메뉴 건너뛰기




Volumn 7, Issue 3, 2016, Pages 240-244

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

Author keywords

aloperine; entry inhibitor; HIV 1

Indexed keywords

4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; ALOPERINE; ALOPERINE DERIVATIVE; FOSTEMSAVIR; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; N (1 BUTYL) 4 TRIFLUOROMETHOXY BENZAMIDE; TEMSAVIR; UNCLASSIFIED DRUG;

EID: 84960893518     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00339     Document Type: Article
Times cited : (66)

References (33)
  • 1
    • 84880917260 scopus 로고    scopus 로고
    • Monitoring selected national HIV prevention and care objectives by using HIV surveillance data - United States and 6 dependent areas - 2012
    • CDC. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data-United States and 6 dependent areas-2012. HIV surveillance supplemental report 2014; 19 (No.3), 2014.
    • (2014) HIV Surveillance Supplemental Report 2014 , vol.19 , Issue.3
    • CDC1
  • 3
    • 59749083393 scopus 로고    scopus 로고
    • Novel targets for antiretroviral therapy: Clinical progress to date
    • Dau, B.; Holodniy, M. Novel targets for antiretroviral therapy: clinical progress to date Drugs 2009) 69, 31-50 10.2165/00003495-200969010-00003
    • (2009) Drugs , vol.69 , pp. 31-50
    • Dau, B.1    Holodniy, M.2
  • 4
    • 10644268549 scopus 로고    scopus 로고
    • Anti-HIV drug development - An overview
    • Pereira, C. F.; Paridaen, J. T. Anti-HIV drug development-an overview Curr. Pharm. Des. 2004, 10, 4005-4037 10.2174/1381612043382459
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 4005-4037
    • Pereira, C.F.1    Paridaen, J.T.2
  • 6
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong, J. K.; Hezareh, M.; Günthard, H. F.; Havlir, D. V.; Ignacio, C. C.; Spina, C. A.; Richman, D. D. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia Science 1997, 278, 1291-1295 10.1126/science.278.5341.1291
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Günthard, H.F.3    Havlir, D.V.4    Ignacio, C.C.5    Spina, C.A.6    Richman, D.D.7
  • 8
    • 0037302334 scopus 로고    scopus 로고
    • Latency in human immunodeficiency virus type 1 infection: No easy answers
    • Persaud, D.; Zhou, Y.; Siliciano, J. M.; Siliciano, R. F. Latency in human immunodeficiency virus type 1 infection: no easy answers J. Virol. 2003, 77, 1659-1665 10.1128/JVI.77.3.1659-1665.2003
    • (2003) J. Virol. , vol.77 , pp. 1659-1665
    • Persaud, D.1    Zhou, Y.2    Siliciano, J.M.3    Siliciano, R.F.4
  • 10
    • 84935122326 scopus 로고    scopus 로고
    • Maraviroc - A CCR5 antagonist for the treatment of HIV-1 infection
    • Van Der Ryst, E. Maraviroc-A CCR5 antagonist for the treatment of HIV-1 infection Front. Immunol. 2015, 6, 277 10.3389/fimmu.2015.00277
    • (2015) Front. Immunol. , vol.6 , pp. 277
    • Van Der Ryst, E.1
  • 11
    • 84946499376 scopus 로고    scopus 로고
    • Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase
    • Patel, R. V.; Park, S. W. Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase Bioorg. Med. Chem. 2015, 23, 5247-5263 10.1016/j.bmc.2015.06.016
    • (2015) Bioorg. Med. Chem. , vol.23 , pp. 5247-5263
    • Patel, R.V.1    Park, S.W.2
  • 12
    • 2942715262 scopus 로고    scopus 로고
    • Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564
    • Yuan, X.; Huang, L.; Ho, P.; Labranche, C.; Chen, C.-H. Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564 Virology 2004, 324, 525-530 10.1016/j.virol.2004.04.009
    • (2004) Virology , vol.324 , pp. 525-530
    • Yuan, X.1    Huang, L.2    Ho, P.3    Labranche, C.4    Chen, C.-H.5
  • 13
    • 33846818812 scopus 로고    scopus 로고
    • Induction of a nonproductive conformational change in gp120 by a small molecule HIV-1 entry inhibitor
    • Huang, L.; Lai, W.-H.; Ho, P.; Chen, C.-H. Induction of a nonproductive conformational change in gp120 by a small molecule HIV-1 entry inhibitor AIDS Res. Hum. Retroviruses 2007, 23, 28-32 10.1089/aid.2006.0137
    • (2007) AIDS Res. Hum. Retroviruses , vol.23 , pp. 28-32
    • Huang, L.1    Lai, W.-H.2    Ho, P.3    Chen, C.-H.4
  • 14
    • 37849013417 scopus 로고    scopus 로고
    • Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of HIV-1
    • Lai, W.-H.; Huang, L.; Ho, P.; Li, Z.-J.; Montefiori, D.; Chen, C.-H. Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of HIV-1 Antimicrob. Agents Chemother. 2008, 52, 128-136 10.1128/AAC.00737-07
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 128-136
    • Lai, W.-H.1    Huang, L.2    Ho, P.3    Li, Z.-J.4    Montefiori, D.5    Chen, C.-H.6
  • 15
    • 0040765435 scopus 로고
    • The alkaloids of Leptorhabdos parviflora Benth
    • Bocharnikova, A. V.; Massagetov, P. S. The alkaloids of Leptorhabdos parviflora Benth Zh. Obshch. Khim. 1964, 34, 1025-1028
