메뉴 건너뛰기




Volumn 56, Issue 1, 2015, Pages 647-653

Metanx and early stages of diabetic retinopathy

Author keywords

Diabetic retinopathy; Inflammation; Metanx; Oxidative stress

Indexed keywords

ALBUMIN; FOLIC ACID; GLYCOSYLATED HEMOGLOBIN; HEME OXYGENASE 1; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; ISOPHANE INSULIN; LUCIGENIN; MECOBALAMIN; METHYLFOLATE; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRIDOXAL 5 PHOSPHATE; STREPTOZOCIN; SUPEROXIDE; UNCLASSIFIED DRUG; CYANOCOBALAMIN; I KAPPA B BETA; METANX; VITAMIN B COMPLEX;

EID: 84961291238     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-15220     Document Type: Article
Times cited : (24)

References (38)
  • 1
    • 65549157077 scopus 로고    scopus 로고
    • Retinal ion regulation in a mouse model of diabetic retinopathy: Natural history and the effect of Cu/Zn superox-ide dismutase overexpression
    • Berkowitz BA, Gradianu M, Bissig D, Kern TS, Roberts R. Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superox-ide dismutase overexpression. Invest Ophthalmol Vis Sci. 2009;50:2351–2358.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2351-2358
    • Berkowitz, B.A.1    Gradianu, M.2    Bissig, D.3    Kern, T.S.4    Roberts, R.5
  • 2
    • 34547674399 scopus 로고    scopus 로고
    • Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    • Zheng L, Du Y, Miller C, et al. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia. 2007;50: 1987–1996.
    • (2007) Diabetologia , vol.50 , pp. 1987-1996
    • Zheng, L.1    Du, Y.2    Miller, C.3
  • 3
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase
    • Kanwar M, Chan PS, Kern TS, Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci. 2007;48:3805–3811.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4
  • 4
    • 48449097142 scopus 로고    scopus 로고
    • 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
    • Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS. 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes. 2008;57:1387–1393.
    • (2008) Diabetes , vol.57 , pp. 1387-1393
    • Gubitosi-Klug, R.A.1    Talahalli, R.2    Du, Y.3    Nadler, J.L.4    Kern, T.S.5
  • 5
    • 84884343947 scopus 로고    scopus 로고
    • Pathogenic role of diabetes-induced PPAR-alpha down-regulation in microvascular dysfunction
    • Hu Y, Chen Y, Ding L, et al. Pathogenic role of diabetes-induced PPAR-alpha down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013;110:15401–15406.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 15401-15406
    • Hu, Y.1    Chen, Y.2    Ding, L.3
  • 6
    • 83055198504 scopus 로고    scopus 로고
    • Beneficial effects of RAGE-Ig fusion protein on early diabetic retinopathy and tactile allodynia
    • Li G, Tang J, Du Y, Lee CA, Kern TS. Beneficial effects of RAGE-Ig fusion protein on early diabetic retinopathy and tactile allodynia. Mol Vis. 2011;17:3156–3165.
    • (2011) Mol Vis , vol.17 , pp. 3156-3165
    • Li, G.1    Tang, J.2    Du, Y.3    Lee, C.A.4    Kern, T.S.5
  • 7
    • 77951214647 scopus 로고    scopus 로고
    • Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function
    • Du Y, Tang J, Li G, et al. Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci. 2010;51:2158–2164.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2158-2164
    • Du, Y.1    Tang, J.2    Li, G.3
  • 8
    • 48249134698 scopus 로고    scopus 로고
    • Role of NADPH oxidase in retinal vascular inflammation
    • Al-Shabrawey M, Rojas M, Sanders T, et al. Role of NADPH oxidase in retinal vascular inflammation. Invest Ophthalmol Vis Sci. 2008;49:3239–3244.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 3239-3244
    • Al-Shabrawey, M.1    Rojas, M.2    Sanders, T.3
  • 9
    • 33748645122 scopus 로고    scopus 로고
    • 5-methyltetrahy-drofolate rapidly improves endothelial function and decreases superoxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    • Antoniades C, Shirodaria C, Warrick N, et al. 5-methyltetrahy-drofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation. 2006;114:1193–1201.
    • (2006) Circulation , vol.114 , pp. 1193-1201
    • Antoniades, C.1    Shirodaria, C.2    Warrick, N.3
  • 10
    • 53549133670 scopus 로고    scopus 로고
    • The methylation, neurotransmitter, and antioxidant connections between folate and depression
    • Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev. 2008;13:216–226.
    • (2008) Altern Med Rev , vol.13 , pp. 216-226
    • Miller, A.L.1
  • 11
    • 79960965495 scopus 로고    scopus 로고
    • Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells
    • Moreira ES, Brasch NE, Yun J. Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells. Free Radic Biol Med. 2011;51:876–883.
