Does cortisol modulate emotion recognition and empathy?

Psychoneuroendocrinology

Volumn 66, Issue , 2016, Pages 221-227

  Duesenberg, Moritz ^a   Weber, Juliane ^a   Schulze, Lars ^b   Schaeuffele, Carmen ^a   Roepke, Stefan ^a   Hellmann Regen, Julian ^a   Otte, Christian ^a   Wingenfeld, Katja ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cortisol; Empathy; Facial emotion recognition; Stress hormones

Indexed keywords

HYDROCORTISONE; PLACEBO;

ADULT; AGE DISTRIBUTION; ANGER; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMOTION; EMPATHY; FACIAL EXPRESSION; FEMALE; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; MALE; MULTIFACETED EMPATHY TEST; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOGNITION; SADNESS; SALIVA LEVEL; SEX DIFFERENCE; TASK PERFORMANCE; YOUNG ADULT; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; FACE; HUMAN RELATION; MENTAL STRESS; ORAL DRUG ADMINISTRATION; PSYCHOLOGY;

ADMINISTRATION, ORAL; ADULT; EMOTIONS; EMPATHY; FACE; FACIAL EXPRESSION; FEMALE; HUMANS; HYDROCORTISONE; INTERPERSONAL RELATIONS; MALE; RECOGNITION (PSYCHOLOGY); STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84960934025     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2016.01.011     Document Type: Article

References (62)

