Ibuprofen-loaded poly(trimethylene carbonate-co-ε-caprolactone) electrospun fibres for nerve regeneration

Journal of Tissue Engineering and Regenerative Medicine

Volumn 10, Issue 3, 2016, Pages E154-E166

  Pires, Liliana R ^a,b   Guarino, Vincenzo ^c   Oliveira, Maria J ^a,d   Ribeiro, Cristina C ^a,e   Barbosa, Mário A ^a,b   Ambrosio, Luigi ^c   Pêgo, Ana Paula ^a,b  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c CNR   (Italy)

^d University of Porto   (Portugal)

^e INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO   (Portugal)

Author keywords

Confocal Raman microscopy; Drug delivery; Electrospinning; Ibuprofen; Inflammation; Nerve guide

Indexed keywords

BIOACTIVITY; CELL CULTURE; CONTROLLED DRUG DELIVERY; DICHLOROMETHANE; DIMETHYLFORMAMIDE; ELECTROSPINNING; FIGHTER AIRCRAFT; MIXTURES; ORGANIC SOLVENTS; TARGETED DRUG DELIVERY;

CONFOCAL RAMAN MICROSCOPY; ELECTROSPUN FIBERS; IBUPROFEN; NERVE GUIDE; NERVE REGENERATION; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; POLY (TRIMETHYLENE CARBONATE); POLYTRIMETHYLENE CARBONATE; STATISTICAL COPOLYMERS; Ε-CAPROLACTONE;

FIBERS;

COPOLYMER; DICHLOROMETHANE; IBUPROFEN; INTERLEUKIN 10; INTERLEUKIN 6; N,N DIMETHYLFORMAMIDE; POLY(TRIMETHYLENE CARBONATE CO EPSILON CAPROLACTONE); PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYTOKINE; DIOXANE DERIVATIVE; POLY(TRIMETHYLENE CARBONATE-CO-EPSILON-CAPROLACTONE); POLYESTER; TRIMETHYLENE CARBONATE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTROSPINNING; HUMAN; HUMAN CELL; MACROPHAGE; NERVE FIBER REGENERATION; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; CELL SHAPE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; DRUG RELEASE; INFRARED SPECTROSCOPY; METABOLISM; NERVE REGENERATION; PROCEDURES; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

ANTI-INFLAMMATORY AGENTS; CELL SHAPE; CELL SURVIVAL; CYTOKINES; DINOPROSTONE; DIOXANES; DRUG LIBERATION; HUMANS; IBUPROFEN; MACROPHAGES; MICROSCOPY, ELECTRON, SCANNING; NERVE REGENERATION; POLYESTERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE ENGINEERING;

EID: 84961207080     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1792     Document Type: Article

References (48)

