-
1
-
-
84908251359
-
A root-expressed L-phenylalanine:4-hydroxyphenylpyruvate aminotransferase is required for tropane alkaloid biosynthesis in Atropa belladonna
-
M.A. Bedewitz, E. Gongora-Castillo, J.B. Uebler, E. Gonzales-Vigil, K.E. Wiegert-Rininger, K.L. Childs, J.P. Hamilton, B. Vaillancourt, Y.S. Yeo, J. Chappell, D. DellaPenna, A.D. Jones, C.R. Buell, and C.S. Barry A root-expressed L-phenylalanine:4-hydroxyphenylpyruvate aminotransferase is required for tropane alkaloid biosynthesis in Atropa belladonna Plant Cell 26 2014 3745 3762
-
(2014)
Plant Cell
, vol.26
, pp. 3745-3762
-
-
Bedewitz, M.A.1
Gongora-Castillo, E.2
Uebler, J.B.3
Gonzales-Vigil, E.4
Wiegert-Rininger, K.E.5
Childs, K.L.6
Hamilton, J.P.7
Vaillancourt, B.8
Yeo, Y.S.9
Chappell, J.10
DellaPenna, D.11
Jones, A.D.12
Buell, C.R.13
Barry, C.S.14
-
2
-
-
42549123527
-
The functional divergence of short-chain dehydrogenases involved in tropinone reduction
-
A. Brock, W. Brandt, and B. Drager The functional divergence of short-chain dehydrogenases involved in tropinone reduction Plant J. 54 2008 388 401
-
(2008)
Plant J.
, vol.54
, pp. 388-401
-
-
Brock, A.1
Brandt, W.2
Drager, B.3
-
3
-
-
84878108186
-
Molecular cloning and characterization of a tropinone reductase from Dendrobium nobile Lindl
-
W. Chen, X.F. Cheng, Z.H. Zhou, J.J. Liu, and H.Z. Wang Molecular cloning and characterization of a tropinone reductase from Dendrobium nobile Lindl Mol. Biol. Rep. 40 2013 1145 1154
-
(2013)
Mol. Biol. Rep.
, vol.40
, pp. 1145-1154
-
-
Chen, W.1
Cheng, X.F.2
Zhou, Z.H.3
Liu, J.J.4
Wang, H.Z.5
-
4
-
-
84878112354
-
Functional characterization of a novel tropinone reductase-like gene in Dendrobium nobile Lindl
-
X.F. Cheng, W. Chen, Z.H. Zhou, J.J. Liu, and H.Z. Wang Functional characterization of a novel tropinone reductase-like gene in Dendrobium nobile Lindl J. Plant Physiol. 170 2013 958 964
-
(2013)
J. Plant Physiol.
, vol.170
, pp. 958-964
-
-
Cheng, X.F.1
Chen, W.2
Zhou, Z.H.3
Liu, J.J.4
Wang, H.Z.5
-
5
-
-
0034177601
-
The cell and developmental biology of alkaloid biosynthesis
-
V. De Luca, and B. St Pierre The cell and developmental biology of alkaloid biosynthesis Trends Plant Sci. 5 2000 168 173
-
(2000)
Trends Plant Sci.
, vol.5
, pp. 168-173
-
-
De Luca, V.1
St Pierre, B.2
-
6
-
-
84879433563
-
An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis
-
E. Dehghan, F.S. Ahmadi, E.G. Ravandi, D.W. Reed, P.S. Covello, and A.R. Bahrami An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis Plant Physiol. Biochem. 70 2013 188 194
-
(2013)
Plant Physiol. Biochem.
