-
1
-
-
84875459651
-
Computational drug repositioning: From data to therapeutics
-
Hurle MR, Yang L, Xie Q, Rajpal DK, Sanseau P, Agarwal P. Computational drug repositioning: from data to therapeutics. Clin Pharmacol Ther 2013; 93: 335–341.
-
(2013)
Clin Pharmacol Ther
, vol.93
, pp. 335-341
-
-
Hurle, M.R.1
Yang, L.2
Xie, Q.3
Rajpal, D.K.4
Sanseau, P.5
Agarwal, P.6
-
2
-
-
70349182290
-
A systems biology view of cancer
-
Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P et al. A systems biology view of cancer. Biochim Biophys Acta 2009; 1796: 129–139.
-
(2009)
Biochim Biophys Acta
, vol.1796
, pp. 129-139
-
-
Laubenbacher, R.1
Hower, V.2
Jarrah, A.3
Torti, S.V.4
Shulaev, V.5
Mendes, P.6
-
3
-
-
33749854572
-
High-throughput screening: Update on practices and success
-
Fox S, Farr-Jones S, Sopchak L, Boggs A, Nicely HW, Khoury R et al. High-throughput screening: update on practices and success. J Biomol Screen 2006; 11: 864–869.
-
(2006)
J Biomol Screen
, vol.11
, pp. 864-869
-
-
Fox, S.1
Farr-Jones, S.2
Sopchak, L.3
Boggs, A.4
Nicely, H.W.5
Khoury, R.6
-
4
-
-
17044373269
-
Finding the target after screening the phenotype
-
Hart CP. Finding the target after screening the phenotype. Drug Discov Today 2005; 10: 513–519.
-
(2005)
Drug Discov Today
, vol.10
, pp. 513-519
-
-
Hart, C.P.1
-
5
-
-
0000356151
-
A nonclonogenic cytotoxicity assay using primary cultures of patient tumor cells for anticancer drug screening
-
Dhar S GJ, Nilsson K, Nygren P, Larsson R. A nonclonogenic cytotoxicity assay using primary cultures of patient tumor cells for anticancer drug screening. J Biomol Screen 1998; 3: 207–216.
-
(1998)
J Biomol Screen
, vol.3
, pp. 207-216
-
-
Dhar, S.G.J.1
Nilsson, K.2
Nygren, P.3
Larsson, R.4
-
6
-
-
77955275498
-
Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue
-
Cree IA, Glaysher S, Harvey AL. Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue. Curr Opin Pharmacol 2010; 10: 375–379.
-
(2010)
Curr Opin Pharmacol
, vol.10
, pp. 375-379
-
-
Cree, I.A.1
Glaysher, S.2
Harvey, A.L.3
-
7
-
-
59149093636
-
Chemosensitivity and chemoresistance testing in ovarian cancer
-
Cree IA. Chemosensitivity and chemoresistance testing in ovarian cancer. Curr Opin Obstet Gynecol 2009; 21: 39–43.
-
(2009)
Curr Opin Obstet Gynecol
, vol.21
, pp. 39-43
-
-
Cree, I.A.1
-
8
-
-
67749139054
-
Predictive tests for individualization of pharmacological cancer treatment
-
Nygren P, Larsson R. Predictive tests for individualization of pharmacological cancer treatment. Expert Opin Med Diagn 2008; 2: 349–360.
-
(2008)
Expert Opin Med Diagn
, vol.2
, pp. 349-360
-
-
Nygren, P.1
Larsson, R.2
-
9
-
-
0033105697
-
Relationship between diagnosisspecific activity of cytotoxic drugs in fresh human tumour cells ex vivo and in the clinic
-
Fridborg H, Jonsson E, Nygren P, Larsson R. Relationship between diagnosisspecific activity of cytotoxic drugs in fresh human tumour cells ex vivo and in the clinic. Eur J Cancer 1999; 35: 424–432.
