Discovery of a dual PRMT5-PRMT7 inhibitor

ACS Medicinal Chemistry Letters

Volumn 6, Issue 4, 2015, Pages 408-412

  Smil, David ^a   Eram, Mohammad S ^a   Li, Fengling ^a   Kennedy, Steven ^a   Szewczyk, Magdalena M ^a   Brown, Peter J ^a   Barsyte Lovejoy, Dalia ^a   Arrowsmith, Cheryl H ^a,b   Vedadi, Masoud ^a   Schapira, Matthieu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

inhibitor; methyltransferases; PRMT5; PRMT7

Indexed keywords

DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; DS 437; METHYLTRANSFERASE INHIBITOR; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN ARGININE METHYLTRANSFERASE 7; RNA METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; DRUG DEVELOPMENT; DRUG SELECTIVITY; HYDROGEN BOND; IC50; METHYLATION; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 84927616008     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500467h     Document Type: Article

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