Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion

Experimental Brain Research

Volumn 234, Issue 4, 2016, Pages 1057-1065

  Wang, Yiheng ^a   Ni, Hongxia ^b   Zhang, Wenrui ^c   Wang, Xiu ^c   Zhang, Haishan ^a  

^a JILIN UNIVERSITY   (China)

^b BEIHUA UNIVERSITY   (China)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Anesthesia; Apoptosis; BDNF; Dorsal root ganglion; miRNA; Neurotoxicity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BUPIVACAINE; MICRORNA; MICRORNA 132; MICRORNA 137; MICRORNA 210; MICRORNA 222; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; LOCAL ANESTHETIC AGENT; MIRN210 MICRORNA, MOUSE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BUPIVACAINE INDUCED NEUROTOXICITY; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NERVE FIBER GROWTH; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL GANGLION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CELLS, CULTURED; DOWN-REGULATION; GANGLIA, SPINAL; MICE; MICE, INBRED C57BL; MICRORNAS;

EID: 84960400280     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/s00221-015-4513-4     Document Type: Article

References (26)

1. Boyce VS, Mendell LM (2014) Neurotrophic factors in spinal cord injury. Handb Exp Pharmacol 220:443–460
2. Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Ragoussis J (2008) hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 14(5):1340–1348
3. Chio CC, Lin JW, Cheng HA, Chiu WT, Wang YH, Wang JJ, Hsing CH, Chen RM (2013) MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells. Arch Toxicol 87(3):459–468
4. Cui C, Xu G, Qiu J, Fan X (2015) Up-regulation of miR-26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting PTEN in bupivacaine injured mouse dorsal root ganglia. Cell Biol Int 39(8):933–942
5. Deng YS, Zhong JH, Zhou XF (2000) BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats. Neurotox Res 1(4):311–322
6. Drummond JC (2015) Early childhood anesthetic neurotoxicity and unmeasured covariates: there’s the RUB. Anesthesiology 122(1):216–217
7. Fasanaro P, Greco S, Lorenzi M, Pescatori M, Brioschi M, Kulshreshtha R, Banfi C, Stubbs A, Calin GA, Ivan M et al (2009) An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem 284(50):35134–35143
8. Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K, Li C, O’Brien-Jenkins A, Katsaros D, Weber BL et al (2008) miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 7(2):255–264
9. Gunter JB (2002) Benefit and risks of local anesthetics in infants and children. Paediatr Drugs 4(10):649–672
10. Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677–736
11. Ma R, Wang X, Lu C, Li C, Cheng Y, Ding G, Liu L, Ding Z (2010) Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism. Neuroscience 167(2):329–342
12. Martinez-Levy GA, Cruz-Fuentes CS (2014) Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system. Yale J Biol Med 87(2):173–186
13. Miller FD, Kaplan DR (2001) Neurotrophin signalling pathways regulating neuronal apoptosis. Cell Mol Life Sci 58(8):1045–1053
14. Miska EA (2005) How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 15(5):563–568
15. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ (2005) Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 84(9):852–857
16. Radwan IA, Saito S, Goto F (2002) The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine bupivacaine mepivacaine and ropivacaine. Anesth Analg 94(2):319–324
17. Sebert ME, Shooter EM (1993) Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury. J Neurosci Res 36(4):357–367
18. Shen KF, Crain SM (1989) Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. Brain Res 491(2):227–242
19. Tal TL, Tanguay RL (2012) Non-coding RNAs—novel targets in neurotoxicity. Neurotoxicology 33(3):530–544
20. Tong M, Brugeaud A, Edge AS (2013) Regenerated synapses between postnatal hair cells and auditory neurons. J Assoc Res Otolaryngol 14(3):321–329
21. Twaroski D, Bosnjak ZJ, Bai X (2015) MicroRNAs: new players in anesthetic-induced developmental neurotoxicity. Pharm Anal Acta 6:357
22. Wang X, Zhang X, Cheng Y, Li C, Zhang W, Liu L, Ding Z (2010) Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3 K/Akt-dependent mechanism. Neurotoxicology 31(1):101–112
23. Weishaupt N, Blesch A, Fouad K (2012) BDNF: the career of a multifaceted neurotrophin in spinal cord injury. Exp Neurol 238(2):254–264
24. Zhao G, Ding X, Guo Y, Chen W (2014) Intrathecal lidocaine neurotoxicity: combination with bupivacaine and ropivacaine and effect of nerve growth factor. Life Sci 112(1–2):10–21
25. Zhou S, Shen D, Wang Y, Gong L, Tang X, Yu B, Gu X, Ding F (2012) microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection. PLoS ONE 7(9):e44768
26. Ziu M, Fletcher L, Savage JG, Jimenez DF, Digicaylioglu M, Bartanusz V (2014) Spatial and temporal expression levels of specific microRNAs in a spinal cord injury mouse model and their relationship to the duration of compression. Spine J 14(2):353–360