Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology

Virulence

Volumn 7, Issue 4, 2016, Pages 387-394

  Hahn, William O ^a   Mikacenic, Carmen ^b   Price, Brenda L ^b   Harju Baker, Susanna ^b   Katz, Ronit ^b   Himmelfarb, Jonathan ^b   Wurfel, Mark M ^b   Liles, W Conrad ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Angiopoietin 1; Angiopoietin 2; Bacteremia; G CSF; Gram negative; Gram positive; IL 6; IL 8; Sepsis; SFAS; SVAM 1; TNFR 1

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 8; PEGSUNERCEPT; BIOLOGICAL MARKER;

ADULT; APOPTOSIS; BACTEREMIA; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIUM CELL; FEMALE; HUMAN; HYPOTENSION; INFLAMMATION; KIDNEY FAILURE; LETTER; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; AGED; BLOOD; COHORT ANALYSIS; IMMUNOLOGY; MICROBIOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RETROSPECTIVE STUDY;

ADULT; AGED; APOPTOSIS; BACTEREMIA; BIOMARKERS; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SEPSIS;

EID: 84961216619     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.1080/21505594.2016.1144003     Document Type: Letter

References (46)

1. D.C.Angus, W.T.Linde-Zwirble, J.Lidicker, G.Clermont, J.Carcillo, M.R.Pinsky. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303–10; PMID:11445675; http://dx.doi.org/10.1097/00003246-200107000-00002
2. SEER Cancer Stat Fact Sheets [Internet]. [cited 2014 Oct 3]; Available from: http://seer.cancer.gov/statfacts/
3. R.P.Dellinger, M.M.Levy, A.Rhodes, D.Annane, H.Gerlach, S.M.Opal, J.E.Sevransky, C.L.Sprung, I.S.Douglas, R.Jaeschke, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41:580–637; PMID:23353941; http://dx.doi.org/10.1097/CCM.0b013e31827e83af
4. M.R.Kimbrell, H.Warshakoon, J.R.Cromer, S.Malladi, J.D.Hood, R.Balakrishna, T.A.Scholdberg, S.A.David. Comparison of the immunostimulatory and proinflammatory activities of candidate Gram-positive endotoxins, lipoteichoic acid, peptidoglycan, and lipopeptides, in murine and human cells. Immunol Lett 2008; 118:132–41; PMID:18468694; http://dx.doi.org/10.1016/j.imlet.2008.03.009
5. J.Branger, S.Knapp, S.Weijer, J.C.Leemans, J.M.Pater, P.Speelman, S.Florquin, T.van der Poll. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 2004; 72:788–94; PMID:14742522; http://dx.doi.org/10.1128/IAI.72.2.788-794.2004
6. G.Elson, I.Dunn-Siegrist, B.Daubeuf, J.Pugin. Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 2007; 109:1574–83; PMID:17038528; http://dx.doi.org/10.1182/blood-2006-06-032961
7. L.Björk, J.Andersson, M.Ceska, U.Andersson. Endotoxin and Staphylococcus aureus enterotoxin A induce different patterns of cytokines. Cytokine 1992; 4:513–9; PMID:1292633; http://dx.doi.org/10.1016/1043-4666(92)90013-H
8. K.W.McConnell, J.E.McDunn, A.T.Clark, W.M.Dunne, D.J.Dixon, I.R.Turnbull, P.J.Dipasco, W.F.Osberghaus, B.Sherman, J.R.Martin, et al. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med 2010; 38:223–41; PMID:19770740; http://dx.doi.org/10.1097/CCM.0b013e3181b4a76b