1. Adolphs R. What does the amygdala contribute to social cognition?. Ann. N. Y. Acad. Sci. 2010, 1191:42-61.
2. Adolphs R., Tranel D., Hamann S., Young A.W., Calder A.J., Phelps E.A., Anderson A., Lee G.P., Damasio A.R. Recognition of facial emotion in nine individuals with bilateral amygdala damage. Neuropsychologia 1999, 37:1111-1117.
3. Allen A.P., Kennedy P.J., Cryan J.F., Dinan T.G., Clarke G. Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test. Neurosci. Biobehav. Rev. 2014, 38:94-124.
4. Amodio D.M., Frith C.D. Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 2006, 7:268-277.
5. Baron-Cohen S., Wheelwright S. The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J. Autism Dev. Disord. 2004, 34:163-175.
6. Bernhardt B.C., Singer T. The neural basis of empathy. Annu. Rev. Neurosci. 2012, 35:1-23.
7. Blair R.J.R. Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populations. Conscious. Cogn. 2005, 14:698-718.
8. Cannon W.B. The wisdom of the body 1932, W.W Norton & Company, Inc.
9. Chen J. Face recognition as a predictor of social cognitive ability: effects of emotion and race on face processing. Asian J. Soc. Psychol. 2014, 17:61-69.
10. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, L. Erlbaum Associates.
11. de Kloet E.R. From receptor balance to rational glucocorticoid therapy. Endocrinology 2014, 155:2754-2769.
12. de Kloet E.R., Joels M., Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 2005, 6:463-475.
13. Deckers J.W., Lobbestael J., van Wingen G.A., Kessels R.P., Arntz A., Egger J.I. The influence of stress on social cognition in patients with borderline personality disorder. Psychoneuroendocrinology 2015, 52:119-129.
14. Dziobek I., Preißler S., Grozdanovic Z., Heuser I., Heekeren H.R., Roepke S. Neuronal correlates of altered empathy and social cognition in borderline personality disorder. NeuroImage 2011, 57:539-548.
15. Dziobek I., Rogers K., Fleck S., Bahnemann M., Heekeren H.R., Wolf O.T., Convit A. Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). J. Autism Dev. Disord. 2008, 38:464-473.
16. Entringer S., Buss C., Kumsta R., Hellhammer D.H., Wadhwa P.D., Wüst S. Prenatal psychosocial stress exposure is associated with subsequent working memory performance in young women. Behav. Neurosci. 2009, 123:886-893.
17. Fischer A.H. Sex differences in emotionality: fact or stereotype?. Fem. Psychol. 1993, 3:303-318.
18. Fiske S.T., Taylor S.E. Social Cognition: From Brains to Culture 2013, SAGE Publications.
19. Frisch J.U., Häusser J.A., Mojzisch A. The Trier Social Stress Test as a paradigm to study how people respond to threat in social interactions. Front. Psychol. 2015, 6:14.
20. Gallagher H.L., Frith C.D. Functional imaging of 'theory of mind'. Trends Cogn. Sci. 2003, 7:77-83.
21. Gallese V., Keysers C., Rizzolatti G. A unifying view of the basis of social cognition. Trends Cogn. Sci. 2004, 8:396-403.
22. Groeneweg F.L., Karst H., de Kloet E.R., Joels M. Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling. Mol. Cell. Endocrinol. 2012, 350:299-309.
23. Gruenewald T.L., Kemeny M.E., Aziz N., Fahey J.L. Acute threat to the social self: shame, social self-esteem, and cortisol activity. Psychosom. Med. 2004, 66:915-924.
24. Harris A.P., Holmes M.C., de Kloet E.R., Chapman K.E., Seckl J.R. Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour. Psychoneuroendocrinology 2013, 38:648-658.
25. Henckens M.J.A.G., van Wingen G.A., Joëls M., Fernández G. Time-dependent corticosteroid modulation of prefrontal working memory processing. Proc. Natl. Acad. Sci. 2011, 108:5801-5806.
26. Hoffmann H., Kessler H., Eppel T., Rukavina S., Traue H.C. Expression intensity: gender and facial emotion recognition: women recognize only subtle facial emotions better than men. Acta Psychol. (Amst.) 2010, 135:278-283.
27. Hofmann S.G., Suvak M., Litz B.T. Sex differences in face recognition and influence of facial affect. Pers. Indiv. Differ. 2006, 40:1683-1690.
28. Hyde J.S. The gender similarities hypothesis. Am. Psychol. 2005, 60:581-592.
29. Hyde J.S., Mertz J.E. Gender, culture, and mathematics performance. Proc. Natl. Acad. Sci. 2009, 106:8801-8807.
30. Ickes W., Gesn P.R., Graham T. Gender differences in empathic accuracy: differential ability or differential motivation?. Pers. Relationship 2000, 7:95-109.
31. Joels M., Baram T.Z. The neuro-symphony of stress. Nat. Rev. Neurosci. 2009, 10:459-466.
32. Kirkland R.A., Peterson E., Baker C.A., Miller S., Pulos S. Meta-analysis reveals adult female superiority in reading the mind in the eyes test. N. Am. J. Psychol. 2013, 15:121-146.
33. Kirschbaum C., Pirke K.M., Hellhammer D.H. The 'Trier Social Stress Test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81.
34. Kuhlmann S., Wolf O.T. A non-arousing test situation abolishes the impairing effects of cortisol on delayed memory retrieval in healthy women. Neurosci. Lett. 2006, 399:268-272.
