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy. Clin Endocrinol (Oxf) 2011;74:377-383
    • (2011) Clin Endocrinol , vol.74 , pp. 377-383
    • Hamilton, E.J.1    Gianatti, E.2    Strauss, B.J.3
  • 6
    • 1842538111 scopus 로고    scopus 로고
    • Association of bioavailable, free, and total testosterone with insulin resistance: Influence of sex hormone-binding globulin and body fat
    • Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ. Association of bioavailable, free, and total testosterone with insulin resistance: Influence of sex hormone-binding globulin and body fat. Diabetes Care 2004;27:861-868
    • (2004) Diabetes Care , vol.27 , pp. 861-868
    • Tsai, E.C.1    Matsumoto, A.M.2    Fujimoto, W.Y.3    Boyko, E.J.4
  • 7
    • 84905010469 scopus 로고    scopus 로고
    • Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: A randomized controlled trial
    • Gianatti EJ, Dupuis P, Hoermann R, et al. Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: A randomized controlled trial. Diabetes Care 2014;37:2098-2107
    • (2014) Diabetes Care , vol.37 , pp. 2098-2107
    • Gianatti, E.J.1    Dupuis, P.2    Hoermann, R.3
  • 8
    • 79956271879 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    • TIMES2 Investigators
    • Jones TH, Arver S, Behre HM, et al.; TIMES2 Investigators. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care 2011;34:828-837
    • (2011) Diabetes Care , vol.34 , pp. 828-837
    • Jones, T.H.1    Arver, S.2    Behre, H.M.3
  • 9
    • 84895430322 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: The BLAST study
    • BLAST Study Group
    • Hackett G, Cole N, BhartiaM, Kennedy D, Raju J, Wilkinson P; BLAST Study Group. Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: The BLAST study. J Sex Med 2014;11:840-856
    • (2014) J Sex Med , vol.11 , pp. 840-856
    • Hackett, G.1    Cole, N.2    Bhartia, M.3    Kennedy, D.4    Raju, J.5    Wilkinson, P.6
  • 10
    • 84940105378 scopus 로고    scopus 로고
    • Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: A systematic review and meta-analysis of randomized controlled clinical trials
    • Oxf
    • Grossmann M, Hoermann R, Wittert G, Yeap BB. Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: A systematic review and meta-analysis of randomized controlled clinical trials. Clin Endocrinol (Oxf) 2015;83:344-351
    • (2015) Clin Endocrinol , vol.83 , pp. 344-351
    • Grossmann, M.1    Hoermann, R.2    Wittert, G.3    Yeap, B.B.4
  • 11
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Task Force, Endocrine Society
    • Bhasin S, Cunningham GR, Hayes FJ, et al.; Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010;95:2536-2559
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 12
    • 0036758313 scopus 로고    scopus 로고
    • Diagnosis of hypogonadism in the aging male
    • Vermeulen A, Kaufman JM. Diagnosis of hypogonadism in the aging male. Aging Male 2002;5:170-176
    • (2002) Aging Male , vol.5 , pp. 170-176
    • Vermeulen, A.1    Kaufman, J.M.2
  • 13
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223
    • (1979) Am J Physiol , vol.237 , pp. 214-223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 14
    • 79951685702 scopus 로고    scopus 로고
    • Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers
    • Lˆe KA, Ventura EE, Fisher JQ, et al. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 2011;34:485-490
    • (2011) Diabetes Care , vol.34 , pp. 485-490
    • Lˆe, K.A.1    Ventura, E.E.2    Fisher, J.Q.3
  • 15
    • 67650364695 scopus 로고    scopus 로고
    • Sex differences in visceral adipose tissue postbariatric surgery compared to matched nonsurgical controls
    • Korner J, Punyanitya M, Taveras C, et al. Sex differences in visceral adipose tissue postbariatric surgery compared to matched nonsurgical controls. Int J Body Compos Res 2008; 6:93-99
    • (2008) Int J Body Compos Res , vol.6 , pp. 93-99
    • Korner, J.1    Punyanitya, M.2    Taveras, C.3
  • 16
    • 73249144834 scopus 로고    scopus 로고
    • Validation of a total testosterone assay using high-turbulence liquid chromatography tandem mass spectrometry: Total and free testosterone reference ranges
    • Salameh WA, Redor-Goldman MM, Clarke NJ, Reitz RE, Caulfield MP. Validation of a total testosterone assay using high-turbulence liquid chromatography tandem mass spectrometry: Total and free testosterone reference ranges. Steroids 2010;75:169-175
    • (2010) Steroids , vol.75 , pp. 169-175
    • Salameh, W.A.1    Redor-Goldman, M.M.2    Clarke, N.J.3    Reitz, R.E.4    Caulfield, M.P.5
  • 17
    • 80052520789 scopus 로고    scopus 로고
    • Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes
    • Dhindsa S, Furlanetto R, Vora M, Ghanim H, Chaudhuri A, Dandona P. Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care 2011;34:1854-1859
    • (2011) Diabetes Care , vol.34 , pp. 1854-1859
    • Dhindsa, S.1    Furlanetto, R.2    Vora, M.3    Ghanim, H.4    Chaudhuri, A.5    Dandona, P.6
  • 18
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature
    • Söderg°ard R, Bäckstr öm T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982;16:801-810
    • (1982) J Steroid Biochem , vol.16 , pp. 801-810
    • Södergard, R.1    Bäckstr Öm, T.2    Shanbhag, V.3    Carstensen, H.4
  • 19
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-3672
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 20
    • 0034915177 scopus 로고    scopus 로고
    • Insulin inhibits intranuclear nuclear factor kappaB and stimulates Ikappa B in mononuclear cells in obese subjects evidence for an antiinflammatory effect?