9. X.-J.Xu, Y.-M.Tang, C.Liao, H.Song, S.-L.Yang, W.-Q.Xu, S.-W.Shi, N.Zhao. Inflammatory cytokine measurement quickly discriminates gram-negative from gram-positive bacteremia in pediatric hematology/oncology patients with septic shock. Intensive Care Med 2013; 39:319–26; PMID:23179333; http://dx.doi.org/10.1007/s00134-012-2752-4
10. R.Abe, S.Oda, T.Sadahiro, M.Nakamura, Y.Hirayama, Y.Tateishi, K.Shinozaki, H.Hirasawa. Gram-negative bacteremia induces greater magnitude of inflammatory response than Gram-positive bacteremia. Crit Care 2010; 14:R27; PMID:20202204; http://dx.doi.org/10.1186/cc8898
11. R.J.Feezor, C.Oberholzer, H.V.Baker, D.Novick, M.Rubinstein, L.L.Moldawer, J.Pribble, S.Souza, C.A.Dinarello, W.Ertel, et al. Molecular characterization of the acute inflammatory response to infections with gram-negative vs. gram-positive bacteria. Infect Immun 2003; 71:5803–13; PMID:14500502; http://dx.doi.org/10.1128/IAI.71.10.5803-5813.2003
12. G.T.Kinasewitz, S.B.Yan, B.Basson, P.Comp, J.A.Russell, A.Cariou, S.L.Um, B.Utterback, P.F.Laterre, J.F.Dhainaut, et al. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 2004; 8:R82–90; PMID:15025782; http://dx.doi.org/10.1186/cc2459
13. B.M.P.Tang, A.S.McLean, I.W.Dawes, S.J.Huang, M.J.Cowley, R.C.Y.Lin. Gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients. Crit Care Med 2008; 36:1125–8; PMID:18379237; http://dx.doi.org/10.1097/CCM.0b013e3181692c0b
14. J.R.Zahar, J.F.Timsit, M.Garrouste-Orgeas, A.Français, A.Vesin, A.Vesim, A.Descorps-Declere, Y.Dubois, B.Souweine, H.Haouache, et al. Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality. Crit Care Med 2011; 39:1886–95; PMID:21516036; http://dx.doi.org/10.1097/CCM.0b013e31821b827c
15. C.Ani, S.Farshidpanah, A.Bellinghausen Stewart, H.B.Nguyen. Variations in organism-specific severe sepsis mortality in the United States: 1999-2008. Crit Care Med 2015; 43:65–77; PMID:25230374; http://dx.doi.org/10.1097/CCM.0000000000000555
16. M.F.Osuchowski, K.Welch, H.Yang, J.Siddiqui, D.G.Remick. Chronic sepsis mortality characterized by an individualized inflammatory response. J Immunol 2007; 179:623–30; PMID:17579084; http://dx.doi.org/10.4049/jimmunol.179.1.623
17. R.S.Hotchkiss, C.M.Coopersmith, J.E.McDunn, T.A.Ferguson. The sepsis seesaw: tilting toward immunosuppression. Nat Med 2009; 15:496–7; PMID:19424209; http://dx.doi.org/10.1038/nm0509-496
18. M.F.Osuchowski, F.Craciun, K.M.Weixelbaumer, E.R.Duffy, D.G.Remick. Sepsis chronically in MARS: systemic cytokine responses are always mixed regardless of the outcome, magnitude, or phase of sepsis. J Immunol 2012; 189:4648–56; PMID:23008446; http://dx.doi.org/10.4049/jimmunol.1201806
19. E.Tamayo, A.Fernández, R.Almansa, E.Carrasco, M.Heredia, C.Lajo, L.Goncalves, J.I.Gómez-Herreras, R.O.de Lejarazu, J.F.Bermejo-Martin. Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock. Eur Cytokine Netw 2011; 22:82–7; PMID:21628135
20. N.A.Hutchins, C.S.Chung, J.N.Borgerding, C.A.Ayala, A.Ayala. Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. Am J Pathol 2013; 182:742–54; PMID:23306157; http://dx.doi.org/10.1016/j.ajpath.2012.11.023
