A single-nucleotide polymorphism in the MicroRNA-146a gene is associated with diabetic nephropathy and sight-threatening diabetic retinopathy in Caucasian patients

Acta Diabetologica

Volumn 53, Issue 4, 2016, Pages 643-650

  Kaidonis, Georgia ^a   Gillies, Mark C ^b   Abhary, Sotoodeh ^a   Liu, Ebony ^a   Essex, Rohan W ^c   Chang, John H ^d,e   Pal, Bishwanath ^e   Sivaprasad, Sobha ^e   Pefkianaki, Maria ^e   Daniell, Mark ^f   Lake, Stewart ^a   Petrovsky, Nikolai ^a   Hewitt, Alex W ^g   Jenkins, Alicia ^h   Lamoureux, Ecosse L ^g,i   Gleadle, Jonathan M ^a   Craig, Jamie E ^a   Burdon, Kathryn P ^a,j  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e MOORFIELDS EYE HOSPITAL   (United Kingdom)

^f ROYAL MELBOURNE HOSPITAL   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h ST VINCENT S HOSPITAL   (Australia)

ⁱ SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^j UNIVERSITY OF TASMANIA   (Australia)

more..

Author keywords

Diabetic macular oedema; Diabetic nephropathy; Diabetic retinopathy; Genetics; microRNA; microRNA 146a

Indexed keywords

HEMOGLOBIN A1C; MICRORNA 146A; ANTIDIABETIC AGENT; INSULIN; MICRORNA; MIRN146 MICRORNA, HUMAN;

ADULT; AGE; ALLELE; ARTICLE; AUSTRALIA; CAUCASIAN; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; MIR 146A GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROLIFERATIVE DIABETIC RETINOPATHY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; AGED; COMPLICATION; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; GENETICS; MACULAR EDEMA; RISK FACTOR;

ADULT; AGED; AUSTRALIA; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MACULAR EDEMA; MALE; MICRORNAS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84961246814     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-016-0850-4     Document Type: Article

References (25)

1. Kempen JH, O’Colmain BJ, Leske MC et al (2004) The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 122:552–563. doi:10.1001/archopht.122.4.552
2. National Association of Diabetes Centers (2010) Australian National Diabetes Information Audit and Benchmarking: Final Report 2009, pp 1–470
3. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820. doi:10.1038/414813a
4. Kowluru RA, Koppolu P, Chakrabarti S, Chen S (2003) Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic Res 37:1169–1180. doi:10.1080/10715760310001604189
5. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
6. Cammaerts S, Strazisar M, De Rijk P, Del Favero J (2015) Genetic variants in microRNA genes: impact on microRNA expression, function, and disease. Front Genet 6:1–12. doi:10.3389/fgene.2015.00186
7. Wang S, Olson EN (2009) AngiomiRs—key regulators of angiogenesis. Curr Opin Genet Dev 19:205–211. doi:10.1016/j.gde.2009.04.002
8. Jazdzewski K, Liyanarachchi S, Swierniak M et al (2009) Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc Natl Acad Sci USA 106:1502–1505. doi:10.1073/pnas.0812591106
9. Li C, Fu W, Zhang Y et al (2015) Meta-analysis of MicroRNA-146a rs2910164 G > C polymorphism association with autoimmune diseases susceptibility, an update based on 24 studies. PLoS ONE 10:e0121918. doi:10.1371/journal.pone.0121918.s003
10. Kutty RK, Nagineni CN, Samuel W et al (2012) Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ. Mol Vis 19:737–750
11. Taganov KD, Boldin MP, Chang K-J, Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103:12481–12486. doi:10.2307/30050590
12. Cowan C, Muraleedharan CK, O’Donnell JJ et al (2014) MicroRNA-146 Inhibits Thrombin-Induced NF-κB Activation and Subsequent Inflammatory Responses in Human Retinal Endothelial Cells. Invest Ophthalmol Vis Sci 55:4944–4951
13. Kovacs B, Lumayag S, Cowan C, Xu S (2011) microRNas in early diabetic retinopathy in streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 52:4402–4409. doi:10.1167/iovs.10-6879
14. Joussen AM, Huang S, Poulaki V et al (2001) In vivo retinal gene expression in early diabetes. Invest Ophthalmol Vis Sci 42:3047–3057
15. Feng B, Chen S, McArthur K et al (2011) miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. Diabetes 60:2975–2984. doi:10.2337/db11-0478
16. Jazdzewski K, Murray EL, Franssila K et al (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105:7269–7274. doi:10.1073/pnas.0802682105
17. Kaidonis G, Abhary S, Daniell M et al (2013) Genetic study of diabetic retinopathy: recruitment methodology and analysis of baseline characteristics. Clin Exp Ophthalmol. doi:10.1111/ceo.12239
18. ETDRS Research Group (1991) Grading diabetic retinopathy from stereoscopic color fundus photographs–an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 98:786–806
19. Purcell S, Cherny SS, Sham PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149–150
20. Ramkaran P, Khan S, Phulukdaree A et al (2013) miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in Young Patients with coronary artery Disease. Cell Biochem Biophys 68:259–266. doi:10.1007/s12013-013-9704-7
21. Ciccacci C, Morganti R, Fusco D et al (2014) Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes. Acta Diabetol. doi:10.1007/s00592-014-0582-2
22. Romeo G, Liu W-H, Asnaghi V et al (2002) Activation of nuclear factor-B induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 51:1–8
23. Roy S, Cagliero E, Lorenzi M (1996) Fibronectin overexpression in retinal microvessels of patients with diabetes. Invest Ophthalmol Vis Sci 37:258–266
24. Huang Y, Liu Y, Li L et al (2014) Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury. BMC Nephrol 15:1–12. doi:10.1186/1471-2369-15-142
25. Huang G-M, Huang K-Y, Lee T-Y, Weng J (2015) An interpretable rule-based diagnostic classification of diabetic nephropathy among type 2 diabetes patients. BMC Bioinf 16(Suppl 1):S5. doi:10.1186/1471-2105-16-S1-S5