1. Adachi K, Yimin Y, Satake K et al. 2005; Localization of cyclooxygenase-2 induced following traumatic spinal cord injury. Neurosci Res 51: 73-80.
2. Adar F. 2008; Raman images from raman maps - spatial resolution, mapping speed, and multivariate techniques for constructing the image. Spectroscopy 23: 14-21.
3. Agarwal S, Wendorff JH, Greiner A. 2009; Progress in the field of electrospinning for tissue engineering applications. Adv Mater 21: 3343-3351.
4. Bölgen N, Menceloglu YZ, Acatay K, Vargel I, Piskin E. 2005; In vitro and in vivo degradation of non-woven materials made of poly(ε-caprolactone) nanofibres prepared by electrospinning under different conditions. J Biomater Sci Polym Ed 16: 1537-1555.
5. Brodbeck WG, Nakayama Y, Matsuda T et al. 2002; Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro. Cytokine 18: 311-319.
6. Cao H, McHugh K, Chew SY et al. 2010; The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. J Biomed Mater Res A 93: 1151-1159.
7. Casha S, Zygun D, McGowan MD et al. 2012; Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain 135: 1224-1236.
8. Chan CC. 2008; Inflammation: beneficial or detrimental after spinal cord injury? Recent Pat CNS Drug Discov 3: 189-199.
9. Chew SY, Wen J, Yim EKF et al. 2005; Sustained release of proteins from electrospun biodegradable fibres. Biomacromolecules 6: 2017-2024.
10. Chiou WF, Shum AYC, Peng CH et al. 2003; Piperlactam S suppresses macrophage migration by impeding F-actin polymerization and filopodia extension. Eur J Pharmacol 458: 217-225.
11. Corey JM, Lin DY, Mycek KB et al. 2007; Aligned electrospun nanofibres specify the direction of dorsal root ganglia neurite growth. J Biomed Mater Res A 83: 636-645.
12. Cui W, Li X, Zhu X et al. 2006; Investigation of drug release and matrix degradation of electrospun poly(dl-lactide) fibres with paracetanol inoculation. Biomacromolecules 7: 1623-1629.
13. Fitch MT, Silver J. 2008; CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol 209: 294-301.
14. Formhals A. 1934; US patent (1, 975, 504).
15. Han J, Branford-White CJ, Zhu LM. 2010; Preparation of poly(ε-caprolactone)/poly(trimethylene carbonate) blend nanofibres by electrospinning. Carbohydr Polym 79: 214-218.
16. Heikkilä P, Harlin A. 2008; Parameter study of electrospinning of polyamide-6. Eur Polym J 44: 3067-3079.
17. Hsu CM, Shivkumar S. 2004; N, N-dimethylformamide additions to the solution for the electrospinning of poly(ε-caprolactone) nanofibres. Macromol Mater Eng 289: 334-340.
18. Hurtado A, Cregg JM, Wang HB et al. 2011; Robust CNS regeneration after complete spinal cord transection using aligned poly-l-lactic acid microfibres. Biomaterials 32: 6068-6079.
19. Jia YT, Kim HY, Gong J et al. 2006; Electrospun nanofibres of block copolymer of trimethylene carbonate and e-caprolactone. J Appl Polym Sci Symp 99: 1462-1470.
20. Jiang X, Mi R, Hoke A et al. 2012; Nanofibrous nerve conduit-enhanced peripheral nerve regeneration. J Tissue Eng Regen Med. DOI: 10.1002/term.1531. [Epub ahead of print]
21. Kim K, Luu YK, Chang C et al. 2004; Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 98: 47-56.
22. Lamanna G, Russier J, Dumortier H et al. 2012; Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons. Biomaterials 33: 5610-5617.
23. Lee YJ, Chuang YC. 2010; Ibuprofen augments pro-inflammatory cytokine release in a mouse model of Vibrio vulnificus infection. Microbiol Immunol 54: 542-550.
24. Lee YS, Arinzeh TL. 2011; Electrospun nanofibrous materials for neural tissue engineering. Polymers 3: 413-426.
25. Liu T, Xu J, Chan BP et al. 2012; Sustained release of neurotrophin-3 and chondroitinase ABC from electrospun collagen nanofibre scaffold for spinal cord injury repair. J Biomed Mater Res A 100A: 236-242.
26. Ma W, St-Jacques B, Cruz Duarte P. 2012; Targeting pain mediators induced by injured nerve-derived COX2 and PGE2 to treat neuropathic pain. Expert Opin Ther Targets 16: 527-540.
27. Martins A, Araújo JV, Reis RL et al. 2007; Electrospun nanostructured scaffolds for tissue engineering applications. Nanomedicine 2: 929-942.
28. Mitchell JA, Akarasereenont P, Thiemermann C et al. 1993; Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 90: 11693-11697.
29. Natu MV, de Sousa HC, Gil MH. 2010; Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibres. Int J Pharm 397: 50-58.
30. Oliveira MI, Santos SG, Oliveira MJ et al. 2012; Chitosan drives anti-inflammatory macrophage polarisation and pro-inflammatory dendritic cell stimulation. Eur Cell Mater 24: 136-153.
31. Pêgo AP, Poot AA, Grijpma DW et al. 2001; Copolymers of trimethylene carbonate and epsilon-caprolactone for porous nerve guides: Synthesis and properties. J Biomater Sci Polym Ed 12: 35-53.
32. Pêgo AP, Poot AA, Grijpma DW et al. 2003; Biodegradable elastomeric scaffolds for soft tissue engineering. J Control Release 87: 69-79.
33. Porcheray F, Viaud S, Rimaniol AC et al. 2005; Macrophage activation switching: an asset for the resolution of inflammation. Clin Exp Immunol 142: 481-489.
34. Rainsford KD. 2009; Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology 17: 275-342.
35. Schaub NJ, Gilbert RJ. 2011; Controlled release of 6-aminonicotinamide from aligned, electrospun fibres alters astrocyte metabolism and dorsal root ganglia neurite outgrowth. J Neural Eng 8: 046026.
36. Schwartz M, London A, Shechter R. 2009; Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity. Neuroscience 158: 1133-1142.
37. Shinji H, Kaiho S, Nakano T et al. 1991; Reorganization of microfilaments in macrophages after LPS stimulation. Exp Cell Res 193: 127-133.
38. Siepmann J, Peppas NA. 2001; Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 48: 139-157.
39. Sirota L, Shacham D, Punsky I et al. 2001; Ibuprofen affects pro- and anti-inflammatory cytokine production by mononuclear cells of preterm newborns. Biol Neonate 79: 103-108.
40. Stuhlmeier KM, Li H, Kao JJ. 1999; Ibuprofen: New explanation for an old phenomenon. Biochem Pharmacol 57: 313-320.
41. Thuret S, Moon LDF, Gage FH. 2006; Therapeutic interventions after spinal cord injury. Nat Rev Neurosci 7: 628-643.
42. Tungprapa S, Jangchud I, Supaphol P. 2007; Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fibre mats. Polymer 48: 5030-5041.
43. Vleggeert-Lankamp CLAM, Wolfs J, Pêgo AP et al. 2008; Effect of nerve graft porosity on the refractory period of regenerating nerve fibres: laboratory investigation. J Neurosurg 109: 294-305.
44. Xie J, MacEwan MR, Schwartz AG et al. 2010; Electrospun nanofibres for neural tissue engineering. Nanoscale 2: 35-44.
45. Yao L, O'Brien N, Windebank A et al. 2009; Orienting neurite growth in electrospun fibrous neural conduits. J Biomed Mater Res B Appl Biomater 90: 483-491.
46. Yu W, Zhao W, Zhu C et al. 2011; Sciatic nerve regeneration in rats by a promising electrospun collagen/poly(ε-caprolactone) nerve conduit with tailored degradation rate. BMC Neurosci 12: 68.
47. Zhao P, Waxman SG, Hains BC. 2007; Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci 27: 2357-2368.
48. Zhou Y, Su Y, Li BL et al. 2003; Nonsteroidal anti-inflammatory drugs can lower amyloidogenic A beta(42) by inhibiting Rho. Science 302: 1215-1217.