-
(1999)
Eur J Cancer
, vol.35
, pp. 424-432
-
-
Fridborg, H.1
Jonsson, E.2
Nygren, P.3
Larsson, R.4
-
10
-
-
84859785457
-
In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues
-
Haglund C, Aleskog A, Nygren P, Gullbo J, Hoglund M, Wickstrom M et al. In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues. Cancer Chemotherapy Pharmacol 2012; 69: 697–707.
-
(2012)
Cancer Chemotherapy Pharmacol
, vol.69
, pp. 697-707
-
-
Haglund, C.1
Aleskog, A.2
Nygren, P.3
Gullbo, J.4
Hoglund, M.5
Wickstrom, M.6
-
11
-
-
79958132098
-
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment
-
Gullbo J, Fryknas M, Rickardson L, Darcy P, Hagg M, Wickstrom M et al. Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment. Biochem Pharmacol 2011; 82: 139–147.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 139-147
-
-
Gullbo, J.1
Fryknas, M.2
Rickardson, L.3
Darcy, P.4
Hagg, M.5
Wickstrom, M.6
-
12
-
-
0026529184
-
Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA)
-
Larsson R, Kristensen J, Sandberg C, Nygren P. Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA). Int J Cancer 1992; 50: 177–185.
-
(1992)
Int J Cancer
, vol.50
, pp. 177-185
-
-
Larsson, R.1
Kristensen, J.2
Sandberg, C.3
Nygren, P.4
-
13
-
-
0017782474
-
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
-
Collins SJ, Gallo RC, Gallagher RE. Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 1977; 270: 347–349.
-
(1977)
Nature
, vol.270
, pp. 347-349
-
-
Collins, S.J.1
Gallo, R.C.2
Gallagher, R.E.3
-
14
-
-
20844431689
-
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations
-
Andersson A, Eden P, Lindgren D, Nilsson J, Lassen C, Heldrup J et al. Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. Leukemia 2005; 19: 1042–1050.
-
(2005)
Leukemia
, vol.19
, pp. 1042-1050
-
-
Andersson, A.1
Eden, P.2
Lindgren, D.3
Nilsson, J.4
Lassen, C.5
Heldrup, J.6
-
15
-
-
0020506009
-
Induction of differentiation of human acute myelogenous leukemia cells: Therapeutic implications
-
Koeffler HP. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 1983; 62: 709–721.
-
(1983)
Blood
, vol.62
, pp. 709-721
-
-
Koeffler, H.P.1
-
16
-
-
0036624916
-
A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
Levis M, Allebach J, Tse KF, Zheng R, Baldwin BR, Smith BD et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood 2002; 99: 3885–3891.
-
(2002)
Blood
, vol.99
, pp. 3885-3891
-
-
Levis, M.1
Allebach, J.2
Tse, K.F.3
Zheng, R.4
Baldwin, B.R.5
Smith, B.D.6
-
17
-
-
33748467107
-
Screening of an annotated compound library for drug activity in a resistant myeloma cell line
-
Rickardson L, Fryknas M, Haglund C, Lovborg H, Nygren P, Gustafsson MG et al. Screening of an annotated compound library for drug activity in a resistant myeloma cell line. Cancer Chemother Pharmacol 2006; 58: 749–758.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 749-758
-
-
Rickardson, L.1
Fryknas, M.2
Haglund, C.3
Lovborg, H.4
Nygren, P.5
Gustafsson, M.G.6
-
18
-
-
50349098488
-
The fluorometric microculture cytotoxicity assay
-
Lindhagen E, Nygren P, Larsson R. The fluorometric microculture cytotoxicity assay. Nat Protoc 2008; 3: 1364–1369.
-
(2008)
Nat Protoc
, vol.3
, pp. 1364-1369
-
-
Lindhagen, E.1
Nygren, P.2
Larsson, R.3
-
19
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006; 313: 1929–1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
-
20
-
-
77958590561
-
Ontologybased meta-analysis of global collections of high-throughput public data
-
Kupershmidt I, Su QJ, Grewal A, Sundaresh S, Halperin I, Flynn J et al. Ontologybased meta-analysis of global collections of high-throughput public data. PLoS One 2010; 5: e13066.
