Conditional deletion of Hsd11b2 in the brain causes salt appetite and hypertension

Circulation

Volumn 133, Issue 14, 2016, Pages 1360-1370

  Evans, Louise C ^a,c   Ivy, Jessica R ^a   Wyrwoll, Caitlin ^a,d   McNairn, Julie A ^a   Menzies, Robert I ^a   Christensen, Thorbjørn H ^a,e   Al Dujaili, Emad A S ^b   Kenyon, Christopher J ^a   Mullins, John J ^a   Seckl, Jonathan R ^a   Holmes, Megan C ^a   Bailey, Matthew A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b QUEEN MARGARET UNIVERSITY   (United Kingdom)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

aldosterone; mineralocorticoids; pressoreceptors; salt; solitary nucleus

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; DEXAMETHASONE; MINERALOCORTICOID RECEPTOR; CORTICOSTERONE; HSD11B2 PROTEIN, MOUSE; MESSENGER RNA; MINERALOCORTICOID ANTAGONIST; NERVE PROTEIN; NES PROTEIN, RAT; NESTIN; POTASSIUM; SALT INTAKE; SPIRONOLACTONE; SYNTHETIC DNA;

11BETA HYDROXYSTEROID DEHYDROGENASE 2 DEFICIENCY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APPARENT MINERALOCORTICOID EXCESS SYNDROME; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; HYPERTENSION; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROMOTER REGION; SALT INTAKE; SODIUM APPETITE; SODIUM BALANCE; SODIUM INTAKE; SODIUM RETENTION; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CRAVING; DEFICIENCY; DRINKING BEHAVIOR; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MINERALOCORTICOID EXCESS SYNDROME, APPARENT; NEPHRON; NERVE CELL; PATHOLOGICAL REFLEX; PATHOPHYSIOLOGY; PHYSIOLOGY; SOLITARY TRACT NUCLEUS; TOXICITY; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; BAROREFLEX; CORTICOSTERONE; CRAVING; DEXAMETHASONE; DRINKING BEHAVIOR; GENES, SYNTHETIC; HYPERTENSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MINERALOCORTICOID EXCESS SYNDROME, APPARENT; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NEPHRONS; NERVE TISSUE PROTEINS; NESTIN; NEURONS; POTASSIUM; RECEPTORS, MINERALOCORTICOID; REFLEX, ABNORMAL; RNA, MESSENGER; SODIUM CHLORIDE, DIETARY; SOLITARY NUCLEUS; SPIRONOLACTONE;

EID: 84960435245     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.019341     Document Type: Article

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