Genome-Wide Association of Serum Uric Acid Concentration: Replication of Sequence Variants in an Island Population of the Adriatic Coast of Croatia

Annals of Human Genetics

Volumn 76, Issue 2, 2012, Pages 121-127

  Karns, Rebekah ^a   Zhang, Ge ^b   Sun, Guangyun ^a   Rao Indugula, Subba ^a   Cheng, Hong ^a   Havas Augustin, Dubravka ^c   Novokmet, Natalija ^c   Rudan, Dusko ^c   Durakovic, Zijad ^c   Missoni, Sasa ^c   Chakraborty, Ranajit ^d   Rudan, Pavao ^c   Deka, Ranjan ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c INSTITUTE FOR ANTHROPOLOGICAL RESEARCH   (Croatia)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Adriatic island population; Genome wide association; Serum uric acid

Indexed keywords

URIC ACID;

ADULT; AGE DISTRIBUTION; ARTICLE; CROATIA; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; URIC ACID BLOOD LEVEL;

CROATIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; URIC ACID;

EID: 84862828563     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2011.00698.x     Document Type: Article

References (33)

1. Adamopoulos, D., Vlassopoulos, C., Seitanides, B., Contoyiannis, P., & Vassilopoulos, P. (1977) The relationship of sex steroids to uric acid levels in plasma and urine. Acta Endocrinol (Copenh) 85, 198-208.
2. Alonso, A., Rodriguez, L. A., Logroscino, G., & Hernan, M. A. (2007) Gout and risk of Parkinson disease: A prospective study. Neurology 69, 1696-1700.
3. Amin, N., van Duijn, C. M., & Aulchenko, Y. S. (2007) A genomic background based method for association analysis in related individuals. PLoS One 2, e1274.
4. Aulchenko, Y. S., Ripke, S., Isaacs, A., & van Duijn, C. M. (2007) GenABEL: An R library for genome-wide association analysis. Bioinformatics 23, 1294-1296.
5. Bacanu, S. A., Devlin, B., & Roeder, K. (2002) Association studies for quantitative traits in structured populations. Genet Epidemiol 22, 78-93.
6. Carvalho, B. S., Louis, T. A., & Irizarry, R. A. (2010) Quantifying uncertainty in genotype calls. Bioinformatics 26, 242-249.
7. Carvalho, B., Bengtsson, H., Speed, T. P., & Irizarry, R. A. (2007) Exploration, normalization, and genotype calls of high-density oligonucleotide SNP array data. Biostatistics 8, 485-499.
8. Charles, B. A., Shriner, D., Doumatey, A., Chen, G., Zhou, J., Huang, H., Herbert, A., Gerry, N. P., Christman, M. F., Adeyemo, A., & Rotimi, C. N. (2011) A genome-wide association study of serum uric acid in African Americans. BMC Med Genomics 4, 17.
9. Davis, J. W., Grandinetti, A., Waslien, C. I., Ross, G. W., White, L. R., & Morens, D. M. (1996) Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease. Am J Epidemiol 144, 480-484.
10. Dehghan, A., Köttgen, A., Yang, Q., Hwang, S. J., Kao, W. L., Rivadeneira, F., Boerwinkle, E., Levy, D., Hofman, A., Astor, B. C., Benjamin, E. J., van Duijn, C. M., Witteman, J. C., Coresh, J., & Fox, C. S. (2008) Association of three genetic loci with uric acid concentration and risk of gout: A genome-wide association study. Lancet 372, 1953-1961.
11. de Lau, L. M., Koudstaal, P. J., Hofman, A., & Breteler, M. M. (2005) Serum uric acid levels and the risk of Parkinson disease. Ann Neurol 58, 797-800.
12. Devlin, B. & Roeder, K. (1999) Genomic control for association studies. Biometrics 55, 997-1004.