    • (2011) Free Radic Biol Med , vol.51 , pp. 876-883
    • Moreira, E.S.1    Brasch, N.E.2    Yun, J.3
  • 13
    • 0019811651 scopus 로고
    • The influence of pyridoxine in diabetic peripheral neuropathy
    • Levin ER, Hanscom TA, Fisher M, et al. The influence of pyridoxine in diabetic peripheral neuropathy. Diabetes Care. 1981;4:606–609.
    • (1981) Diabetes Care , vol.4 , pp. 606-609
    • Levin, E.R.1    Hanscom, T.A.2    Fisher, M.3
  • 14
    • 0021978238 scopus 로고
    • Effects of vitamin B12 and B6 on 2,5-hexanedione-induced neuropathy
    • Misumi J, Nagano M, Kaisaku J, Hitoshi T. Effects of vitamin B12 and B6 on 2,5-hexanedione-induced neuropathy. Arch Toxicol. 1985;56:204–206.
    • (1985) Arch Toxicol , vol.56 , pp. 204-206
    • Misumi, J.1    Nagano, M.2    Kaisaku, J.3    Hitoshi, T.4
  • 15
    • 80053298786 scopus 로고    scopus 로고
    • Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 50-phosphate
    • Walker MJ Jr, Morris LM, Cheng D. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 50-phosphate. Rev Neurol Dis. 2010;7:132–139.
    • (2010) Rev Neurol Dis , vol.7 , pp. 132-139
    • Walker, M.J.1    Morris, L.M.2    Cheng, D.3
  • 16
    • 82555200904 scopus 로고    scopus 로고
    • Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobala-min, and pyridoxal 50-phosphate
    • Jacobs AM, Cheng D. Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobala-min, and pyridoxal 50-phosphate. Rev Neurol Dis. 2011;8:39– 47.
    • (2011) Rev Neurol Dis , vol.8
    • Jacobs, A.M.1    Cheng, D.2
  • 17
    • 84872528309 scopus 로고    scopus 로고
    • A medicinal food provides food for thought in managing diabetic neuropathy
    • Vinik AI. A medicinal food provides food for thought in managing diabetic neuropathy. Am J Med. 2013;126:95–96.
    • (2013) Am J Med , vol.126 , pp. 95-96
    • Vinik, A.I.1
  • 18
    • 84864381328 scopus 로고    scopus 로고
    • Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats
    • Shevalye H, Watcho P, Stavniichuk R, Dyukova E, Lupachyk S, Obrosova IG. Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats. Diabetes. 2012;61: 2126–2133.
    • (2012) Diabetes , vol.61 , pp. 2126-2133
    • Shevalye, H.1    Watcho, P.2    Stavniichuk, R.3    Dyukova, E.4    Lupachyk, S.5    Obrosova, I.G.6
  • 19
    • 84872593274 scopus 로고    scopus 로고
    • Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial
    • Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med. 2013;126:141–149.
    • (2013) Am J Med , vol.126 , pp. 141-149
    • Fonseca, V.A.1    Lavery, L.A.2    Thethi, T.K.3
  • 20
    • 84880300341 scopus 로고    scopus 로고
    • Intervention with vitamins in patients with nonproliferative diabetic retinopathy: A pilot study
    • Smolek MK, Notaroberto NF, Jaramillo AG, Pradillo LR. Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study. Clin Ophthalmol. 2013;7: 1451–1458.
    • (2013) Clin Ophthalmol , vol.7 , pp. 1451-1458
    • Smolek, M.K.1    Notaroberto, N.F.2    Jaramillo, A.G.3    Pradillo, L.R.4
  • 21
    • 77952028243 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy
    • Kern TS, Du Y, Miller CM, Hatala DA, Levin LA. Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol. 2010;176:2550– 2558.
    • (2010) Am J Pathol , vol.176
    • Kern, T.S.1    Du, Y.2    Miller, C.M.3    Hatala, D.A.4    Levin, L.A.5
  • 22
    • 33847028707 scopus 로고    scopus 로고
    • Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    • Kern TS, Miller CM, Du Y, et al. Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes. 2007;56:373–379.
    • (2007) Diabetes , vol.56 , pp. 373-379
    • Kern, T.S.1    Miller, C.M.2    Du, Y.3
  • 23
    • 0344012015 scopus 로고    scopus 로고
    • Hyperglycemia increases mitochon-drial superoxide in retina and retinal cells
    • Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochon-drial superoxide in retina and retinal cells. Free Radic Biol Med. 2003;35:1491–1499.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1491-1499
    • Du, Y.1    Miller, C.M.2    Kern, T.S.3
  • 25
    • 7044228789 scopus 로고    scopus 로고
    • A central role for inflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18:1450–1452.
    • (2004) FASEB J , vol.18 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki, V.2    Le, M.L.3
  • 26
    • 33847037432 scopus 로고    scopus 로고
    • Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy
    • Zheng L, Howell SJ, Hatala DA, Huang K, Kern TS. Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes. 2007;56:337–345.
    • (2007) Diabetes , vol.56 , pp. 337-345
