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Volumn 35, Issue 39, 2016, Pages 5191-5201

Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; GESTAGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR B; PROTEIN KINASE B; SMALL INTERFERING RNA; AKT1 PROTEIN, HUMAN; FUSED HETEROCYCLIC RINGS; PROGESTERONE RECEPTOR; PROMEGESTONE;

EID: 84961390334     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2016.56     Document Type: Article
Times cited : (41)

References (41)
  • 1
    • 84989772874 scopus 로고    scopus 로고
    • National Cancer Institute. SEER Stat Fact Sheets
    • National Cancer Institute. SEER Stat Fact Sheets: Endometrial Cancer, vol. 2015, 2015
    • (2015) Endometrial Cancer , vol.2015
  • 2
    • 61449282506 scopus 로고    scopus 로고
    • The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
    • Bansal N, Yendluri V, Wenham RM. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control 2009; 16: 8-13
    • (2009) Cancer Control , vol.16 , pp. 8-13
    • Bansal, N.1    Yendluri, V.2    Wenham, R.M.3
  • 3
    • 79960681651 scopus 로고    scopus 로고
    • Fertility-sparing therapy in young women with endometrial cancer: 2010 update
    • Erkanli S, Ayhan A. Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer 2010; 20: 1170-1187
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 1170-1187
    • Erkanli, S.1    Ayhan, A.2
  • 4
    • 4644277448 scopus 로고    scopus 로고
    • Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: A literature review
    • Ramirez PT, Frumovitz M, Bodurka DC, Sun CC, Levenback C. Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: A literature review. Gynecol Oncol 2004; 95: 133-138
    • (2004) Gynecol Oncol , vol.95 , pp. 133-138
    • Ramirez, P.T.1    Frumovitz, M.2    Bodurka, D.C.3    Sun, C.C.4    Levenback, C.5
  • 5
    • 84925387336 scopus 로고    scopus 로고
    • Progestins in the fertility-sparing treatment and retreatment of patients with primary and recurrent endometrial cancer
    • Park JY, Nam JH. Progestins in the fertility-sparing treatment and retreatment of patients with primary and recurrent endometrial cancer. Oncologist 2015; 20: 270-278
    • (2015) Oncologist , vol.20 , pp. 270-278
    • Park, J.Y.1    Nam, J.H.2
  • 6
    • 34447579172 scopus 로고    scopus 로고
    • Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women
    • Ushijima K, Yahata H, Yoshikawa H, Konishi I, Yasugi T, Saito T et al. Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol 2007; 25: 2798-2803
    • (2007) J Clin Oncol , vol.25 , pp. 2798-2803
    • Ushijima, K.1    Yahata, H.2    Yoshikawa, H.3    Konishi, I.4    Yasugi, T.5    Saito, T.6
  • 7
    • 0033003177 scopus 로고    scopus 로고
    • Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group
    • Thigpen JT, Brady MF, Alvarez RD, Adelson MD, Homesley HD, Manetta et al. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group. J Clin Oncol 1999; 17: 1736-1744
    • (1999) J Clin Oncol , vol.17 , pp. 1736-1744
    • Thigpen, J.T.1    Brady, M.F.2    Alvarez, R.D.3    Adelson, M.D.4    Homesley, H.D.5    Manetta6
  • 8
    • 79953162950 scopus 로고    scopus 로고
    • Progesterone: The ultimate endometrial tumor suppressor
    • Yang S, Thiel KW, Leslie KK. Progesterone: the ultimate endometrial tumor suppressor. Trends Endocrinol Metab 2011; 22: 145-152
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 145-152
    • Yang, S.1    Thiel, K.W.2    Leslie, K.K.3
  • 9
    • 0035056263 scopus 로고    scopus 로고
    • Molecular tools to reestablish progestin control of endometrial cancer cell proliferation
    • Dai D, Kumar NS, Wolf DM, Leslie KK. Molecular tools to reestablish progestin control of endometrial cancer cell proliferation. Am J Obstet Gynecol 2001; 184: 790-797
