Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study

Journal of Steroid Biochemistry and Molecular Biology

Volumn 158, Issue , 2016, Pages 149-156

  Sapkota, Bishwa R ^a   Hopkins, Ruth ^a   Bjonnes, Andrew ^f   Ralhan, Sarju ^c   Wander, Gurpreet S ^c   Mehra, Narinder K ^d   Singh, Jai Rup ^e   Blackett, Piers R ^a   Saxena, Richa ^f   Sanghera, Dharambir K ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c Hero DMC Heart Institute   (India)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^e CENTRAL UNIVERSITY OF PUNJAB   (India)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

25(OH)D levels (ELISA); Genome wide association study; Punjabi Sikhs; Type 2 diabetes; Vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; HEPATOCYTE NUCLEAR FACTOR 3BETA; HYDROXYCOLECALCIFEROL;

ARTICLE; ASIAN; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEALTH DISPARITY; HISPANIC; HUMAN; INDIAN; IVL GENE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRINCIPAL COMPONENT ANALYSIS; PUNJABI (PEOPLE); SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; AGED; BLOOD; CASE CONTROL STUDY; CAUCASIAN; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; INDIA; MALE; MIDDLE AGED;

ADULT; AGED; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; HYDROXYCHOLECALCIFEROLS; INDIA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84960406058     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.12.014     Document Type: Article

References (44)

