Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer

Journal of Ethnopharmacology

Volumn 184, Issue , 2016, Pages 196-207

  Boeing, Thaise ^a   Da Silva, Luisa Mota ^a   Somensi, Lincon Bordignon ^a   Cury, Benhur Judah ^a   Michels Costa, Ana Paula ^a   Petreanu, Marcel ^a   Niero, Rivaldo ^a   De Andrade, Sérgio Faloni ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Antiulcer; Gastric healing; Gastroprotector; Luteolin; Vernonia condensata

Indexed keywords

ANTIULCER AGENT; CATALASE; CRUDE ETHANOLIC EXTRACT FROM LEAVES OF VERNONIA CONDENSATA; GLUTATHIONE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; LIPID HYDROPEROXIDE; MUCIN; MYELOPEROXIDASE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ALCOHOL; INDOMETACIN; PEROXIDASE; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GASTRITIS; MEDICINAL PLANT; MOUSE; NONHUMAN; OXIDATIVE STRESS; RAT; STOMACH PROTECTION; STOMACH ULCER; ULCER HEALING; VERNONIA; VERNONIA CONDENSATA; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHYTOTHERAPY; PLANT LEAF; RABBITS AND HARES; STOMACH MUCOSA; WISTAR RAT;

ANIMALS; ANTI-ULCER AGENTS; CATALASE; ETHANOL; FEMALE; GASTRIC MUCOSA; GASTRITIS; GLUTATHIONE; H(+)-K(+)-EXCHANGING ATPASE; INDOMETHACIN; MICE; MUCINS; PEROXIDASE; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RABBITS; RATS, WISTAR; STOMACH ULCER; SUPEROXIDE DISMUTASE; VERNONIA;

EID: 84960913529     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.02.049     Document Type: Article

References (48)