-
(2010)
Plos One
, vol.5
-
-
Kupershmidt, I.1
Su, Q.J.2
Grewal, A.3
Sundaresh, S.4
Halperin, I.5
Flynn, J.6
-
21
-
-
75549089718
-
Network and pathway analysis of compoundprotein interactions
-
Brennan RJ, Nikolskya T, Bureeva S. Network and pathway analysis of compoundprotein interactions. Methods Mol Biol 2009; 575: 225–247.
-
(2009)
Methods Mol Biol
, vol.575
, pp. 225-247
-
-
Brennan, R.J.1
Nikolskya, T.2
Bureeva, S.3
-
22
-
-
0030589620
-
Development of a highvolume in situ mRNA hybridization assay for the quantification of gene expression utilizing scintillating microplates
-
Harris DW, Kenrick MK, Pither RJ, Anson JG, Jones DA. Development of a highvolume in situ mRNA hybridization assay for the quantification of gene expression utilizing scintillating microplates. Anal Biochem 1996; 243: 249–256.
-
(1996)
Anal Biochem
, vol.243
, pp. 249-256
-
-
Harris, D.W.1
Kenrick, M.K.2
Pither, R.J.3
Anson, J.G.4
Jones, D.A.5
-
23
-
-
8844264615
-
A flexible data analysis tool for chemical genetic screens
-
Kelley BP, Lunn MR, Root DE, Flaherty SP, Martino AM, Stockwell BR. A flexible data analysis tool for chemical genetic screens. Chem Biol 2004; 11: 1495–1503.
-
(2004)
Chem Biol
, vol.11
, pp. 1495-1503
-
-
Kelley, B.P.1
Lunn, M.R.2
Root, D.E.3
Flaherty, S.P.4
Martino, A.M.5
Stockwell, B.R.6
-
24
-
-
84874025639
-
Old drug, new target: Ellipticines selectively inhibit RNA polymerase I transcription
-
Andrews WJ, Panova T, Normand C, Gadal O, Tikhonova IG, Panov KI. Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription. J Biol Chem 2013; 288: 4567–4582.
-
(2013)
J Biol Chem
, vol.288
, pp. 4567-4582
-
-
Andrews, W.J.1
Panova, T.2
Normand, C.3
Gadal, O.4
Tikhonova, I.G.5
Panov, K.I.6
-
25
-
-
50349099662
-
Individualized Tumor Response Testing in Leukemia and Lymphoma
-
1st edn, Informa Healthcare: New York, NY, USA
-
Bosanquet A, Nygren P, Weisenthal L. Individualized Tumor Response Testing in Leukemia and Lymphoma. In: Innovative Leukemia and Lymphoma Therapy. 1st edn, Informa Healthcare: New York, NY, USA, 2008.
-
(2008)
Innovative Leukemia and Lymphoma Therapy
-
-
Bosanquet, A.1
Nygren, P.2
Weisenthal, L.3
-
26
-
-
79955799029
-
Beyond DNA binding-a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
-
Ehsanian R, Van Waes C, Feller SM. Beyond DNA binding-a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers. Cell Commun Signal 2011; 9: 13.
-
(2011)
Cell Commun Signal
, vol.9
-
-
Ehsanian, R.1
van Waes, C.2
Feller, S.M.3
-
27
-
-
10144229414
-
Pharmacokinetics of quinacrine in the treatment of prion disease
-
Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M et al. Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infect Dis 2004; 4: 53.
-
(2004)
BMC Infect Dis
, vol.4
, pp. 53
-
-
Yung, L.1
Huang, Y.2
Lessard, P.3
Legname, G.4
Lin, E.T.5
Baldwin, M.6
-
28
-
-
75149144542
-
New hopes from old drugs: Revisiting DNA-binding small molecules as anticancer agents
-
Gurova K. New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents. Future Oncol 2009; 5: 1685–1704.
-
(2009)
Future Oncol
, vol.5
, pp. 1685-1704
-
-
Gurova, K.1
-
29
-
-
84856328050
-
Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity
-
Preet R, Mohapatra P, Mohanty S, Sahu SK, Choudhuri T, Wyatt MD et al. Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. Int J Cancer 2012; 130: 1660–1670.