35. Lee T.M., Liu H.L., Hoosain R., Liao W.T., Wu C.T., Yuen K.S., Chan C.C., Fox P.T., Gao J.H. Gender differences in neural correlates of recognition of happy and sad faces in humans assessed by functional magnetic resonance imaging. Neurosci. Lett. 2002, 333:13-16.
36. Maggio N., Segal M. Steroid modulation of hippocampal plasticity: switching between cognitive and emotional memories. Front. Cell. Neurosci. 2012, 6:12.
37. Miller D.I., Halpern D.F. The new science of cognitive sex differences. Trends Cogn. Sci. 2014, 18:37-45.
38. Nater U.M., Rohleder N. Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology 2009, 34:486-496.
39. Olsson A., Ochsner K.N. The role of social cognition in emotion. Trends Cogn. Sci. 2008, 12:65-71.
40. Phelps E.A. Human emotion and memory: interactions of the amygdala and hippocampal complex. Curr. Opin. Neurobiol. 2004, 14:198-202.
41. Phelps E.A. Emotion and cognition: insights from studies of the human amygdala. Annu. Rev. Psychol. 2006, 57:27-53.
42. Roelofs K., Bakvis P., Hermans E.J., van Pelt J., van Honk J. The effects of social stress and cortisol responses on the preconscious selective attention to social threat. Biol. Psychol. 2007, 75:1-7.
43. Rohleder N., Nater U.M., Wolf J.M., Ehlert U., Kirschbaum C. Psychosocial Stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity?. Ann. N. Y. Acad. Sci. 2004, 1032:258-263.
44. Rubin R.D., Watson P.D., Duff M.C., Cohen N.J. The role of the hippocampus in flexible cognition and social behavior. Front. Hum. Neurosci. 2014, 8:742.
45. Rueckert L., Branch B., Doan T. Are gender differences in empathy due to differences in emotional reactivity?. Psychology 2011, 02:574-578.
46. Rueckert L., Naybar N. Gender differences in empathy: the role of the right hemisphere. Brain Cogn. 2008, 67:162-167.
47. Shamay-Tsoory S.G., Aharon-Peretz J., Perry D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 2009, 132:617-627.
48. Smeets T., Dziobek I., Wolf O.T. Social cognition under stress: differential effects of stress-induced cortisol elevations in healthy young men and women. Horm. Behav. 2009, 55:507-513.
49. Taylor S.E., Klein L.C., Lewis B.P., Gruenewald T.L., Gurung R.A., Updegraff J.A. Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol. Rev. 2000, 107:411-429.
50. Terfehr K., Wolf O., Schlosser N., Fernando S., Otte C., Muhtz C., Beblo T., Driessen M., Spitzer C., Löwe B., Wingenfeld K. Hydrocortisone impairs working memory in healthy humans, but not in patients with major depressive disorder. Psychopharmacology 2011, 215:71-79.
51. Thoma M.V., Kirschbaum C., Wolf J.M., Rohleder N. Acute stress responses in salivary alpha-amylase predict increases of plasma norepinephrine. Biol. Psychol. 2012, 91:342-348.
52. Tibi-Elhanany Y., Shamay-Tsoory S.G. Social cognition in social anxiety: first evidence for increased empathic abilities. Isr. J. Psychiatry Relat. Sci. 2011, 48:98-106.
53. Tomova L., von Dawans B., Heinrichs M., Silani G., Lamm C. Is stress affecting our ability to tune into others?: evidence for gender differences in the effects of stress on self-other distinction. Psychoneuroendocrinology 2014, 43:95-104.
54. Tottenham N., Tanaka J.W., Leon A.C., McCarry T., Nurse M., Hare T.A., Marcus D.J., Westerlund A., Casey B.J., Nelson C. The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Res. 2009, 168:242-249.
55. van Ast V.A., Cornelisse S., Meeter M., Joels M., Kindt M. Time-dependent effects of cortisol on the contextualization of emotional memories. Biol. Psychiatry 2013, 74:809-816.
56. von Dawans B., Fischbacher U., Kirschbaum C., Fehr E., Heinrichs M. The social dimension of stress reactivity: acute stress increases prosocial behavior in humans. Psychol. Sci. 2012, 23:651-660.
57. Watzka M., Beyenburg S., Blümcke I., Elger C.E., Bidlingmaier F., Stoffel-Wagner B. Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus. Neurosci. Lett. 2000, 290:121-124.
58. Watzka M., Bidlingmaier F., Beyenburg S., Henke R.T., Clusmann H., Elger C.E., Schramm J., Klingmüller D., Stoffel-Wagner B. Corticosteroid receptor mRNA expression in the brains of patients with epilepsy. Steroids 2000, 65:895-901.
59. Wingenfeld K., Driessen M., Terfehr K., Schlosser N., Fernando S.C., Otte C., Beblo T., Spitzer C., Lowe B., Wolf O.T. Effects of cortisol on memory in women with borderline personality disorder: role of co-morbid post-traumatic stress disorder and major depression. Psychol. Med. 2013, 43:495-505.
60. Wingenfeld K., Kuehl L.K., Janke K., Hinkelmann K., Dziobek I., Fleischer J., Otte C., Roepke S. Enhanced emotional empathy after mineralocorticoid receptor stimulation in women with borderline personality disorder and healthy women. Neuropsychopharmacology 2014, 39:1799-1804.
61. Wolf O.T. Stress and memory in humans: twelve years of progress?. Brain Res. 2009, 1293:142-154.
62. Wolf O.T., Schulte J.M., Drimalla H., Hamacher-Dang T.C., Knoch D., Dziobek I. Enhanced emotional empathy after psychosocial stress in young healthy men. Stress 2015, 18:631-637.