Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures

Cardiovascular Toxicology

Volumn 16, Issue 2, 2016, Pages 163-171

  Aragon, Mario J ^a   Chrobak, Izabela ^b,c   Brower, Jeremy ^c   Roldan, Luis ^a   Fredenburgh, Laura E ^b,c   McDonald, Jacob D ^c   Campen, Matthew J ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Cardiovascular; Diesel; Endothelium; Exhaust; Gasoline; Particulate matter; Wood smoke

Indexed keywords

ACETYLCHOLINE; GASOLINE; OZONE; TOXIC SUBSTANCE; AIR POLLUTANT; AUTACOID; EXHAUST GAS; PARTICULATE MATTER; VASODILATOR AGENT;

AIR POLLUTANT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BIOLOGICAL ACTIVITY; BLOOD BIOCHEMISTRY; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR INFLAMMATION; CEREBROVASCULAR ENDOTHELIAL CELL; CONTROLLED STUDY; DIESEL ENGINE; DUST; ECOTOXICITY; ENDOTHELIUM CELL; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; GENE; GENE EXPRESSION; INFLAMMATORY GENE; INHALATION; MALE; MIXED VEHICLE EMISSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOKE; SUSPENDED PARTICULATE MATTER; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASODILATATION; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; AORTA; BLOOD; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; METABOLISM; ORGAN CULTURE TECHNIQUE; PARTICULATE MATTER; PHYSIOLOGY; SERUM; TOXICITY;

AIR POLLUTANTS; ANIMALS; AORTA; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; MALE; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PARTICULATE MATTER; SERUM; VASODILATOR AGENTS; VEHICLE EMISSIONS;

EID: 84961195644     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-015-9325-z     Document Type: Article

References (27)

1. Allen, R. W., Carlsten, C., Karlen, B., Leckie, S., van Eeden, S., Vedal, S., et al. (2011). An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. American Journal of Respiratory and Critical Care Medicine,183, 1222–1230.
2. Bell, M. L., Ebisu, K., Leaderer, B. P., Gent, J. F., Lee, H. J., Koutrakis, P., et al. (2014). Associations of PM(2). (5) constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥65 years of age. Environmental Health Perspectives,122, 138–144.
3. Brook, R. D., Cakmak, S., Turner, M. C., Brook, J. R., Crouse, D. L., Peters, P. A., et al. (2013). Long-term fine particulate matter exposure and mortality from diabetes in Canada. Diabetes Care,36, 3313–3320.
4. Campen, M., Robertson, S., Lund, A., Lucero, J., & McDonald, J. (2014). Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology,26, 353–360.
5. Channell, M. M., Paffett, M. L., Devlin, R. B., Madden, M. C., & Campen, M. J. (2012). Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model. Toxicological Sciences,127, 179–186.
6. Cung, H., Aragon, M., Anderson, J., Nawarskas, J., Roldan, C., Sood, A., Qualls, C., Campen, M. J. (2015). Characterization of a novel endothelial biosensor assay reveals increased cumulative serum inflammatory potential in stabilized coronary artery disease patients. Journal of Translational Medicine, minor revisions.
7. Forchhammer, L., Møller, P., Riddervold, I. S., Bønløkke, J., Massling, A., Sigsgaard, T., et al. (2012). Controlled human wood smoke exposure: Oxidative stress, inflammation and microvascular function. Particle and Fibre Toxicology. doi:10.1186/1743-8977-9-7.
8. Hoffmann, B., Moebus, S., Dragano, N., Mohlenkamp, S., Memmesheimer, M., Erbel, R., et al. (2009). Residential traffic exposure and coronary heart disease: Results from the Heinz Nixdorf Recall Study. Biomarkers: Biochemical indicators of exposure, response, and susceptibility to chemicals,14(Suppl 1), 74–78.
9. Hunter, A. L., Unosson, J., Bosson, J. A., Langrish, J. P., Pourazar, J., Raftis, J. B., et al. (2014). Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters. Particle and Fibre Toxicology,11, 62.
10. Liberda, E. N., Cuevas, A. K., Qu, Q., & Chen, L. C. (2014). The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells. Inhalation Toxicology,26, 588–597.
11. Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods,25, 402–408.
12. Mauderly, J. L., & Seilkop, S. K. (2014). The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer biological responses in rodents. Inhalation Toxicology,26, 668–690.
13. McDonald, J. D., Barr, E. B., & White, R. K. (2004). Design, characterization, and evaluation of a small-scale diesel exhaust exposure system. Aerosol Science Technology,38, 62–78.
14. McDonald, J. D., Barr, E. B., White, R. K., Kracko, D., Chow, J. C., Zielinska, B., & Grosjean, E. (2008). Generation and characterization of gasoline engine exhaust inhalation exposure atmospheres. Inhalation Toxicology,20, 1157–1168.
15. Mercer, R. R., Scabilloni, J. F., Hubbs, A. F., Wang, L., Battelli, L. A., McKinney, W., et al. (2013). Extrapulmonary transport of MWCNT following inhalation exposure. Particle and Fibre Toxicology,10, 38.
16. Mills, N. L., Tornqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., et al. (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation,112, 3930–3936.
17. Otterbein, L. E., Zuckerbraun, B. S., Haga, M., Liu, F., Song, R., Usheva, A., et al. (2003). Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nature Medicine,9, 183–190.
18. Pope, C. A, 3rd, Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004). Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation,109, 71–77.
19. Postlethwait, E. M., Langford, S. D., & Bidani, A. (1990). Reactive absorption of nitrogen dioxide by pulmonary epithelial lining fluid. Journal of Applied Physiology,69, 523–531.
20. Postlethwait, E. M., Langford, S. D., & Bidani, A. (1994). Determinants of inhaled ozone absorption in isolated rat lungs. Toxicology and Applied Pharmacology,125, 77–89.
21. 3 exposure. Toxicological Sciences,134, 304–311.
22. Ross, R. (1999). Atherosclerosis—An inflammatory disease. New England Journal of Medicine,340, 115–126.
23. Sarnat, J. A., Marmur, A., Klein, M., Kim, E., Russell, A. G., Sarnat, S. E., et al. (2008). Fine particle sources and cardiorespiratory morbidity: An application of chemical mass balance and factor analytical source-apportionment methods. Environmental Health Perspectives,116, 459–466.
24. Schisler, J. C., Ronnebaum, S. M., Madden, M., Channell, M. M., Campen, M. J., Willis, M. S. (2015). Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhalation Toxicology (in press).
25. Seilkop, S. K., Campen, M. J., Lund, A. K., McDonald, J. D., & Mauderly, J. L. (2012). Identification of chemical components of combustion emissions that affect pro-atherosclerotic vascular responses in mice. Inhalation Toxicology,24, 270–287.
26. Unosson, J., Blomberg, A., Sandstrom, T., Muala, A., Boman, C., Nystrom, R., et al. (2013). Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans. Particle and Fibre Toxicology,10, 20.
27. Vedal, S., Campen, M. J., McDonald, J. D., Kaufman, J. D., Larson, T. V., Sampson, P. D., et al. (2013). National particle component toxicity (NPACT) initiative report on cardiovascular effects. Research Report,178, 238.