메뉴 건너뛰기




Volumn 4, Issue 2, 2015, Pages

The inflammatory microenvironment in brain metastases: Potential treatment target?

Author keywords

Brain metastases (BM); Checkpoint inhibitor; Inflammatory microenviroment; Tumor infiltrating lymphocyte (TIL)

Indexed keywords

ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; ANTIINFLAMMATORY AGENT;

EID: 84960343832     PISSN: 23043865     EISSN: 23043873     Source Type: Journal    
DOI: 10.3978/j.issn.2304-3865.2015.06.03     Document Type: Review
Times cited : (52)

References (59)
  • 1
    • 84863020427 scopus 로고    scopus 로고
    • Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    • Sperduto PW, Kased N, Roberge D, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 2012;30:419-25.
    • (2012) J Clin Oncol , vol.30 , pp. 419-425
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3
  • 2
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014;41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 3
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman WH, Pagès F, Sautès-Fridman C, et al. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012;12:298-306.
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pagès, F.2    Sautès-Fridman, C.3
  • 4
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313:1960-4.
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 5
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    • Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol 2014;232:199-209.
    • (2014) J Pathol , vol.232 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3
  • 6
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer. N Engl J Med 2015;372:2018-28.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 7
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus Ipilimumab in Advanced Melanoma
    • [Epub ahead of print]
    • Robert C, Schachter J, Long GV, et al. Pembrolizumab versus Ipilimumab in Advanced Melanoma. N Engl J Med 2015. [Epub ahead of print].
    • (2015) N Engl J Med
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 8
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
    • Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol 2015;33:1430-7.
    • (2015) J Clin Oncol , vol.33 , pp. 1430-1437
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3
  • 9
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 10
    • 84906277065 scopus 로고    scopus 로고
    • Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation
    • Roh-Johnson M, Bravo-Cordero JJ, Patsialou A, et al. Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation. Oncogene 2014;33:4203-12.
    • (2014) Oncogene , vol.33 , pp. 4203-4212
    • Roh-Johnson, M.1    Bravo-Cordero, J.J.2    Patsialou, A.3
  • 11
    • 84913537715 scopus 로고    scopus 로고
    • Invasive breast carcinoma cells from patients exhibit MenaINV-and macrophage-dependent transendothelial migration
    • Pignatelli J, Goswami S, Jones JG, et al. Invasive breast carcinoma cells from patients exhibit MenaINV-and macrophage-dependent transendothelial migration. Sci Signal 2014;7:ra112.
    • (2014) Sci Signal , vol.7
    • Pignatelli, J.1    Goswami, S.2    Jones, J.G.3
  • 12
    • 2142810865 scopus 로고    scopus 로고
    • Macrophages: modulators of breast cancer progression
    • discussion 68-72, 259-69
    • Lin EY, Pollard JW. Macrophages: modulators of breast cancer progression. Novartis Found Symp 2004;256:158-68; discussion 68-72, 259-69.
    • (2004) Novartis Found Symp , vol.256 , pp. 158-168
    • Lin, E.Y.1    Pollard, J.W.2
  • 13
    • 0037444293 scopus 로고    scopus 로고
    • Active specific immunotherapy against occult brain metastasis
    • Lu W, Su J, Kim LS, et al. Active specific immunotherapy against occult brain metastasis. Cancer Res 2003;63:1345-50.
    • (2003) Cancer Res , vol.63 , pp. 1345-1350
    • Lu, W.1    Su, J.2    Kim, L.S.3
  • 14
    • 77949890714 scopus 로고    scopus 로고
    • Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain
    • Hinton CV, Avraham S, Avraham HK. Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis 2010;27:97-105.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 97-105
    • Hinton, C.V.1    Avraham, S.2    Avraham, H.K.3
  • 15
    • 3543065871 scopus 로고    scopus 로고
    • Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells
    • Lee BC, Lee TH, Avraham S, et al. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res 2004;2:327-38.
    • (2004) Mol Cancer Res , vol.2 , pp. 327-338
    • Lee, B.C.1    Lee, T.H.2    Avraham, S.3
  • 16
