Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Age

Volumn 37, Issue 1, 2015, Pages

  Neto, Walter Krause ^a   Gama, Eliane Florencio ^a   Rocha, Leandro Yanase ^a   Ramos, Carla Cristina ^a   Taets, Wagner ^a   Scapini, Katia Bilhar ^b   Ferreira, Janaina B ^b   Rodrigues, Bruno ^a   Caperuto, Érico ^a,c  

^a SÃO JUDAS TADEU UNIVERSITY   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

Author keywords

Androgen therapy; Elderly men; Fat free mass; Testosterone

Indexed keywords

PLACEBO; TESTOSTERONE; ANDROGEN;

AGING; ANDROGEN THERAPY; ARTICLE; ELDERLY CARE; FAT MASS; FUNCTIONAL ASSESSMENT; HORMONE ACTION; HUMAN; LEAN BODY WEIGHT; MUSCLE MASS; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; TREATMENT RESPONSE; WEIGHT GAIN; AGED; BODY MASS; BODY WEIGHT; DRUG EFFECTS; HORMONE SUBSTITUTION; MALE; META ANALYSIS; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANDROGENS; BODY MASS INDEX; BODY WEIGHT; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MIDDLE AGED; TESTOSTERONE;

EID: 84961290781     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-014-9742-0     Document Type: Article

References (39)