13. Devlin, B., Roeder, K., & Bacanu, S. A. (2001) Unbiased methods for population-based association studies. Genet Epidemiol 21, 273-284.
14. Döring, A., Gieger, C., Mehta, D., Gohlke, H., Prokisch, H., Coassin, S., Fischer, G., Henke, K., Klopp, N., Kronenberg, F., Paulweber, B., Pfeufer, A., Rosskopf, D., Völzke, H., Illig, T., Meitinger, T., Wichmann, H. E., & Meisinger, C. (2008) SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet 40, 430-436.
15. Hindorff, L. A., Junkins, H. A., Hall, P. N., Mehta, J. P., & Manolio, T. A. (2011) A catalog of published genome-wide association studies. April 10, 2011.
16. International HapMap Consortium (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861.
17. Karns, R., Zhang, G., Jeran, N., Havas-Augustin, D., Missoni, S., Niu, W., Indugula, S. R., Sun, G., Durakovic, Z., Narancic, N. S., Rudan, P., Chakraborty, R., & Deka, R. (2011) Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia. Eur J Hum Genet 19, 341-346.
18. Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farrall, M., Johansson, A., Nyholt, D. R., Aulchenko, Y., Beckmann, J. S., Bergmann, S., Bochud, M., Brown, M., Campbell, H. for the EUROSPAN Consortium, Connell, J., Dominiczak, A., Homuth, G., Lamina, C., McCarthy, M. I. for the ENGAGE Consortium, Meitinger, T., Mooser, V., Munroe, P., Nauck, M., Peden, J., Prokisch, H., Salo, P., Salomaa, V., Samani, N. J., Schlessinger, D., Uda, M., Völker, U., Waeber, G., Waterworth, D., Wang-Sattler, R., Wright, A. F., Adamski, J., Whitfield, J. B., Gyllensten, U., Wilson, J. F., Rudan, I., Pramstaller, P., Watkins, H. for the PROCARDIS Consortium, Doering, A., Wichmann, H. E. for the KORA Study, Spector, T. D., Peltonen, L., Völzke, H., Nagaraja, R., Vollenweider, P., Caulfield, M. for the WTCCC, Illig, T., & Gieger, C. (2009) Meta-analysis of 28, 141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5, e1000504.
19. Li, S., Sanna, S., Maschio, A., Busonero, F., Usala, G., Mulas, A., Lai, S., Dei, M., Orrù, M., Albai, G., Bandinelli, S., Schlessinger, D., Lakatta, E., Scuteri, A., Najjar, S. S., Guralnik, J., Naitza, S., Crisponi, L., Cao, A., Abecasis, G., Ferrucci, L., Uda, M., Chen, W. M., & Nagaraja, R. (2007) The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3, e194.
20. Li, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) Genotype imputation. Annu Rev Genomics Hum Genet 10, 387-406.
21. Maraganore, D. M., de Andrade, M., Lesnick, T. G., Strain, K. J., Farrer, M. J., Rocca, W. A., Pant, P. V., Frazer, K. A., Cox, D. R., & Ballinger, D. G. (2005) High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet 77, 685-693.
22. McArdle, P. F., Parsa, A., Chang, Y. P., Weir, M. R., O'Connell, J. R., Mitchell, B. D., & Shuldiner, A. R. (2008) Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order Amish. Arthritis Rheum 58, 2874-2881.
23. Page, T. & Coleman, M. (2000) Purine metabolism abnormalities in a hyperuricosuric subclass of autism. Biochim Biophys Acta 1500, 291-296.
24. Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) LocusZoom: Regional visualization of genome-wide association scan results. Bioinformatics 26, 2336-2337.
