Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Hunter, Amanda L ^a   Unosson, Jon ^b   Bosson, Jenny A ^b   Langrish, Jeremy P ^a   Pourazar, Jamshid ^b   Raftis, Jennifer B ^c   Miller, Mark R ^a   Lucking, Andrew J ^a   Boman, Christoffer ^b   Nyström, Robin ^b   Donaldson, Kenneth ^c   Flapan, Andrew D ^d   Shah, Anoop ^a   Pung, Louis ^a   Sadiktsis, Ioannis ^e   Masala, Silvia ^e   Westerholm, Roger ^e   Sandström, Thomas ^b   Blomberg, Anders ^b   Newby, David E ^a   Mills, Nicholas L ^a   more..

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Air pollution; Fire fighters; Thrombosis; Vascular function; Wood smoke

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CARBOXYHEMOGLOBIN; CD40 ANTIGEN; CD40 LIGAND; NITROPRUSSIDE SODIUM; PADGEM PROTEIN; POLYCYCLIC AROMATIC HYDROCARBON; POLYURETHAN; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENT; VERAPAMIL; BIOLOGICAL MARKER; SMOKE;

ADULT; AIR POLLUTION; ANTIGEN EXPRESSION; ARTERIAL PRESSURE; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; BLOOD CLOTTING; BLOOD VESSEL FUNCTION; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEHYDRATION; EX VIVO STUDY; EXERCISE; FIBRINOLYSIS; FIRE FIGHTER; FLOW CYTOMETRY; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SMOKE; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM; VASODILATATION; WOOD; ADRENERGIC SYSTEM; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CROSSOVER PROCEDURE; CYCLING; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; IMMUNOLOGY; LUNG BURN; METABOLISM; PATHOPHYSIOLOGY; RISK; THROMBOSIS; UNITED KINGDOM; VASCULAR DISEASES; YOUNG ADULT;

ADULT; BICYCLING; BIOMARKERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FIREFIGHTERS; HUMANS; MALE; PLATELET ACTIVATION; RISK; SCOTLAND; SMOKE; SMOKE INHALATION INJURY; THROMBOSIS; VASCULAR DISEASES; VASCULAR STIFFNESS; VASOMOTOR SYSTEM; WOOD; YOUNG ADULT;

EID: 84924248846     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0062-4     Document Type: Article

References (59)