    • Zheng, L.1    Howell, S.J.2    Hatala, D.A.3    Huang, K.4    Kern, T.S.5
  • 27
    • 9444222740 scopus 로고    scopus 로고
    • Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system
    • Prusky GT, Alam NM, Beekman S, Douglas RM. Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest Ophthalmol Vis Sci. 2004;45:4611–4616.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 4611-4616
    • Prusky, G.T.1    Alam, N.M.2    Beekman, S.3    Douglas, R.M.4
  • 28
    • 84922190513 scopus 로고    scopus 로고
    • Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, RAGE, leukocytes, and aldose reductase
    • Lee CA, Li G, Patel MD, et al. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, RAGE, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci. 2013;93:135–143.
    • (2013) Invest Ophthalmol Vis Sci , vol.93 , pp. 135-143
    • Lee, C.A.1    Li, G.2    Patel, M.D.3
  • 29
    • 0027271798 scopus 로고
    • Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs
    • Engerman RL, Kern TS. Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs. Diabetes. 1993;42:820–825.
    • (1993) Diabetes , vol.42 , pp. 820-825
    • Engerman, R.L.1    Kern, T.S.2
  • 30
    • 84870383668 scopus 로고    scopus 로고
    • Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice
    • Li G, Veenstra AA, Talahalli RR, et al. Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes. 2012;61:3294–3303.
    • (2012) Diabetes , vol.61 , pp. 3294-3303
    • Li, G.1    Veenstra, A.A.2    Talahalli, R.R.3
  • 31
    • 0028890354 scopus 로고
    • Induction of heme oxygenase 1 in the retina by intense visible light: Suppression by the antioxidant dimethylurea
    • Kutty RG, Kutty G, Wiggert B, Chader GE, Darrow RM, Organisciak DT. Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylurea. Proc Natl Acad Sci U S A. 1995;92:1177–1181.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1177-1181
    • Kutty, R.G.1    Kutty, G.2    Wiggert, B.3    Chader, G.E.4    Darrow, R.M.5    Organisciak, D.T.6
  • 32
    • 0030065052 scopus 로고    scopus 로고
    • NO-mediated activation of heme oxygenase: Endogenous cytopro-tection against oxidative stress to endothelium
    • Motterlini R, Foresti R, Intaglietta M, Winslow RM. NO-mediated activation of heme oxygenase: endogenous cytopro-tection against oxidative stress to endothelium. Am J Physiol. 1996;270:H107–H114.
    • (1996) Am J Physiol , vol.270 , pp. H107-H114
    • Motterlini, R.1    Foresti, R.2    Intaglietta, M.3    Winslow, R.M.4
  • 33
    • 77950625277 scopus 로고    scopus 로고
    • The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells
    • Mandal P, Park PH, McMullen MR, Pratt BT, Nagy LE. The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells. Hepatol-ogy. 2010;51:1420–1429.
    • (2010) Hepatol-Ogy , vol.51 , pp. 1420-1429
    • Mandal, P.1    Park, P.H.2    McMullen, M.R.3    Pratt, B.T.4    Nagy, L.E.5
  • 34
    • 78049492112 scopus 로고    scopus 로고
    • Adiponectin and heme oxygenase-1 suppress TLR4/ MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure
    • Mandal P, Roychowdhury S, Park PH, Pratt BT, Roger T, Nagy LE. Adiponectin and heme oxygenase-1 suppress TLR4/ MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure. J Immunol. 2010;185:4928– 4937.
    • (2010) J Immunol , vol.185
    • Mandal, P.1    Roychowdhury, S.2    Park, P.H.3    Pratt, B.T.4    Roger, T.5    Nagy, L.E.6
  • 35
    • 63849118178 scopus 로고    scopus 로고
    • Role of nitric oxide, superoxide, peroxyni-trite and poly(ADP-ribose) polymerase in diabetic retinopathy
    • Zheng L, Kern T. Role of nitric oxide, superoxide, peroxyni-trite and poly(ADP-ribose) polymerase in diabetic retinopathy. Front Biosci. 2009;14:3974–3987.
    • (2009) Front Biosci , vol.14 , pp. 3974-3987
    • Zheng, L.1    Kern, T.2
  • 36
    • 0033753702 scopus 로고    scopus 로고
    • Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia
    • Kern TS, Tang J, Mizutani M, et al. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci. 2000;41:3972–3978.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3972-3978
    • Kern, T.S.1    Tang, J.2    Mizutani, M.3
  • 37
    • 0035434119 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
    • Kowluru RA, Tang J, Kern TS. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes. 2001;50:1938–1942.
    • (2001) Diabetes , vol.50 , pp. 1938-1942
    • Kowluru, R.A.1    Tang, J.2    Kern, T.S.3
  • 38
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase
    • Kanwar M, Chan PS, Kern TS, Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci. 2007;48:3805–3811.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.