-
(2012)
Int J Cancer
, vol.130
, pp. 1660-1670
-
-
Preet, R.1
Mohapatra, P.2
Mohanty, S.3
Sahu, S.K.4
Choudhuri, T.5
Wyatt, M.D.6
-
30
-
-
77953533783
-
Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin
-
Jani TS, DeVecchio J, Mazumdar T, Agyeman A, Houghton JA. Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. J Biol Chem 2010; 285: 19162–19172.
-
(2010)
J Biol Chem
, vol.285
, pp. 19162-19172
-
-
Jani, T.S.1
Devecchio, J.2
Mazumdar, T.3
Agyeman, A.4
Houghton, J.A.5
-
31
-
-
28444472744
-
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors
-
Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 2005; 102: 17448–17453.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17448-17453
-
-
Gurova, K.V.1
Hill, J.E.2
Guo, C.3
Prokvolit, A.4
Burdelya, L.G.5
Samoylova, E.6
-
32
-
-
61349141840
-
9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways
-
Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV et al. 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. Oncogene 2009; 28: 1151–1161.
-
(2009)
Oncogene
, vol.28
, pp. 1151-1161
-
-
Guo, C.1
Gasparian, A.V.2
Zhuang, Z.3
Bosykh, D.A.4
Komar, A.A.5
Gudkov, A.V.6
-
33
-
-
74849113809
-
Anti-malaria drug blocks proteotoxic stress response: Anti-cancer implications
-
Neznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV et al. Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. Cell Cycle 2009; 8: 3960–3970.
-
(2009)
Cell Cycle
, vol.8
, pp. 3960-3970
-
-
Neznanov, N.1
Gorbachev, A.V.2
Neznanova, L.3
Komarov, A.P.4
Gurova, K.V.5
Gasparian, A.V.6
-
34
-
-
0029793039
-
Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay
-
Tiberghien F, Loor F. Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs 1996; 7: 568–578.
-
(1996)
Anticancer Drugs
, vol.7
, pp. 568-578
-
-
Tiberghien, F.1
Loor, F.2
-
35
-
-
84897099801
-
Targeting the nucleolus for cancer intervention
-
Quin JE, Devlin JR, Cameron D, Hannan KM, Pearson RB, Hannan RD. Targeting the nucleolus for cancer intervention. Biochim Biophys Acta 2014; 1842: 802–816.
-
(2014)
Biochim Biophys Acta
, vol.1842
, pp. 802-816
-
-
Quin, J.E.1
Devlin, J.R.2
Cameron, D.3
Hannan, K.M.4
Pearson, R.B.5
Hannan, R.D.6
-
36
-
-
0025245508
-
Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerases
-
Huff AC, Kreuzer KN. Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerases. J Biol Chem 1990; 265: 20496–20505.
-
(1990)
J Biol Chem
, vol.265
, pp. 20496-20505
-
-
Huff, A.C.1
Kreuzer, K.N.2
-
37
-
-
84922356652
-
Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation
-
Pan XN, Chen JJ, Wang LX, Xiao RZ, Liu LL, Fang ZG et al. Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation. PloS One 2014; 9: e105381.
-
(2014)
Plos One
, vol.9
-
-
Pan, X.N.1
Chen, J.J.2
Wang, L.X.3
Xiao, R.Z.4
Liu, L.L.5
Fang, Z.G.6
-
38
-
-
84925352454
-
Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia
-
Falantes JF, Trujillo P, Piruat JI, Calderon C, Marquez-Malaver FJ, Martin-Antonio B et al. Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia. Clin Lymphoma Myeloma Leuk 2015; 15: 236–244.
-
(2015)
Clin Lymphoma Myeloma Leuk
, vol.15
, pp. 236-244
-
-
Falantes, J.F.1
Trujillo, P.2
Piruat, J.I.3
Calderon, C.4
Marquez-Malaver, F.J.5
Martin-Antonio, B.6
|