메뉴 건너뛰기




Volumn , Issue , 2016, Pages 57-76

Regulatory mechanisms for malignant properties of cancer cells with disialyl and monosialyl gangliosides

Author keywords

Cancer associated antigen; Ganglioside; Glycosyltransferase; Integrin; Lipid rafts; Melanoma; Metastasis

Indexed keywords


EID: 84960489314     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-4-431-55939-9_4     Document Type: Chapter
Times cited : (5)

References (119)
  • 1
    • 23844455213 scopus 로고    scopus 로고
    • Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-gd2 monoclonal antibodies: Roles of anoikis
    • Aixinjueluo W, Furukawa K, Zhang Q, Hamamura K, Tokuda N, Yoshida S, Ueda R (2005) Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis. J Biol Chem 280:29828–29836
    • (2005) J Biol Chem , vol.280 , pp. 29828-29836
    • Aixinjueluo, W.1    Furukawa, K.2    Zhang, Q.3    Hamamura, K.4    Tokuda, N.5    Yoshida, S.6    Ueda, R.7
  • 2
    • 4544297158 scopus 로고    scopus 로고
    • Mucin macromolecules in normal, adenomatous, and carcinomatous colon: Evidence for the neotransformation
    • Aksoy N, Akinci OF (2004) Mucin macromolecules in normal, adenomatous, and carcinomatous colon: evidence for the neotransformation. Macromol Biosci 4:483–496
    • (2004) Macromol Biosci , vol.4 , pp. 483-496
    • Aksoy, N.1    Akinci, O.F.2
  • 4
    • 33846798278 scopus 로고    scopus 로고
    • Small cell lung cancer and targeted therapies
    • Blackhall FH, Shepherd FA (2007) Small cell lung cancer and targeted therapies. Curr Opin Oncol 19:103–108
    • (2007) Curr Opin Oncol , vol.19 , pp. 103-108
    • Blackhall, F.H.1    Shepherd, F.A.2
  • 5
    • 0032760680 scopus 로고    scopus 로고
    • Pathways of o-glycan biosynthesis in cancer cells
    • Brockhausen I (1999) Pathways of O-glycan biosynthesis in cancer cells. Biochim Biophys Acta 1473:67–95
    • (1999) Biochim Biophys Acta , vol.1473 , pp. 67-95
    • Brockhausen, I.1
  • 6
    • 34250769529 scopus 로고    scopus 로고
    • Immunolocalisation of members of the polypeptide n-acetylgalactosaminyl transferase (Ppgalnac-t) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer
    • Brooks SA, Carter TM, Bennett EP, Clausen H, Mandel U (2007) Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer. Acta Histochem 109:273–284
    • (2007) Acta Histochem , vol.109 , pp. 273-284
    • Brooks, S.A.1    Carter, T.M.2    Bennett, E.P.3    Clausen, H.4    Mandel, U.5
  • 7
    • 0032527642 scopus 로고    scopus 로고
    • Structure and origin of ordered lipid domains in biological membranes
    • Brown DA, London E (1998) Structure and origin of ordered lipid domains in biological membranes. J Membr Biol 164:103–114
    • (1998) J Membr Biol , vol.164 , pp. 103-114
    • Brown, D.A.1    London, E.2
  • 10
    • 84855194547 scopus 로고    scopus 로고
    • Treatment of high-risk neuroblastoma with anti-gd2 antibodies
    • Castel V, Segura V, Canete A (2010) Treatment of high-risk neuroblastoma with anti-GD2 antibodies. Clin Transl Oncol 12:788–793
    • (2010) Clin Transl Oncol , vol.12 , pp. 788-793
    • Castel, V.1    Segura, V.2    Canete, A.3
  • 12
    • 0037427804 scopus 로고    scopus 로고
    • Suppression of lung metastasis of mouse lewis lung cancer p29 with transfection of the ganglioside gm2/gd2 synthase gene
    • Chen HH, Fukumoto S, Furukawa K, Nakao A, Akiyama S, Urano T (2003) Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. Int J Cancer 103:169–176
    • (2003) Int J Cancer , vol.103 , pp. 169-176
    • Chen, H.H.1    Fukumoto, S.2    Furukawa, K.3    Nakao, A.4    Akiyama, S.5    Urano, T.6
  • 13
    • 0022445270 scopus 로고
    • Biosynthesis and expression of the disialoganglioside gd2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis
    • Cheresh DA, Rosenberg J, Mujoo K, Hirschowitz L, Reisfeld RA (1986) Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis. Cancer Res 46:5112–5118
    • (1986) Cancer Res , vol.46 , pp. 5112-5118
    • Cheresh, D.A.1    Rosenberg, J.2    Mujoo, K.3    Hirschowitz, L.4    Reisfeld, R.A.5
  • 16
    • 77956008635 scopus 로고    scopus 로고
    • Gm1 /gd1b /ga1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line
    • Dong Y, Ikeda K, Hamamura K, Zhang Q, Kondo Y, Matsumoto Y, Ohmi Y, Yamauchi Y, Furukawa K, Taguchi R (2010) GM1 /GD1b /GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Cancer Sci 101:2039–2047
