Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation

Science

Volumn 351, Issue 6277, 2016, Pages 1094-1097

  Uphoff, Stephan ^a,b   Lord, Nathan D ^b   Okumus, Burak ^b   Potvin Trottier, Laurent ^b   Sherratt, David J ^a   Paulsson, Johan ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS AND CELL COMPONENTS; COLIFORM BACTERIUM; DAMAGE; DNA; GENE EXPRESSION; HETEROGENEITY; MUTATION; PROTEIN; STOCHASTICITY;

ALKYLATION; ARTICLE; AUTOFLUORESCENCE; CELL GROWTH; CELL HETEROGENEITY; CELL SUBPOPULATION; DNA ALKYLATION; DNA DAMAGE; ESCHERICHIA COLI; EVOLUTIONARY ADAPTATION; GENE EXPRESSION; GENETIC VARIABILITY; MISMATCH REPAIR; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; STATISTICS;

ESCHERICHIA COLI;

ADA PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; MESYLIC ACID METHYL ESTER; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MUTAGENIC AGENT; TRANSCRIPTION FACTOR;

ALKYLATION; DNA DAMAGE; DNA MISMATCH REPAIR; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; METHYL METHANESULFONATE; MUTAGENS; MUTATION RATE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; STOCHASTIC PROCESSES; TRANSCRIPTION FACTORS;

EID: 84960172027     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac9786     Document Type: Article

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