The cell and developmental biology of alkaloid biosynthesis

Trends in Plant Science

Volumn 5, Issue 4, 2000, Pages 168-173

  De Luca, Vincenzo ^a   St Pierre, Benoit ^b  

^a Nov Agribus Biotechnol Res Inc   (United States)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID;

BIOSYNTHESIS; CHLOROPLAST; METABOLISM; PLANT; REVIEW;

ALKALOIDS; CHLOROPLASTS; PLANTS;

EID: 0034177601     PISSN: 13601385     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1360-1385(00)01575-2     Document Type: Review

References (35)

1. Mann, J. (1992) Murder, Magic and Medicine, Oxford University Press
2. Wink, M. (1999) Plant secondary metabolites: Biochemistry, function and biotechnology. In Biochemistry of Plant Secondary Metabolism (Annual Plant Reviews) (Vol. 2) (Wink, M., ed.), pp. 1-16, Sheffield Academic Press
3. Kutchan, T.M. (1995) Alkaloid biosynthesis - The basis for metabolic engineering of medicinal plants. Plant Cell 7, 1059-1070
4. Chou, W.M. and Kutchan, T.M. (1998) Enzymatic oxidations in the biosynthesis of complex alkaloids. Plant J. 15, 289-300
5. Wink, M. and Roberts, M.F. (1998) Compartmentation of alkaloid biosynthesis, transport and storage. In Alkaloids: Biochemistry, Ecology and Medicinal Applications (Roberts, M.F. and Wink, M., eds), pp. 239-262, Plenum Press
6. Facchini, P. (1999) Plant secondary metabolism: Out of the evolutionary abyss. Trends Plant Sci. 4, 382-384
7. De Carolis, E. and De Luca, V. (1994) 2-oxoglutarate-dependent dioxygenases and related enzymes: Biochemical characterization. Phytochemistry 36, 1093-1107
8. St-Pierre, B. et al. (1998) The terminal Ο-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer. Plant J. 14, 703-713
9. Flores, H.E. et al. (1999) 'Radicle' biochemistry: The biology of root-specific metabolism. Trends Plant Sci. 4, 220-226
10. Waller, G.R. and Nowacki, E.K. (1979) Alkaloid Biology and Metabolism in Plants, Plenum Press
11. Hibi, N. et al. (1994) Gene expression in tobacco low nicotine mutants. Plant Cell 6, 723-735
12. Hibi, N. et al. (1992) Putrescine-Ν-methyltransferase in cultured roots of Hyoscyamus albus. Plant Physiol. 100, 826-835
13. Suzuki, K. et al. (1999) Expression of Atropa belladonna putrescine Ν-methyltransferase in root pericycle. Plant Cell Physiol. 40, 289-297
14. Suzuki, K. et al. (1999) An Atropa belladonna hyoscyamine 6α-hydroxylase gene is differentially expressed in the root pericycle and anthers. Plant Mol. Biol. 40, 141-152
15. Zabetakis, I. et al. (1998) The biosynthetic relationship between littorine and hyoscyamine in transformed roots of Datura stramonium. Plant Cell Rep. 18, 341-345
16. Nakajima, K. et al. (1993) Two tropinone reductases with different stereospecificities are short chain dehydrogenases evolved from a common ancestor. Proc. Natl. Acad. Sci. U. S. A. 90, 9591-9595
17. Nakajima, K. and Hashimoto, T. (1999) Two tropinone reductases, that catalyse opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns. Plant Cell Physiol. 40, 1099-1107
18. Hashimoto, T. and Yamada, Y. (1994) Alkaloid biogenesis: Molecular aspects. Annu. Rev. Plant Physiol. Plant Mol. Biol. 45, 257-285
19. De Luca, V. (1993) Indole alkaloid biosynthesis. In Methods in Plant Biochemistry. Enzymes of Secondary Metabolism (Vol. 9) (Lea, P., ed.), pp. 345-368, Academic Press
20. Meijer, A.M. et al. (1993) Regulation of enzymes and genes involved in terpenoid indole alkaloid biosyntheis in Catharanthus roseus. J. Plant Res. (Special Issue) 3, 145-164
21. McKnight, T.D. et al. (1991) Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants. Planta 185, 148-152
22. Van Tellingen, O. et al. (1992) Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives. Anticancer Res. 12, 1699-1715
23. Van der Heijden, R. et al. (1989) Cell and tissue cultures of Catharanthus roseus (L.) G. Don: A literature survey. Plant Cell, Tissue Organ Cult. 18, 231-280
24. St-Pierre, B. and De Luca, V. (1995) A cytochrome P450 monooxygenase catalyses the first step in the conversion of tabersonine to vindoline in Catharanthus roseus. Plant Physiol. 109, 131-139
25. Vazquez-Flota, F. et al. (1997) Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate-dependent dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus. Plant Mol. Biol. 34, 935-948
26. Schroder, G. et al. (1999) Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: Tabersonine 16-hydroxylase. FEBS Lett. 458, 97-102
27. St-Pierre, B. et al. (1999) Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11, 887-900
28. Sottomayor, M. et al. (1998) Purification and characterization of a-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don. FEBS Lett. 428, 299-303
29. Suzuki, H. et al. (1996) Subcellular localization of acyltransferases for quinolizidine alkaloid biosynthesis in Lupinus. Phytochemistry 42, 1557-1562
30. Kutchan, T.M. and Zenk, M. (1993) Enzymology and molecular biology of benzophenanthridine alkaloid biosynthesis. J. Plant Res. (Special issue) 3, 165-173
31. Facchini, P.J. and De Luca, V. (1995) Phloem-specific expression of tyrosine/dopa decarboxylase genes and the biosynthesis of isoquinoline alkaloids in opium poppy. Plant Cell 7, 1811-1821
32. Dittrich, H. and Kutchan, T.M. (1991) Molecular cloning, expression and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response to pathogen attack. Proc. Natl. Acad. Sci. U. S. A. 88, 9969-9973
33. McKnight, T.D. et al. (1990) Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus. Nucleic Acids Res. 18, 4939
34. Ober, D. and Hartmann, T. (1999) Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase. Proc. Natl. Acad. Sci. U. S. A. 96, 14777-14782
35. Menke, F.L. et al. (1999) A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J. 18, 4455-4463