    • (2010) Cancer Sci , vol.101 , pp. 2039-2047
    • Dong, Y.1    Ikeda, K.2    Hamamura, K.3    Zhang, Q.4    Kondo, Y.5    Matsumoto, Y.6    Ohmi, Y.7    Yamauchi, Y.8    Furukawa, K.9    Taguchi, R.10
  • 17
    • 84855803916 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on cancer: Glycolipids as targets for tumour immunotherapy
    • Durrant LG, Noble P, Spendlove I (2012) Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy. Clin Exp Immunol 167:206–215
    • (2012) Clin Exp Immunol , vol.167 , pp. 206-215
    • Durrant, L.G.1    Noble, P.2    Spendlove, I.3
  • 18
    • 0028873047 scopus 로고
    • Prevention of apoptotic neuronal death by gm1 ganglioside. Involvement of trk neurotrophin receptors
    • Ferrari G, Anderson BL, Stephens RM, Kaplan DR, Greene LA (1995) Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. J Biol Chem 270:3074–3080
    • (1995) J Biol Chem , vol.270 , pp. 3074-3080
    • Ferrari, G.1    Erson, B.L.2    Stephens, R.M.3    Kaplan, D.R.4    Greene, L.A.5
  • 19
    • 0017316413 scopus 로고
    • Biosynthesis and function of gangliosides
    • Fishman PH, Brady RO (1976) Biosynthesis and function of gangliosides. Science 194:906–915
    • (1976) Science , vol.194 , pp. 906-915
    • Fishman, P.H.1    Brady, R.O.2
  • 21
    • 0000205623 scopus 로고    scopus 로고
    • Enhancement of in vitro and in vivo anti-tumor activity of anti-gd2 monoclonal antibody 220–51 against human neuroblastoma by granulocytemacrophage colony-stimulating factor and granulocyte colony-stimulating factor
    • Fukuda M, Horibe K, Furukawa K (1998) Enhancement of in vitro and in vivo anti-tumor activity of anti-GD2 monoclonal antibody 220–51 against human neuroblastoma by granulocytemacrophage colony-stimulating factor and granulocyte colony-stimulating factor. Int J Mol Med 2:471–475
    • (1998) Int J Mol Med , vol.2 , pp. 471-475
    • Fukuda, M.1    Horibe, K.2    Furukawa, K.3
  • 22
    • 0034008003 scopus 로고    scopus 로고
    • Gd3 synthase gene expression in pc12 cells results in the continuous activation of trka and erk1/2 and enhanced proliferation
    • Fukumoto S, Mutoh T, Hasegawa T, Miyazaki H, Okada M, Goto G, Furukawa K, Urano T (2000) GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation. J Biol Chem 275:5832–5838
    • (2000) J Biol Chem , vol.275 , pp. 5832-5838
    • Fukumoto, S.1    Mutoh, T.2    Hasegawa, T.3    Miyazaki, H.4    Okada, M.5    Goto, G.6    Furukawa, K.7    Urano, T.8
  • 23
    • 34447511417 scopus 로고    scopus 로고
    • Biosignals modulated by tumor-associated carbohydrate antigens: Novel targets for cancer therapy
    • Furukawa K, Hamamura K, Aixinjueluo W (2006) Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy. Ann N Y Acad Sci 1086:185–198
    • (2006) Ann N Y Acad Sci , vol.1086 , pp. 185-198
    • Furukawa, K.1    Hamamura, K.2    Aixinjueluo, W.3
  • 24
    • 50449086453 scopus 로고    scopus 로고
    • Molecules in the signaling pathway activated by gangliosides can be targets of therapeutics for malignant melanomas
    • Furukawa K, Hamamura K, Nakashima H (2008) Molecules in the signaling pathway activated by gangliosides can be targets of therapeutics for malignant melanomas. Proteomics 8:3312–3316
    • (2008) Proteomics , vol.8 , pp. 3312-3316
    • Furukawa, K.1    Hamamura, K.2    Nakashima, H.3
  • 25
    • 84867742532 scopus 로고    scopus 로고
    • Disialyl gangliosides enhance tumor phenotypes with differential modalities
    • Furukawa K, Hamamura K, Ohkawa Y, Ohmi Y (2012a) Disialyl gangliosides enhance tumor phenotypes with differential modalities. Glycoconj J 29:579–584
    • (2012) Glycoconj J , vol.29 , pp. 579-584
    • Furukawa, K.1    Hamamura, K.2    Ohkawa, Y.3    Ohmi, Y.4
  • 27
    • 84892836534 scopus 로고    scopus 로고
    • Ganglioside gd3 induces convergence and synergism of adhesion and hepatocyte growth factor/met signals in melanomas
    • Furukawa K, Kambe M, Miyata M, Ohkawa Y, Tajima O (2014) Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas. Cancer Sci 105:52–63
    • (2014) Cancer Sci , vol.105 , pp. 52-63
    • Furukawa, K.1    Kambe, M.2    Miyata, M.3    Ohkawa, Y.4    Tajima, O.5
  • 29
    • 0027447690 scopus 로고
    • Gd2 ganglioside on human t-lymphotropic virus type i-infected t cells: Possible activation of beta- 1,4-n-acetylgalactosaminyltransferase gene by p40tax