1. H. Aebi Catalase in vitro Methods Enzymol. 105 1984 121 126
2. M.L. Anson The estimation of pepsin, trypsin, papain, and Cathepsin with hemoglobin J. Gen. Physiol. 22 1938 79 89
3. T. Arakawa, T. Watanabe, T. Tanigawa, K. Tominaga, Y. Fujiwara, and K. Morimoto Quality of ulcer healing in gastrointestinal tract: its pathophysiology and clinical relevance World J. Gastroenterol. 18 2012 4811 4822
4. A. Arnous, D.P. Makris, and P. Kefalas Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines J. Agric. Food Chem. 49 2001 5736 5742
5. M.S. Blois Antioxidant determinations by the use of a stable free radical Nature 181 1958 1199 1200
6. P.P. Bradley, D.A. Priebat, R.D. Christensen, and G. Rothstein Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker J. Investig. Dermatol. 78 1982 206 209
7. Brasil, 2011. Agência Nacional de Vigilância Sanitária. Formulário de Fitoterápicos da Farmacopéia Brasileira/Agência Nacional de Vigilância Sanitária. Brasília: Anvisa. 126p. Available in (http://www.anvisa.gov.br/hotsite/farmacopeiabrasileira/conteudo/Formulario-de-Fitoterapicos-da-Farmacopeia-Brasileira.pdf).
8. Brasil, 2009. Ministério da Saúde. Direção de Administração e Finanças. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. RENISUS - Relação Nacional de Plantas Medicinais de Interesse ao SUS. Available in (http://portalsaude.saude.gov.br/images/pdf/2014/maio/07/renisus.pdf).
9. P.S.-F. Calabuig, M.J.M. Relloso, and J.C.P. Cubero La mucosa gástrica como estructura diana de agresiones proinflamatorias persistentes Gastroenterol. Hepatol. 32 2009 294 306
10. F.A. Chen, A.B. Wu, and C.Y. Chen The influence of treatments on the free radical scavenging activity of burdock and variations of its active Food Chem. 86 2004 479 484
11. N.H.P. Cnubben, I.M.C.M. Rietjens, H. Wortelboer, J. Van Zanden, and P.J. Van Bladeren The interplay of glutathione-related processes in antioxidant defense Environ. Toxicol. Pharmacol. 10 2001 141 152
12. S. Dacha, M. Razvi, J. Massaad, Q. Cai, and M. Wehbi Hypergastrinemia Gastroenterology 3 2015 201 208
13. L.M. Da Silva, T. Boeing, L.B. Somensi, B.J. Cury, V.M.B. Steimbach, A.C.O. Silveira, R. Niero, V. Cechinel-Filho, J.R. Santin, and S.F. Andrade Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: in vitro and in vivo studies J. Ethnopharmacol. 175 2015 75 85
14. J.B. Da Silva, V.D.S. Temponi, C.M. Gasparetto, R.L. Fabri, D.M.D.O. Aragão, N.D.C.C. Pinto, A. Ribeiro, E. Scio, G. Del-Vechio-Vieira, O.V. De Sousa, and M.S. Alves Vernonia condensata Baker (Asteraceae): a promising source of antioxidants Oxid. Med. Cell. Longev. 13 2013 1 9
15. L.M. De Young, J.B. Kheifets, S.J. Ballaron, and J.M. Young Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents Agents Actions 26 1989 335 341
16. V.S. Frutuoso, M.R.R. Gurjão, R.S.B. Cordeiro, and M.A. Martins Analgesic and anti-ulcerogenic effects of a polar extract from leaves of Vernonia Condensata Planta Med. 60 1994 21 25
17. A. Harris, and J.J. Misiewicz ABC of the upper gastrointestinal tract: management of Helicobacter pylori infection BMJ 323 2001 1047 1050
18. C.A. Hiruma-Lima, L.M. Batista, A.B.A. Almeida, L.P. Magri, L.C. Santos, W. Vilegas, and A.R.M.S. Brito Antiulcerogenic action of ethanolic extract of the resin from Virola Surinamensis Warb. (Myristicaceae) J. Ethnopharmacol. 122 2009 406 409
19. +2 in the presence of xilenol orange. Comparison with the TBA assay and an iodometric method Lipids 26 1991 853 856
20. E. Kallaya, P. Suthiluk, V. Naruemon, and T. Duangporn Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats World J. Gastroenterol. 12 13 2006 2034 2039
21. N. Kangwan, J.M. Park, E.H. Kim, and K.B. Hahm Quality of healing of gastric ulcers: natural products beyond acid suppression World J. Gastrointest. Pathophysiol. 5 2014 40 47
22. J. Khan, A. Alexander, A.S. Saraf, and S. Saraf Luteolin-phospholipid complex: preparation, characterization and biological evaluation J. Pharm. Pharmacol. 66 2014 1451 1462
23. S. Kwiecien, K. Jasnos, M. Magierowski, Z. Sliwowski, R. Pajdo, B. Brzozowski, T. Mach, D. Wojcik, and T. Brzozowski Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress - induced gastric injury J. Physiol. Pharmacol. 65 5 2014 613 622