21. P.Gais, D.Reim, G.Jusek, T.Rossmann-Bloeck, H.Weighardt, K.Pfeffer, F.Altmayr, K.-P.Janssen, B.Holzmann. Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 2012; 188:5833–7; PMID:22586041; http://dx.doi.org/10.4049/jimmunol.1200038
22. N.Lerolle, D.Nochy, E.Guérot, P.Bruneval, J.Y.Fagon, J.L.Diehl, G.Hill. Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 2010; 36:471–8; PMID:19924395; http://dx.doi.org/10.1007/s00134-009-1723-x
23. H.Yagi, A.Soto-Gutierrez, N.Navarro-Alvarez, Y.Nahmias, Y.Goldwasser, Y.Kitagawa, A.W.Tilles, R.G.Tompkins, B.Parekkadan, M.L.Yarmush. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther 2010; 18:1857–64; PMID:20664529; http://dx.doi.org/10.1038/mt.2010.155
24. K.M.Mohler, D.S.Torrance, C.A.Smith, R.G.Goodwin, K.E.Stremler, V.P.Fung, H.Madani, M.B.Widmer. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol 1993; 151:1548–61; PMID:8393046
25. A.Oberholzer, S.M.Souza, S.K.Tschoeke, C.Oberholzer, A.Abouhamze, J.P.Pribble, L.L.Moldawer. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock 2005; 23:488–93; PMID:15897799
26. J.R.Gamble, J.Drew, L.Trezise, A.Underwood, M.Parsons, L.Kasminkas, J.Rudge, G.Yancopoulos, M.A.Vadas. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ Res 2000; 87:603–7; PMID:11009566; http://dx.doi.org/10.1161/01.RES.87.7.603
27. A.V.Benest, K.Kruse, S.Savant, M.Thomas, A.M.Laib, E.K.Loos, U.Fiedler, H.G.Augustin. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS One 2013; 8:e70459; PMID:23940579; http://dx.doi.org/10.1371/journal.pone.0070459
28. T.Ziegler, J.Horstkotte, C.Schwab, V.Pfetsch, K.Weinmann, S.Dietzel, I.Rohwedder, R.Hinkel, L.Gross, S.Lee, et al. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest [Internet] 2013; 123(8):3436–3445
29. R.S.Hotchkiss, K.W.Tinsley, P.E.Swanson, R.E.Schmieg, Jr, J.J.Hui, K.C.Chang, D.F.Osborne, B.D.Freeman, J.P.Cobb, T.G.Buchman, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 2001; 166:6952–63; PMID:11359857; http://dx.doi.org/10.4049/jimmunol.166.11.6952
30. C.Marsik, T.Halama, F.Cardona, W.Wlassits, F.Mayr, J.Pleiner, B.Jilma. Regulation of Fas (APO-1, CD95) and Fas ligand expression in leukocytes during systemic inflammation in humans. Shock 2003; 20:493–6; PMID:14625471; http://dx.doi.org/10.1097/01.shk.0000097248.97298.ea
31. R.S.Hotchkiss, S.B.Osmon, K.C.Chang, T.H.Wagner, C.M.Coopersmith, I.E.Karl. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 2005; 174:5110–8; PMID:15814742; http://dx.doi.org/10.4049/jimmunol.174.8.5110
32. I.De Freitas, M.Fernández-Somoza, E.Essenfeld-Sekler, J.E.Cardier. Serum levels of the apoptosis-associated molecules, tumor necrosis factor-α/tumor necrosis factor type-I receptor and Fas/FasL, in sepsis. Chest 2004; 125:2238–46; http://dx.doi.org/10.1378/chest.125.6.2238
33. S.Li, L.Zhang, Q.Yao, L.Li, N.Dong, J.Rong, W.Gao, X.Ding, L.Sun, X.Chen, et al. Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature 2013; 501:242–6; PMID:23955153; http://dx.doi.org/10.1038/nature12436