25. Puig, J. G., Michán, A. D., Jiménez, M. L., Pérez de Ayala, C., Mateos, F. A., Capitán, C. F., de Miguel, E., & Gijón, J. B. (1991) Female gout. Clinical spectrum and uric acid metabolism. Arch Intern Med 151, 726-732.
26. Rudan, P., Sujoldzic, A., Simic, D., Bennett, L. A., & Roberts, D. F. (1992) Population structure in the eastern Adriatic: The influence of historical processes, migration patterns, isolation and ecological pressures, and their interaction. In: Isolation, migration and health (eds. D. F. Roberts, N. Fujiki, & K. Torizuka), pp. 204-218. Cambridge: Cambridge University Press.
27. Vitart, V., Rudan, I., Hayward, C., Gray, N. K., Floyd, J., Palmer, C. N., Knott, S. A., Kolcic, I., Polasek, O., Graessler, J., Wilson, J. F., Marinaki, A., Riches, P. L., Shu, X., Janicijevic, B., Smolej-Narancic, N., Gorgoni, B., Morgan, J., Campbell, S., Biloglav, Z., Barac-Lauc, L., Pericic, M., Klaric, I. M., Zgaga, L., Skaric-Juric, T., Wild, S. H., Richardson, W. A., Hohenstein, P., Kimber, C. H., Tenesa, A., Donnelly, L. A., Fairbanks, L. D., Aringer, M., McKeigue, P. M., Ralston, S. H., Morris, A. D., Rudan, P., Hastie, N. D., Campbell, H., & Wright, A. F. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40, 437-42.
28. Wallace, C., Newhouse, S. J., Braund, P., Zhang, F., Tobin, M., Falchi, M., Ahmadi, K., Dobson, R. J., Marçano, A. C., Hajat, C., Burton, P., Deloukas, P., Brown, M., Connell, J. M., Dominiczak, A., Lathrop, G. M., Webster, J., Farrall, M., Spector, T., Samani, N. J., Caulfield, M. J., & Munroe, P. B. (2008) Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipidemia. Am J Hum Genet 82, 139-49.
29. Weiss, L. A. Arking, D. E.; Gene Discovery Project of Johns Hopkins & the Autism Consortium, Daly, M. J., & Chakravarti, A. (2009) A genome-wide linkage and association scan reveals novel loci for autism. Nature 461, 802-808.
30. Weisskopf, M. G., O'Reilly, E., Chen, H., Schwarzschild, M. A., & Ascherio, A. (2007) Plasma urate and risk of Parkinson's disease. Am J Epidemiol 166, 561-567.
31. Yang, Q., Köttgen, A., Dehghan, A., Smith, A. V., Glazer, N. L., Chen, M. H., Chasman, D. I., Aspelund, T., Eiriksdottir, G., Harris, T. B., Launer, L., Nalls, M., Hernandez, D., Arking, D. E., Boerwinkle, E., Grove, M. L., Li, M., Linda Kao, W. H., Chonchol, M., Haritunians, T., Li, G., Lumley, T., Psaty, B. M., Shlipak, M., Hwang, S. J., Larson, M. G., O'Donnell, C. J., Upadhyay, A., van Duijn, C. M., Hofman, A., Rivadeneira, F., Stricker, B., Uitterlinden, A. G., Paré, G., Parker, A. N., Ridker, P. M., Siscovick, D. S., Gudnason, V., Witteman, J. C., Fox, C. S., & Coresh, J. (2010) Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet 3, 523-530.
32. Zemunik, T., Boban, M., Lauc, G., Janković, S., Rotim, K., Vatavuk, Z., Bencić, G., Dogas, Z., Boraska, V., Torlak, V., Susac, J., Zobić, I., Rudan, D., Pulanić, D., Modun, D., Mudnić, I., Gunjaca, G., Budimir, D., Hayward, C., Vitart, V., Wright, A. F., Campbell, H., & Rudan, I. (2009) Genome-wide association study of biochemical traits in Korcula Island, Croatia. Croat Med J 50, 23-33.
33. Zhang, G., Karns, R., Narancic, N. S., Sun, G., Cheng, H., Missoni, S., Durakovic, Z., Rudan, P., Chakraborty, R., & Deka, R. (2010) Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. PLoS One 5, e10375.