    • Furukawa K, Akagi T, Nagata Y, Yamada Y, Shimotohno K, Cheung NK, Shiku H (1993) GD2 ganglioside on human T-lymphotropic virus type I-infected T cells: possible activation of beta- 1,4-N-acetylgalactosaminyltransferase gene by p40tax. Proc Natl Acad Sci USA 90:1972–1976
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1972-1976
    • Furukawa, K.1    Akagi, T.2    Nagata, Y.3    Yamada, Y.4    Shimotohno, K.5    Cheung, N.K.6    Shiku, H.7
  • 31
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424–2428
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 32
    • 0022262016 scopus 로고
    • Aberrant glycosylation in cancer cell membranes as focused on glycolipids: Overview and perspectives
    • Hakomori S (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives. Cancer Res 45:2405–2414
    • (1985) Cancer Res , vol.45 , pp. 2405-2414
    • Hakomori, S.1
  • 33
    • 0031928904 scopus 로고    scopus 로고
    • Signal transduction through glyco- (Sphingo)lipids. Introduction and recent studies on glyco(sphingo)lipid-enriched microdomains
    • Hakomori S, Yamamura S, Handa AK (1998) Signal transduction through glyco- (sphingo)lipids. Introduction and recent studies on glyco(sphingo)lipid-enriched microdomains. Ann N Y Acad Sci 845:1–10
    • (1998) Ann N Y Acad Sci , vol.845 , pp. 1-10
    • Hakomori, S.1    Yamamura, S.2    Handa, A.K.3
  • 34
    • 0036677372 scopus 로고    scopus 로고
    • Glycosylation defining cancer malignancy: New wine in an old bottle
    • Hakomori S (2002a) Glycosylation defining cancer malignancy: new wine in an old bottle. Proc Natl Acad Sci USA 99:10231–10233
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10231-10233
    • Hakomori, S.1
  • 36
    • 0037201965 scopus 로고    scopus 로고
    • Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: Essential basis to define tumor malignancy
    • Hakomori S, Handa K (2002) Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy. FEBS Lett 531:88–92
    • (2002) FEBS Lett , vol.531 , pp. 88-92
    • Hakomori, S.1    Handa, K.2
  • 37
    • 77951898430 scopus 로고    scopus 로고
    • Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility
    • Hakomori SI (2010) Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility. FEBS Lett 584:1901–1906
    • (2010) FEBS Lett , vol.584 , pp. 1901-1906
    • Hakomori, S.I.1
  • 38
    • 40849103028 scopus 로고    scopus 로고
    • Focal adhesion kinase as well as p130cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside gd3 in melanoma cells
    • Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, Yamamoto N, Ueda M, Furukawa K (2008) Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Biochim Biophys Acta 1780:513–519
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 513-519
    • Hamamura, K.1    Tsuji, M.2    Ohkawa, Y.3    Nakashima, H.4    Miyazaki, S.5    Urano, T.6    Yamamoto, N.7    Ueda, M.8    Furukawa, K.9
  • 41
    • 0029665593 scopus 로고    scopus 로고
    • Anti-ganglioside gm2 monoclonal antibody-dependent killing of human lung cancer cells by lymphocytes and monocytes
    • Hanibuchi M, Yano S, Nishioka Y, Yanagawa H, Sone S (1996) Anti-ganglioside GM2 monoclonal antibody-dependent killing of human lung cancer cells by lymphocytes and monocytes. Jpn J Cancer Res 87:497–504
    • (1996) Jpn J Cancer Res , vol.87 , pp. 497-504
    • Hanibuchi, M.1    Yano, S.2    Nishioka, Y.3    Yanagawa, H.4    Sone, S.5
  • 42
    • 0028173085 scopus 로고
    • Isolation of gd3 synthase gene by expression cloning of gm3 alpha-2,8-sialyltransferase cdna using anti-gd2 monoclonal antibody
    • Haraguchi M, Yamashiro S, Yamamoto A, Furukawa K, Takamiya K, Lloyd KO, Shiku H (1994) Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Proc Natl Acad Sci USA 91:10455–10459
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10455-10459
    • Haraguchi, M.1    Yamashiro, S.2    Yamamoto, A.3    Furukawa, K.4    Takamiya, K.5    Lloyd, K.O.6    Shiku, H.7
  • 43
    • 84868099850 scopus 로고    scopus 로고
    • Proteomic analysis of ganglioside-associated membrane molecules: Substantial basis for molecular clustering
    • Hashimoto N, Hamamura K, Kotani N, Furukawa K, Kaneko K, Honke K, Furukawa K (2012) Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering. Proteomics 12:3154–3163
    • (2012) Proteomics , vol.12 , pp. 3154-3163
    • Hashimoto, N.1    Hamamura, K.2    Kotani, N.3    Furukawa, K.4    Kaneko, K.5    Honke, K.6    Furukawa, K.7
  • 45
    • 0026055260 scopus 로고