    • Dandona P, Aljada A,Mohanty P, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: Evidence for an antiinflammatory effect? J Clin Endocrinol Metab 2001;86:3257-3265
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3257-3265
    • Dandona, P.1    Aljada, A.2    Mohanty, P.3
  • 21
    • 0642343055 scopus 로고    scopus 로고
    • A simple self-report diary for assessing psychosexual function in hypogonadal men
    • Lee KK, Berman N, Alexander GM, Hull L, Swerdloff RS, Wang C. A simple self-report diary for assessing psychosexual function in hypogonadal men. J Androl 2003;24:688-698
    • (2003) J Androl , vol.24 , pp. 688-698
    • Lee, K.K.1    Berman, N.2    Alexander, G.M.3    Hull, L.4    Swerdloff, R.S.5    Wang, C.6
  • 22
    • 2442543161 scopus 로고    scopus 로고
    • Longterm testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men
    • Wang C, Cunningham G, Dobs A, et al. Longterm testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 2004;89:2085-2098
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2085-2098
    • Wang, C.1    Cunningham, G.2    Dobs, A.3
  • 23
    • 8344248424 scopus 로고    scopus 로고
    • Diabetes is associated independently of body composition with bmd and bone volume in olderwhite and blackmen and women: The health aging and body composition study
    • Health ABC Study
    • Strotmeyer ES, Cauley JA, Schwartz AV, et al.; Health ABC Study.Diabetes is associated independently of body composition with BMD and bone volume in olderwhite and blackmen and women: The Health, Aging, and Body Composition Study. J Bone Miner Res 2004;19:1084-1091
    • (2004) J Bone Miner Res , vol.19 , pp. 1084-1091
    • Strotmeyer, E.S.1    Cauley, J.A.2    Schwartz, A.V.3
  • 24
    • 84862326636 scopus 로고    scopus 로고
    • Testosterone therapy increased muscle mass and lipid oxidation in aging men
    • Dordr
    • Frederiksen L, Højlund K, Hougaard DM, Brixen K, Andersen M. Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age (Dordr) 2012;34:145-156
    • (2012) Age , vol.34 , pp. 145-156
    • Frederiksen, L.1    Højlund, K.2    Hougaard, D.M.3    Brixen, K.4    Andersen, M.5
  • 25
    • 0345275811 scopus 로고    scopus 로고
    • Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects
    • Tripathy D, Mohanty P, Dhindsa S, et al. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes 2003;52:2882-2887
    • (2003) Diabetes , vol.52 , pp. 2882-2887
    • Tripathy, D.1    Mohanty, P.2    Dhindsa, S.3
  • 26
    • 0029084869 scopus 로고
    • Effects of fat on glucose uptake and utilization in patients with noninsulin-dependent diabetes
    • Boden G, Chen X. Effects of fat on glucose uptake and utilization in patients with noninsulin-dependent diabetes. J Clin Invest 1995;96:1261-1268
    • (1995) J Clin Invest , vol.96 , pp. 1261-1268
    • Boden, G.1    Chen, X.2
  • 27
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 2002;277:42394-42398
    • (2002) J Biol Chem , vol.277 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 28
    • 0346250165 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance: Potential links with inflammation
    • Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: Potential links with inflammation. Int J Obes Relat Metab Disord 2003;27(Suppl. 3):S6-S11
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 6-11
    • Perseghin, G.1    Petersen, K.2    Shulman, G.I.3
  • 29
    • 0031941815 scopus 로고    scopus 로고
    • Proteintyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
    • Byon JC, Kusari AB, Kusari J. Proteintyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol Cell Biochem 1998;182:101-108
    • (1998) Mol Cell Biochem , vol.182 , pp. 101-108
    • Byon, J.C.1    Kusari, A.B.2    Kusari, J.3
  • 30
    • 28244446188 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis
    • Kushner JA, Simpson L, Wartschow LM, et al. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem 2005;280:39388-39393
    • (2005) J Biol Chem , vol.280 , pp. 39388-39393
    • Kushner, J.A.1    Simpson, L.2    Wartschow, L.M.3
  • 31
    • 77957567733 scopus 로고    scopus 로고
    • Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism andmetabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study
    • Aversa A, Bruzziches R, Francomano D, et al. Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism andmetabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study. J Sex Med 2010;7:3495-3503
    • (2010) J Sex Med , vol.7 , pp. 3495-3503
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3
  • 32
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study
    • Oxf
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ, Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study. Clin Endocrinol (Oxf) 2010;73: 602-612
    • (2010) Clin Endocrinol , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 33
    • 84897489268 scopus 로고    scopus 로고
    • Effects of long-term testosterone therapy on patients with diabesity results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes
    • Haider A, Yassin A, Doros G, Saad F. Effects of long-term testosterone therapy on patients with "diabesity": Results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes. Int J Endocrinol 2014;2014:683515
    • (2014) Int J Endocrinol , vol.2014 , pp. 683515
    • Haider, A.1    Yassin, A.2    Doros, G.3    Saad, F.4
  • 34
    • 0001765369 scopus 로고
    • Androgen treatment of abdominally obese men
    • Marin P, Holmäng S, Gustafsson C, et al. Androgen treatment of abdominally obese men. Obes Res 1993;1:245-251
    • (1993) Obes Res , vol.1 , pp. 245-251
    • Marin, P.1    Holmäng, S.2    Gustafsson, C.3
  • 35
    • 0027102382 scopus 로고
    • The effects of testosterone treatment on body composition and metabolism in middle-aged obese men
    • Marin P, Holmäng S, Jönsson L, et al. The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord 1992;16: 991-997
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 991-997
    • Marin, P.1    Holmäng, S.2    Jönsson, L.3
  • 36
    • 0026929033 scopus 로고
    • Androgen treatment of middle-aged, obese men: Effects on metabolism, muscle and adipose tissues
    • Marin P, Krotkiewski M, Björntorp P. Androgen treatment of middle-aged, obese men: Effects on metabolism, muscle and adipose tissues. Eur J Med 1992;1:329-336
    • (1992) Eur J Med , vol.1 , pp. 329-336
    • Marin, P.1    Krotkiewski, M.2    Björntorp, P.3
  • 37
    • 84922706701 scopus 로고    scopus 로고
    • Testosterone supplementation improves carbohydrate and lipid metabolism in some older men with abdominal obesity
    • Sattler F, He J, Chukwuneke J, et al. Testosterone supplementation improves carbohydrate and lipid metabolism in some older men with abdominal obesity. J Gerontol Geriatr Res 2014;3:1000159
    • (2014) J Gerontol Geriatr Res , vol.3 , pp. 1000159
    • Sattler, F.1    He, J.2    Chukwuneke, J.3
  • 38
    • 34547660521 scopus 로고    scopus 로고
    • Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men
    • Basu R, Dalla Man C, Campioni M, et al. Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care 2007;30:1972-1978
    • (2007) Diabetes Care , vol.30 , pp. 1972-1978
    • Basu, R.1    Dalla Man, C.2    Campioni, M.3
  • 39
    • 0031724427 scopus 로고    scopus 로고
    • Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism
    • Tripathy D, Shah P, Lakshmy R, Reddy KS. Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res 1998;30:642-645
    • (1998) Horm Metab Res , vol.30 , pp. 642-645
    • Tripathy, D.1    Shah, P.2    Lakshmy, R.3    Reddy, K.S.4
  • 40
    • 69949178483 scopus 로고    scopus 로고
    • Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone
    • Heufelder AE, Saad F, Bunck MC, Gooren L. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl 2009;30:726-733
    • (2009) J Androl , vol.30 , pp. 726-733
    • Heufelder, A.E.1    Saad, F.2    Bunck, M.C.3    Gooren, L.4
  • 41
    • 79952034926 scopus 로고    scopus 로고
    • Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus
    • Gopal RA, Bothra N, Acharya SV, et al. Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus. Endocr Pract 2010;16:570-576
    • (2010) Endocr Pract , vol.16 , pp. 570-576
    • Gopal, R.A.1    Bothra, N.2    Acharya, S.V.3


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