24. K. Kubo, H. Uehara, T. Kubota, T. Nozu, M. Moruya, Y. Watanabe, E. Shoji, S.B. Santos, K. Harada, and Y. Kongo Effects of ranitidine on gastric vesicles containing H+, K+-ATPase adenosine triphosphatase in rats Scand. J. Gastroenterol. 30 1995 944 951
25. L. Laine, K. Takeuchi, and A. Tarnawski Gastric mucosal defense and cytoprotection: bench to bedside Gastroenterology 135 2008 41 60
26. M. Lemos, J.R. Santin, L.C. Klein-Júnior, R. Niero, and S.F. Andrade Gastroprotective activity of hydroalcoholic extract obtained from the leaves of Brassica oleracea var. acephala DC in different animal models J. Ethnopharmacol. 130 2011 503 507
27. Y. Lin, R. Shi, X. Wang, and H.M. Shen Luteolin, a flavonoid with potential for cancer prevention and therapy Curr. Cancer Drug Targets 8 2008 634 646
28. H. Lorenzi, and F.J.A. Matos Plantas Medicinais no Brasil: Nativas e Exóticas second ed. 2008 Instituto Plantarum Nova Odessa
29. P. Malfertheiner, F.K.L. Chan, and K.E.L. Mccoll Peptic ulcer disease Lancet 374 2009 1449 1461
30. S. Marklund, and G. Marklund Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase Eur. J. Biochem. 47 1974 469 474
31. Y. Morimoto, K. Shimohara, S. Oshima, and T. Sukamoro Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine Jpn. J. Pharmacol. 57 1991 495 505
32. R. Mowry, and C.H. Winkler The coloration of acidic carbo hydrates of bacteria and fungi in tissue sections with special reference to capsules of Cryptococcus Neoformans, Pneumococci and Staphilococci Am. J. Pathol. 32 1956 628 629
33. Y. Niv, D. Boltin, M. Halpern, M. Cohen, Z. Levi, A. Vilkin, S. Morgenstern, V. Manugian, E.S.T. Lawrence, P. Gagneux, S. Kaur, P. Sharma, S.K. Batra, and S.B. Ho Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers World J. Gastroenterol. 20 2014 14913 14920
34. P.A. Nwafor, F.K. Okwuasaba, and L.G. Binda Antidiarrhoel and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats J. Ethnopharmacol. 72 2000 421 427
35. S. Okabe, L.A. Roth, and J. Pfeier A method of experimental penetrating gastric and duodenal ulcers in rats Am. J. Dig. Dis. 16 1971 277 280
36. S. Okabe, and K. Amagase An overview of acetic acid ulcer models-the history and state of the art of peptic ulcer research Biol. Pharm. Bull. 28 2005 1321 1341
37. I.T. Pereira, L.M. Burci, L.M. Da Silva, C.H. Baggio, M. Heller, G.A. Micke, M.G. Pizzolatti, M.C. Marques, and M.F. Werner Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process Phytother. Res. 27 2013 1067 1073
38. K.P. Randau, D.C. Florencio, C.P. Ferreira, and H.S. Xavier Estudo farmacognóstico de Croton rhamnifolius H.B.K. e Croton rhamnifolioides Pax & Hoffm. (Euphorbiaceae) Braz. J. Pharmacogn. 14 2004 89 96
39. J.P. Raufman Peptic activity and gastroduodenal mucosal damage Yale J. Biol. Med. 69 1996 85 90
40. A.L. Ribeiro, A.L. Shimada, C.B. Hebeda, T.F. De Oliveira, A.P. De Melo Loureiro, W.P.F. Dos Reis, A.M. Santos, W.T. De Lima, and S.H. Farsky In vivo hydroquinone exposure alters circulating neutrophil activities and impairs LPS-induced lung inflammation in mice Toxicology 288 2011 1 7
41. M.L. Schubert Gastric secretion Curr. Opin. Gastroenterol. 27 2011 536 542
42. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1 1968 192 205
43. H. Shay, S.A. Komarov, S.S. Fels, D. Marenze, M. Grunstein, and H. Siplet A simple method for the uniform production of gastric ulceration in the rat Gastroenterology 5 1945 43 61
44. E. Sheen, and G. Triadafilopoulos Adverse effects of long-term proton pump inhibitor therapy Dig. Dis. Sci. 56 2011 931 950
45. A.T. Shimoyama, J.R. Santin, I.D. Machado, A.M.O. Silva, I.L.P. De Melo, J. Mancini-Filho, and S.H.P. Farsky Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer Naunyn-Schmiede. Arch. Pharmacol. 386 2013 5 14
46. K. Thorsen, J.A. Soreide, J.T. Kvaloy, T. Glomsaker, and K. Soreide Epidemiology of perforated peptic ulcer: age- and gender-adjusted analysis of incidence and mortality World J. Gastroenterol. 19 2013 347 354
47. J.L. Wallace Mechanisms of protection and healing: current knowledge and future research Am. J. Med. 110 2001 19S 22S
48. A. Yamamoto Proteolytic enzymes G. Reed, Enzymes in Food Processing second ed. 1975 Academic London 123 179