    • Ganglioside antigens in tissue sections of skin, naevi, and melanoma-- implications for treatment of melanoma
    • Hersey P (1991) Ganglioside antigens in tissue sections of skin, naevi, and melanoma-- implications for treatment of melanoma. Cancer Treat Res 54:137–151
    • (1991) Cancer Treat Res , vol.54 , pp. 137-151
    • Hersey, P.1
  • 46
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surface
    • Hollingsworth MA, Swanson BJ (2004) Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4:45–60
    • (2004) Nat Rev Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 47
    • 0004712263 scopus 로고
    • Regression of cutaneous metastatic melanoma by intralesional injection with human monoclonal antibody to ganglioside gd2
    • Irie RF, Morton DL (1986) Regression of cutaneous metastatic melanoma by intralesional injection with human monoclonal antibody to ganglioside GD2. Proc Natl Acad Sci USA 83:8694–8698
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8694-8698
    • Irie, R.F.1    Morton, D.L.2
  • 48
    • 0024602132 scopus 로고
    • Human monoclonal antibody to ganglioside gm2 for melanoma treatment
    • Irie RF, Matsuki T, Morton DL (1989) Human monoclonal antibody to ganglioside GM2 for melanoma treatment. Lancet 1:786–787
    • (1989) Lancet , vol.1 , pp. 786-787
    • Irie, R.F.1    Matsuki, T.2    Morton, D.L.3
  • 49
    • 79951801155 scopus 로고    scopus 로고
    • The tn antigen-structural simplicity and biological complexity
    • Ju T, Otto VI, Cummings RD (2011) The Tn antigen-structural simplicity and biological complexity. Angew Chem Int Ed Engl 50:1770–1791
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 1770-1791
    • Ju, T.1    Otto, V.I.2    Cummings, R.D.3
  • 51
    • 40749118374 scopus 로고    scopus 로고
    • Current relevance of incomplete synthesis and neo-synthesis for cancer associated alteration of carbohydrate determinants--hakomori’s concepts revisited
    • Kannagi R, Yin J, Miyazaki K, Izawa M (2008) Current relevance of incomplete synthesis and neo-synthesis for cancer associated alteration of carbohydrate determinants--Hakomori’s concepts revisited. Biochim Biophys Acta 1780:525–531
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 525-531
    • Kannagi, R.1    Yin, J.2    Miyazaki, K.3    Izawa, M.4
  • 53
    • 33750596103 scopus 로고    scopus 로고
    • Fundamental study of small interfering rnas for ganglioside gd3 synthase as a therapeutic target of lung cancers
    • Ko K, Furukawa K, Takahashi T, Urano T, Sanai Y, Nagino Y, Nimura Y, Furukawa K (2006) Fundamental study of small interfering RNAs for ganglioside GD3 synthase as a therapeutic target of lung cancers. Oncogene 25:6924–6935
    • (2006) Oncogene , vol.25 , pp. 6924-6935
    • Ko, K.1    Furukawa, K.2    Takahashi, T.3    Urano, T.4    Sanai, Y.5    Nagino, Y.6    Nimura, Y.7    Furukawa, K.8
  • 54
  • 55
    • 84862800913 scopus 로고    scopus 로고
    • Membrane mechanisms for signal transduction: The coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes
    • Kusumi A, Fujiwara TK, Morone N, Yoshida KJ, Chadda R, Xie M, Kasai RS, Suzuki KG (2012) Membrane mechanisms for signal transduction: the coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes. Semin Cell Dev Biol 23:126–144
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 126-144
    • Kusumi, A.1    Fujiwara, T.K.2    Morone, N.3    Yoshida, K.J.4    Chadda, R.5    Xie, M.6    Kasai, R.S.7    Suzuki, K.G.8
  • 56
    • 0024313217 scopus 로고
    • Human monoclonal antibodies to glycolipids and other carbohydrate antigens: Dissection of the humoral immune response in cancer patients
    • Lloyd KO, Old LJ (1989) Human monoclonal antibodies to glycolipids and other carbohydrate antigens: dissection of the humoral immune response in cancer patients. Cancer Res 49:3445–3451
    • (1989) Cancer Res , vol.49 , pp. 3445-3451
    • Lloyd, K.O.1    Old, L.J.2
  • 57
    • 70349871692 scopus 로고    scopus 로고
    • Gangliosides in cell recognition and membrane protein regulation
    • Lopez PH, Schnaar RL (2009) Gangliosides in cell recognition and membrane protein regulation. Curr Opin Struct Biol 19:549–557
    • (2009) Curr Opin Struct Biol , vol.19 , pp. 549-557
    • Lopez, P.H.1    Schnaar, R.L.2
  • 58
    • 0037203318 scopus 로고    scopus 로고
    • Gd3 ganglioside and apoptosis