, vol.70
, pp. 188-194
-
-
Dehghan, E.1
Ahmadi, F.S.2
Ravandi, E.G.3
Reed, D.W.4
Covello, P.S.5
Bahrami, A.R.6
-
7
-
-
0037195484
-
Analysis of tropane and related alkaloids
-
B. Drager Analysis of tropane and related alkaloids J. Chromatogr. A 978 2002 1 35
-
(2002)
J. Chromatogr. A
, vol.978
, pp. 1-35
-
-
Drager, B.1
-
8
-
-
31344443596
-
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism
-
B. Drager Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism Phytochemistry 67 2006 327 337
-
(2006)
Phytochemistry
, vol.67
, pp. 327-337
-
-
Drager, B.1
-
9
-
-
0037067783
-
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases
-
C. Filling, K.D. Berndt, J. Benach, S. Knapp, T. Prozorovski, E. Nordling, R. Ladenstein, H. Jornvall, and U. Oppermann Critical residues for structure and catalysis in short-chain dehydrogenases/reductases J. Biol. Chem. 277 2002 25677 25684
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25677-25684
-
-
Filling, C.1
Berndt, K.D.2
Benach, J.3
Knapp, S.4
Prozorovski, T.5
Nordling, E.6
Ladenstein, R.7
Jornvall, H.8
Oppermann, U.9
-
10
-
-
0001741417
-
Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus Niger
-
T. Hashimoto, K. Nakajima, G. Ongena, and Y. Yamada Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus niger Plant Physiol. 100 1992 836 845
-
(1992)
Plant Physiol.
, vol.100
, pp. 836-845
-
-
Hashimoto, T.1
Nakajima, K.2
Ongena, G.3
Yamada, Y.4
-
11
-
-
0001180010
-
Production of tropane alkaloids in genetically-engineered root cultures
-
T. Hashimoto, D.J. Yun, and Y. Yamada Production of tropane alkaloids in genetically-engineered root cultures Phytochemistry 32 1993 713 718
-
(1993)
Phytochemistry
, vol.32
, pp. 713-718
-
-
Hashimoto, T.1
Yun, D.J.2
Yamada, Y.3
-
12
-
-
84862998899
-
Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae
-
J. Jirschitzka, G.W. Schmidt, M. Reichelt, B. Schneider, J. Gershenzon, and J.C. D'Auria Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae Proc. Natl. Acad. Sci. USA 109 2012 10304 10309
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 10304-10309
-
-
Jirschitzka, J.1
Schmidt, G.W.2
Reichelt, M.3
Schneider, B.4
Gershenzon, J.5
D'Auria, J.C.6
-
13
-
-
35348897875
-
Molecular cloning and characterization of a new cDNA encoding hyoscyamine 6 beta-hydroxylase from roots of Anisodus acutangulus
-
G. Kai, J. Chen, L. Li, G. Zhou, L. Zhou, L. Zhang, Y. Chen, and L. Zhao Molecular cloning and characterization of a new cDNA encoding hyoscyamine 6 beta-hydroxylase from roots of Anisodus acutangulus J. Biochem. Mol. Biol. 40 2007 715 722
-
(2007)
J. Biochem. Mol. Biol.
, vol.40
, pp. 715-722
-
-
Kai, G.1
Chen, J.2
Li, L.3
Zhou, G.4
Zhou, L.5
Zhang, L.6
Chen, Y.7
Zhao, L.8
-
14
-
-
73949092455
-
Molecular cloning and characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloid production in AaTRI-transformed hairy roots
-
G.Y. Kai, L. Li, Y.X. Jiang, X.M. Yan, Y. Zhang, X. Lu, P. Liao, and J.B. Chen Molecular cloning and characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloid production in AaTRI-transformed hairy roots Biotechnol. Appl. Biochem. 54 2009 177 186
-
(2009)
Biotechnol. Appl. Biochem.
, vol.54
, pp. 177-186
-
-
Kai, G.Y.1
Li, L.2
Jiang, Y.X.3
Yan, X.M.4
Zhang, Y.5
Lu, X.6
Liao, P.7
Chen, J.B.8
-
15
-
-
33750990234
-
Immunolocalisation of two tropinone reductases in potato (Solanum tuberosum L.) root, stolon, and tuber sprouts
-
H. Kaiser, U. Richter, R. Keiner, A. Brabant, B. Hause, and B. Drager Immunolocalisation of two tropinone reductases in potato (Solanum tuberosum L.) root, stolon, and tuber sprouts Planta 225 2006 127 137
-
(2006)
Planta
, vol.225
, pp. 127-137
-
-
Kaiser, H.1
Richter, U.2
Keiner, R.3
Brabant, A.4
Hause, B.5
Drager, B.6
-
16
-
-
0028445983
-
Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle
-
T. Kanegae, H. Kajiya, Y. Amano, T. Hashimoto, and Y. Yamada Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle Plant Physiol. 105 1994 483 490
-
(1994)
Plant Physiol.