    • 84873323242 scopus 로고    scopus 로고
    • Role of the systemic immune system in brain metastasis
    • Hamilton A, Sibson NR. Role of the systemic immune system in brain metastasis. Mol Cell Neurosci 2013;53:42-51.
    • (2013) Mol Cell Neurosci , vol.53 , pp. 42-51
    • Hamilton, A.1    Sibson, N.R.2
  • 17
    • 33846329139 scopus 로고    scopus 로고
    • Tumour-associated host cells participating at invasion and metastasis: targets for therapy?
    • Mareel M, Madani I. Tumour-associated host cells participating at invasion and metastasis: targets for therapy? Acta Chir Belg 2006;106:635-40.
    • (2006) Acta Chir Belg , vol.106 , pp. 635-640
    • Mareel, M.1    Madani, I.2
  • 18
    • 84879372754 scopus 로고    scopus 로고
    • Premetastatic soil and prevention of breast cancer brain metastasis
    • Liu Y, Kosaka A, Ikeura M, et al. Premetastatic soil and prevention of breast cancer brain metastasis. Neuro Oncol 2013;15:891-903.
    • (2013) Neuro Oncol , vol.15 , pp. 891-903
    • Liu, Y.1    Kosaka, A.2    Ikeura, M.3
  • 19
    • 84899037133 scopus 로고    scopus 로고
    • Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells
    • Chuang HN, Lohaus R, Hanisch UK, et al. Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells. J Vis Exp 2013;(80):e50881.
    • (2013) J Vis Exp , Issue.80
    • Chuang, H.N.1    Lohaus, R.2    Hanisch, U.K.3
  • 20
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 2009;4:e6562.
    • (2009) PLoS One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 21
    • 77953215400 scopus 로고    scopus 로고
    • Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis
    • Lorger M, Felding-Habermann B. Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am J Pathol 2010;176:2958-71.
    • (2010) Am J Pathol , vol.176 , pp. 2958-2971
    • Lorger, M.1    Felding-Habermann, B.2
  • 22
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008;13:206-20.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3
  • 23
    • 73849129203 scopus 로고    scopus 로고
    • Real-time imaging reveals the single steps of brain metastasis formation
    • Kienast Y, von Baumgarten L, Fuhrmann M, et al. Real-time imaging reveals the single steps of brain metastasis formation. Nat Med 2010;16:116-22.
    • (2010) Nat Med , vol.16 , pp. 116-122
    • Kienast, Y.1    von Baumgarten, L.2    Fuhrmann, M.3
  • 24
    • 84883681998 scopus 로고    scopus 로고
    • Natural and induced T regulatory cells in cancer
    • Adeegbe DO, Nishikawa H. Natural and induced T regulatory cells in cancer. Front Immunol 2013;4:190.
    • (2013) Front Immunol , vol.4 , pp. 190
    • Adeegbe, D.O.1    Nishikawa, H.2
  • 25
  • 26
    • 84875234590 scopus 로고    scopus 로고
    • Insights into cell-to-cell and cell-to-blood-vessel communications in the brain: in vivo multiphoton microscopy
    • Osswald M, Winkler F. Insights into cell-to-cell and cell-to-blood-vessel communications in the brain: in vivo multiphoton microscopy. Cell Tissue Res 2013;352:149-59.
    • (2013) Cell Tissue Res , vol.352 , pp. 149-159
    • Osswald, M.1    Winkler, F.2
  • 27
    • 84872686569 scopus 로고    scopus 로고
    • Characterization of the inflammatory response to solid cancer metastases in the human brain
    • Berghoff AS, Lassmann H, Preusser M, et al. Characterization of the inflammatory response to solid cancer metastases in the human brain. Clin Exp Metastasis 2013;30:69-81.
    • (2013) Clin Exp Metastasis , vol.30 , pp. 69-81
    • Berghoff, A.S.1    Lassmann, H.2    Preusser, M.3
  • 28
    • 76249106734 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors
    • Ojalvo LS, Whittaker CA, Condeelis JS, et al. Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 2010;184:702-12.
    • (2010) J Immunol , vol.184 , pp. 702-712
    • Ojalvo, L.S.1    Whittaker, C.A.2    Condeelis, J.S.3
  • 29
    • 33846293595 scopus 로고    scopus 로고
    • Probing the microenvironment of mammary tumors using multiphoton microscopy
    • Sidani M, Wyckoff J, Xue C, et al. Probing the microenvironment of mammary tumors using multiphoton microscopy. J Mammary Gland Biol Neoplasia 2006;11:151-63.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 151-163
    • Sidani, M.1    Wyckoff, J.2    Xue, C.3
  • 30
    • 84943241524 scopus 로고    scopus 로고
    • Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
    • [Epub ahead of print]
    • Berghoff AS, Kiesel B, Widhalm G, et al. Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma. Neuro Oncol 2014. [Epub ahead of print].
    • (2014) Neuro Oncol
