Neuronal correlates of altered empathy and social cognition in borderline personality disorder

NeuroImage

Volumn 57, Issue 2, 2011, Pages 539-548

  Dziobek, Isabel ^a,b   Preißler, Sandra ^c   Grozdanovic, Zarko ^c   Heuser, Isabella ^b,c   Heekeren, Hauke R ^a,b   Roepke, Stefan ^b,c  

^a MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Borderline personality disorder; Empathy; FMRI; Social cognition

Indexed keywords

ADULT; ARTICLE; BORDERLINE STATE; BRAIN FUNCTION; CONTROLLED STUDY; EMOTIONALITY; EMPATHY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INSULA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SKIN CONDUCTANCE; SOCIAL COGNITION; SUPERIOR TEMPORAL GYRUS; SUPERIOR TEMPORAL SULCUS;

ADULT; BORDERLINE PERSONALITY DISORDER; BRAIN; BRAIN MAPPING; COGNITION; EMOTIONS; EMPATHY; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; SOCIAL BEHAVIOR; SOCIAL PERCEPTION;

EID: 80955177654     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.05.005     Document Type: Article

References (58)

1. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR 2000, American Psychiatric Press, Washington, DC. 4th ed., text revision ed. American Psychiatric Association (Ed.).
2. Amstadter A. Emotion regulation and anxiety disorders. J. Anxiety Disord. 2008, 22:211-221.
3. Bandettini P.A., Wong E.C., Binder J.R., Rao S.M., Jesmanowicz A., Aaron E.A., Lowry T.F., Forster H.M., Hinks R.S., Hyde J.S. Functional MRI using the BOLD approach: dynamic characteristics and data analysis methods. Diffusion and Perfusion: Magnetic Resonance Imaging 1995, 335-362. Raven, New York. D. Le Bihan (Ed.).
4. Blair R.J. Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populations. Conscious. Cogn. 2005, 14:698-718.
5. Bohus M., Limberger M.F., Frank U., Chapman A.L., Kuhler T., Stieglitz R.D. Psychometric properties of the Borderline Symptom List (BSL). Psychopathology 2007, 40:126-132.
6. Brendel G.R., Stern E., Silbersweig D.A. Defining the neurocircuitry of borderline personality disorder: functional neuroimaging approaches. Dev. Psychopathol. 2005, 17:1197-1206.
7. Carrington S.J., Bailey A.J. Are there theory of mind regions in the brain? A review of the neuroimaging literature. Hum. Brain Mapp. 2009, 30:2313-2335.
8. Davis M.H. Measuring individual differences in empathy: evidence for a multidimensional approach. J. Pers. Soc. Psychol. 1983, 44:14.
9. Davis M.H. Empathy: A Social Psychological Approach 1994, Westview Press, Boulder, CO.
10. Decety J., Meyer M. From emotion resonance to empathic understanding: a social developmental neuroscience account. Dev. Psychopathol. 2008, 20:1053-1080.
11. Decety J., Moriguchi Y. The empathic brain and its dysfunction in psychiatric populations: implications for intervention across different clinical conditions. BioPsychoSocial Medicine 2007, 1:22.
12. Domes G., Schulze L., Herpertz S.C. Emotion recognition in borderline personality disorder-a review of the literature. J. Pers. Disord. 2009, 23:6-19.
13. Dyck M., Habel U., Slodczyk J., Schlummer J., Backes V., Schneider F., Reske M. Negative bias in fast emotion discrimination in borderline personality disorder. Psychol. Med. 2009, 39:855-864.
14. Dziobek I., Rogers K., Fleck S., Bahnemann M., Heekeren H.R., Wolf O.T., Convit A. Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). J. Autism Dev. Disord. 2008, 38:464-473.
15. Eisenberg N., Fabes R.A., Murphy B., Karbon M., Maszk P., Smith M., O'Boyle C., Suh K. The relations of emotionality and regulation to dispositional and situational empathy-related responding. J. Pers. Soc. Psychol. 1994, 66:776-797.
