Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk

BMC Genetics

Volumn 16, Issue 1, 2015, Pages

  Han, Xu ^a   Gui, Lixuan ^a   Liu, Bing ^a   Wang, Jing ^a   Li, Yaru ^a   Dai, Xiayun ^a   Li, Jun ^a   Yang, Binyao ^a   Qiu, Gaokun ^a   Feng, Jing ^a   Zhang, Xiaomin ^a   Wu, Tangchun ^a   He, Meian ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Coronary heart disease; Gene environment interaction; Polymorphism; Uric acid

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; GLUCOSE TRANSPORTER; SLC2A9 PROTEIN, HUMAN; TUMOR PROTEIN;

ABCG2 GENE; ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY RISK; FEMALE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HAN CHINESE; HIGH RISK POPULATION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SLC2A9 GENE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CORONARY ARTERY DISEASE; GENETICS; METABOLISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; ATP-BINDING CASSETTE TRANSPORTERS; CASE-CONTROL STUDIES; CORONARY DISEASE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; URIC ACID;

EID: 84961523233     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/s12863-015-0162-7     Document Type: Article

References (44)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6-e245.
2. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, et al. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet. 2011;43(4):345-9.
3. Gustavsson J, Mehlig K, Leander K, Strandhagen E, Bjorck L, Thelle DS, et al. Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. Atherosclerosis. 2012;220(2):486-92.
4. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum. 2009;61(2):225-32.
5. Kathiresan S, Altschuler D, Anand S, Ardissino D, Asselta R, Ball SG, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41 (3):334-41.
6. Fievet C, Nuttens MC, Ducimetiere P, Fruchart JC, Bertrand M, Salomez JL. Relation of arteriographically defined coronary artery disease to serum lipoprotein particles mapped with monoclonal antibodies. Circulation. 1991;84(1):153-9.
7. Sundell J, Raitakari OT, Viikari J, Kantola I, Nuutila P, Knuuti J. Both BMI and waist circumference are associated with coronary vasoreactivity in overweight and obese men. Obes Facts. 2012;5(5):693-9.
8. Dehghan A, Kottgen A, Yang Q, Hwang S, Kao W, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372(9654):1953-61.
9. Avram Z, Krishnan E. Hyperuricaemia-where nephrology meets rheumatology. Rheumatology. 2008;47(7):960-4.
10. Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, et al. Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men. Intern Med. 2008;47(13):1175-80.
11. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003;41(6):1287-93.
12. Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, et al. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. PLoS ONE. 2009;4(11):e7729.
13. Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol. 2004;33(1):30-42.
14. Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013;99(11):759-66.
15. Kivity S, Kopel E, Maor E, Abu-Bachar F, Segev S, Sidi Y, et al. Association of serum uric acid and cardiovascular disease in healthy adults. Am J Cardiol. 2013;111(8):1146-51.
16. Ndrepepa G, Braun S, King L, Fusaro M, Tada T, Cassese S, et al. Uric acid and prognosis in angiography-proven coronary artery disease. Eur J Clin Investig. 2013;43(3):256-66.
17. Jeemon P, Prabhakaran D. Does uric acid qualify as an independent risk factor for cardiovascular mortality? Clin Sci. 2013;124(4):255-7.
18. Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008;82(1):139-49.
19. Qi L, Parast L, Cai T, Powers C, Gervino EV, Hauser TH, et al. Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. J Am Coll Cardiol. 2011;58(25):2675-82.
20. Chen LK, Lin MH, Lai HY, Hwang SJ, Chiou ST. Uric acid: a surrogate of insulin resistance in older women. Maturitas. 2008;59(1):55-61.
21. Moriarity JT, Folsom AR, Iribarren C, Nieto FJ, Rosamond WD. Serum uric acid and risk of coronary heart disease: Atherosclerosis Risk in Communities (ARIC) study. Ann Epidemiol. 2000;10(3):136-43.
22. Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, Baessler A, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS ONE. 2008;3(4):e1948.
23. Qin L, Yang Z, Gu HX, Lu S, Shi Q, Xing Y, et al. Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. Bmc Cardiovasc Disor. 2014;14.
24. Chien KL, Hsu HC, Sung FC, Su TC, Chen MF, Lee YT. Hyperuricemia as a risk factor on cardiovascular events in Taiwan: the Chin-Shan Community Cardiovascular Cohort study. Atherosclerosis. 2005;183(1):147-55.
25. Yang Q, Kottgen A, Dehghan A, Smith AV, Glazer NL, Chen MH, et al. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet. 2010;3(6):523-30.
26. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, et al. SLC2A9 is a high-capacity urate transporter in humans. PLoS Med. 2008;5(10):e197.
27. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009;5(6):e1000504.
28. Guan M, Zhou D, Ma W, Chen Y, Zhang J, Zou H. Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method. Clin Rheumatol. 2011;30(1):29-35.
29. Reitsma PH, Reinhard W, Stark K, Neureuther K, Wiedmann S, Sedlacek K, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS ONE. 2008;3(4):e1948.
30. Karns R, Zhang G, Sun G, Rao Indugula S, Cheng H, Havas-Augustin D, et al. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. Ann Hum Genet. 2012;76(2):121-7.
31. Gunjaca G, Boban M, Pehlic M, Zemunik T, Budimir D, Kolcic I, et al. Predictive value of 8 genetic loci for serum uric acid concentration. Croat Med J. 2010;51(1):23-31.
32. Yang B, Mo Z, Wu C, Yang H, Yang X, He Y, et al. A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genet. 2014;7:10.
33. Palmer TM, Nordestgaard BG, Benn M, Tybjaerg-Hansen A, Davey Smith G, Lawlor DA, et al. Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ. 2013;347:f4262.
34. Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, et al. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol. 2007;27(9):2030-6.
35. Hamajima N, Okada R, Kawai S, Hishida A, Morita E, Yin G, et al. Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population. Mol Genet Metab. 2011;103(4):378-82.
36. Sun X, Jiang F, Zhang R, Tang SS, Chen M, Peng DF, et al. Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population. Acta Pharmacol Sin. 2014;35(11):1421-7.
37. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation. 1994;90(1):583-612.
38. Puavilai G, Chanprasertyotin S, Sriphrapradaeng A. Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization. Diabetes Res Clin Pract. 1999;44(1):21-6.
39. Zhou L, Zhang X, He M, Cheng L, Chen Y, Hu FB, et al. Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population. Arterioscler Thromb Vasc Biol. 2008;28(11):2085-9.
40. Kim JY, Oh S, Chang MR, Cho YG, Park KH, Paek YJ, et al. Comparability and utility of body composition measurement vs. anthropometric measurement for assessing obesity related health risks in Korean men. Int J Clin Pract. 2013;67(1):73-80.
41. Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, et al. Genetic predisposition to obesity leads to increased risk of type 2 diabetes. Diabetologia. 2011;54(4):776-82.
42. Didelez V, Sheehan N. Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res. 2007;16(4):309-30.
43. van der Harst P, Bakker SJ, de Boer RA, Wolffenbuttel BH, Johnson T, Caulfield MJ, et al. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Hum Mol Genet. 2010;19(2):387-95.
44. Chen P, Zhao L, Zou P, Xu H, Lu A, Zhao P. The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature. BMC Cancer. 2012;12:383.