    • (2001) Am J Obstet Gynecol , vol.184 , pp. 790-797
    • Dai, D.1    Kumar, N.S.2    Wolf, D.M.3    Leslie, K.K.4
  • 10
    • 0036468261 scopus 로고    scopus 로고
    • Progesterone inhibits human endometrial cancer cell growth and invasiveness: Down-regulation of cellular adhesion molecules through progesterone B receptors
    • Dai D, Wolf DM, Litman ES, White MJ, Leslie KK. Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors. Cancer Res 2002; 62: 881-886
    • (2002) Cancer Res , vol.62 , pp. 881-886
    • Dai, D.1    Wolf, D.M.2    Litman, E.S.3    White, M.J.4    Leslie, K.K.5
  • 11
    • 0037223051 scopus 로고    scopus 로고
    • Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines
    • Smid-Koopman E, Blok LJ, Kuhne LC, Burger CW, Helmerhorst TJ, Brinkmann AO et al. Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines. J Soc Gynecol Invest 2003; 10: 49-57
    • (2003) J Soc Gynecol Invest , vol.10 , pp. 49-57
    • Smid-Koopman, E.1    Blok, L.J.2    Kuhne, L.C.3    Burger, C.W.4    Helmerhorst, T.J.5    Brinkmann, A.O.6
  • 12
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network, Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y et al. Integrated genomic characterization of endometrial carcinoma. Nature 2013; 497: 67-73
    • (2013) Nature , vol.497 , pp. 67-73
    • Kandoth, C.1    Schultz, N.2    Cherniack, A.D.3    Akbani, R.4    Liu, Y.5
  • 13
    • 79951722712 scopus 로고    scopus 로고
    • Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer
    • Gu C, Zhang Z, Yu Y, Liu Y, Zhao F, Yin L et al. Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer. Cancer Sci 2011; 102: 557-564
    • (2011) Cancer Sci , vol.102 , pp. 557-564
    • Gu, C.1    Zhang, Z.2    Yu, Y.3    Liu, Y.4    Zhao, F.5    Yin, L.6
  • 14
    • 84864265147 scopus 로고    scopus 로고
    • Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin
    • Pant A, Lee II, Lu Z, Rueda BR, Schink J, Kim JJ. Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS One 2012; 7: e41593
    • (2012) PLoS One , vol.7 , pp. e41593
    • Pant, A.1    Lee, I.I.2    Lu, Z.3    Rueda, B.R.4    Schink, J.5    Kim, J.J.6
  • 15
    • 84860163258 scopus 로고    scopus 로고
    • Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes
    • Clarke CL, Graham JD. Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PLoS One 2012; 7: e35859
    • (2012) PLoS One , vol.7 , pp. e35859
    • Clarke, C.L.1    Graham, J.D.2
  • 16
    • 84874243484 scopus 로고    scopus 로고
    • Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
    • Mohammed H, D'Santos C, Serandour AA, Ali HR, Brown GD, Atkins et al. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep 2013; 3: 342-349
    • (2013) Cell Rep , vol.3 , pp. 342-349
    • Mohammed, H.1    D'Santos, C.2    Serandour, A.A.3    Ali, H.R.4    Brown, G.D.5    Atkins6
  • 17
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 401-410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 18
    • 48649088412 scopus 로고    scopus 로고
    • Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    • Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP et al. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 2008; 68: 5619-5627
    • (2008) Cancer Res , vol.68 , pp. 5619-5627
    • Daikoku, T.1    Hirota, Y.2    Tranguch, S.3    Joshi, A.R.4    DeMayo, F.J.5    Lydon, J.P.6
  • 19
    • 84864489010 scopus 로고    scopus 로고
    • Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus
    • Rubel CA, Lanz RB, Kommagani R, Franco HL, Lydon JP, DeMayo FJ. Research resource: genome-wide profiling of progesterone receptor binding in the mouse uterus. Mol Endocrinol 2012; 26: 1428-1442
