Mineralocorticoid Receptor Antagonism: A Promising Therapeutic Approach to Treat Ischemic AKI

Nephron

Volumn 134, Issue 1, 2016, Pages 10-13

  Barrera Chimal, Jonatan ^a   Bobadilla, Norma A ^b   Jaisser, Frédéric ^a  

^a INSERM   (France)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Acute renal injury; Aldosterone; Endothelial nitric oxide synthase; Endothelin 1; Nitrix oxide

Indexed keywords

ALDOSTERONE; DEXAMETHASONE; FINERENONE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; DRUG MECHANISM; HUMAN; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVIEW; RODENT; VASOCONSTRICTION; ACUTE KIDNEY INJURY; ANIMAL; COMPLICATION; PHYSIOLOGY;

ACUTE KIDNEY INJURY; ALDOSTERONE; ANIMALS; HUMANS; MINERALOCORTICOID RECEPTOR ANTAGONISTS; RATS; REPERFUSION INJURY;

EID: 84961233596     PISSN: 16608151     EISSN: 22353186     Source Type: Journal    
DOI: 10.1159/000445080     Document Type: Review

References (15)

1. Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W, Vanholder R: Acute kidney injury: an increasing global concern. Lancet 2013;382:170-179.
2. Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group: Renal hemodynamics in AKI: in search of new treatment targets. J Am Soc Nephrol 2016;27:49-58.
3. Sharfuddin AA, Molitoris BA: Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 2011;7:189-200.
4. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011;121:4210-4221.
5. Mejía-Vilet JM, Ramírez V, Cruz C, Uribe N, Gamba G, Bobadilla NA: Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol 2007;293:F78-F86.
6. Sánchez-Pozos K, Barrera-Chimal J, Garzón-Muvdi J, Pérez-Villalva R, Rodríguez-Romo R, Cruz C, Gamba G, Bobadilla NA: Recovery from ischemic acute kidney injury by spironolactone administration. Nephrol Dial Transplant 2012;27:3160-3169.
7. Ramírez V, Trujillo J, Valdes R, Uribe N, Cruz C, Gamba G, Bobadilla NA: Adrenalectomy prevents renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 2009;297:F932-F942.
8. Fagart J, Hillisch A, Huyet J, Bärfacker L, Fay M, Pleiss U, Pook E, Schäfer S, Rafestin-Oblin ME, Kolkhof P: A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem 2010;285:29932-29940.
9. Kolkhof P, Nowack C, Eitner F: Nonsteroidal antagonists of the mineralocorticoid receptor. Curr Opin Nephrol Hypertens 2015;24:417-424.
10. Pitt B, Anker SD, Böhm M, Gheorghiade M, Køber L, Krum H, Maggioni AP, Ponikowski P, Voors AA, Zannad F, Nowack C, Kim SY, Pieper A, Kimmeskamp-Kirschbaum N, Filippatos G: Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease. Eur J Heart Fail 2015;17:224-232.
11. Barrera-Chimal J, Prince S, Fadel F, El Moghrabi S, Warnock DG, Kolkhof P, Jaisser F: Sulfenic acid modification of endothelin B receptor is responsible for the benefit of a nonsteroidal mineralocorticoid receptor antagonist in renal ischemia. J Am Soc Nephrol 2016;27:398-404.
12. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA: Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 2012;126:963-974.
13. Juncos LA, Juncos LI: Mineralocorticoid receptor antagonism in AKI: a new hope? J Am Soc Nephrol 2016;27:335-337.
14. Barrera-Chimal J, Pérez-Villalva R, Rodríguez-Romo R, Reyna J, Uribe N, Gamba G, Bobadilla NA: Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury. Kidney Int 2013;83:93-103.
15. Ojeda-Cervantes M, Barrera-Chimal J, Alberú J, Pérez-Villalva R, Morales-Buenrostro LE, Bobadilla NA: Mineralocorticoid receptor blockade reduced oxidative stress in renal transplant recipients: a double-blind, randomized pilot study. Am J Nephrol 2013;37:481-490.