    • Malisan F, Testi R (2002) GD3 ganglioside and apoptosis. Biochim Biophys Acta 1585:179–187
    • (2002) Biochim Biophys Acta , vol.1585 , pp. 179-187
    • Malisan, F.1    Testi, R.2
  • 60
    • 84882445310 scopus 로고    scopus 로고
    • Trimeric tn antigen on syndecan 1 produced by ppgalnac-t13 enhances cancer metastasis via a complex formation with integrin a5ß1 and matrix metalloproteinase 9
    • Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, Okajima T, Furukawa K, Urano T (2013) Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin a5ß1 and matrix metalloproteinase 9. J Biol Chem 288:24264–24276
    • (2013) J Biol Chem , vol.288 , pp. 24264-24276
    • Matsumoto, Y.1    Zhang, Q.2    Akita, K.3    Nakada, H.4    Hamamura, K.5    Tsuchida, A.6    Okajima, T.7    Furukawa, K.8    Urano, T.9
  • 63
    • 84861152766 scopus 로고    scopus 로고
    • Promising therapeutic targets in neuroblastoma
    • Matthay KK, George RE, Yu AL (2012) Promising therapeutic targets in neuroblastoma. Clin Cancer Res 18:2740–2753
    • (2012) Clin Cancer Res , vol.18 , pp. 2740-2753
    • Matthay, K.K.1    George, R.E.2    Yu, A.L.3
  • 65
    • 0023159987 scopus 로고
    • Expression of gd3 ganglioside in childhood t-cell lymphoblastic malignancies
    • Merritt WD, Casper JT, Lauer SJ, Reaman GH (1987) Expression of GD3 ganglioside in childhood T-cell lymphoblastic malignancies. Cancer Res 47:1724–1730
    • (1987) Cancer Res , vol.47 , pp. 1724-1730
    • Merritt, W.D.1    Casper, J.T.2    Lauer, S.J.3    Reaman, G.H.4
  • 66
    • 0037192830 scopus 로고    scopus 로고
    • Overexpression of ganglioside gm1 results in the dispersion of platelet-derived growth factor receptor from glycolipidenriched microdomains and in the suppression of cell growth signals
    • Mitsuda T, Furukawa K, Fukumoto S, Miyazaki H, Urano T (2002) Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipidenriched microdomains and in the suppression of cell growth signals. J Biol Chem 277:11239–11246
    • (2002) J Biol Chem , vol.277 , pp. 11239-11246
    • Mitsuda, T.1    Furukawa, K.2    Fukumoto, S.3    Miyazaki, H.4    Urano, T.5
  • 67
    • 84896093513 scopus 로고    scopus 로고
    • Uvb-irradiated keratinocytes induce melanoma-associated ganglioside gd3 synthase gene in melanocytes via secretion of tumor necrosis factor a and interleukin 6
    • Miyata M, Ichihara M, Tajima O, Sobue S, Kambe M, Sugiura K, Furukawa K (2014) UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor a and interleukin 6. Biochem Biophys Res Commun 445:504–510
    • (2014) Biochem Biophys Res Commun , vol.445 , pp. 504-510
    • Miyata, M.1    Ichihara, M.2    Tajima, O.3    Sobue, S.4    Kambe, M.5    Sugiura, K.6    Furukawa, K.7
  • 68
    • 0030868544 scopus 로고    scopus 로고
    • Expression cloning of rat cdna encoding udp-galactose: Gd2 beta 1,3-galactosyltransferase that determines the expression of gd1b/gm1/ga1
    • Miyazaki H, Fukumoto S, Okada M, Hasegawa T, Furukawa K (1997) Expression cloning of rat cDNA encoding UDP-galactose: GD2 beta 1,3-galactosyltransferase that determines the expression of GD1b/GM1/GA1. J Biol Chem 272:24794–24799
    • (1997) J Biol Chem , vol.272 , pp. 24794-24799
    • Miyazaki, H.1    Fukumoto, S.2    Okada, M.3    Hasegawa, T.4    Furukawa, K.5
  • 70
    • 0037090422 scopus 로고    scopus 로고
    • The role of syndecan-2 in regulation of actin-cytoskeletal organization of lewis lung carcinoma-derived metastatic clones
    • Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M (2002) The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones. Biochem J 363:201–209
    • (2002) Biochem J , vol.363 , pp. 201-209
    • Munesue, S.1    Kusano, Y.2    Oguri, K.3    Itano, N.4    Yoshitomi, Y.5    Nakanishi, H.6    Yamashina, I.7    Okayama, M.8
  • 72
    • 0344585437 scopus 로고    scopus 로고
    • Lipid rafts: Elusive or illusivę
    • Munro S (2003) Lipid rafts: elusive or illusivę Cell 115:377–388
    • (2003) Cell , vol.115 , pp. 377-388
    • Munro, S.1
  • 74
    • 0028831886 scopus 로고
    • Functional roles of gangliosides in bio-signaling
    • Nagai Y (1995) Functional roles of gangliosides in bio-signaling. Behav Brain Res 66:99–104
    • (1995) Behav Brain Res , vol.66 , pp. 99-104
    • Nagai, Y.1
  • 75
    • 34147139397 scopus 로고    scopus 로고
    • Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside gd3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties
    • Nakashima H, Hamamura K, Houjou T, Taguchi R, Yamamoto N, Mitsudo K, Tohnai I, Ueda M, Urano T, Furukawa K (2007) Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties. Cancer Sci 98:512–520
    • (2007) Cancer Sci , vol.98 , pp. 512-520
    • Nakashima, H.1    Hamamura, K.2    Houjou, T.3    Taguchi, R.4    Yamamoto, N.5    Mitsudo, K.6    Tohnai, I.7    Ueda, M.8    Urano, T.9    Furukawa, K.10
  • 76
    • 4043164892 scopus 로고    scopus 로고
    • Overexpressed gm1 suppresses nerve growth factor (Ngf) signals by modulating the intracellular localization of ngf receptors and membrane fluidity in pc12 cells
    • Nishio M, Fukumoto S, Furukawa K, Ichimura A, Miyazaki H, Kusunoki S, Urano T (2004) Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells. J Biol Chem 279:33368–33378
    • (2004) J Biol Chem , vol.279 , pp. 33368-33378
    • Nishio, M.1    Fukumoto, S.2    Furukawa, K.3    Ichimura, A.4    Miyazaki, H.5    Kusunoki, S.6    Urano, T.7
  • 77
    • 45849105540 scopus 로고    scopus 로고
    • Essential roles of integrinmediated signaling for the enhancement of malignant properties of melanomas based on the expression of gd3
    • Ohkawa Y, Miyazaki S, Miyata M, Hamamura K, Furukawa K (2008) Essential roles of integrinmediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3. Biochem Biophys Res Commun 373:14–19
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 14-19
    • Ohkawa, Y.1    Miyazaki, S.2    Miyata, M.3    Hamamura, K.4    Furukawa, K.5
  • 78
    • 77956245951 scopus 로고    scopus 로고
    • Ganglioside gd3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains
    • Ohkawa Y, Miyazaki S, Hamamura K, Kambe M, Miyata M, Tajima O, Ohmi Y, Yamauchi Y, Furukawa K (2010) Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. J Biol Chem 285:27213–27223
    • (2010) J Biol Chem , vol.285 , pp. 27213-27223
    • Ohkawa, Y.1    Miyazaki, S.2    Hamamura, K.3    Kambe, M.4    Miyata, M.5    Tajima, O.6    Ohmi, Y.7    Yamauchi, Y.8    Furukawa, K.9
  • 79
    • 0029972113 scopus 로고    scopus 로고
    • High expression of ganglioside alpha-2,8-sialyltransferase (Gd3 synthase) gene in adult t-cell leukemia cells unrelated to the gene expression of human t-lymphotropic virus type i
    • Okada M, Furukawa K, Yamashiro S, Yamada Y, Haraguchi M, Horibe K, Kato K, Tsuji Y (1996) High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I. Cancer Res 56:2844–2848
    • (1996) Cancer Res , vol.56 , pp. 2844-2848
    • Okada, M.1    Furukawa, K.2    Yamashiro, S.3    Yamada, Y.4    Haraguchi, M.5    Horibe, K.6    Kato, K.7    Tsuji, Y.8
  • 80
    • 0019349540 scopus 로고
    • Cancer immunology: The search for specificity--G. H. A. Clowes memorial lecture
    • Old LJ (1981) Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture. Cancer Res 41:361–375
    • (1981) Cancer Res , vol.41 , pp. 361-375
    • Old, L.J.1
  • 81
    • 84873951706 scopus 로고    scopus 로고
    • Targeted immunotherapy for high-risk neuroblastoma-- the role of monoclonal antibodies
    • Parsons K, Bernhardt B, Strickland B (2013) Targeted immunotherapy for high-risk neuroblastoma-- the role of monoclonal antibodies. Ann Pharmacother 47:210–218
    • (2013) Ann Pharmacother , vol.47 , pp. 210-218
    • Parsons, K.1    Bernhardt, B.2    Strickland, B.3
  • 82
    • 41949099869 scopus 로고    scopus 로고
    • Dissecting lipid raft facilitated cell signaling pathways in cancer
    • Patra SK (2008) Dissecting lipid raft facilitated cell signaling pathways in cancer. Biochim Biophys Acta 1785:182–206
    • (2008) Biochim Biophys Acta , vol.1785 , pp. 182-206
    • Patra, S.K.1
  • 83
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through met
    • Peinado H et al (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18:883–891
    • (2012) Nat Med , vol.18 , pp. 883-891
    • Peinado, H.1
  • 84
    • 0018748995 scopus 로고
    • Lipid composition of human malignant melanoma tumors at various levels of malignant growth
    • Portoukalian J, Zwingelstein G, Doré JF (1979) Lipid composition of human malignant melanoma tumors at various levels of malignant growth. Eur J Biochem 94:19–23
    • (1979) Eur J Biochem , vol.94 , pp. 19-23
    • Portoukalian, J.1    Zwingelstein, G.2    Doré, J.F.3
  • 85
    • 0020003718 scopus 로고
    • Gd3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody
    • Pukel CS, Lloyd KO, Travassos LR, Dippold WG, Oettgen HF, Old LJ (1982) GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody. J Exp Med 155:1133–1147
    • (1982) J Exp Med , vol.155 , pp. 1133-1147
    • Pukel, C.S.1    Lloyd, K.O.2    Travassos, L.R.3    Dippold, W.G.4    Oettgen, H.F.5    Old, L.J.6
  • 86
    • 84877979838 scopus 로고    scopus 로고
    • Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide
    • Quann K, Gonzales DM, Mercier I, Wang C, Sotgia F, Pestell RG, Lisanti MP, Jasmin JF (2013) Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle 12:1510–1520
    • (2013) Cell Cycle , vol.12 , pp. 1510-1520
    • Quann, K.1    Gonzales, D.M.2    Mercier, I.3    Wang, C.4    Sotgia, F.5    Pestell, R.G.6    Lisanti, M.P.7    Jasmin, J.F.8
  • 88
    • 0025761198 scopus 로고
    • Ganglioside gm3: Gd3 ratio as an index for the management of melanoma
    • Ravindranath MH, Tsuchida T, Morton DL, Irie RF (1991) Ganglioside GM3: GD3 ratio as an index for the management of melanoma. Cancer 67:3029–3035
    • (1991) Cancer , vol.67 , pp. 3029-3035
    • Ravindranath, M.H.1    Tsuchida, T.2    Morton, D.L.3    Irie, R.F.4
  • 90
    • 0024153327 scopus 로고
    • Characteristics of cultured human melanocytes from different stages of tumor progression
    • Rodeck U, Herlyn M (1988) Characteristics of cultured human melanocytes from different stages of tumor progression. Cancer Treat Res 43:3–16
    • (1988) Cancer Treat Res , vol.43 , pp. 3-16
    • Rodeck, U.1    Herlyn, M.2
  • 91
    • 0021955583 scopus 로고
    • Ganglioside gd2 specificity of monoclonal antibodies to human neuroblastoma cell
    • Saito M, Yu RK, Cheung NK (1985) Ganglioside GD2 specificity of monoclonal antibodies to human neuroblastoma cell. Biochem Biophys Res Commun 127:1–7
    • (1985) Biochem Biophys Res Commun , vol.127 , pp. 1-7
    • Saito, M.1    Yu, R.K.2    Cheung, N.K.3
  • 94
    • 0021685055 scopus 로고
    • Differential expression of ganglioside gd3 by human leukocytes and leukemia cells
    • Siddiqui B, Buehler J, DeGregorio MW, Macher BA (1984) Differential expression of ganglioside GD3 by human leukocytes and leukemia cells. Cancer Res 44:5262–5265
    • (1984) Cancer Res , vol.44 , pp. 5262-5265
    • Siddiqui, B.1    Buehler, J.2    DeGregorio, M.W.3    Macher, B.A.4
  • 95
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569–572
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 96
    • 77957167810 scopus 로고    scopus 로고
    • Revitalizing membrane rafts: New tools and insights
    • Simons K, Gerl MJ (2010) Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol 11:688–699
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 688-699
    • Simons, K.1    Gerl, M.J.2
  • 97
    • 0034304851 scopus 로고    scopus 로고
    • Lipid rafts and signal transduction
    • Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31–39
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 31-39
    • Simons, K.1    Toomre, D.2
  • 100
    • 0022851585 scopus 로고
    • Modification of the metastatic potential of tumor cells by drugs
    • Takenaga K (1986) Modification of the metastatic potential of tumor cells by drugs. Cancer Metastasis Rev 5:67–75
    • (1986) Cancer Metastasis Rev , vol.5 , pp. 67-75
    • Takenaga, K.1
  • 102
    • 0037205044 scopus 로고    scopus 로고
    • Signaling pathways for pc12 cell differentiation: Making the right connections
    • Vaudry D, Stork PJ, Lazarovici P, Eiden LE (2002) Signaling pathways for PC12 cell differentiation: making the right connections. Science 296:1648–1649
    • (2002) Science , vol.296 , pp. 1648-1649
    • Vaudry, D.1    Stork, P.J.2    Lazarovici, P.3    Eiden, L.E.4
  • 104
    • 0028209301 scopus 로고
    • Detection of glioma- associated gangliosides gm2, gd2, gd3, 30-isolm1 30,60-isold1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies
    • Wikstrand CJ, Fredman P, Svennerholm L, Bigner DD (1994) Detection of glioma- associated gangliosides GM2, GD2, GD3, 30-isoLM1 30,60-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies. Prog Brain Res 101:213–223
    • (1994) Prog Brain Res , vol.101 , pp. 213-223
    • Wikstrand, C.J.1    Fredman, P.2    Svennerholm, L.3    Bigner, D.D.4
  • 105
    • 13644266312 scopus 로고    scopus 로고
    • Caveolin-1 in oncogenic transformation, cancer, and metastasis
    • Williams TM, Lisanti MP (2005) Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol 288:C494–506
