Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion

Biochemistry

Volumn 53, Issue 50, 2014, Pages 7884-7892

  Wang, Min ^a   Fuhrmann, Jakob ^b   Thompson, Paul R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Department of Chemistry Scripps Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; ARGININE; CATALYSIS; CELL DEATH; ENZYME ACTIVITY; METHYLATION; PROTEINS;

BINDING POCKETS; CAENORHABDITIS ELEGANS; LONG RANGE INTERACTIONS; MECHANISTIC STUDIES; PROTEIN SUBSTRATE; PROTEIN-ARGININE METHYLTRANSFERASE; REGIOSPECIFICITY; SUBSTRATE RECOGNITION;

SUBSTRATES;

ENZYME; HISTONE H4; METHYLOSOME PROTEIN 50; PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE 5; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; HISTONE; MEP50 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PRMT5 PROTEIN, C ELEGANS; PRMT5 PROTEIN, HUMAN; PROTEIN ARGININE METHYLTRANSFERASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CATALYSIS; ENZYME ACTIVITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METHYLATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; ALLOSTERISM; ANIMAL; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SF9 CELL LINE; SPODOPTERA;

CAENORHABDITIS ELEGANS; HEXAPODA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC REGULATION; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATALYSIS; CATALYTIC DOMAIN; HISTONES; HUMANS; METHYLATION; MULTIPROTEIN COMPLEXES; PROTEIN-ARGININE N-METHYLTRANSFERASES; SF9 CELLS; SPODOPTERA;

EID: 84919797401     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501279g     Document Type: Article

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