Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

Neuro-Oncology

Volumn 18, Issue 1, 2016, Pages 58-69

  Van Der Vos, Kristan E ^a,b   Abels, Erik R ^a   Zhang, Xuan ^a   Lai, Charles ^a   Carrizosa, Esteban ^a   Oakley, Derek ^a   Prabhakar, Shilpa ^a   Mardini, Osama ^a   Crommentuijn, Matheus H W ^a   Skog, Johan ^a   Krichevsky, Anna M ^a   Stemmer Rachamimov, Anat ^a   Mempel, Thorsten R ^a   El Khoury, Joseph ^a   Hickman, Suzanne E ^a   Breakefield, Xandra O ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

brain tumors; exosomes; extracellular vesicles; microglia; microRNA

Indexed keywords

CELL PROTEIN; CYTOKINE; MESSENGER RNA; MICRORNA; MICRORNA 21; MICRORNA 451; TRANSFER RNA; UNCLASSIFIED DRUG; MIRN21 MICRORNA, HUMAN; MIRN451 MICRORNA, HUMAN; MYC PROTEIN; MYC PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MONITORING; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; EXOSOME; GENE TARGETING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VIVO STUDY; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NEWBORN; NONHUMAN; ONCOGENE C MYC; PHENOTYPE; PRIMARY TUMOR; PROTEIN ANALYSIS; RNA ANALYSIS; ANIMAL; BRAIN; BRAIN TUMOR; C57BL MOUSE; METABOLISM; MULTIPHOTON MICROSCOPY; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; EXTRACELLULAR VESICLES; GLIOBLASTOMA; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROGLIA; MICRORNAS; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84960442277     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nov244     Document Type: Article

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