1. Kales SN, Soteriades ES, Christoudias SG, Christiani DC: Firefighters and on-duty deaths from coronary heart disease: a case control study. Environ Health 2003, 2:14.
2. Kales SN, Soteriades ES, Christophi CA, Christiani DC: Emergency duties and deaths from heart disease among firefighters in the United States. N Engl J Med 2007, 356:1207-1215.
3. Bolstad-Johnson DM, Burgess JL, Crutchfield CD, Storment S, Gerkin R, Wilson JR: Characterization of firefighter exposures during fire overhaul. AIHAJ 2000, 61:636-641.
4. Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA: Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 2002, 360:1203-1209.
5. Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD: Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 2007, 356:447-458.
6. Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H: Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004, 351:1721-1730.
7. Langrish JP, Bosson J, Unosson J, Muala A, Newby DE, Mills NL, Blomberg A, Sandstrom T: Cardiovascular effects of particulate air pollution exposure: time course and underlying mechanisms. J Intern Med 2012, 272:224-239.
8. Beelen R, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer P, Nieuwenhuijsen M, Vineis P, Xun WW, Katsouyanni K, Dimakopoulou K, Oudin A, Forsberg B, Modig L, Havulinna AS, Lanki T, Turunen A, Oftedal B, Nystad W, Nafstad P, De Faire U, Pedersen NL, Ostenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, et al: Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet 2014, 383:785-795.
9. Mustafic H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, Perier MC, Marijon E, Vernerey D, Empana JP, Jouven X: Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA 2012, 307:713-721.
10. Cesaroni G, Forastiere F, Stafoggia M, Andersen ZJ, Badaloni C, Beelen R, Caracciolo B, de Faire U, Erbel R, Eriksen KT, Fratiglioni L, Galassi C, Hampel R, Heier M, Hennig F, Hilding A, Hoffmann B, Houthuijs D, Jockel KH, Korek M, Lanki T, Leander K, Magnusson PK, Migliore E, Ostenson CG, Overvad K, Pedersen NL JJP, Penell J, Pershagen G, et al: Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ 2014, 348:f7412.
11. Shah AS, Langrish JP, Nair H, McAllister DA, Hunter AL, Donaldson K, Newby DE, Mills NL: Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet 2013, 382:1039-1048.
12. Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE: Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005, 112:3930-3936.
13. Lucking AJ, Lundback M, Mills NL, Faratian D, Barath SL, Pourazar J, Cassee FR, Donaldson K, Boon NA, Badimon JJ, Sandstrom T, Blomberg A, Newby DE: Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J 2008, 29:3043-3051.
14. Unosson J, Blomberg A, Sandström T, Muala A, Boman C, Nyström R, Westerholm R, Mills N, Newby D, Langrish J, Bosson J: Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans. Part Fibre Toxicol 2013, 10:20.
15. Londahl J, Pagels J, Boman C, Swietlicki E, Massling A, Rissler J, Blomberg A, Bohgard M, Sandstrom T: Deposition of biomass combustion aerosol particles in the human respiratory tract. Inhal Toxicol 2008, 20:923-933.
16. Lamberg HNK, Tissari J, Ruusunen J, Yli-Pirlä P, Sippula O, Tapanainen M, Jalava P, Makkonen U, Teinilä K, Saarnio K, Hillamo R, Hirvonen M, Jokiniemi J: Physicochemical characterization of fine particles from small-scale wood combustion. Atmos Environ 2011, 45:7635-7643.
17. Forchhammer L, Moller P, Riddervold IS, Bonlokke J, Massling A, Sigsgaard T, Loft S: Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function. Part Fibre Toxicol 2012, 9:7.
18. Swiston JR, Davidson W, Attridge S, Li GT, Brauer M, van Eeden SF: Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters. Eur Respir J 2008, 32:129-138.
19. Adetona O, Zhang JJ, Hall DB, Wang JS, Vena JE, Naeher LP: Occupational exposure to woodsmoke and oxidative stress in wildland firefighters. Sci Total Environ 2013, 449:269-275.
20. Hejl AM, Adetona O, Diaz-Sanchez D, Carter JD, Commodore AA, Rathbun SL, Naeher LP: Inflammatory effects of woodsmoke exposure among wildland firefighters working at prescribed burns at the Savannah River Site, SC. J Occup Environ Hyg 2013, 10:173-180.
21. Morrison D, Rahman I, Lannan S, MacNee W: Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med 1999, 159:473-479.
22. Furchgott R, Jothianandan D: Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels 1991, 28:52-61.
23. Lucking AJ, Lundback M, Barath SL, Mills NL, Sidhu MK, Langrish JP, Boon NA, Pourazar J, Badimon JJ, Gerlofs-Nijland ME, Cassee FR, Boman C, Donaldson K, Sandstrom T, Newby DE, Blomberg A: Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation 2011, 123:1721-1728.
24. Langrish JP, Lundback M, Barath S, Soderberg S, Mills NL, Newby DE, Sandstrom T, Blomberg A: Exposure to nitrogen dioxide is not associated with vascular dysfunction in man. Inhal Toxicol 2010, 22:192-198.
25. Nawrot TS, Perez L, Kunzli N, Munters E, Nemery B: Public health importance of triggers of myocardial infarction: a comparative risk assessment. Lancet 2011, 377:732-740.
26. Smith DL, Manning TS, Petruzzello SJ: Effect of strenuous live-fire drills on cardiovascular and psychological responses of recruit firefighters. Ergonomics 2001, 44:244-254.
27. Angerer P, Kadlez-Gebhardt S, Delius M, Raluca P, Nowak D: Comparison of cardiocirculatory and thermal strain of male firefighters during fire suppression to exercise stress test and aerobic exercise testing. Am J Cardiol 2008, 102:1551-1556.
28. Smith DL, Horn GP, Petruzzello SJ, Fahey G, Woods J, Fernhall B: Clotting and fibrinolytic changes after firefighting activities. Med Sci Sports Exerc 2014, 46:448-454.
29. Smith DL, Petruzzello SJ, Goldstein E, Ahmad U, Tangella K, Freund GG, Horn GP: Effect of live-fire training drills on firefighters' platelet number and function. Prehospital Emerg Care 2011, 15:233-239.
30. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE: Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators. New Engl J Med 1993, 329:1677-1683.
31. Manning JE, Griggs TR: Heart rates in fire fighters using light and heavy breathing equipment: similar near-maximal exertion in response to multiple work load conditions. J Occup Med 1983, 25:215-218.
32. Sothmann MS, Saupe K, Jasenof D, Blaney J: Heart rate response of firefighters to actual emergencies. Implications for cardiorespiratory fitness. J Occup Med 1992, 34:797-800.
33. Del Sal M, Barbieri E, Garbati P, Sisti D, Rocchi MB, Stocchi V: Physiologic responses of firefighter recruits during a supervised live-fire work performance test. J Strength Cond Res 2009, 23:2396-2404.
34. Naeher LP, Brauer M, Lipsett M, Zelikoff JT, Simpson CD, Koenig JQ, Smith KR: Woodsmoke health effects: a review. Inhal Toxicol 2007, 19:67-106.
35. Tornqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, Macnee W, Donaldson K, Soderberg S, Newby DE, Sandstrom T, Blomberg A: Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 2007, 176:395-400.
36. Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S: Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environ Health Perspect 2014, 122:624-630.
37. Devlin RB, Ghio AJ, Kehrl H, Sanders G, Cascio W: Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur Respir J Suppl 2003, 40:76s-80s.
38. Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Allen G, Verrier M, Cherry R, Verrier R: Ambient pollution and heart rate variability. Circulation 2000, 101:1267-1273.
39. Pope CA 3rd, Verrier RL, Lovett EG, Larson AC, Raizenne ME, Kanner RE, Schwartz J, Villegas GM, Gold DR, Dockery DW: Heart rate variability associated with particulate air pollution. Am Heart J 1999, 138:890-899.
40. Sadiktsis I, Koegler JH, Benham T, Bergvall C, Westerholm R: Particulate associated polycyclic aromatic hydrocarbon exhaust emissions from a portable power generator fueled with three different fuels-A comparison between petroleum diesel and two biodiesels. Fuel 2014, 115:573-580.
41. Lundback M, Mills NL, Lucking A, Barath S, Donaldson K, Newby DE, Sandstrom T, Blomberg A: Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol 2009, 6:7.
42. Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, Newby DE: Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007, 357:1075-1082.
43. Barath S, Mills NL, Lundback M, Tornqvist H, Lucking AJ, Langrish JP, Soderberg S, Boman C, Westerholm R, Londahl J, Donaldson K, Mudway IS, Sandstrom T, Newby DE, Blomberg A: Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol 2010, 7:19.
44. Langrish JP, Lundback M, Mills NL, Johnston NR, Webb DJ, Sandstrom T, Blomberg A, Newby DE: Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans. Hypertension 2009, 54:910-915.
45. Langrish JP, Mills NL, Chan JK, Leseman DL, Aitken RJ, Fokkens PH, Cassee FR, Li J, Donaldson K, Newby DE, Jiang L: Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol 2009, 6:8.
46. Langrish JP, Unosson J, Bosson J, Barath S, Muala A, Blackwell S, Soderberg S, Pourazar J, Megson IL, Treweeke A, Sandstrom T, Newby DE, Blomberg A, Mills NL: Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. J Am Heart Assoc 2013, 2:e004309.
47. Newby DE, Wright RA, Dawson P, Ludlam CA, Boon NA, Fox KA, Webb DJ: The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man. Cardiovasc Res 1998, 38:485-492.
48. Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, Webb DJ: Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation 1999, 99:1411-1415.
49. Lucking AJ, Visvanathan A, Philippou H, Fraser S, Grant PJ, Connolly TM, Gardell SJ, Feuerstein GZ, Fox KA, Booth NA, Newby DE: Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost 2010, 8:1333-1339.
50. Leonard SS, Castranova V, Chen BT, Schwegler-Berry D, Hoover M, Piacitelli C, Gaughan DM: Particle size-dependent radical generation from wildland fire smoke. Toxicology 2007, 236:103-113.
51. Albalak R, Bruce N, McCracken JP, Smith KR, De Gallardo T: Indoor respirable particulate matter concentrations from an open fire, improved cookstove, and LPG/open fire combination in a rural Guatemalan community. Environ Sci Technol 2001, 35:2650-2655.
52. Masala S, Ahmed T, Bergvall C, Westerholm R: Improved efficiency of extraction of polycyclic aromatic hydrocarbons (PAHs) from the National Institute of Standards and Technology (NIST) Standard Reference Material Diesel Particulate Matter (SRM 2975) using accelerated solvent extraction. Anal Bioanal Chem 2011, 401:3305-3315.
53. Masala S, Rannug U, Westerholm R: Pressurized liquid extraction as an alternative to the Soxhlet extraction procedure stated in the US EPA method TO-13A for the recovery of polycyclic aromatic hydrocarbons adsorbed on polyurethane foam plugs. Anal Methods 2014, 6:8420-8425.
54. Christensen A, Ostman C, Westerholm R: Ultrasound-assisted extraction and on-line LC-GC-MS for determination of polycyclic aromatic hydrocarbons (PAH) in urban dust and diesel particulate matter. Anal Bioanal Chem 2005, 381:1206-1216.
55. Dikalov S, Skatchkov M, Bassenge E: Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Biochem Biophys Res Commun 1997, 230:54-57.
56. Taylor EL, Rossi AG, Shaw CA, Dal Rio FP, Haslett C, Megson IL: GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism. Br J Pharmacol 2004, 143:179-185.
57. Robinson SD, Ludlam CA, Boon NA, Newby DE: Phosphodiesterase type 5 inhibition does not reverse endothelial dysfunction in patients with coronary heart disease. Heart 2006, 92:170-176.
58. Newby DE, Wright RA, Ludlam CA, Fox KA, Boon NA, Webb DJ: An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium. Thromb Haemost 1997, 78:1242-1248.
59. Harding SA, Sarma J, Din JN, Maciocia PM, Newby DE, Fox KA: Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus. Heart 2006, 92:1335-1337.