16. Fan Y., Duncan N.W., de Greck M., Northoff G. Is there a core neural network in empathy? An fMRI based quantitative meta-analysis. Neurosci. Biobehav. Rev. 2011, 35:903-911.
17. First M.B., Spitzer R.L., Smith B.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) 1997, American Psychiatric Publishing, Inc.
18. Fonagy P., Bateman A. The development of borderline personality disorder-a mentalizing model. J. Pers. Disord. 2008, 22:4-21.
19. Fonagy P., Leigh T., Steele M., Steele H., Kennedy R., Mattoon G., Target M., Gerber A. The relation of attachment status, psychiatric classification, and response to psychotherapy. J. Consult. Clin. Psychol. 1996, 64:22-31.
20. Frith C., Frith U. Theory of mind. Curr. Biol. 2005, 15:R644-R646.
21. Grant B.F., Chou S.P., Goldstein R.B., Huang B., Stinson F.S., Saha T.D., Smith S.M., Dawson D.A., Pulay A.J., Pickering R.P., Ruan W.J. Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry 2008, 69:533-545.
22. Gunderson J.G. Disturbed relationships as a phenotype for borderline personality disorder. Am. J. Psychiatry 2007, 164:1637-1640.
23. Guttman H.A., Laporte L. Empathy in families of women with borderline personality disorder, anorexia nervosa, and a control group. Fam. Process 2000, 39:345-358.
24. Harned M.S., Rizvi S.L., Linehan M.M. Impact of co-occurring posttraumatic stress disorder on suicidal women with borderline personality disorder. Am. J. Psychiatry 2010, 167:1210-1217.
25. Hein G., Knight R.T. Superior temporal sulcus-it's my area: or is it?. J. Cogn. Neurosci. 2008, 20:2125-2136.
26. Jackson P.L., Brunet E., Meltzoff A.N., Decety J. Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia 2006, 44:752-761.
27. Jenkinson M., Bannister P., Brady M., Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002, 17:825-841.
28. Jenkinson M., Smith S. A global optimisation method for robust affine registration of brain images. Med. Image Anal. 2001, 5:143-156.
29. King-Casas B., Sharp C., Lomax-Bream L., Lohrenz T., Fonagy P., Montague P.R. The rupture and repair of cooperation in borderline personality disorder. Science 2008, 321:806-810.
30. Kirchner J.C., Hatri A., Heekeren H.R., Dziobek I. Autistic symptomatology, face processing abilities, and eye fixation patterns. J. Autism Dev. Disord. 2011, 41(2):158-167.
31. Lamm C., Batson C.D., Decety J. The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J. Cogn. Neurosci. 2007, 19:42-58.
32. Lamm C., Decety J., Singer T. Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage 2011, 54:2492-2502.
33. Lang P.J., Bradley M.M., Cuthbert B.N. International Affective Picture System (IAPS): Technical Manual and Affective Ratings 1999, University of Florida, Center for Research in Psychophysiology, Gainesville.
34. Levine D., Marziali E., Hood J. Emotion processing in borderline personality disorders. J. Nerv. Ment. Dis. 1997, 185:240-246.
35. Lobbestael J., Arntz A., Bernstein D.P. Disentangling the relationship between different types of childhood maltreatment and personality disorders. J. Pers. Disord. 2010, 24:285-295.
36. McGlashan T.H., Grilo C.M., Skodol A.E., Gunderson J.G., Shea M.T., Morey L.C., Zanarini M.C., Stout R.L. The Collaborative Longitudinal Personality Disorders Study: baseline Axis I/II and II/II diagnostic co-occurrence. Acta Psychiatr. Scand. 2000, 102:256-264.
37. Minzenberg M.J., Poole J.H., Vinogradov S. Social-emotion recognition in borderline personality disorder. Compr. Psychiatry 2006, 47:468-474.
