PRMT5 is essential for the eIF4E-mediated 5′-cap dependent translation

Biochemical and Biophysical Research Communications

Volumn 452, Issue 4, 2014, Pages 1016-1021

  Lim, Ji Hong ^a   Lee, Yoon Mi ^a   Lee, Gibok ^a   Choi, Yong Joon ^b   Lim, Beong Ou ^a   Kim, Young Jun ^a   Choi, Dong Kug ^a   Park, Jong Wan ^b  

^a Konkuk University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

5 5 Cap dependent translation; c Myc; Cyclin D1; eIF4E; Protein arginine methyltransferase

Indexed keywords

CYCLIN D1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E; MESSENGER RNA; MYC PROTEIN; ONCOPROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; EIF4ENIF1 PROTEIN, HUMAN; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; PRMT5 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ARTICLE; CELL CYCLE PROGRESSION; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; RNA ANALYSIS; RNA TRANSLATION; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LUNG NEOPLASMS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN-ARGININE N-METHYLTRANSFERASES;

EID: 84907889209     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.033     Document Type: Article

References (23)

1. Y. Yang, and M.T. Bedford Protein arginine methyltransferases and cancer Nat. Rev. Cancer 13 2013 37 50
2. V. Karkhanis, Y.J. Hu, R.A. Baiocchi, A.N. Imbalzano, and S. Sif Versatility of PRMT5-induced methylation in growth control and development Trends Biochem. Sci. 36 2011 633 641
3. L. Wang, S. Pal, and S. Sif Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells Mol. Cell. Biol. 28 2008 6262 6277
4. S. Pal, R.A. Baiocchi, J.C. Byrd, M.R. Grever, S.T. Jacob, and S. Sif Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma EMBO J. 26 2007 3558 3569
5. M.A. Powers, M.M. Fay, R.E. Factor, A.L. Welm, and K.S. Ullman Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4 Cancer Res. 71 2011 5579 5587
6. J.M. Kim, H.Y. Sohn, S.Y. Yoon, J.H. Oh, J.O. Yang, J.H. Kim, K.S. Song, S.M. Rho, H.S. Yoo, Y.S. Kim, J.G. Kim, and N.S. Kim Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells Clin. Cancer Res. 11 2005 473 482
7. R. Ibrahim, D. Matsubara, W. Osman, T. Morikawa, A. Goto, S. Morita, S. Ishikawa, H. Aburatani, D. Takai, J. Nakajima, M. Fukayama, T. Niki, and Y. Murakami Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition Hum. Pathol. 45 2014 1397 1405
8. Z. Gu, S. Gao, F. Zhang, Z. Wang, W. Ma, R.E. Davis, and Z. Wang Protein arginine methyltransferase 5 is essential for growth of lung cancer cells Biochem J. 446 2012 235 241
9. C. Nicholas, J. Yang, S.B. Peters, M.A. Bill, R.A. Baiocchi, F. Yan, S. Sif, S. Tae, E. Gaudio, X. Wu, M.R. Grever, G.S. Young, and G.B. Lesinski PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.) PLoS One 8 2013 e74710
10. F. Yan, L. Alinari, M.E. Lustberg, L.K. Martin, H.M. Cordero-Nieves, Y. Banasavadi-Siddegowda, S. Virk, J. Barnholtz-Sloan, E.H. Bell, J. Wojton, N.K. Jacob, A. Chakravarti, M.O. Nowicki, X. Wu, R. Lapalombella, J. Datta, B. Yu, K. Gordon, A. Haseley, J.T. Patton, P.L. Smith, J. Ryu, X. Zhang, X. Mo, G. Marcucci, G. Nuovo, C.H. Kwon, J.C. Byrd, E.A. Chiocca, C. Li, S. Sif, S. Jacob, S. Lawler, B. Kaur, and R.A. Baiocchi Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma Cancer Res. 74 2014 1752 1765
11. P. Aggarwal, L.P. Vaites, J.K. Kim, H. Mellert, B. Gurung, H. Nakagawa, M. Herlyn, X. Hua, A.K. Rustgi, S.B. McMahon, and J.A. Diehl Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase Cancer Cell 18 2010 329 340
12. T.Y. Wei, C.C. Juan, J.Y. Hisa, L.J. Su, Y.C. Lee, H.Y. Chou, J.M. Chen, Y.C. Wu, S.C. Chiu, C.P. Hsu, K.L. Liu, and C.T. Yu Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade Cancer Sci. 103 2012 1640 1650
13. A. Scoumanne, J. Zhang, and X. Chen PRMT5 is required for cell-cycle progression and p53 tumor suppressor function Nucleic Acids Res. 37 2009 4965 4976
14. E.C. Cho, S. Zheng, S. Munro, G. Liu, S.M. Carr, J. Moehlenbrink, Y.C. Lu, L. Stimson, O. Khan, R. Konietzny, J. McGouran, A.S. Coutts, B. Kessler, D.J. Kerr, and N.B. Thangue Arginine methylation controls growth regulation by E2F-1 EMBO J. 31 2012 1785 1797
15. X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat. Rev. Mol. Cell Biol. 10 2009 307 318
16. A.C. Hsieh, and D. Ruggero Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer Clin. Cancer Res. 16 2010 4914 4920
17. J.R. Graff, B.W. Konicek, T.M. Vincent, R.L. Lynch, D. Monteith, S.N. Weir, P. Schwier, A. Capen, R.L. Goode, M.S. Dowless, Y. Chen, H. Zhang, S. Sissons, K. Cox, A.M. McNulty, S.H. Parsons, T. Wang, L. Sams, S. Geeganage, L.E. Douglass, B.L. Neubauer, N.M. Dean, K. Blanchard, J. Shou, L.F. Stancato, J.H. Carter, and E.G. Marcusson Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity J. Clin. Invest. 117 2007 2638 2648
18. J.H. Lim, Y.J. Choi, C.H. Cho, and J.W. Park Protein arginine methyltransferase 5 is an essential component of the hypoxia-inducible factor 1 signaling pathway Biochem. Biophys. Res. Commun. 418 2012 254 259
19. B. Raught, and A.C. Gingras EIF4E activity is regulated at multiple levels Int. J. Biochem. Cell Biol. 31 1999 43 57
20. J. Ren, Y. Wang, Y. Liang, Y. Zhang, S. Bao, and Z. Xu Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis J. Biol. Chem. 285 2010 12695 12705
21. J.M. Hsu, C.T. Chen, C.K. Chou, H.P. Kuo, L.Y. Li, C.Y. Lin, H.J. Lee, Y.N. Wang, M. Liu, H.W. Liao, B. Shi, C.C. Lai, M.T. Bedford, C.H. Tsai, and M.C. Hung Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation Nat. Cell Biol. 13 2011 174 181
22. Y. Jia, V. Polunovsky, P.B. Bitterman, and C.R. Wagner Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target Med. Res. Rev. 32 2012 786 814
23. S. Fan, Y. Li, P. Yue, F.R. Khuri, and S.Y. Sun The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation Neoplasia 12 2010 346 356