1. Abbasi AA, Drinka PJ, Mattson DE, Rudman D (1993) Low circulating levels of insulin-like growth factors and testosterone in chronically institutionalized elderly men. J Am Geriatr Soc 41(9):975–982
2. Allan CA, Forbes EA, Strauss BJ, McLachlan RI (2008) Testosterone therapy increases sexual desire in ageing men with low-normal testosterone levels and symptoms of androgen deficiency. Int J Impot Res 20(4):396–401
3. Aya K, Alhawagri M, Hagen-Stapleton A, et al (2005) NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest 115:1848–54
4. Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O’Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell Em St Clair C, Pabst KM, Harman SM (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288 (18): 2282–92
5. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW (2005) Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab 90(2):678–688
6. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM (2010) Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95(6):2536–2559
7. Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S (2005) Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 60(11):1451–1457
8. Demchenko YN, Glebov OK, Zingone A, et al (2010) Classical and/or alternative NFkappaB pathway activation in multiple myeloma. Blood 115:3541–52
9. Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, Aleman A, Lock TM, Bosch JL, Grobbee DE, van der Schouw YT (2008) Effect of testosterone replacement therapy on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA 299(1):39–52. doi:10.1001/jama.2007.51, Erratum in: JAMA. 2008 Feb 13;299(6):634
10. Ferrando AA, Sheffield-Moore M, Paddon-Jones D, Wolfe RR, Urban RJ (2003) Differential anabolic effects of testosterone and amino acid feeding in older men. J Clin Endocrinol Metab 88(1):358–62
11. Iannuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol: Med Sci 57A(12):M772–M777
12. Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A, Fabbri A (2005) Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf) 63(3):280–293, Review
13. Kenny AM, Prestwood KM, Raisz LG (2000) Short-term effects of intramuscular and transdermal testosterone on bone turnover, prostate symptoms, cholesterol, and hematocrit in men over age 70 with low testosterone levels. Endocr Res 26(2):153–168
14. Kenny AM, Prestwood KM, Gruman CA, Marcello KM, Raisz LG (2001) Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 56(5):M266–M272
15. Kenny AM, Kleppinger A, Annis K, Rathier M, Browner B, Judge JO, McGee D (2010) Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty. J Am Geriatr Soc 58(6):1134–1143. doi:10.1111/j.1532-5415.2010.02865.x
16. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700
17. Liverman C, Blazer D (2005) Testosterone in aging: directions for clinical research. National Academy Press, Washington, DC
18. McGill JJ, Shoskes DA, Sabanegh ES (2012) Androgen deficiency in older men: indications, advantages, and pitfalls of testosterone replacement therapy. Cleve Clin J Med 79(11):797–806
19. Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SS (1998) The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf) 49(4):421–432
20. Morley JS, Bridson J, Nash TP, Miles JB, White S, Makin MK (2003) Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial. Palliat Med 17(7):576–587
21. Ottenbacher KJ, Ottenbacher ME, Ottenbacher AJ, Acha AA, Ostir GV (2006) Androgen treatment and muscle strength in elderly men: a meta-analysis. J Am Geriatr Soc 54(11):1666–1673
22. Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL (2005) Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90(3):1502–1510
23. Qin W, Pan J, Wu Y et al (2010) Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1alpha. Biochem Biophys Res Commun 403:473–478
24. Sattler FR, Castaneda-Sceppa C, Binder EF, Schroeder ET, Wang Y, Bhasin S, Kawakubo M, Stewart Y, Yarasheski KE, Ulloor J, Colletti P, Roubenoff R, Azen SP (2009) Testosterone and growth hormone improve body composition and muscle performance in older men. J Clin Endocrinol Metab 94(6):1991–2001. doi:10.1210/jc.2008-2338
25. Schroeder ET, Terk M, Sattler FR (2003a) Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies. Am J Physiol Endocrinol Metab 285(1):E16–E24
26. Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M, Sattler FR (2003b) Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Am J Physiol Endocrinol Metab 284(1):E120–E128
27. Schroeder ET, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler FR (2004) Treatment with oxandrolone and the durability of effects in older men. J Appl Physiol (1985) 96(3):1055–1062
28. Schroeder ET, Vallejo AF, Zheng L, Stewart Y, Flores C, Nakao S, Martinez C, Sattler FR (2005) Six-week improvements in muscle mass and strength during androgen therapy in older men. J Gerontol A Biol Sci Med Sci 60(12):1586–92
29. Sculthorpe N, Solomon AM, Sinanan AC et al (2012) Androgens affect myogenesis in vitro and increase local IGF-1 expression. Med Sci Sports Exercise 44:610–615
30. Sheffield-Moore M, Dillon EL, Casperson SL, Gilkison CR, Paddon-Jones D, Durham WJ, Grady JJ, Urban RJ (2011) A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. J Clin Endocrinol Metab 96(11):E1831–E1837. doi:10.1210/jc.2011-1262
31. Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Lenrow DA, Holmes JH, Dlewati A, Santanna J, Rosen CJ, Strom BL (1999) Effect of testosterone replacement therapy on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 84(8):2647–53
32. Starkey JM, Haidacher SJ, LeJeune WS, et al (2006) Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex. Diabetes 55:1252–9
33. Steidle C, Schwartz S, Jacoby K, Sebree T, Smith T, Bachand R, North American AA2500 T Gel Study Group (2003) AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J Clin Endocrinol Metab 88(6):2673–2681
34. Tenover JL (1998) Male hormone replacement therapy including "andropause". Endocrinol Metab Clin North Am 27(4):969–87, x. Review
35. Urban RJ, Dillon EL, Choudhary S, Zhao Y, Horstman AM, Tilton RG, Sheffield-Moore M (2014) Translational studies in older men using testosterone to treat sarcopenia. Trans Am Clin Climatol Assoc 125:27–44
36. Wittert GA, Chapman IM, Haren MT, Mackintosh S, Coates P, Morley JE (2003) Oral testosterone treatment increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci 58(7):618–625
37. Wu Y, Bauman WA, Blitzer RD et al (2010) Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR. Biochem Biophys Res Commun 400:679–683
38. Xu L, Freeman G, Cowling BJ, Schooling CM (2013) Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med 11:108
39. Yang D, Li J, Yuan Z, Liu X (2013) Effect of hormone replacement therapy on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS One 8(5):e62329. doi:10.1371/journal.pone.0062329, Print 2013