34. A.Paunel-Görgülü, S.Flohé, M.Scholz, J.Windolf, T.Lögters. Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis. Crit Care 2011; 15:R20; PMID:21232130; http://dx.doi.org/10.1186/cc9965
35. C.E.Ventetuolo, M.M.Levy. Biomarkers: diagnosis and risk assessment in sepsis. Clin Chest Med 2008; 29:591–603, vii; PMID:18954695; http://dx.doi.org/10.1016/j.ccm.2008.07.001
36. E.Jordana-Lluch, M.Giménez, M.D.Quesada, B.Rivaya, C.Marcó, M.J.Domínguez, F.Arméstar, E.Martró, V.Ausina. Evaluation of the Broad-Range PCR/ESI-MS technology in blood specimens for the molecular diagnosis of bloodstream infections. PLoS One 2015; 10:e0140865; PMID:26474394; http://dx.doi.org/10.1371/journal.pone.0140865
37. TM in the daily routine of a diagnostic laboratory. Diagn Microbiol Infect Dis 2013; 76:413–8; PMID:23747029; http://dx.doi.org/10.1016/j.diagmicrobio.2013.04.027
38. B.J.Glavan, T.D.Holden, C.H.Goss, R.A.Black, M.J.Neff, A.B.Nathens, T.R.Martin, M.M.Wurfel. ARDSnet Investigators. Genetic variation in the FAS gene and associations with acute lung injury. Am J Respir Crit Care Med 2011; 183:356–63; PMID:20813889; http://dx.doi.org/10.1164/rccm.201003-0351OC
39. T.C.Horan, M.Andrus, M.A.Dudeck. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36:309–32; PMID:18538699; http://dx.doi.org/10.1016/j.ajic.2008.03.002
40. Y.Hirakata, N.Furuya, M.Iwata, F.Kashitani, M.Ishikawa, S.Yumoto, K.Yasui, H.Endoh, A.Marui, M.Kaku, et al. Assessment of clinical significance of positive blood cultures of relatively low-virulence isolates. J Med Microbiol 1996; 44:195–8; PMID:8636936; http://dx.doi.org/10.1099/00222615-44-3-195
41. M.M.Levy, M.P.Fink, J.C.Marshall, E.Abraham, D.Angus, D.Cook, J.Cohen, S.M.Opal, J.L.Vincent, G.Ramsay, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:1250–6; PMID:12682500; http://dx.doi.org/10.1097/01.CCM.0000050454.01978.3B
42. W.A.Knaus, D.P.Wagner, E.A.Draper, J.E.Zimmerman, M.Bergner, P.G.Bastos, C.A.Sirio, D.J.Murphy, T.Lotring, A.Damiano. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991; 100:1619–36; PMID:1959406; http://dx.doi.org/10.1378/chest.100.6.1619
43. S.M.Opal, G.E.Garber, S.P.LaRosa, D.G.Maki, R.C.Freebairn, G.T.Kinasewitz, J.F.Dhainaut, S.B.Yan, M.D.Williams, D.E.Graham, et al. Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated). Clin Infect Dis 2003; 37:50–8; PMID:12830408; http://dx.doi.org/10.1086/375593
44. R.S.Hotchkiss, P.E.Swanson, B.D.Freeman, K.W.Tinsley, J.P.Cobb, G.M.Matuschak, T.G.Buchman, I.E.Karl. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230–51; PMID:10446814; http://dx.doi.org/10.1097/00003246-199907000-00002
45. R.Huttunen, J.Syrjänen, R.Vuento, J.Laine, M.Hurme, J.Aittoniemi. Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: a prospective cohort study. J Infect 2012; 64:276–81; PMID:22207003; http://dx.doi.org/10.1016/j.jinf.2011.12.006
46. C.Mikacenic, W.O.Hahn, B.L.Price, S.Harju-Baker, R.Katz, K.C.Kain, J.Himmelfarb, W.C.Liles, M.M.Wurfel. Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness. PLoS One 2015; 10:e0141251; PMID:26492036; http://dx.doi.org/10.1371/journal.pone.0141251