, vol.105
, pp. 483-490
-
-
Kanegae, T.1
Kajiya, H.2
Amano, Y.3
Hashimoto, T.4
Yamada, Y.5
-
17
-
-
84873257048
-
Molecular cloning and catalytic characterization of a recombinant tropine biosynthetic tropinone reductase from Withania coagulans leaf
-
A.K. Kushwaha, N.S. Sangwan, S. Tripathi, and R.S. Sangwan Molecular cloning and catalytic characterization of a recombinant tropine biosynthetic tropinone reductase from Withania coagulans leaf Gene 516 2013 238 247
-
(2013)
Gene
, vol.516
, pp. 238-247
-
-
Kushwaha, A.K.1
Sangwan, N.S.2
Tripathi, S.3
Sangwan, R.S.4
-
18
-
-
84884569638
-
Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): Biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns
-
A.K. Kushwaha, N.S. Sangwan, P.K. Trivedi, A.S. Negi, L. Misra, and R.S. Sangwan Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns Plos One 8 2013
-
(2013)
Plos One
, vol.8
-
-
Kushwaha, A.K.1
Sangwan, N.S.2
Trivedi, P.K.3
Negi, A.S.4
Misra, L.5
Sangwan, R.S.6
-
19
-
-
33646592543
-
Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus Niger reveals a cytochrome P450 involved in littorine rearrangement
-
R. Li, D.W. Reed, E.W. Liu, J. Nowak, L.E. Pelcher, J.E. Page, and P.S. Covello Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement Chem. Biol. 13 2006 513 520
-
(2006)
Chem. Biol.
, vol.13
, pp. 513-520
-
-
Li, R.1
Reed, D.W.2
Liu, E.W.3
Nowak, J.4
Pelcher, L.E.5
Page, J.E.6
Covello, P.S.7
-
20
-
-
84957426039
-
Reference gene selection for gene expression studies using quantitative real-time PCR normalization in Atropa belladonna
-
J.D. Li, M. Chen, F. Qiu, B.F. Qin, W.H. Liu, N.B. Wu, X.Z. Lan, Q. Wang, Z.H. Liao, and K.X. Tang Reference gene selection for gene expression studies using quantitative real-time PCR normalization in Atropa belladonna Plant Mol. Biol. Rep. 32 2014 1002 1014
-
(2014)
Plant Mol. Biol. Rep.
, vol.32
, pp. 1002-1014
-
-
Li, J.D.1
Chen, M.2
Qiu, F.3
Qin, B.F.4
Liu, W.H.5
Wu, N.B.6
Lan, X.Z.7
Wang, Q.8
Liao, Z.H.9
Tang, K.X.10
-
21
-
-
0034858845
-
Distribution of hyoscyamine and scopolamine in Datura stramonium
-
E. Miraldi, A. Masti, S. Ferri, and I. Barni Comparini Distribution of hyoscyamine and scopolamine in Datura stramonium Fitoterapia 72 2001 644 648
-
(2001)
Fitoterapia
, vol.72
, pp. 644-648
-
-
Miraldi, E.1
Masti, A.2
Ferri, S.3
Barni Comparini, I.4
-
22
-
-
0037300536
-
Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus
-
E. Moyano, K. Jouhikainen, P. Tammela, J. Palazon, R.M. Cusido, M.T. Pinol, T.H. Teeri, and K.M. Oksman-Caldentey Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus J. Exp. Bot. 54 2003 203 211
-
(2003)
J. Exp. Bot.
, vol.54
, pp. 203-211
-
-
Moyano, E.1
Jouhikainen, K.2
Tammela, P.3
Palazon, J.4
Cusido, R.M.5
Pinol, M.T.6
Teeri, T.H.7
Oksman-Caldentey, K.M.8
-
23
-
-
0033227533
-
Two tropinone reductases, that catalyze opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns
-
K. Nakajima, and T. Hashimoto Two tropinone reductases, that catalyze opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns Plant Cell Physiol. 40 1999 1099 1107
-
(1999)
Plant Cell Physiol.