    • (2012) Mol Endocrinol , vol.26 , pp. 1428-1442
    • Rubel, C.A.1    Lanz, R.B.2    Kommagani, R.3    Franco, H.L.4    Lydon, J.P.5    DeMayo, F.J.6
  • 20
    • 34948872466 scopus 로고    scopus 로고
    • Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells
    • Takano M, Lu Z, Goto T, Fusi L, Higham J, Francis J et al. Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells. Mol Endocrinol 2007; 21: 2334-2349
    • (2007) Mol Endocrinol , vol.21 , pp. 2334-2349
    • Takano, M.1    Lu, Z.2    Goto, T.3    Fusi, L.4    Higham, J.5    Francis, J.6
  • 21
    • 84923651435 scopus 로고    scopus 로고
    • FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization
    • Vasquez YM, Mazur EC, Li X, Kommagani R, Jiang L, Chen R et al. FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization. Mol Endocrinol 2015; 29: 421-433
    • (2015) Mol Endocrinol , vol.29 , pp. 421-433
    • Vasquez, Y.M.1    Mazur, E.C.2    Li, X.3    Kommagani, R.4    Jiang, L.5    Chen, R.6
  • 22
    • 37849043339 scopus 로고    scopus 로고
    • Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells
    • Goto T, Takano M, Albergaria A, Briese J, Pomeranz KM, Cloke B et al. Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene 2008; 27: 9-19
    • (2008) Oncogene , vol.27 , pp. 9-19
    • Goto, T.1    Takano, M.2    Albergaria, A.3    Briese, J.4    Pomeranz, K.M.5    Cloke, B.6
  • 23
    • 33646926129 scopus 로고    scopus 로고
    • 14-3-3 proteins: A historic overview
    • Aitken A. 14-3-3 proteins: A historic overview. Semin Cancer Biol 2006; 16: 162-172
    • (2006) Semin Cancer Biol , vol.16 , pp. 162-172
    • Aitken, A.1
  • 24
    • 34447316146 scopus 로고    scopus 로고
    • 14-3-3 sigma increases the transcriptional activity of the androgen receptor in the absence of androgens
    • Quayle SN, Sadar MD. 14-3-3 sigma increases the transcriptional activity of the androgen receptor in the absence of androgens. Cancer Lett 2007; 254: 137-145
    • (2007) Cancer Lett , vol.254 , pp. 137-145
    • Quayle, S.N.1    Sadar, M.D.2
  • 26
    • 0030887128 scopus 로고    scopus 로고
    • Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein
    • Wakui H, Wright AP, Gustafsson J, Zilliacus J. Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein. J Biol Chem 1997; 272: 8153-8156
    • (1997) J Biol Chem , vol.272 , pp. 8153-8156
    • Wakui, H.1    Wright, A.P.2    Gustafsson, J.3    Zilliacus, J.4
  • 27
    • 0035064047 scopus 로고    scopus 로고
    • Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140
    • Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA. Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. Mol Endocrinol 2001; 15: 501-511
    • (2001) Mol Endocrinol , vol.15 , pp. 501-511
    • Zilliacus, J.1    Holter, E.2    Wakui, H.3    Tazawa, H.4    Treuter, E.5    Gustafsson, J.A.6
  • 29
    • 10944243659 scopus 로고    scopus 로고
    • Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression
    • Lodygin D, Diebold J, Hermeking H. Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression. Oncogene 2004; 23: 9034-9041
    • (2004) Oncogene , vol.23 , pp. 9034-9041
    • Lodygin, D.1    Diebold, J.2    Hermeking, H.3
  • 30
    • 28444444897 scopus 로고    scopus 로고
    • Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma
    • Nakayama H, Sano T, Motegi A, Oyama T, Nakajima T. Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. Pathol Int 2005; 55: 707-715
    • (2005) Pathol Int , vol.55 , pp. 707-715
    • Nakayama, H.1    Sano, T.2    Motegi, A.3    Oyama, T.4    Nakajima, T.5
  • 31
    • 20144365373 scopus 로고    scopus 로고
    • Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation
