Genome-Wide Association Study Identifies Variants in Casein Kinase II (CSNK2A2) to be Associated With Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort

Circulation: Cardiovascular Genetics

Volumn 7, Issue 3, 2014, Pages 287-295

  Saxena, Richa ^a,c   Bjonnes, Andrew ^a,c   Prescott, Jennifer ^b,e   Dib, Patrick ^d   Natt, Praveen ^d   Lane, Jacqueline ^a,c   Lerner, Megan ^d   Cooper, Jackie A ^f   Ye, Yuanqing ^g   Li, Ka Wah ^f   Maubaret, Cécilia G ^f   Codd, Veryan ^h   Brackett, Daniel ^d   Mirabello, Lisa ⁱ   Kraft, Peter ^e   Dinney, Colin P ^g   Stowell, Donald ^d   Peyton, Marvin ^d   Ralhan, Sarju ^j   Wander, Gurpreet S ^j   Mehra, Narinder K ^k   Salpea, Klelia D ^d,f   Gu, Jian ^g   Wu, Xifeng ^g   Mangino, Massimo ^h   Hunter, David J ^b,c,e   De Vivo, Immaculata ^b,e   Humphries, Steve E ^f   Samani, Nilesh J ^h   Spector, Tim D ^h   Savage, Sharon A ⁱ   Sanghera, Dharambir K ^d   more..

^a Center for Human Genetic Research   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h Cardiovascular Genetics BHF Laboratories Institute Cardiovascular Sciences University College London ^*  (United Kingdom)

ⁱ NATIONAL CANCER INSTITUTE   (United States)

^j Hero DMC Heart Institute   (India)

^k ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

more..

Author keywords

Cardiovascular diseases; Diabetes mellitus; Genome wide association study; Telomere length; Type 2

Indexed keywords

CASEIN KINASE II; TELOMERIC REPEAT BINDING FACTOR 1;

ARTICLE; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CHROMOSOME; CHROMOSOME 16Q; DIABETES MELLITUS; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HEART DISEASE; HUMAN; LEUKOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TELOMERE; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT ANALYSIS; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; INDIA; MALE; META ANALYSIS; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; RELIGION; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASEIN KINASE II; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INDIA; LEUKOCYTES; MALE; MIDDLE AGED; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RELIGION; TELOMERE; YOUNG ADULT;

EID: 84903588606     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000412     Document Type: Article

References (53)

1. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet. 2001;358:472-473.
2. Valdes AM, Richards JB, Gardner JP, Swaminathan R, Kimura M, Xiaobin L, et al. Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporos Int. 2007;18:1203-1210.
3. Thomas P, O' Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev. 2008;129:183-190.
4. Tentolouris N, Nzietchueng R, Cattan V, Poitevin G, Lacolley P, Papazafiropoulou A, et al. White blood cells telomere length is shorter in males with type 2 diabetes and microalbuminuria. Diabetes Care. 2007;30:2909-2915.
5. Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, et al; West of Scotland Coronary Prevention Study Group. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369:107-114.
6. Sanders JL, Newman AB. Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35:112-131.
7. Mather KA, Jorm AF, Parslow RA, Christensen H. Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci. 2011;66:202-213.
8. Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, Effros R, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 1993;52:661-667.
9. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, et al. Telomere length in the newborn. Pediatr Res. 2002;52:377-381.
10. Carroll JE, Diez-Roux AV, Adler NE, Seeman TE. Socioeconomic factors and leukocyte telomere length in a multi-ethnic sample: findings from the multi-ethnic study of atherosclerosis (MESA). Brain Behav Immun. 2013;28:108-114.
11. Diez Roux AV, Ranjit N, Jenny NS, Shea S, Cushman M, Fitzpatrick A, et al. Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis. Aging Cell. 2009;8:251-257.
12. Adaikalakoteswari A, Balasubramanyam M, Mohan V. Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med. 2005;22:1151-1156.
13. Salpea KD, Talmud PJ, Cooper JA, Maubaret CG, Stephens JW, Abelak K, et al. Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis. 2010;209:42-50.
14. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, Aviv A. Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension. 2000;36:195-200.
15. Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, Lu X, et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet. 2006;78:480-486.
16. Aviv A. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res. 2012;730:68-74.
17. Mangino M, Richards JB, Soranzo N, Zhai G, Aviv A, Valdes AM, et al. A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. J Med Genet. 2009;46:451-454.
18. Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010;107:9293-9298.
19. Prescott J, Kraft P, Chasman DI, Savage SA, Mirabello L, Berndt SI, et al. Genome-wide association study of relative telomere length. PLoS One. 2011;6:e19635.
20. Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, et al; Wellcome Trust Case Control Consortium. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010;42:197-199.
21. Harte AL, da Silva NF, Miller MA, Cappuccio FP, Kelly A, O'Hare JP, et al. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. Exp Diabetes Res. 2012;2012:895185.
22. Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, et al DIAGRAM; MuTHER; AGEN. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes. 2013;62:1746-1755.
23. Diagnosis and classification of diabetes mellitus. Diab care. 2004;27(suppl 1):S5-S10.
24. Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet. 2008;9:59.
25. Schierer A, Been LF, Ralhan S, Wander GS, Aston CE, Sanghera DK. Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort. Pharmacogenet Genomics. 2012;22:95-104.
26. Sanghera DK, Been LF, Ralhan S, Wander GS, Mehra NK, Singh JR, et al. Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study. PLoS One. 2011;6:e21188.
27. Sanghera DK, Been L, Ortega L, Wander GS, Mehra NK, Aston CE, et al. Testing the association of novel meta-Analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. J Hum Genet. 2009;54:162-168.
28. Braun TR BL, Blackett PR, Sanghera DK. Vitamin d deficiency and cardio-metabolic risk in a north indian community with highly prevalent type 2 diabetes. J Diabetes Metab. 2012;3: 213.
29. Sanghera DK, Nath SK, Ortega L, Gambarelli M, Kim-Howard X, Singh JR, et al. TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels. Ann Hum Genet. 2008;72(pt 4):499-509.
30. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
31. Salpea KD, Nicaud V, Tiret L, Talmud PJ, Humphries SE; EARS II Group. The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II. J Mol Med (Berl). 2008;86:815-824.
32. Gu J, Chen M, Shete S, Amos CI, Kamat A, Ye Y, et al. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila). 2011;4:514-521.
33. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45:422-427, 427e1.
34. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559-575.
35. Nalls MA, Simon-Sanchez J, Gibbs JR, Paisan-Ruiz C, Bras JT, Tanaka T, et al. Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics. PLoS Genet. 2009;5:e1000415.
36. Marchini J, Howie B, Myers S, McVean G, Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet. 2007;39:906-913.
37. Howie B, Marchini J, Stephens M. Genotype imputation with thousands of genomes. Genes, Genom, Genet 2011;1:457-470.
38. Marchini J, Howie B. Genotype imputation for genome-wide association studies. Nat Rev Genet. 2010;11:499-511.
39. Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, et al. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491:56-65.
40. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-Analysis of genomewide association scans. Bioinformatics. 2010;26:2190-2191.
41. Han B, Eskin E. Interpreting meta-Analyses of genome-wide association studies. PLoS Genet. 2012;8:e1002555.
42. Bhattacharjee S, Rajaraman P, Jacobs KB, Wheeler WA, Melin BS, Hartge P, et al; GliomaScan Consortium. A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits. Am J Hum Genet. 2012;90:821-835.
43. Wang YY, Chen AF, Wang HZ, Xie LY, Sui KX, Zhang QY. Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease. Aging Male. 2011;14:27-32.
44. Zee RY, Castonguay AJ, Barton NS, Germer S, Martin M. Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study. Transl Res. 2010;155:166-169.
45. Mukherjee M, Brouilette S, Stevens S, Shetty KR, Samani NJ. Association of shorter telomeres with coronary artery disease in Indian subjects. Heart. 2009;95:669-673.
46. Ruzzene M, Penzo D, Pinna LA. Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem J. 2002;364(pt 1):41-47.
47. Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J. 2003;369(pt 1):1-15.
48. Oganesian L, Karlseder J. Telomeric armor: the layers of end protection. J Cell Sci. 2009;122(pt 22):4013-4025.
49. Kim MK, Kang MR, Nam HW, Bae YS, Kim YS, Chung IK. Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J Biol Chem. 2008;283:14144-14152.
50. Gao Y, Wang HY. Casein kinase 2 Is activated and essential for Wnt/betacatenin signaling. J Biol Chem. 2006;281:18394-18400.
51. Sanghera DK, Bhatti JS, Bhatti GK, Ralhan SK, Wander GS, Singh JR, et al. The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial results. Hum Biol. 2006;78:43-63.
52. Yang Z, Ye J, Li C, Zhou D, Shen Q, Wu J, et al. Drug addiction is associated with leukocyte telomere length. Sci Rep. 2013;3:1542.
53. Drury SS, Theall K, Gleason MM, Smyke AT, De Vivo I, Wong JY, et al. Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry. 2012;17:719-727.