1. M.F. Hollick, and T.C. Chen Vitamin D deficiency a worldwide problem with health consequences Am. J. Clin. Nutr. 87 2008 10805 10868
2. P. Autier, M. Boniol, C. Pizot, and P. Mullie Vitamin D status and ill health: a systematic review Lancet Diabetes Endocrinol. 2 1 2014 76 89
3. C.V. Harinarayan, T. Ramalakshmi, and U. Venkataprasad High prevalence of low dietary calcium and low vitamin D status in healthy south Indians Asia Pac. J. Clin. Nutr. 13 4 2004 359 364
4. T.R. Braun, L.F. Been, P.R. Blackett, and D.K. Sanghera Vitamin D deficiency and cardio-metabolic risk in a North Indian Community with highly prevalent type 2 diabetes J. Diabetes Metab. 3 2012 213
5. M. Wjst, J. Altmuller, C. Braig, M. Bahnweg, and E. Andre A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families J. Steroid Biochem. Mol. Biol. 103 3-5 2007 799 802
6. F.X. Bu, L. Armas, J. Lappe, Y. Zhou, G. Gao, H.W. Wang, and et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects Hum. Genet. 128 5 2010 549 556
7. D. Hunter, M. De Lange, H. Snieder, A.J. MacGregor, R. Swaminathan, R.V. Thakker, and et al. Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation J. Bone Miner. Res. 16 2 2001 371 378
8. S.V. Ramagopalan, A. Heger, A.J. Berlanga, N.J. Maugeri, M.R. Lincoln, and A. Burrell A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution Genome Res. 20 10 2010 1352 1360
9. J. Ahn, K. Yu, R. Stolzenberg-Solomon, K.C. Simon, M.L. McCullough, L. Gallicchio, and et al. Genome-wide association study of circulating vitamin D levels Hum. Mol. Genet. 19 13 2010 2739 2745
10. T.J. Wang, F. Zhang, J.B. Richards, B. Kestenbaum, J.B. van Meurs, D. Berry, and et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study Lancet 376 9736 2010 180 188
11. R. Saxena, D. Saleheen, L.F. Been, M.L. Garavito, T. Braun, A. Bjonnes, and et al. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India Diabetes 62 5 2013 1746 1755
12. R. Saxena, A. Bjonnes, J. Prescott, P. Dib, P. Natt, J. Lane, and et al. Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort Circ. Cardiovasc. Genet. 7 3 2014 287 295
13. A.D.A. Guidlines Diagnosis and classification of diabetes mellitus Diabetes Care 27 Suppl. 1 2004 S5 S10
14. W.E. Panel Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies Lancet 363 9403 2004 157 163
15. L.F. Been, J.L. Hatfield, A. Shankar, C.E. Aston, S. Ralhan, G.S. Wander, and et al. A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity Nutr. Metab. Cardiovasc. Dis. 22 11 2012 944 951
16. D.K. Sanghera, L. Ortega, S. Han, J. Singh, S.K. Ralhan, G.S. Wander, and et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk BMC Med. Genet. 9 2008 59
17. D.K. Sanghera, F.Y. Demirci, L. Been, L. Ortega, S. Ralhan, G.S. Wander, and et al. PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor Metabolism 59 4 2010 492 501
18. H.S. Kahn, T.M. Morgan, L.D. Case, D. Dabelea, E.J. Mayer-Davis, J.M. Lawrence, and et al. Association of type 1 diabetes with month of birth among U.S. youth: the search for diabetes in youth study Diabetes Care 32 11 2009 2010 2015
19. J.L. Vacek, S.R. Vanga, M. Good, S.M. Lai, D. Lakkireddy, and P.A. Howard Vitamin D deficiency and supplementation and relation to cardiovascular health Am. J. Cardiol. 109 3 2012 359 363
20. A. Deleskog, A. Hilding, K. Brismar, A. Hamsten, S. Efendic, and C.G. Ostenson Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance Diabetologia 55 6 2012 1668 1678
21. L. Yan, B. Zhou, X. Wang, S. D'Ath, A. Laidlaw, M.A. Laskey, and et al. Older people in China and the United Kingdom differ in the relationships among parathyroid hormone, vitamin D, and bone mineral status Bone 33 4 2003 620 627
22. E.M. Awumey, D.A. Mitra, B.W. Hollis, R. Kumar, and N.H. Bell Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study J. Clin. Endocrinol. Metab. 83 1 1998 169 173
23. S.S. Harris Vitamin D and African Americans J. Nutr. 136 4 2006 1126 1129
24. C.W. Lo, P.W. Paris, and M.F. Holick Indian and Pakistani immigrants have the same capacity as Caucasians to produce vitamin D in response to ultraviolet irradiation Am. J. Clin. Nutr. 44 5 1986 683 685
25. C.D. Engelman, K.J. Meyers, J.T. Ziegler, K.D. Taylor, N.D. Palmer, S.M. Haffner, and et al. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study J. Steroid Biochem. Mol. Biol. 122 4 2010 186 192
26. J. Jensen Gene regulatory factors in pancreatic development Dev. Dyn. 229 1 2004 176 200
27. C.S. Lee, J.R. Friedman, J.T. Fulmer, and K.H. Kaestner The initiation of liver development is dependent on Foxa transcription factors Nature 435 7044 2005 944 947
28. K.A. Lantz, M.Z. Vatamaniuk, J.E. Brestelli, J.R. Friedman, F.M. Matschinsky, and K.H. Kaestner Foxa2 regulates multiple pathways of insulin secretion J. Clin. Invest. 114 4 2004 512 520
29. V. Lamba, J.C. Panetta, S. Strom, and E.G. Schuetz Genetic predictors of interindividual variability in hepatic CYP3A4 expression J. Pharmacol. Exp. Ther. 332 3 2010 1088 1099
30. R. Tabassum, S. Chavali, O.P. Dwivedi, N. Tandon, and D. Bharadwaj Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians J. Hum. Genet. 53 11-12 2008 957 965
31. M.E. Johnson, J. Schug, A.D. Wells, K.H. Kaestner, and S.F. Grant Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits J. Clin. Endocrinol. Metab. 99 8 2014 E1580 E1585
32. K. Fulzele, R.C. Riddle, D.J. DiGirolamo, X. Cao, C. Wan, D. Chen, and et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition Cell 142 2 2010 309 319
33. M. Ferron, J. Wei, T. Yoshizawa, A. Del Fattore, R.A. DePinho, A. Teti, and et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 2 2010 296 308
34. Y. Yoshikawa, A. Kode, L. Xu, I. Mosialou, B.C. Silva, M. Ferron, and et al. Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism J. Bone Miner. Res. 26 9 2011 2012 2025
35. J.M. Tonne, T. Sakuma, M.C. Deeds, M. Munoz-Gomez, M.A. Barry, and Y.C. Kudva Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced beta-cell damage and pancreatic Glp-1 gene therapy Dis. Model Mech. 6 5 2013 1236 1245
36. J. Hosomi, J. Hosoi, E. Abe, T. Suda, and T. Kuroki Regulation of terminal differentiation of cultured mouse epidermal cells by 1 alpha, 25-dihydroxyvitamin D3 Endocrinology 113 6 1983 1950 1957
37. D.D. Bikle, D. Ng, Y. Oda, K. Hanley, K. Feingold, and Z. Xie The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3 J. Invest. Dermatol. 119 5 2002 1109 1113
38. W.E. Stumpf, M. Sar, F.A. Reid, Y. Tanaka, and H.F. DeLuca Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid Science 206 4423 1979 1188 1190
39. J. Zhang, W. Li, J. Liu, W. Wu, H. Ouyang, and Q. Zhang Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: an update by meta-analysis Mol. Cell. Endocrinol. 355 1 2012 135 142
40. J.A. Randerson-Moor, J.C. Taylor, F. Elliott, Y.M. Chang, S. Beswick, K. Kukalizch, and et al. Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data Eur. J. Cancer 45 18 2009 3271 3281
41. G.R. Ji, M. Yao, C.Y. Sun, Z.H. Li, Z. Han, and TaqI BsmI ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis Bone 47 3 2010 681 686
42. L. Gao, Y. Tao, L. Zhang, and Q. Jin Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis Int. J. Tuberc. Lung Dis. 14 1 2010 15 23
43. Y.H. Lee, S.C. Bae, S.J. Choi, J.D. Ji, and G.G. Song Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis Mol. Biol. Rep. 38 6 2011 3643 3651
44. A.R. Webb, L. Kline, and M.F. Holick Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin J. Clin. Endocrinol. Metab. 67 2 1988 373 378