, vol.40
, pp. 1099-1107
-
-
Nakajima, K.1
Hashimoto, T.2
-
24
-
-
0027449067
-
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor
-
K. Nakajima, T. Hashimoto, and Y. Yamada Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor Proc. Natl. Acad. Sci. USA 90 1993 9591 9595
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9591-9595
-
-
Nakajima, K.1
Hashimoto, T.2
Yamada, Y.3
-
25
-
-
0032574829
-
Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold
-
K. Nakajima, A. Yamashita, H. Akama, T. Nakatsu, H. Kato, T. Hashimoto, J. Oda, and Y. Yamada Crystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold Proc. Natl. Acad. Sci. USA 95 1998 4876 4881
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4876-4881
-
-
Nakajima, K.1
Yamashita, A.2
Akama, H.3
Nakatsu, T.4
Kato, H.5
Hashimoto, T.6
Oda, J.7
Yamada, Y.8
-
26
-
-
0033523086
-
Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductases
-
K. Nakajima, H. Kato, J. Oda, Y. Yamada, and T. Hashimoto Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductases J. Biol. Chem. 274 1999 16563 16568
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16563-16568
-
-
Nakajima, K.1
Kato, H.2
Oda, J.3
Yamada, Y.4
Hashimoto, T.5
-
28
-
-
0032329608
-
Tropic acid ester biosynthesis in Datura stramonium and related species
-
D. O'Hagan, and R.J. Robins Tropic acid ester biosynthesis in Datura stramonium and related species Chem. Soc. Rev. 27 1998 207 212
-
(1998)
Chem. Soc. Rev.
, vol.27
, pp. 207-212
-
-
O'Hagan, D.1
Robins, R.J.2
-
29
-
-
34548323862
-
Tropane and nicotine alkaloid biosynthesis-novel approaches towards biotechnological production of plant-derived pharmaceuticals
-
K.M. Oksman-Caldentey Tropane and nicotine alkaloid biosynthesis-novel approaches towards biotechnological production of plant-derived pharmaceuticals Curr. Pharm. Biotechnol. 8 2007 203 210
-
(2007)
Curr. Pharm. Biotechnol.
, vol.8
, pp. 203-210
-
-
Oksman-Caldentey, K.M.1
-
30
-
-
12744267344
-
Short-chain dehydrogenases/reductases (SDR): The 2002 update
-
U. Oppermann, C. Filling, M. Hult, N. Shafqat, X. Wu, M. Lindh, J. Shafqat, E. Nordling, Y. Kallberg, B. Persson, and H. Jornvall Short-chain dehydrogenases/reductases (SDR): the 2002 update Chem. Biol. Interact. 143-144 2003 247 253
-
(2003)
Chem. Biol. Interact.
, vol.143-144
, pp. 247-253
-
-
Oppermann, U.1
Filling, C.2
Hult, M.3
Shafqat, N.4
Wu, X.5
Lindh, M.6
Shafqat, J.7
Nordling, E.8
Kallberg, Y.9
Persson, B.10
Jornvall, H.11
-
31
-
-
0028500354
-
The reduction of tropinone in Datura stramonium root cultures by two specific reductases
-
A. Portsteffen, B. Drager, and A. Nahrstedt The reduction of tropinone in Datura stramonium root cultures by two specific reductases Phytochemistry 37 1994 391 400
-
(1994)
Phytochemistry
, vol.37
, pp. 391-400
-
-
Portsteffen, A.1
Drager, B.2
Nahrstedt, A.3
-
33
-
-
74849093082
-
Expression of hyoscyamine 6 beta-hydroxylase in the root pericycle cells and accumulation of its product scopolamine in leaf and stem tissues of Datura metel L
-
K.K. Pramod, S. Singh, and C. Jayabaskaran Expression of hyoscyamine 6 beta-hydroxylase in the root pericycle cells and accumulation of its product scopolamine in leaf and stem tissues of Datura metel L Plant Sci. 178 2010 202 206
-
(2010)
Plant Sci.
, vol.178
, pp. 202-206
-
-
Pramod, K.K.1
Singh, S.2
Jayabaskaran, C.3
-
34
-
-
84895801979
-
Expression pattern of genes involved in tropane alkaloids biosynthesis and tropane alkaloids accumulation in Atropa belladonna
-
W. Qiang, Y.X. Wang, Q.Z. Zhang, J.D. Li, K. Xia, N.B. Wu, and Z.H. Liao Expression pattern of genes involved in tropane alkaloids biosynthesis and tropane alkaloids accumulation in Atropa belladonna Zhongguo Zhong Yao Za Zhi 39 2014 52 58
-
(2014)
Zhongguo Zhong Yao Za Zhi
, vol.39
, pp. 52-58
-
-
Qiang, W.1
Wang, Y.X.2
Zhang, Q.Z.3
Li, J.D.4
Xia, K.5
Wu, N.B.6
Liao, Z.H.7
-
35
-
-
84954446871
-
Cloning and expression of the key enzyme hyoscyamine 6 beta-hydroxylase gene (DaH6H) in scopolamine biosynthesis of Datura arborea
-
W. Qiang, Y.L. Hou, X. Li, K. Xia, and Z.H. Liao Cloning and expression of the key enzyme hyoscyamine 6 beta-hydroxylase gene (DaH6H) in scopolamine biosynthesis of Datura arborea Acta Pharm. Sin. 50 2015 1346 1355
-
(2015)
Acta Pharm. Sin.