38. New A.S., Goodman M., Triebwasser J., Siever L.J. Recent advances in the biological study of personality disorders. Psychiatr. Clin. North Am. 2008, 31:441-461. vii.
39. Paus T. Mapping brain maturation and cognitive development during adolescence. Trends Cogn. Sci. 2005, 9:60-68.
40. Preißler S., Dziobek I., Ritter K., Heekeren H.R., Roepke S. Social cognition in borderline personality disorder: evidence for disturbed recognition of the emotions, thoughts, and intentions of others. Front. Behav. Neurosci 2010, 4:182. 10.3389/fnbeh.2010.00182.
41. Putnam K.M., Silk K.R. Emotion dysregulation and the development of borderline personality disorder. Dev. Psychopathol. 2005, 17:899-925.
42. Ritter K., Dziobek I., Preissler S., Ruter A., Vater A., Fydrich T., Lammers C.H., Heekeren H.R., Roepke S. Lack of empathy in patients with narcissistic personality disorder. Psychiatry Research 2011, 187(1-2):241-247.
43. Saxe R., Kanwisher N. People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind". Neuroimage 2003, 19:1835-1842.
44. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 1998, 59:22-33. quiz 34-57.
45. Singer T. The neuronal basis and ontogeny of empathy and mind reading: review of literature and implications for future research. Neurosci. Biobehav. Rev. 2006, 30:855-863.
46. Singer T., Critchley H.D., Preuschoff K. A common role of insula in feelings, empathy and uncertainty. Trends Cogn. Sci. 2009, 13:334-340.
47. Singer T., Lamm C. The social neuroscience of empathy. Ann. N.Y. Acad. Sci. 2009, 1156:81-96.
48. Smith S.M. Fast robust automated brain extraction. Hum. Brain Mapp. 2002, 17:143-155.
49. Smith S.M., Jenkinson M., Woolrich M.W., Beckmann C.F., Behrens T.E., Johansen-Berg H., Bannister P.R., De Luca M., Drobnjak I., Flitney D.E., Niazy R.K., Saunders J., Vickers J., Zhang Y., De Stefano N., Brady J.M., Matthews P.M. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004, 23:208-219.
50. Taylor S.F., Liberzon I. Neural correlates of emotion regulation in psychopathology. Trends Cogn. Sci. 2007, 11:413-418.
51. Unoka Z., Seres I., Aspan N., Bodi N., Keri S. Trust game reveals restricted interpersonal transactions in patients with borderline personality disorder. J. Pers. Disord. 2009, 23:399-409.
52. Weinberger D.R., Berman K.F. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London. Series B. Biological Sciences 1996, 351:1495-1503.
53. Wolff S., Stiglmayr C., Bretz H.J., Lammers C.H., Auckenthaler A. Emotion identification and tension in female patients with borderline personality disorder. Br. J. Clin. Psychol. 2007, 46:347-360.
54. Wyk B.C., Hudac C.M., Carter E.J., Sobel D.M., Pelphrey K.A. Action understanding in the superior temporal sulcus region. Psychol. Sci. 2009, 20:771-777.
55. Zaki J., Weber J., Bolger N., Ochsner K. The neural bases of empathic accuracy. Proceedings National Academy Sciences USA 2009, 106:11382-11387.
56. Zanarini M.C., Frankenburg F.R., Dubo E.D., Sickel A.E., Trikha A., Levin A., Reynolds V. Axis I comorbidity of borderline personality disorder. Am. J. Psychiatry 1998, 155:1733-1739.
57. Zanarini M.C., Frankenburg F.R., Hennen J., Reich D.B., Silk K.R. Prediction of the 10-year course of borderline personality disorder. Am. J. Psychiatry 2006, 163:827-832.
58. Zanarini M.C., Frankenburg F.R., Reich D.B., Fitzmaurice G. Time to attainment of recovery from borderline personality disorder and stability of recovery: a 10-year prospective follow-up study. Am. J. Psychiatry 2010, 167:663-667.