    • Berghoff, A.S.1    Kiesel, B.2    Widhalm, G.3
  • 31
    • 77956603258 scopus 로고    scopus 로고
    • Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way
    • Pukrop T, Dehghani F, Chuang HN, et al. Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia 2010;58:1477-89.
    • (2010) Glia , vol.58 , pp. 1477-1489
    • Pukrop, T.1    Dehghani, F.2    Chuang, H.N.3
  • 32
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • Hiratsuka S, Watanabe A, Aburatani H, et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 2006;8:1369-75.
    • (2006) Nat Cell Biol , vol.8 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3
  • 33
    • 84931031427 scopus 로고    scopus 로고
    • Increased circulating CD14(+)HLA-DR-/low myeloid-derived suppressor cells are associated with poor prognosis in patients with small-cell lung cancer
    • [Epub ahead of print]
    • Tian T, Gu X, Zhang B, et al. Increased circulating CD14(+)HLA-DR-/low myeloid-derived suppressor cells are associated with poor prognosis in patients with small-cell lung cancer. Cancer Biomark 2015. [Epub ahead of print].
    • (2015) Cancer Biomark
    • Tian, T.1    Gu, X.2    Zhang, B.3
  • 34
    • 84894754747 scopus 로고    scopus 로고
    • Microenvironmental clues for glioma immunotherapy
    • Platten M, Ochs K, Lemke D, et al. Microenvironmental clues for glioma immunotherapy. Curr Neurol Neurosci Rep 2014;14:440.
    • (2014) Curr Neurol Neurosci Rep , vol.14 , pp. 440
    • Platten, M.1    Ochs, K.2    Lemke, D.3
  • 35
    • 84941022331 scopus 로고    scopus 로고
    • Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases
    • In Press
    • Berghoff AS, Fuchs E, Ricken G, et al. Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. Oncoimmunol 2015. In Press.
    • (2015) Oncoimmunol
    • Berghoff, A.S.1    Fuchs, E.2    Ricken, G.3
  • 36
    • 84907198355 scopus 로고    scopus 로고
    • Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199
    • Adams S, Gray RJ, Demaria S, et al. Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199. J Clin Oncol 2014;32:2959-66.
    • (2014) J Clin Oncol , vol.32 , pp. 2959-2966
    • Adams, S.1    Gray, R.J.2    Demaria, S.3
  • 37
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J, Mandai M, Iwasaki M, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A 2007;104:3360-5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 38
    • 84911473583 scopus 로고    scopus 로고
    • FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis
    • Takenaka M, Seki N, Toh U, et al. FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis. Mol Clin Oncol 2013;1:625-32.
    • (2013) Mol Clin Oncol , vol.1 , pp. 625-632
    • Takenaka, M.1    Seki, N.2    Toh, U.3
  • 39
    • 83555174415 scopus 로고    scopus 로고
    • Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
    • Tao H, Mimura Y, Aoe K, et al. Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells. Lung Cancer 2012;75:95-101.
    • (2012) Lung Cancer , vol.75 , pp. 95-101
    • Tao, H.1    Mimura, Y.2    Aoe, K.3
  • 40
    • 84899091942 scopus 로고    scopus 로고
    • T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases
    • Pugh SA, Harrison RJ, Primrose JN, et al. T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases. BMC Cancer 2014;14:180.
    • (2014) BMC Cancer , vol.14 , pp. 180
    • Pugh, S.A.1    Harrison, R.J.2    Primrose, J.N.3
  • 41
    • 84881229549 scopus 로고    scopus 로고
    • Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin
    • Remark R, Alifano M, Cremer I, et al. Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin. Clin Cancer Res 2013;19:4079-91.
    • (2013) Clin Cancer Res , vol.19 , pp. 4079-4091
    • Remark, R.1    Alifano, M.2    Cremer, I.3
  • 42
    • 84884413571 scopus 로고    scopus 로고
    • Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study
    • Cimino-Mathews A, Ye X, Meeker A, et al. Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study. Hum Pathol 2013;44:2055-63.
    • (2013) Hum Pathol , vol.44 , pp. 2055-2063
    • Cimino-Mathews, A.1    Ye, X.2    Meeker, A.3
  • 43
    • 77951629658 scopus 로고    scopus 로고
    • B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice
    • DiLillo DJ, Yanaba K, Tedder TF. B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. J Immunol 2010;184:4006-16.
    • (2010) J Immunol , vol.184 , pp. 4006-4016
    • DiLillo, D.J.1    Yanaba, K.2    Tedder, T.F.3
  • 44
    • 84925266488 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases
    • Berghoff AS, Ricken G, Widhalm G, et al. Tumor infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases. Histopathology 2015;66:289-99.
    • (2015) Histopathology , vol.66 , pp. 289-299
    • Berghoff, A.S.1    Ricken, G.2    Widhalm, G.3
  • 45
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015;372:320-30.
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 46
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    • Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 2015;16:257-65.
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3
  • 47
    • 84927574518 scopus 로고    scopus 로고
    • Immune modulation for cancer therapy
    • Naidoo J, Page DB, Wolchok JD. Immune modulation for cancer therapy. Br J Cancer 2014;111:2214-9.
    • (2014) Br J Cancer , vol.111 , pp. 2214-2219
    • Naidoo, J.1    Page, D.B.2    Wolchok, J.D.3
  • 48
    • 84921937656 scopus 로고    scopus 로고
    • Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues
    • Berghoff AS, Bartsch R, Wöhrer A, et al. Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues. Acta Neuropathol 2014;128:879-91.
    • (2014) Acta Neuropathol , vol.128 , pp. 879-891
    • Berghoff, A.S.1    Bartsch, R.2    Wöhrer, A.3
  • 49
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji RR, Chasalow SD, Wang L, et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 2012;61:1019-31.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1019-1031
    • Ji, R.R.1    Chasalow, S.D.2    Wang, L.3
  • 50
    • 84901415366 scopus 로고    scopus 로고
    • Alleviation of brain edema and restoration of functional independence by bevacizumab in brain-metastatic breast cancer: a case report
    • Berghoff AS, Sax C, Klein M, et al. Alleviation of brain edema and restoration of functional independence by bevacizumab in brain-metastatic breast cancer: a case report. Breast Care (Basel) 2014;9:134-6.
    • (2014) Breast Care (Basel) , vol.9 , pp. 134-136
    • Berghoff, A.S.1    Sax, C.2    Klein, M.3
  • 51
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 52
    • 84923566461 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes (TILs) and PD-L1 expression in non-small cell lung cancer brain metastases (BM) and matched primary tumors (PT)
    • Berghoff AS, Inan C, Ricken G, et al. Tumor-infiltrating lymphocytes (TILs) and PD-L1 expression in non-small cell lung cancer brain metastases (BM) and matched primary tumors (PT). Ann Oncol 2014;25:465-6.
    • (2014) Ann Oncol , vol.25 , pp. 465-466
    • Berghoff, A.S.1    Inan, C.2    Ricken, G.3
  • 53
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
    • Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012;13:459-65.
    • (2012) Lancet Oncol , vol.13 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3
  • 54
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 55
    • 84655165056 scopus 로고    scopus 로고
    • Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy
    • Harmankaya K, Erasim C, Koelblinger C, et al. Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy. Med Oncol 2011;28:1140-4.
    • (2011) Med Oncol , vol.28 , pp. 1140-1144
    • Harmankaya, K.1    Erasim, C.2    Koelblinger, C.3
  • 56
    • 84926653062 scopus 로고    scopus 로고
    • Single-center study under a French Temporary Authorization for Use (TAU) protocol for ipilimumab in metastatic melanoma: negative impact of baseline corticosteroids
    • Chasset F, Pages C, Biard L, et al. Single-center study under a French Temporary Authorization for Use (TAU) protocol for ipilimumab in metastatic melanoma: negative impact of baseline corticosteroids. Eur J Dermatol 2015;25:36-44.
    • (2015) Eur J Dermatol , vol.25 , pp. 36-44
    • Chasset, F.1    Pages, C.2    Biard, L.3
  • 57
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009;15:7412-20.
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 58
    • 84928938600 scopus 로고    scopus 로고
    • Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment
    • Kiess AP, Wolchok JD, Barker CA, et al. Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment. Int J Radiat Oncol Biol Phys 2015;92:368-75.
    • (2015) Int J Radiat Oncol Biol Phys , vol.92 , pp. 368-375
    • Kiess, A.P.1    Wolchok, J.D.2    Barker, C.A.3
  • 59
    • 84904061705 scopus 로고    scopus 로고
    • Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
    • Grimaldi AM, Simeone E, Giannarelli D, et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 2014;3:e28780.
    • (2014) Oncoimmunology , vol.3
    • Grimaldi, A.M.1    Simeone, E.2    Giannarelli, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.