Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior

Current Biology

Volumn 25, Issue 22, 2015, Pages 2964-2968

  Giachello, Carlo N G ^a   Baines, Richard A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN;

ANIMAL; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; EMBRYOLOGY; EPILEPSY; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDY; GENETICS; METABOLISM; MOTONEURON; MUTATION; NERVOUS SYSTEM FUNCTION; OPTOGENETICS; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PROCEDURES; SEIZURE;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYONIC DEVELOPMENT; EPILEPSY; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC ASSOCIATION STUDIES; MOTOR NEURONS; MUTATION; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; OPTOGENETICS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEIZURES;

EID: 84960815426     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2015.09.040     Document Type: Article

References (33)

1. C.A. Doll, and K. Broadie Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models Front. Cell. Neurosci. 8 2014 30
2. T. Kroon, M.C. Sierksma, and R.M. Meredith Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective Front. Syst. Neurosci. 7 2013 75
3. R.M. Meredith, J. Dawitz, and I. Kramvis Sensitive time-windows for susceptibility in neurodevelopmental disorders Trends Neurosci. 35 2012 335 344
4. S.C. Baraban Emerging epilepsy models: insights from mice, flies, worms and fish Curr. Opin. Neurol. 20 2007 164 168
5. V.T. Cunliffe, R.A. Baines, C.N. Giachello, W.H. Lin, A. Morgan, M. Reuber, C. Russell, M.C. Walker, and R.S. Williams Epilepsy research methods update: understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms Seizure 24 2015 44 51
6. B.P. Grone, and S.C. Baraban Animal models in epilepsy research: legacies and new directions Nat. Neurosci. 18 2015 339 343
7. T. Fergestad, B. Bostwick, and B. Ganetzky Metabolic disruption in Drosophila bang-sensitive seizure mutants Genetics 173 2006 1357 1364
8. L. Parker, M. Padilla, Y. Du, K. Dong, and M.A. Tanouye Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures Genetics 187 2011 523 534
9. L. Sun, J. Gilligan, C. Staber, R.J. Schutte, V. Nguyen, D.K. O'Dowd, and R. Reenan A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure J. Neurosci. 32 2012 14145 14155
10. B. Stone, L. Evans, J. Coleman, and D. Kuebler Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila Brain Res. 1496 2013 94 103
11. S.N. Ehaideb, A. Iyengar, A. Ueda, G.J. Iacobucci, C. Cranston, A.G. Bassuk, D. Gubb, J.D. Axelrod, S. Gunawardena, C.F. Wu, and J.R. Manak prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies Proc. Natl. Acad. Sci. USA 111 2014 11187 11192
12. N.I. Muraro, and R.A. Baines Drosophila melanogaster in the study of epilepsy SEB Exp Biol Ser 60 2008 141 160
13. + current contributes to seizure in the slamdance bang-sensitive Drosophila mutant J. Neurophysiol. 106 2011 18 29
14. B. Ganetzky, and C.F. Wu Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila melanogaster Genetics 100 1982 597 614
15. W. Zhang, W. Ge, and Z. Wang A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons Eur. J. Neurosci. 26 2007 2405 2416
16. G.E. Stilwell, S. Saraswati, J.T. Littleton, and S.W. Chouinard Development of a Drosophila seizure model for in vivo high-throughput drug screening Eur. J. Neurosci. 24 2006 2211 2222
17. W.H. Lin, C. Günay, R. Marley, A.A. Prinz, and R.A. Baines Activity-dependent alternative splicing increases persistent sodium current and promotes seizure J. Neurosci. 32 2012 7267 7277
18. J. Lee, and C.F. Wu Electroconvulsive seizure behavior in Drosophila: analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants J. Neurosci. 22 2002 11065 11079
19. D. Kuebler, and M.A. Tanouye Modifications of seizure susceptibility in Drosophila J. Neurophysiol. 83 2000 998 1009
20. L. Pownser The effects of temperature on the duration of the developmental stages of Drosophila melanogaster Physiol. Zool. 8 1935 474 520
21. R.A. Baines, J.P. Uhler, A. Thompson, S.T. Sweeney, and M. Bate Altered electrical properties in Drosophila neurons developing without synaptic transmission J. Neurosci. 21 2001 1523 1531
22. J. Rohrbough, and K. Broadie Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae J. Neurophysiol. 88 2002 847 860
23. J. Tønnesen, A.T. Sørensen, K. Deisseroth, C. Lundberg, and M. Kokaia Optogenetic control of epileptiform activity Proc. Natl. Acad. Sci. USA 106 2009 12162 12167
24. F. Berglind, M. Ledri, A.T. Sørensen, L. Nikitidou, M. Melis, P. Bielefeld, D. Kirik, K. Deisseroth, M. Andersson, and M. Kokaia Optogenetic inhibition of chemically induced hypersynchronized bursting in mice Neurobiol. Dis. 65 2014 133 141
25. I. Sukhotinsky, A.M. Chan, O.J. Ahmed, V.R. Rao, V. Gradinaru, C. Ramakrishnan, K. Deisseroth, A.K. Majewska, and S.S. Cash Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model PLoS ONE 8 2013 e62013
26. C.C. Chiang, T.P. Ladas, L.E. Gonzalez-Reyes, and D.M. Durand Seizure suppression by high frequency optogenetic stimulation using in vitro and in vivo animal models of epilepsy Brain Stimulat. 7 2014 890 899
27. R.C. Wykes, J.H. Heeroma, L. Mantoan, K. Zheng, D.C. MacDonald, K. Deisseroth, K.S. Hashemi, M.C. Walker, S. Schorge, and D.M. Kullmann Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy Sci. Transl. Med. 4 2012 161ra152
28. J.T. Paz, T.J. Davidson, E.S. Frechette, B. Delord, I. Parada, K. Peng, K. Deisseroth, and J.R. Huguenard Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury Nat. Neurosci. 16 2013 64 70
29. C. Armstrong, E. Krook-Magnuson, M. Oijala, and I. Soltesz Closed-loop optogenetic intervention in mice Nat. Protoc. 8 2013 1475 1493
30. E. Krook-Magnuson, C. Armstrong, M. Oijala, and I. Soltesz On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy Nat. Commun. 4 2013 1376
31. R.A. Baines, and M. Bate Electrophysiological development of central neurons in the Drosophila embryo J. Neurosci. 18 1998 4673 4683
32. S.J. Crisp, J.F. Evers, and M. Bate Endogenous patterns of activity are required for the maturation of a motor network J. Neurosci. 31 2011 10445 10450
33. R.A. Baines Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS J. Neurosci. 23 2003 8664 8672