, vol.50
, pp. 1346-1355
-
-
Qiang, W.1
Hou, Y.L.2
Li, X.3
Xia, K.4
Liao, Z.H.5
-
36
-
-
84900012741
-
Effects of acetylsalicylic acid and UV-B on gene expression and tropane alkaloid biosynthesis in hairy root cultures of Anisodus luridus
-
B.F. Qin, L.L. Ma, Y.X. Wang, M. Chen, X.Z. Lan, N.B. Wu, and Z.H. Liao Effects of acetylsalicylic acid and UV-B on gene expression and tropane alkaloid biosynthesis in hairy root cultures of Anisodus luridus Plant Cell, Tissue Organ Cult. 117 2014 483 490
-
(2014)
Plant Cell, Tissue Organ Cult.
, vol.117
, pp. 483-490
-
-
Qin, B.F.1
Ma, L.L.2
Wang, Y.X.3
Chen, M.4
Lan, X.Z.5
Wu, N.B.6
Liao, Z.H.7
-
37
-
-
14544305686
-
Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures
-
U. Richter, G. Rothe, A.K. Fabian, B. Rahfeld, and B. Drager Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures J. Exp. Bot. 56 2005 645 652
-
(2005)
J. Exp. Bot.
, vol.56
, pp. 645-652
-
-
Richter, U.1
Rothe, G.2
Fabian, A.K.3
Rahfeld, B.4
Drager, B.5
-
38
-
-
0041374254
-
Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase
-
G. Rothe, A. Hachiya, Y. Yamada, T. Hashimoto, and B. Drager Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase J. Exp. Bot. 54 2003 2065 2070
-
(2003)
J. Exp. Bot.
, vol.54
, pp. 2065-2070
-
-
Rothe, G.1
Hachiya, A.2
Yamada, Y.3
Hashimoto, T.4
Drager, B.5
-
39
-
-
0033137062
-
An Atropa belladonna hyoscyamine 6 beta-hydroxylase gene is differentially expressed in the root pericycle and anthers
-
K. Suzuki, D.J. Yun, X.Y. Chen, Y. Yamada, and T. Hashimoto An Atropa belladonna hyoscyamine 6 beta-hydroxylase gene is differentially expressed in the root pericycle and anthers Plant Mol. Biol. 40 1999 141 152
-
(1999)
Plant Mol. Biol.
, vol.40
, pp. 141-152
-
-
Suzuki, K.1
Yun, D.J.2
Chen, X.Y.3
Yamada, Y.4
Hashimoto, T.5
-
40
-
-
80555150598
-
Enhancing the scopolamine production in transgenic plants of Atropa belladonna by overexpressing pmt and h6h genes
-
X.R. Wang, M. Chen, C.X. Yang, X.Q. Liu, L. Zhang, X.Z. Lan, K.X. Tang, and Z.H. Liao Enhancing the scopolamine production in transgenic plants of Atropa belladonna by overexpressing pmt and h6h genes Physiol. Plant 143 2011 309 315
-
(2011)
Physiol. Plant
, vol.143
, pp. 309-315
-
-
Wang, X.R.1
Chen, M.2
Yang, C.X.3
Liu, X.Q.4
Zhang, L.5
Lan, X.Z.6
Tang, K.X.7
Liao, Z.H.8
-
41
-
-
44949127129
-
Alkaloid biosynthesis: Metabolism and trafficking
-
J. Ziegler, and P.J. Facchini Alkaloid biosynthesis: Metabolism and trafficking Annu. Rev. Plant Biol. 59 2008 735 769
-
(2008)
Annu. Rev. Plant Biol.
, vol.59
, pp. 735-769
-
-
Ziegler, J.1
Facchini, P.J.2
|