    • (1964) Zh. Obshch. Khim. , vol.34 , pp. 1025-1028
    • Bocharnikova, A.V.1    Massagetov, P.S.2
  • 17
    • 84906260094 scopus 로고    scopus 로고
    • Identification and synthesis of quinolizidines with anti-influenza A virus activity
    • Dang, Z.; Jung, K.; Zhu, L.; Lai, W.-H.; Xie, H.; Lee, K. H.; Huang, L.; Chen, C.-H. Identification and synthesis of quinolizidines with anti-influenza A virus activity ACS Med. Chem. Lett. 2014, 5, 942-946 10.1021/ml500236n
    • (2014) ACS Med. Chem. Lett. , vol.5 , pp. 942-946
    • Dang, Z.1    Jung, K.2    Zhu, L.3    Lai, W.-H.4    Xie, H.5    Lee, K.H.6    Huang, L.7    Chen, C.-H.8
  • 19
    • 0942279616 scopus 로고    scopus 로고
    • Bifunctional anti-HIV-1 small molecules with two novel mechanisms of action
    • Huang, L.; Xiong, Y.; Aiken, C.; Chen, C.-H. Bifunctional anti-HIV-1 small molecules with two novel mechanisms of action Antimicrob. Agents Chemother. 2004, 48, 663-665 10.1128/AAC.48.2.663-665.2004
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 663-665
    • Huang, L.1    Xiong, Y.2    Aiken, C.3    Chen, C.-H.4
  • 20
    • 32844457052 scopus 로고    scopus 로고
    • Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives
    • Huang, L.; Ho, P.; Lee, K. H.; Chen, C.-H. Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives Bioorg. Med. Chem. 2006, 14, 2279-2289 10.1016/j.bmc.2005.11.016
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 2279-2289
    • Huang, L.1    Ho, P.2    Lee, K.H.3    Chen, C.-H.4
  • 21
    • 84875202040 scopus 로고    scopus 로고
    • New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1
    • Dang, Z.; Lai, W.; Ho, P.; Zhu, L.; Qian, K.; Lee, K. H.; Huang, L.; Chen, C.-H. New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1 J. Med. Chem. 2013, 56, 2029-2037 10.1021/jm3016969
    • (2013) J. Med. Chem. , vol.56 , pp. 2029-2037
    • Dang, Z.1    Lai, W.2    Ho, P.3    Zhu, L.4    Qian, K.5    Lee, K.H.6    Huang, L.7    Chen, C.-H.8
  • 22
    • 84864418445 scopus 로고    scopus 로고
    • Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants
    • Dang, Z.; Qian, K.; Ho, P.; Zhu, L.; Lee, K. H.; Huang, L.; Chen, C. H. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants Bioorg. Med. Chem. Lett. 2012, 22, 5190-5194 10.1016/j.bmcl.2012.06.080
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5190-5194
    • Dang, Z.1    Qian, K.2    Ho, P.3    Zhu, L.4    Lee, K.H.5    Huang, L.6    Chen, C.H.7
  • 24
    • 84907817849 scopus 로고    scopus 로고
    • Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction derived from BMS-378806
    • Liu, T.; Huang, B.; Zhan, P.; De Clercq, E.; Liu, X. Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction derived from BMS-378806 Eur. J. Med. Chem. 2014, 86, 481-490 10.1016/j.ejmech.2014.09.012
    • (2014) Eur. J. Med. Chem. , vol.86 , pp. 481-490
    • Liu, T.1    Huang, B.2    Zhan, P.3    De Clercq, E.4    Liu, X.5
  • 25
    • 84863229866 scopus 로고    scopus 로고
    • Inhibitors of human immunodeficiency virus type 1 (HIV-1), attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)
    • Kadow, J. F.; Ueda, Y.; Meanwell, N. A.; Connolly, T. P.; Wang, T.; Chen, C. P.; Yeung, K. S.; Zhu, J.; Bender, J. A.; Yang, Z.; Parker, D.; Lin, P. F.; Colonno, R. J.; Mathew, M.; Morgan, D.; Zheng, M.; Chien, C.; Grasela, D. Inhibitors of human immunodeficiency virus type 1 (HIV-1), attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043) J. Med. Chem. 2012, 55, 2048-2056 10.1021/jm201218m
    • (2012) J. Med. Chem. , vol.55 , pp. 2048-2056
    • Kadow, J.F.1    Ueda, Y.2    Meanwell, N.A.3    Connolly, T.P.4    Wang, T.5    Chen, C.P.6    Yeung, K.S.7    Zhu, J.8    Bender, J.A.9    Yang, Z.10    Parker, D.11    Lin, P.F.12    Colonno, R.J.13    Mathew, M.14    Morgan, D.15    Zheng, M.16    Chien, C.17    Grasela, D.18
  • 31
    • 84882297831 scopus 로고    scopus 로고
    • Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors
    • Li, Z.; Zhou, N.; Sun, Y.; Ray, N.; Lataillade, M.; Hanna, G. J.; Krystal, M. Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors Antimicrob. Agents Chemother. 2013, 57, 4172-4180 10.1128/AAC.00513-13
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 4172-4180
    • Li, Z.1    Zhou, N.2    Sun, Y.3    Ray, N.4    Lataillade, M.5    Hanna, G.J.6    Krystal, M.7
  • 32
    • 84874660180 scopus 로고    scopus 로고
    • HIV-1 entry inhibitors: Recent development and clinical use
    • Henrich, T. J.; Kuritzkes, D. R. HIV-1 entry inhibitors: recent development and clinical use Curr. Opin. Virol. 2013, 3, 51-57 10.1016/j.coviro.2012.12.002
    • (2013) Curr. Opin. Virol. , vol.3 , pp. 51-57
    • Henrich, T.J.1    Kuritzkes, D.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.