Povidone-iodine ointment demonstrates in vitro efficacy against biofilm formation

International Wound Journal

Volumn 14, Issue 1, 2017, Pages 172-179

  Hoekstra, Matthias J ^a   Westgate, Samantha J ^b   Mueller, Stefan ^c  

^a Burns Research Institute   (Netherlands)

^b SciTech Daresbury   (United Kingdom)

^c MUNDIPHARMA GMBH   (Germany)

Author keywords

Biofilm; Candida albicans; Methicillin resistant Staphylococcus aureus (MRSA); Povidone iodine ointment (PVP I); Pseudomonas aeruginosa

Indexed keywords

BACITRACIN; BETAINE; CHLORHEXIDINE GLUCONATE; FUSIDIC ACID; OCTENIDINE; PHOSPHATE BUFFERED SALINE; POVIDONE IODINE; PSEUDOMONIC ACID; ANTIINFECTIVE AGENT; TOPICAL ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BIOFILM; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; OINTMENT; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; DRUG EFFECTS; HUMAN;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; BIOFILMS; CANDIDA ALBICANS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; POVIDONE-IODINE; PSEUDOMONAS AERUGINOSA;

EID: 84960357451     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/iwj.12578     Document Type: Article

References (51)

1. Crovetti G, Martinelli G, Issi M, Barone M, Guizzard M, Campanati B, Moroni M, Carabelli A. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci 2004;30:145–51.
2. Falanga V. The chronic wound: impaired healing and solutions in the context of wound bed preparation. Blood Cells Mol Dis 2004;32:88–94.
3. Bryant RA, Nix DP. Acute and chronic wounds: current management concepts, 4th edn. Mosby, Elsevier, 2011.
4. Dow G, Browne A, Sibbald RG. Infection in chronic wounds: controversies in diagnosis and treatment. Ostomy Wound Manage 1999;45:23–7, 29–40; quiz 41–2.
5. Kingsley A. The wound infection continuum and its application to clinical practice. Ostomy Wound Manage 2003;49(Suppl. 7A):1–7.
6. Costerton JW, Geesey GG, Cheng KJ. How bacteria stick. Sci Am 1978;238:86–95.
7. Cooper R, Okhiria O. Biofilms, wound infection and the issue of control. Wounds UK 2006;2:48–56.
8. Ceri H, Olson ME, Stremick C, Read RR, Morck D, Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol 1999;37:1771–6.
9. Kramer A et al. Polypragmasia in the therapy of infected wounds - conclusions drawn from the perspectives of low temperature plasma technology for plasma wound therapy. GMS Krankenhhyg Interdiszip 2008;3:Doc13.
10. Driffield K, Woodmansey E., Floyd H, The use of silver-containing dressings to prevent biofilm formation by single and mixed bacterial flora. Poster presentation #285, EMWA, 2008.
11. Kunisada T, Yamada K, Oda S, et al. Investigation on the efficacy of povidone-iodine against antiseptic-resistant species. Dermatology 1997;195(2 Suppl):14–8.
12. Akiyama H, Oono T, Saito M. Assessment of cadexomer iodine against Staphylococcus aureus biofilm in vivo and in vitro using confocal laser scanning microscopy. J Dermatol 2004;31:529–34.
13. Garnes AL, Davidson E, Taylor LE, et al. Clinical evaluation of povidone-iodine aerosol spray in surgical practice. Am J Surg 1959;97:49–53.
14. Fleischer W, Reimer K. Povidone-iodine in antisepsis – state of the art. Dermatology 1997;195(2 Suppl):3–9.
15. Lanker KB, Widmer HR, Frey F. Nondevelopment of resistance by bacteria during hospital use of povidone-iodine. Dermatology 1997;195(Suppl. 2):10–3.
16. Drosou A, Falabella A, Kirsner RS. Antiseptics on wounds: an area of controversy. Wounds 2003;15:149–66.
17. Mertz PM, Oliveira-Gandia MF, Davis SC. The evaluation of a cadexomer iodine wound dressing on methicillin resistant Staphylococcus aureus (MRSA) in acute wounds. Dermatol Surg 1999;25:89–93.
18. Danielsen L, Cherry GW, Harding K, et al. Cadexomer iodine in ulcers colonised by Pseudomonas aeruginosa. J Wound Care 1997;6:169–72.
19. Cooper RA. Iodine revisited. Int Wound J 2007;4:124–37.
20. Fumal I, Braham C, Paquet P, et al. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology 2002;204(Suppl. 1):70–4.
21. Bennett LL, Rosenblum RS, Perlov C, et al. An in vivo comparison of topical agents on wound repair. Plast Reconstr Surg 2001;108:675–87.
22. Beukelman CJ, van den Berg AJ, Hoekstra MJ, et al. Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel) for wound healing in vitro. Burns 2008;34:845–55.
23. Konig B, Reimer K, Fleischer W, et al. Effects of Betaisodona on parameters of host defense. Dermatology 1997;195(2 Suppl):42–8.
