Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine a

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 13, 2015, Pages 4080-4085

  Schewitz Bowers, Lauren P ^a,b   Lait, Philippa J P ^a,b   Copland, David A ^a,b   Chen, Ping ^c   Wu, Wenting ^c   Dhanda, Ashwin D ^a,f   Vistica, Barbara P ^c   Williams, Emily L ^a,b   Liu, Baoying ^c   Jawad, Shayma ^c   Li, Zhiyu ^c   Tucker, William ^c   Hirani, Sima ^c   Wakabayashi, Yoshiyuki ^d   Zhu, Jun ^d   Sen, Nida ^c   Conway Campbell, Becky L ^a   Gery, Igal ^c   Dick, Andrew D ^a,b,f   Wei, Lai ^c,g   Nussenblatt, Robert B ^c,e   Lee, Richard W J ^a,b,f   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c NATIONAL EYE INSTITUTE   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f BRISTOL EYE HOSPITAL   (United Kingdom)

^g SUN YAT SEN UNIVERSITY   (China)

Author keywords

Calcineurin inhibition; Glucocorticoid; Steroid resistance; Th17; Uveitis

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 17; TACROLIMUS; CALCINEURIN INHIBITOR; CYCLOSPORIN; STEROID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE UVEITIS; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; EXPERIMENTAL UVEITIS; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MEMORY T LYMPHOCYTE; MOUSE; MURINE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STEROID RESISTANCE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TREATMENT RESPONSE; ANIMAL; CELL NUCLEUS; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; METABOLISM; PHENOTYPE; TRANSGENIC MOUSE;

MURINAE;

ANIMALS; AUTOIMMUNITY; CALCINEURIN; CALCINEURIN INHIBITORS; CD4-POSITIVE T-LYMPHOCYTES; CELL NUCLEUS; CELL PROLIFERATION; CYCLOSPORINE; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, TRANSGENIC; PHENOTYPE; STEROIDS; TH17 CELLS;

EID: 84961291196     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418316112     Document Type: Article

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