    • Mhawech P, Benz A, Cerato C, Greloz V, Assaly M, Desmond JC et al. Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation. Mod Pathol 2005; 18: 340-348
    • (2005) Mod Pathol , vol.18 , pp. 340-348
    • Mhawech, P.1    Benz, A.2    Cerato, C.3    Greloz, V.4    Assaly, M.5    Desmond, J.C.6
  • 32
    • 38049018539 scopus 로고    scopus 로고
    • 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation
    • Winter S, Simboeck E, Fischle W, Zupkovitz G, Dohnal I, Mechtler K et al. 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J 2008; 27: 88-99
    • (2008) EMBO J , vol.27 , pp. 88-99
    • Winter, S.1    Simboeck, E.2    Fischle, W.3    Zupkovitz, G.4    Dohnal, I.5    Mechtler, K.6
  • 33
    • 0034624062 scopus 로고    scopus 로고
    • Estrogen signals to the preservation of endothelial cell form and function
    • Razandi M, Pedram A, Levin ER. Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem 2000; 275: 38540-38546
    • (2000) J Biol Chem , vol.275 , pp. 38540-38546
    • Razandi, M.1    Pedram, A.2    Levin, E.R.3
  • 34
    • 84939618585 scopus 로고    scopus 로고
    • Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2
    • Gibson DA, Greaves E, Critchley HO, Saunders PT. Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2. Hum Reprod 2015; 30: 1290-1301
    • (2015) Hum Reprod , vol.30 , pp. 1290-1301
    • Gibson, D.A.1    Greaves, E.2    Critchley, H.O.3    Saunders, P.T.4
  • 35
    • 0029829884 scopus 로고    scopus 로고
    • Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis
    • Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 1996; 81: 3112-3118
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3112-3118
    • Shifren, J.L.1    Tseng, J.F.2    Zaloudek, C.J.3    Ryan, I.P.4    Meng, Y.G.5    Ferrara, N.6
  • 36
    • 57349131692 scopus 로고    scopus 로고
    • Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway
    • Hsu SP, Ho PY, Juan SH, Liang YC, Lee WS. Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway. Cell Mol Life Sci 2008; 65: 3839-3850
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3839-3850
    • Hsu, S.P.1    Ho, P.Y.2    Juan, S.H.3    Liang, Y.C.4    Lee, W.S.5
  • 38
    • 80052261516 scopus 로고    scopus 로고
    • Progestins inhibit estradiol-induced vascular endothelial growth factor and stromal cell-derived factor 1 in human endometrial stromal cells
    • Okada H, Okamoto R, Tsuzuki T, Tsuji S, Yasuda K, Kanzaki H. Progestins inhibit estradiol-induced vascular endothelial growth factor and stromal cell-derived factor 1 in human endometrial stromal cells. Fertil Steril 2011; 96: 786-791
    • (2011) Fertil Steril , vol.96 , pp. 786-791
    • Okada, H.1    Okamoto, R.2    Tsuzuki, T.3    Tsuji, S.4    Yasuda, K.5    Kanzaki, H.6
  • 39
    • 84893469062 scopus 로고    scopus 로고
    • Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation
    • Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM et al. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell 2014; 156: 549-562
    • (2014) Cell , vol.156 , pp. 549-562
    • Goddard, L.M.1    Murphy, T.J.2    Org, T.3    Enciso, J.M.4    Hashimoto-Partyka, M.K.5    Warren, C.M.6
  • 40
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 41
    • 84886500048 scopus 로고    scopus 로고
    • MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth
    • Sefton EC, Qiang W, Serna V, Kurita T, Wei JJ, Chakravarti D et al. MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth. Endocrinology 2013; 154: 4046-4057.
    • (2013) Endocrinology , vol.154 , pp. 4046-4057
    • Sefton, E.C.1    Qiang, W.2    Serna, V.3    Kurita, T.4    Wei, J.J.5    Chakravarti, D.6


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