PRMT5-mediated methylation of NF-κB p65 at Arg174 is required for endothelial CXCL11 gene induction in response to TNF-α and IFN-γ costimulation

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Harris, Daniel P ^a,b   Chandrasekharan, Unnikrishnan M ^a   Bandyopadhyay, Smarajit ^a   Willard, Belinda ^a   DiCorleto, Paul E ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; CXCL11 CHEMOKINE; GAMMA INTERFERON; LYSINE; MESSENGER RNA; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PRMT5 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MUTANT; PROMOTER REGION; PROTEIN METHYLATION; RNA INTERFERENCE; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; METHYLATION; MUTATION; UMBILICAL VEIN ENDOTHELIAL CELL;

CELLS, CULTURED; CHEMOKINE CXCL11; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERFERON-GAMMA; METHYLATION; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN-ARGININE N-METHYLTRANSFERASES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960510803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148905     Document Type: Article

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