A novel property of povidon-iodine: Inhibition of excessive protease levels in chronic non-healing wounds [7]

Journal of Investigative Dermatology

Volumn 126, Issue 12, 2006, Pages 2731-2733

  Eming, Sabine A ^a   Smola Hess, Sigrun ^a   Kurschat, Peter ^a   Hirche, Doris ^a   Krieg, Thomas ^a   Smola, Hans ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b Paul Hartmann AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DISINFECTANT AGENT; MATRIX METALLOPROTEINASE; PLASMIN; POVIDONE IODINE;

CHRONIC WOUND; DECUBITUS; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; GRANULATION TISSUE; HUMAN; LEG ULCER; LETTER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TISSUE LEVEL; TISSUE REGENERATION; WOUND DRESSING; WOUND HEALING; WOUND HEALING IMPAIRMENT; ZYMOGRAPHY;

CHRONIC DISEASE; HUMANS; LEG ULCER; PEPTIDE HYDROLASES; POVIDONE-IODINE; PROTEASE INHIBITORS; VENOUS INSUFFICIENCY; WOUND HEALING;

EID: 33751112476     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700474     Document Type: Letter

References (16)

1. Cooper ML, Laxer JA, Hansbrough JF (1991) The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes. J Trauma 31:775-82
2. Fleischer W, Reimer K (1997) Povidone-iodine in antisepsis - state of the art. Dermatology 195(Suppl 2):3-9
3. Fumal I, Braham C, Paquet P, Pierard-Franchimont C, Pierard GE (2002) The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology 204(Suppl 1):70-4
4. James TJ, Hughes MA, Cherry GW, Taylor RP (2003) Evidence of oxidative stress in chronic venous ulcers. Wound Repair Regen 11:172-6
5. Kjolseth D, Frank JM, Barker JH, Anderson GL, Rosenthal AI, Acland RD et al. (1994) Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am Coll Surg 179:305-12
6. Lauer G, Sollberg S, Cole M, Flamme I, Stürzebecher J, Mann K et al. (2000) Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 115:12-8
7. Lineaweaver W, Howard R, Soucy D, McMorris S, Freeman J, Crain C et al. (1985a) Topical antimicrobial toxicity. Arch Surg 120:267-70
8. Lineaweaver W, McMorris S, Soucy D, Howard R (1985b) Cellular and bacterial toxicities of topical antimicrobials. Plast Reconstr Surg 75:394-6
9. Mandy SH (1985) Evaluation of a new povidone-iodine-impregnated polyethylene oxide gel occlusive dressing. J Am Acad Dermatol 13:655-9
10. Palolahti M, Lauharanta J, Stephens RW, Kuusela P, Vaheri A (1993) Proteolytic activity in leg ulcer exudates. Exp Dermatol 2:29-37
11. Reimer K, Vogt PM, Broegmann B, Hauser J, Rossbach O, Kramer A et al. (2000) An innovative topical drug formulation for wound healing and infection treatment: in vitro and in vivo investigations of a povidone-iodine liposome hydrogel. Dermatology 201:235-41
12. Smoot EC III, Kucan JO, Roth A, Mody N, Debs N (1991) In vitro toxicity testing for antibacterials against human keratinocytes. Plast Reconstr Surg 87:917-24
13. Trengove NJ, Stacey MC, MacAuley S, Bennett N, Gibson J, Burslem F et al. (1999) Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen 7:442-52
14. Vogt PM, Hauser J, Rossbach O, Bosse B, Fleischer W, Steinau HU et al. (2001) Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepis. A new concept in wound therapy. Wound Repair Regen 9:116-22
15. Wysocki AB, Grinnell F (1990) Fibronectin profiles in normal and chronic wound fluid. Lab Invest 63:825-31
16. Wysocki AB, Staiano-Coico L, Grinnell F (1993) Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Dermatol 101:64-8