Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition

eLife

Volumn 5, Issue JANUARY2016, 2016, Pages

  Dambacher, Corey M ^a   Worden, Evan J ^b,c   Herzik, Mark A ^a   Martin, Andreas ^b,c   Lander, Gabriel C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

26S HOLOENZYME; APROTININ; DEUBIQUITINASE; ENZYME; HETERODIMER; HOLOENZYME; LEUPEPTIN; PEPSTATIN; PROTEASOME; RPN11 ENZYME; UNCLASSIFIED DRUG; ATP DEPENDENT 26S PROTEASE;

ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; ELECTRON MICROSCOPY; GENE ACTIVATION; GENE MUTATION; HYDROGEN BOND; IMAGE PROCESSING; IMAGE RECONSTRUCTION; MUTAGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS; TETRATRICOPEPTIDE REPEAT; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DNA MUTATIONAL ANALYSIS; ENZYMOLOGY; METABOLISM; MOLECULAR MODEL; SACCHAROMYCES CEREVISIAE; ULTRASTRUCTURE;

CRYOELECTRON MICROSCOPY; DEUBIQUITINATING ENZYMES; DNA MUTATIONAL ANALYSIS; MODELS, MOLECULAR; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE;

EID: 84960914544     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.13027     Document Type: Article

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