Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepsis. A new concept in wound therapy

Wound Repair and Regeneration

Volumn 9, Issue 2, 2001, Pages 116-122

  Vogt, Peter M ^a   Hauser, Jorg ^a   Robbach, Oliver ^a   Bosse, Bjoern ^b   Fleischer, Wolfgang ^b   Steinau, Han Ulrich ^a   Reimer, Karen ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MUNDIPHARMA GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETASOM; LIOTHYRONINE; LIPOSOME; POVIDONE IODINE; THYROTROPIN; THYROXINE;

ADULT; ANTISEPSIS; ARTICLE; BURN; CELL SURFACE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EPITHELIZATION; FEMALE; HUMAN; HYDROGEL; IMPEDANCE; MALE; MOISTURE; NOCICEPTION; PAIN ASSESSMENT; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN GRAFT; WOUND HEALING;

ADULT; ANTI-INFECTIVE AGENTS, LOCAL; EPITHELIUM; FEMALE; HUMANS; HYDROGELS; LIPOSOMES; MALE; PILOT PROJECTS; POVIDONE-IODINE; SKIN TRANSPLANTATION; WOUND HEALING; WOUND INFECTION;

EID: 0035018318     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2001.00116.x     Document Type: Article

References (20)

1. Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature 1962;193:293-4.
2. Winter G, Scales JT. Effect of air drying and dressings on the surface of a wound. Nature 1963;197:91-2.
3. Dyson M, Young S, Pendle CL, Webster DF, Lang SM. Comparison of the effects of moist and dry conditions on dermal repair. J Invest Dermatol 1988;91:434-8.
4. Hinman CD, Maibach H. Effect of air exposure and occlusion on experimental human skin wounds. Nature 1963;200:377-8.
5. Jonkman MF, Bruin P, Hoeksma EA, Nieuwenhuis P, Klasen HJ, Pennings A, Molenaar I. A clot-inducing wound covering with high vapour permeability: enhancing effects on epidermal wound healing in partial-thickness wounds in guinea pigs. Surgery 1988; 104:537-45.
6. Jonkman MF, Hoeksma EA, Nieuwenhuis P. Accelerated epithelialization under a highly vapor-permeable wound dressing is associated with increased precipitation of fibrin (ogen) and fibronectin. J Invest Dermatol 1990;94:477-84.
7. Vogt, PM, Andree C, Breuing K, Liu PY, Slama J, Helo G, Eriksson E. Dry, moist, and wet skin wound repair. Ann Plast Surg 1995; 34:493-9. Discussion 499-500.
8. Hutchinson JJ, McGuckin M. Occlusive dressings: a microbiologic and clinical review. Am J Infection Cont 1990;18:257-68.
9. Robson MC, Heggers JP. Delayed wound closure based on bacterial counts. J Surg Oncol 1970;2:379-83.
10. Reimer K, Fleischer W, Brögmann B, Schreier H, Burkhard P. Lanzendörfer A, Gümbel H, Hoekstra H, Behrens-Baumann W. Povidine-iodine liposomes - an overview. Dermatology 1997;195: 93-9.
11. Hagedorn M, Hauptmann S, Essinger U, Kaden P, Mittermayer C. In vitro and in vivo studies of local disinfection and wound healing. Hautarzt 1995;46:319-24.
12. Gregoriadis G. The carrier potential of liposomes in biology and medicine. N Engl J Med 1976;295:704-10.
13. Niesmann MR. The use of liposomes as drug carriers in ophthalmology. Crit Rec Ther Drug Carrier Sys 1992;9:1-38.
14. Reimer K, Schreier H, Erdos G, König B, König W, Fleischer W. Molekulare effekte eines mikrobiziden Wirkstoffes auf relevante mikroorganismen: elektronenmikroskopische und biochemische Untersuchungen zu polyvidon-iod. Zentr bl Hyg Umweltmed 1997/ 1998;200:423-34.
15. Schreier H, Erdos G, Reimer K, König B, König W, Fleischer W. Molecular effects of povidone-iodine on relevant microorganisms: an electron microscopic and biochemical study. Dermatology 1997;195 (2 Suppl):111-6.
16. Nelson CV, Miller SF, Eppinger M, Finley RK. Micrografts. II: Evaluation of 25:1, 50:1, and 100:1 expansion skin grafts in the porcine model. J Burn Care Rehabil 1995;16:31-35.
17. Wutzler P, Sauerbrei A, Klöcking R, Straube E, Schacke M, Thust R, Fleischer W, Reimer K. Virucidal and chlamydicidal activities of eye drops with povidone-iodine (PVP-I) liposomes. Ophthalmic Research. In press.
18. Vogt PM, Lehnhardt M, Wagner D, Jansen V, Steinau HU. Determination of endogenous growth factors in human wound fluid temporal presence and profiles of secretion. Plast Reconstr Surg 1998; 102:117-23.
19. Lamme EN, Gustafsson TO, Middelkoop E. Cadexamer-iodine ointment shows stimulation of epidermal regeneration in experimental full-thickness wounds. Ach Dermatol Res 1998 290:18-24.
20. Clark RAF, Lanigan JM, Della Pelle P, Manseau E, Dvorak H, Colvin B. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound epithelialization. J Invest Dermatol 1982 79:264-9.