24. Eming SA, Smola-Hess S, Kurschat P, et al. A novel property of povidon-iodine: inhibition of excessive protease levels in chronic non-healing wounds. J Invest Dermatol 2006;126:2731–3.
25. Damour O, Hua SZ, Lasne F, et al. Cytotoxicity evaluation of antiseptics and antibiotics on cultured human fibroblasts and keratinocytes. Burns 1992;18:479–85.
26. Vehmeyer-Heeman M, Van den Kerckhove E, Gorissen K, et al. Povidone-iodine ointment: no effect of split skin graft healing time. Burns 2005;31:489–94.
27. Vogt PM, Hauser J, Rossbach O, et al. Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepis. A new concept in wound therapy. Wound Repair Regen 2001;9:116–22.
28. Vogt PM, Reimer K, Hauser J, et al. PVP-iodine in hydrosomes and hydrogel – a novel concept in wound therapy leads to enhanced epithelialization and reduced loss of skin grafts. Burns 2006;32:698–705.
29. ASTM International. ASTM E2871-13: Standard test method for evaluating disinfectant efficacy against Pseudomonas aeruginosa biofilm grown in CDC biofilm reactor using the single tube method, West Conshohocken, PA, USA, 2013.
30. ASTM International. ASTM E2647-13: Standard test method for quantification of Pseudomonas aeruginosa biofilm grown using drip flow biofilm reactor with low shear and continuous flow, West Conshohocken, PA, USA, 2013.
31. ASTM International. ASTM E2799-12: Standard test method for testing disinfectant efficacy against Pseudomonas aeruginosa biofilm using the MBEC assay, West Conshohocken, PA, USA, 2012.
32. Dobie D, Gray J. Fusidic acid resistance in Staphylococcus aureus. Arch Dis Child 2004;89:74–7.
33. Brown EM, Thomas P. Fusidic acid resistance in Staphylococcus aureus isolates. Lancet 2002;359:803.
34. Brown EM, Wise R. Fusidic acid cream for impetigo. Fusidic acid should be used with restraint. BMJ 2002;324:1394.
35. Owen SE, Cheesbrough JS. Fusidic acid cream for impetigo. Findings cannot be extrapolated. BMJ 2002;324:1394.
36. Zadik P, Young N. Fusidic acid cream for impetigo. Resistance trends must be monitored. BMJ 2002;324:1394.
37. Stoddart B, Collyns T, Denton M. Fusidic acid cream for impetigo. Problem may be clinically important. BMJ 2002;324:1394.
38. Weston VC, Boswell TC, Finch RG, et al. Fusidic acid cream for impetigo. Emergence of resistance to fusidic acid limits its use. BMJ 2002;324:1394.
39. Romanelli M, Dini V, Barbanera S, et al. Evaluation of the efficacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation. Skin Pharmacol Physiol 2010;23(Suppl):41–4.
40. Minnich KE, Stolarick R, Wilkins RG, et al. The effect of a wound care solution containing polyhexanide and betaine on bacterial counts: results of an in vitro study. Ostomy Wound Manage 2012;58:32–6.
41. Suzuki M, Yamada K, Nagao M, et al. Antimicrobial ointments and methicillin-resistant Staphylococcus aureus USA300. Emerg Infect Dis 2011;17:1917–20.
42. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds 2008;20:171–5.
43. Hughes J, Mellows G. Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid. Biochem J 1978;176:305–18.
44. Patel JB, Gorwitz RJ, Jernigan JA. Mupirocin resistance. Clin Infect Dis 2009;49:935–41.
45. Hadiati DR, Hakimi M, Nurdiati DS, et al. Skin preparation for preventing infection following caesarean section. Cochrane Database Syst Rev 2014;9:CD007462.
46. Eisenbeiß W, Siemers F, Amtsberg G, et al. Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma 2012;2:71–9.
47. Laato M, Niinikoski J, Lundberg C, et al. Inflammatory reaction and blood flow in experimental wounds inoculated with Staphylococcus aureus. Eur Surg Res 1988;20:33–8.
48. Wall IB, Davies CE, Hill KE, et al. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair Regen 2002;10:346–53.
49. Bowler PG. The 10(5) bacterial growth guideline: reassessing its clinical relevance in wound healing. Ostomy Wound Manage 2003;49:44–53.
50. Beuth. Chemical disinfectants and antiseptics – Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in food, industrial, domestic and institutional areas – Test method and requirements (phase 2, step 1) English version of DIN EN 1276:2010-01. DIN EN 1276, 2010.
51. Percival SL, Finnegan S, Donelli G, et al. Antiseptics for treating infected wounds: efficacy on biofilms and effect of pH. Crit Rev Microbiol 2016;42:293–309.