The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?

Physiology and Behavior

Volumn 152, Issue , 2015, Pages 473-478

  Blundell, J E ^a   Finlayson, G ^a   Gibbons, C ^a   Caudwell, P ^b   Hopkins, M ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

Energy balance; Energy intake; Fat mass; Fat free mass; Resting metabolic rate

Indexed keywords

INSULIN; LEPTIN;

APPETITE; ARTICLE; BODY MASS; CALORIC INTAKE; ENERGY BALANCE; ENERGY EXPENDITURE; FAT FREE MASS; FAT MASS; FOOD INTAKE; HUMAN; OBESITY; PRIORITY JOURNAL; RESTING METABOLIC RATE; ANIMAL; BASAL METABOLIC RATE; BIOLOGICAL MODEL; BODY COMPOSITION; EATING; PHYSIOLOGY; PORTION SIZE; REST;

ANIMALS; APPETITE; BASAL METABOLISM; BODY COMPOSITION; EATING; HUMANS; MODELS, BIOLOGICAL; PORTION SIZE; REST;

EID: 84961144775     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2015.05.031     Document Type: Article

References (47)

1. Anand B.K., Brobeck J.R. Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 1951, 24(2):123.
2. Blundell J. Is there a role for serotonin (5-hydroxytryptamine) in feeding?. Int. J. Obes. (Lond) 1976, 1(1):15-42.
3. Sainsbury A., Zhang L. Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Mol. Cell. Endocrinol. 2010, 316(2):109-119.
4. Badman M.K., Flier J.S. The gut and energy balance: visceral allies in the obesity wars. Science 2005, 307(5717):1909.
5. Wade G.N. Regulation of body fat content?. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286(1):R14-R15.
6. Mayer J. Glucostatic mechanism of regulation of food intake. N. Engl. J. Med. 1953, 249(1):13.
7. Mellinkoff S.M., et al. Relationship between serum amino acid concentration and fluctuations in appetite. J. Appl. Physiol. 1956, 8(5):535.
8. Kennedy G. The role of depot fat in the hypothalamic control of food intake in the rat. Series B-Biological Sciences 1953, 140:578.
9. Zhang Y., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372(6505):425-432.
10. Morton G., et al. Central nervous system control of food intake and body weight. Nature 2006, 443(7109):289-295.
11. Woods S.C., Ramsay D.S. Food intake, metabolism and homeostasis. Physiol. Behav. 2011, 104(1):4-7.
12. Rosen E.D., Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444(7121):847-853.
13. Leibel R.L. The role of leptin in the control of body weight. Nutr. Rev. 2002, 60(s10):S15-S19.
14. Jequier E., Tappy L. Regulation of body weight in humans. Physiol. Rev. 1999, 79(2):451.
15. Chan J.L., et al. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J. Clin. Investig. 2003, 111(9):1409-1421.
16. Schwartz M.W. An inconvenient truth about obesity. Molecular Metabolism 2012, 1(1-2):2.
17. Hall K.D., et al. Quantification of the effect of energy imbalance on bodyweight. Lancet 2011, 378(9793):826-837.
18. Thomas, D., et al., Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis. Obesity Reviews, 2012.
19. Speakman J.R. If body fatness is under physiological regulation, then how come we have an obesity epidemic?. Physiology 2014, 29(2):88-98.
20. Egger G., Swinburn B. An "ecological" approach to the obesity pandemic. BMJ: British Medical Journal 1997, 315(7106):477.
21. Stubbs R., et al. A decrease in physical activity affects appetite, energy, and nutrient balance in lean men feeding ad libitum. Am. J. Clin. Nutr. 2004, 79(1):62.
22. Schlögl M., et al. Overfeeding over 24 hours does not activate brown adipose tissue in humans. J. Clin. Endocrinol. Metab. 2013, 98(12):E1956-E1960.
23. Blundell J., Hill A. Analysis of hunger: inter-relationships with palatability, nutrient composition and eating. Recent Advances in Obesity Research 1985, 118-129. Libbey, London.
24. Lenard N.R., Berthoud H.R. Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity 2012, 16(S3):S11-S22.
25. Blundell J.E., MacDiarmid J.I. Passive overconsumption fat intake and short-term energy balance. Ann. N. Y. Acad. Sci. 1997, 827(1):392-407.
26. Blundell J., Macdiarmid J. Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. J. Am. Diet. Assoc. 1997, 97(7):S63-S69.
27. Edholm O.G., et al. The energy expenditure and food intake of individual men. Br. J. Nutr. 1955, 9(03):286-300.
28. Edholm O. Energy balance in man. Studies carried out by the Division of Human Physiology, National Institute for Medical Research. J. Hum. Nutr. 1977, 31(6):413-431. UK.
29. Mayer J., Roy P., Mitra K. Relation between caloric intake, body weight, and physical work: studies in an industrial male population in West Bengal. Am. J. Clin. Nutr. 1956, 4(2):169.
30. Caudwell P., et al. The influence of physical activity on appetite control: an experimental system to understand the relationship between exercise-induced energy expenditure and energy intake. Proc. Nutr. Soc. 2011, 70(02):171-180.
31. Blundell J.E. What foods do people habitually eat? A dilemma for nutrition, an enigma for psychology. Am. J. Clin. Nutr. 2000, 71(1):3-5.
32. Archer E., Hand G.A., Blair S.N. Validity of US nutritional surveillance: National Health and Nutrition Examination Survey caloric energy intake data, 1971-2010. PLoS One 2013, 8(10):e76632.
33. Blundell J.E., et al. Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans. Br. J. Nutr. 2012, 107(03):445-449.
34. Smith R. The ethics of ignorance. J. Med. Ethics 1992, 18(3):117.
35. Lissner L., et al. Body composition and energy intake: do overweight women overeat and underreport?. Am. J. Clin. Nutr. 1989, 49(2):320-325.
36. Weise C., et al. Body composition and energy expenditure predict ad-libitum food and macronutrient intake in humans. Int. J. Obes. (Lond) 2013, 10.1038/ijo.2013.85.
37. Blundell, J.E. et al., Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation. Dis. Model. Mech., 2012. 5(5): p. 608-613.
38. Pedersen, B.K. and M.A. Febbraio, Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol., 2012. 8(8): p. 457-465.
39. Ravussin E., et al. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J. Clin. Investig. 1986, 78(6):1568-1578.
40. Caudwell P., et al. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am. J. Clin. Nutr. 2013, 97(1):7-14.
41. Gibbons C., et al. Validation of a new hand-held electronic data capture method for continuous monitoring of subjective appetite sensations. Int. J. Behav. Nutr. Phys. Act. 2011, 8(1):57-64.
42. Stubbs R.J., et al. Measuring the difference between actual and reported food intakes in the context of energy balance under laboratory conditions. Br. J. Nutr. 2014, 111(11):2032-2043.
43. Dulloo A.G., Jacquet J., Girardier L. Poststarvation hyperphagia and body fat overshooting in humans: a role for feedback signals from lean and fat tissues. Am. J. Clin. Nutr. 1997, 65(3):717-723.
44. Millward D.J. A protein-stat mechanism for regulation of growth and maintenance of the lean body mass. Nutr. Res. Rev. 1995, 8(01):93-120.
45. Flint A., et al. Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: a meta-analysis of test meal studies. Br. J. Nutr. 2007, 98(1):17-25.
46. Rosenbaum M., et al. Energy intake in weight-reduced humans. Brain Res. 2010, 1350:95-102.
47. Gutin B. Diet vs exercise for the prevention of pediatric obesity: the role of exercise. Int. J. Obes. (Lond) 2011, 35(1):29-32.