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. C494-C506
    • Williams, T.M.1    Lisanti, M.P.2
  • 108
    • 0029610984 scopus 로고
    • Expression of alpha 2,8-sialyltransferase (Gd3 synthase) gene in human cancer cell lines: High level expression in melanomas and up-regulation in activated t lymphocytes
    • Yamashiro S, Okada M, Haraguchi M, Furukawa K, Lloyd KO, Shiku H (1995) Expression of alpha 2,8-sialyltransferase (GD3 synthase) gene in human cancer cell lines: high level expression in melanomas and up-regulation in activated T lymphocytes. Glycoconj J 12:894–900
    • (1995) Glycoconj J , vol.12 , pp. 894-900
    • Yamashiro, S.1    Okada, M.2    Haraguchi, M.3    Furukawa, K.4    Lloyd, K.O.5    Shiku, H.6
  • 109
    • 28844438444 scopus 로고    scopus 로고
    • Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells
    • Yanagisawa M, Taga T, Nakamura K, Ariga T, Yu RK (2005) Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells. J Neurochem 95:1311–1320
    • (2005) J Neurochem , vol.95 , pp. 1311-1320
    • Yanagisawa, M.1    Taga, T.2    Nakamura, K.3    Ariga, T.4    Yu, R.K.5
  • 110
    • 0024146873 scopus 로고
    • Glycolipids and gliomas
    • Yates AJ (1988) Glycolipids and gliomas. Neurochem Pathol 8:157–180
    • (1988) Neurochem Pathol , vol.8 , pp. 157-180
    • Yates, A.J.1
  • 111
    • 0029073704 scopus 로고
    • Ganglioside modulation of the pdgf receptor. A model for ganglioside functions
    • Yates AJ, Saqr HE, Van Brocklyn J (1995) Ganglioside modulation of the PDGF receptor. A model for ganglioside functions. J Neurooncol 24:65–73
    • (1995) J Neurooncol , vol.24 , pp. 65-73
    • Yates, A.J.1    Saqr, H.E.2    Van Brocklyn, J.3
  • 112
    • 84880677140 scopus 로고    scopus 로고
    • Insights from mixture cure modeling of molecular markers for prognosis in breast cancer
    • Yilmaz YE, Lawless JF, Andrulis IL, Bull SB (2013) Insights from mixture cure modeling of molecular markers for prognosis in breast cancer. J Clin Oncol 31:2047–2054
    • (2013) J Clin Oncol , vol.31 , pp. 2047-2054
    • Yilmaz, Y.E.1    Lawless, J.F.2    Rulis, I.L.3    Bull, S.B.4
  • 113
    • 34447641458 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase is modulated by gm3 interaction with n-linked glcnac termini of the receptor
    • Yoon SJ, Nakayama K, Hikita T, Handa K, Hakomori SI (2005) Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. Proc Natl Acad Sci USA 103:18987–18991
    • (2005) Proc Natl Acad Sci USA , vol.103 , pp. 18987-18991
    • Yoon, S.J.1    Nakayama, K.2    Hikita, T.3    Handa, K.4    Hakomori, S.I.5
  • 114
    • 0036053357 scopus 로고    scopus 로고
    • An anti-gd2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via jnk (C-jun terminal kinase) activation
    • Yoshida S, Kawaguchi H, Sato S, Ueda R, Furukawa K (2002) An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn J Cancer Res 93:816–824
    • (2002) Jpn J Cancer Res , vol.93 , pp. 816-824
    • Yoshida, S.1    Kawaguchi, H.2    Sato, S.3    Ueda, R.4    Furukawa, K.5
  • 115
    • 0035872467 scopus 로고    scopus 로고
    • Ganglioside g(D2) in small cell lung cancer cell lines: Enhancement of cell proliferation and mediation of apoptosis
    • Yoshida S, Fukumoto S, Kawaguchi H, Sato S, Ueda R, Furukawa K (2001) Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. Cancer Res 61:4244–4252
    • (2001) Cancer Res , vol.61 , pp. 4244-4252
    • Yoshida, S.1    Fukumoto, S.2    Kawaguchi, H.3    Sato, S.4    Ueda, R.5    Furukawa, K.6
  • 116
    • 84872180204 scopus 로고    scopus 로고
    • Development of antibody therapeutics for small cell lung cancer
    • Zhan J, Han Q, Wang K (2013) Development of antibody therapeutics for small cell lung cancer. Expert Opin Investig Drugs 22:235–244
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 235-244
    • Zhan, J.1    Han, Q.2    Wang, K.3
  • 117
    • 33745806165 scopus 로고    scopus 로고
    • Metastatic potential of mouse lewis lung cancer cells is regulated via ganglioside gm1 by modulating the matrix metalloprotease-9 localization in lipid rafts
    • Zhang Q, Furukawa K, Chen HH, Sakakibara T, Urano T (2006) Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts. J Biol Chem 281:18145–18155
    • (2006) J Biol Chem , vol.281 , pp. 18145-18155
    • Zhang, Q.1    Furukawa, K.2    Chen, H.H.3    Sakakibara, T.4    Urano, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.