Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels

Metabolism: Clinical and Experimental

Volumn 65, Issue 4, 2016, Pages 463-474

  Huang, Qian ^a   Chen, Yuan ^a   Gong, Nian ^a   Wang, Yong Xiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Diabetic neuropathic pain; Methylglyoxal; Methylglyoxal scavengers; Nav1.8; TRPA1

Indexed keywords

A 803467; A 967079; AMINOGUANIDINE; ANALGESIC AGENT; DEXTRO ARGININE; FORMALDEHYDE; GABAPENTIN; GLUCOSE; METFORMIN; METHYLGLYOXAL; SODIUM CHANNEL NAV1.8; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ANTIDIABETIC AGENT; FURAN DERIVATIVE; GLUCOSE BLOOD LEVEL; OXIME; SCN10A PROTEIN, RAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPA1 PROTEIN, RAT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HIND PAW; HYPERALGESIA; INCUBATION TIME; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; COMPLICATION; DIABETIC NEUROPATHY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; NEURALGIA; PAIN MEASUREMENT; WISTAR RAT;

ANALGESICS; ANILINE COMPOUNDS; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; FURANS; HYPERALGESIA; HYPOGLYCEMIC AGENTS; MALE; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; NEURALGIA; OXIMES; PAIN MEASUREMENT; PYRUVALDEHYDE; RATS; RATS, WISTAR; TRPC CATION CHANNELS;

EID: 84960397195     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.12.002     Document Type: Article

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